13 Drugs and Supplements that May Help Slow the Aging Process of the Brain

Our actual age may differ from the age at which our brains appear to be

Julian Tromer / Aramie

Seven genes are associated with particularly fast aging in the brain, but 13 drugs and supplements can reduce their effectiveness.

The activity of many genes contributes to the difference in our actual age and biological age of the brain, defined by what our cells show, creating what is known as the brain age gap.

To find the genes that accelerate brain aging and broaden this gap, huang Z Jiang University in China and his colleagues trained a deep learning model called 3D-vit in several medical records and used others to give accurate responses.

It was then used to analyze data from nearly 39,000 people with health, genetics and lifestyle information, along with biological samples stored in UK biobanks. These participants averaged 64 years old, with about half of them female.

3D-vit identified MRI scan signatures of participants that could be used to estimate biological brain age. Signs of accelerated aging appear in particular in the brain regions known as the Lentif type nuclei involved in cognition such as attention and working memory, and in the hindlimbs of internal capsules (the internal limbs used for thought and language processing) that connect various regions to the brain’s cerebral cortex.

Huang and his colleagues also found that participants’ scores on cognitive tests decreased as the brain age gap increased.

Comparing their gene variants to the estimated brain gap size, there are flags on 64 influential genes, but Huang and his colleagues focused on seven. map, TNFSF12, GZMB, SIRPB1, gnly, NMB and C1RLin part because all of this has a particularly strong effect on brain aging.

Clinical trials also show that the activity could be targeted by 13 drugs or supplements. These include cholecalciferol, a vitamin D deficiency supplement. Dasatinibleukemia drugs; diclofenac, non-steroidal anti-inflammatory drugs; Doconexent, omega-3 fatty acids; estradiol, a type of estrogen commonly used in hormone replacement therapy. Hydrocortisone is commonly used to treat eczema. Mechamylamine, a drug that lowers blood pressure.

The others were like that nicotinePlaster Lone to relieve vaginal pain during sex during menopause. Supplements quercetin and resveratrol. Sirolimus is commonly used to suppress the immune system after kidney transplantation. and testosterone.

However, the researchers write that people should be encouraged to consider the potential risks associated with taking medications and supplements, as these interventions can have unintended negative consequences.

Many genes affect brain aging, but here the authors say that they use an approach that prioritizes people with the greatest effect. Dario Valenzano At the Leibniz Institute on Aging in Jena, Germany. “This work provides a specific target for direct follow-up experiments and clinical interventions.”

But it’s hard to know how big these genes actually affect the aging brain. Richard Shiou King’s College London. “Just having a specific genetic profile doesn’t mean that genes always play a role.”

Genes can be silenced or turned on by a variety of lifestyle and environmental factors, such as smoking and alcohol consumption. These can also predispose people to cognitive decline or brain aging.

The study uses data in the UK biobank, so it is not clear whether the findings will be translated to people all over the world, says SIOW. In other groups, such as Africa, South America and East Asia, work is needed to find it, he says.