Microdosing LSD does not effectively treat ADHD

Taking small repeated doses of the psychedelic drug LSD does not reduce ADHD symptoms more than placebo.

Microdosing psychedelic drugs involve taking them several times a week in small amounts, sufficient to avoid experiencing hallucinations. There is little evidence to support this, but there is a broad view that this can increase happiness, creativity and focus. Additionally, some studies have reported that people who microdose as a way to treat ADHD have improved symptoms, but these studies have been observed and rely on self-reported data.

To more rigorously test the effects of drugs on ADHD, Matthias Liechti The University of Basel, Switzerland and his colleagues conducted the first randomized controlled trial of LSD microdoshing for ADHD. They recruited 53 adults living in the Netherlands or Switzerland who had been diagnosed with ADHD and experienced moderate to severe symptoms. Twenty-seven participants received 20 mirogram doses of LSD twice a week at the upper microodour limit, yet only a fifth of the standard dose, while the rest were given a placebo.

Symptoms of ADHD were assessed at the start of the study and were assessed 6 weeks later using a 54-point scale. On average, participants receiving the placebo had an average score reduction of approximately 7 percentage points. This is not a major difference, suggesting that LSD is better than a placebo for improving ADHD symptoms, says Liechti.

However, he says the dosage may have been unsuitable for treating ADHD. LSD, similar to how ADHD medications currently work, may need to be taken daily to experience a reduction in symptoms, he says Conor Murray At the University of California, Los Angeles.

“We still need to check if there is an acute dose while the drug is in your body – does it alleviate the symptoms?” Murray says. “It's kind of the first step, if not, you rarely even have to ask if there's a permanent change.”