The World’s Oldest Person Had a Youthful Microbiome and an “Extraordinary Genome.”

From January 17, 2023, to August 19, 2024, Maria Blañas Morera from Spain was formally recognized as the oldest person in the world until her passing at the age of 117 years and 168 days. To investigate the secrets behind her remarkable longevity, a team of researchers explored her genetics, microbiome, and lifestyle.

When Morera was 116, the researchers gathered samples of her blood, saliva, and stool for genetic analysis. “Her genome was exceptional, enriched with variants known to extend lifespans in other species such as dogs, worms, and flies,” noted team member Manel Esterler at the Josep Carreras Leukemia Research Institute in Barcelona, Spain.

Showing no signs of dementia, Morera also possessed numerous genetic variants that helped maintain low blood lipid levels, protecting her heart and cognitive functions, according to Esteller. “Simultaneously, she lacked genetic mutations linked to conditions such as cancer, Alzheimer’s disease, or metabolic disorders.”

The researchers discovered that her lipid metabolism was one of the most efficient recorded. “Her lipid profile was remarkable, with very low cholesterol,” Esterer mentioned. “This efficiency was tied to her modest diet and genetic traits that enabled the rapid metabolism of damaged molecules.”

Esteller noted that Morela abstained from alcohol and smoking and adhered to a Mediterranean diet comprising vegetables, fruits, legumes, and olive oil, along with three servings of sugar-free yogurt daily.

Further assessments indicated that Morela maintained a robust immune system typically seen in younger individuals, alongside a gut microbiota characteristic of much younger people.

One of the most “astonishing” findings was a high concentration of Actinobacteriota bacteria in her gut, including well-known probiotics like Bifidobacteria. This abundance typically declines with age but tends to increase among centenarians and supercentenarians, offering various anti-aging benefits, such as reducing inflammation.

The researchers believe that her yogurt intake may have continually replenished her levels of Bifidobacteria. “This may suggest that dietary interventions can be linked to prolonged lifespan by influencing gut microbiota, along with preventing obesity and other health issues,” Esterer added.

Lastly, scientists examined whether there was a significant difference between Morela’s biological age and her chronological age by constructing an epigenetic clock based on her DNA methylation. This process involves adding or removing chemical tags that regulate gene expression. “Her biological age appeared 23 years younger than her actual age, contributing significantly to her longevity,” remarked Esterer.

Previous studies indicate that supercentenarians may carry genetic mutations associated with various medical conditions, such as Alzheimer’s disease and cardiovascular issues. Nevertheless, they somehow manage to overcome these obstacles and attain extraordinary lifespans. “There are limited studies on supercentenarians, and many only focus on one aspect, like microbiomes,” explained Esteller. “Our research demonstrates that overcoming such maladies is a blend of advantageous genetics and other elements, including beneficial gut microbiota, delayed biological aging indicated by a youthful epigenome, and lifestyle factors such as avoiding smoking, alcohol, and maintaining a low-fat diet.”

Richard Farragher from the University of Brighton in the UK acknowledged that the study highlights the plethora of assessments available to longevity researchers, cautioning that a case study of one individual could risk being perceived as a scientific “So-So Story.”

He explains that there are two key reasons behind the survival of extremely long-lived individuals: “First, there’s something extraordinary about them, perhaps genetically, and second, survival biases due to their fortunate circumstances,” said Farragher.

If luck plays a role, he asserts that to substantiate her longevity, Morela belonged to a family with a history of long lifespans that wasn’t documented in the study.