Revolutionary Breakthrough: One Dose of New Cholesterol Treatment Lowers Levels by 69%

The innovative drug Single Shot can reduce cholesterol levels by as much as 69%. Preliminary findings from clinical trials have not yet undergone peer review.

Known as Verve-102, this treatment could revolutionize heart attack prevention and significantly lower LDL cholesterol levels (often referred to as “bad” cholesterol) with a single injection.

While statins can achieve similar cholesterol reductions, they typically require daily administration.

“This is the future,” stated Professor Riyaz Patel, an academic from the University of London and a doctor at Barts Health NHS Trust involved in the trial – BBC Science Focus.

“This is not a fantasy; it’s reality. We are actively implementing it. I was providing this treatment to my patient during the exam.”

Unlike statins, which gradually lower cholesterol, Verve-102 aims for a one-time alteration by “turning off” a specific gene called PCSK9 in the liver. This gene is crucial in managing the levels of LDL cholesterol that the liver can detect and eliminate from the bloodstream.

In simpler terms, a reduction in PCSK9 means less LDL in the bloodstream.

“The results are stunning,” Patel remarked. “This drug disables a small segment of your DNA, and your LDL cholesterol will be permanently 50% lower thereafter. That’s a game-changer!”

Cholesterol builds up in blood vessel walls, leading to plaque formation that can obstruct blood flow.

Elevated LDL cholesterol levels heighten the risk of this buildup, prompting millions (over 40 million in the US and over 7 million in the UK) to take daily medications like statins for cholesterol management.

The VERVE-102 clinical trial included 14 participants with familial hypercholesterolemia, a genetic disorder that heightens the risk of heart disease, heart attacks, and strokes due to extremely high LDL cholesterol levels.

Initial outcomes from Verve-102 injections show that all participants reacted positively to the treatment with no severe side effects.

Responses varied by dosage. The lowest dose group experienced an average LDL reduction of 21%, while the intermediate group showed a 41% reduction, and the high-dose group saw a 53% reduction.

Remarkably, one individual in the high-dose group achieved a 69% reduction in LDL cholesterol after receiving Verve-102.

Dr. Eugene Braunwald, a distinguished medical professor and Hershey’s professor of medicine at Harvard Medical School who did not take part in the study, noted that the preliminary data is “promising” and indicates “the potential for a new era in cardiovascular disease treatment.”

Verve is actively recruiting participants for further stages of clinical trials involving even higher Verve-102 doses in the UK, Canada, Israel, Australia, and New Zealand. The final results are expected to be revealed in the latter half of 2025.

Read more:

About our experts

Professor Riyaz Patel is a consultant cardiologist and clinical academic scholar at University College London (UCL) and Barts Health NHS Trust. He is a fully funded clinician scientist with the British Heart Foundation and serves as a professor of cardiology at UCL, where he investigates the causes of heart disease, focusing on cardiovascular risks and the genetics of coronary heart disease. He has established and led new cardiovascular prevention services at Barts Heart Center.