If antibiotics don't work, drugs that destroy the outer membrane of certain bacteria may be effective against infections. It has been successful in killing bacterial species that are resistant to most treatments and is currently being tested for safety in humans.
Antibiotic resistance is a major threat to global health. Approximately 1.3 million people died worldwide in 2019, with an additional 4 million deaths. Of particular concern is carbapenem resistance. Acinetobacter baumannii (CRAB), is classified by the World Health Organization as a Priority 1 serious pathogen for the following reasons:
Source: www.newscientist.com