The Picower Institute for Learning and Memory studied Drosophila neurons to understand the diversity of neuronal communication. They found that the protein complexin plays a critical role in controlling the release of neurotransmitters. The study revealed that RNA editing of complexin produces different protein versions, impacting how neurons communicate and synapses grow.
Neurons produce up to eight different versions of neurotransmitter releases, which regulate proteins and change how neurons communicate with other cells. This research by neurobiologists at the Picower Institute for Learning and Memory sheds light on the molecular mechanism behind the diversity of neural discourse. They focused on Drosophila neurons as a model for understanding fundamental properties common to neurons in various organisms. The study highlights the role of complexins in controlling neuronal communication through the release of neurotransmitters.
The research revealed that RNA editing of complexin 7A can result in up to eight different versions of the protein, which can significantly impact the communication and functionality of individual neurons. The study also showed that other important proteins involved in synaptic glutamate release, such as synapsin and Syx1A, can be edited at different levels, affecting synaptic communication. The research was supported by the National Institutes of Health, the JPB Foundation, and the Picower Institute for Learning and Memory.
Source: scitechdaily.com
