In a recent study, researchers examined the ancient microbial DNA of 483 mammoths, preserved for over a million years. This included 440 newly analyzed unpublished samples from Steppe Mammoths dating back 1.1 million years. Through metagenome screening, contaminant filtering, damage pattern analysis, and phylogenetic inference, they identified 310 microorganisms linked to various mammoth tissues.
Ginet et al. Partial genome reconstruction of erysipelothrix, representing the oldest confirmed host-related microbial DNA from the oldest mammoth samples. Image credit: Ginet et al., doi: 10.1016/j.cell.2025.08.003.
“Envision a mammoth tooth from a million years ago,” stated Dr. Benjamin Ginette, a postdoctoral researcher at Stockholm’s Paleogenetic Centre and the Swedish Museum of Natural History.
“Imagine if it still harbors traces of ancient microorganisms that existed alongside this mammoth?”
“Our findings push the boundaries of microbial DNA research beyond a million years, unlocking new avenues for understanding how host-associated microorganisms evolved in tandem with their hosts.”
The team discovered six microbial groups consistently linked to mammoth hosts, including relatives of Actinobacillus, Pasturella, Streptococcus, and erysipelothrix. Some of these microbes may have been pathogenic.
For instance, one Pasturella bacteria identified in this study is closely related to the pathogens responsible for a fatal outbreak among African elephants.
Given that African and Asian elephants are the closest living relatives of mammoths, these results raise concerns about whether mammoths could also be susceptible to similar infectious diseases.
Remarkably, scientists have reconstructed a partial genome of erysipelothrix from a Steppe Mammoth that lived 1.1 million years ago, marking the oldest known host-related microbial DNA ever recovered.
This advances our understanding of the interactions between ancient hosts and their microbiota.
“As microorganisms evolved rapidly, acquiring reliable DNA data spanning over a million years has felt like tracing a path that continually rewrites itself,” noted Dr. Tom van der Bark of the Paleobiological Centre and the Museum of Natural History in Sweden.
“Our discoveries illustrate that ancient artifacts can retain biological insights far beyond the host genome, offering a perspective on how microorganisms influenced Pleistocene ecosystem adaptation, disease, and extinction.”
Determining the exact impact of the identified microorganisms on mammoth health is challenging due to DNA degradation and limited comparative data, but this study provides an unparalleled view into the microbiota of extinct megafaunas.
The findings suggest that multiple microbial lines coexisted with mammoths for hundreds of thousands of years, spanning vast geographical areas and evolutionary timescales, from the extinction of woolly mammoths on Lengel Island over a million years ago to their decline around 4,000 years ago.
“This research opens a new chapter in understanding the biology of extinct species,” says Professor Love Darren, a researcher at the Swedish Museum of Natural History and the Paleogenetic Centre at Stockholm University.
“Not only can researchers study the mammoth genome itself, but they can also begin to explore the microbial communities that cohabited with it.”
This study was published this week in the journal Cell.
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Benjamin Ginet et al. Ancient host-related microorganisms recovered from mammoths. Cell published online on September 2, 2025. doi: 10.1016/j.cell.2025.08.003
Source: www.sci.news
