Study: Eating Methyladaptogen-Rich Foods May Lower Epigenetic Aging Indicators

As we age, the likelihood of developing chronic non-infectious diseases increases, necessitating interventions that target the aging process. One of the measures used to assess biological aging in these interventions is an algorithm that analyzes DNA methylation patterns, referred to as epigenetic clocks. This new research focuses on identifying beneficial nutritional components such as green tea, oolong tea, turmeric, rosemary, garlic, and berries.

“We have observed numerous individuals struggling with their health,” stated Dr. Jamie L. Villanueva, a researcher at Washington University and the National University of Natural Medicine.

“The DNA methylation pattern, which acts as a chemical marker in DNA, can reveal whether a person is aging faster or slower than anticipated.”

“This research employed Horvath’s epigenetic clock, a widely recognized method, to assess changes in epigenetic age.”

Researchers studied healthy men aged 50-72 who had previously undertaken an 8-week program featuring a plant-based, nutritious diet, complemented by guidance on exercise, sleep, and stress management.

The team investigated individual dietary variations to understand why some participants exhibited greater improvements in their epigenetic age compared to others.

The findings showed that participants consuming higher amounts of methyladaptogenic foods—like turmeric, rosemary, garlic, berries, green tea, and oolong tea—experienced a notable reduction in their epigenetic age.

These positive effects remained significant even after accounting for weight changes and initial epigenetic ages, indicating a direct impact of the foods on aging markers.

“In hierarchical linear regression analyses, foods assessed as polyphenol modulators of DNA methylation, previously categorized as methyladaptogens, demonstrated a significant linear association with changes in epigenetic age after controlling for baseline epigenetic age acceleration and alterations in body weight,” the researchers explained.

The natural compounds in methyladaptogenic foods are known to influence gene behavior through their effects on DNA methylation.

Prior research has indicated that these compounds may support healthy aging and lower the risk of conditions like heart disease and cognitive decline.

Though this study involved a relatively small cohort of middle-aged men, it contributes to the expanding body of global research suggesting that diets rich in polyphenols found in vegetables, fruits, and tea are linked to slower aging.

The results reinforce previous studies on Mediterranean and traditional Japanese diets, renowned for their health benefits.

“Future studies should involve a larger and more diverse population and explore these findings using updated tools for measuring epigenetic aging,” the author noted.

“Based on current findings, this study underscores practical, food-based strategies that can help mitigate epigenetic aging and promote long-term health.”

Study published in the journal aging.

____

Jamie L. Villanueva et al. 2025. Dietary relationships with epigenetic age decline: secondary data analysis of methylated diet and lifestyle studies. aging 17(4):994-1010; doi:10.18632/aging.206240