Cancer cells grow abnormally and are difficult to control. Scientists call this growth on the lining of the stomach stomach cancer. Gastric cancer is a global health concern in the United States, East Asia, and Eastern Europe. There are usually no symptoms at the time of onset, but it often affects people infected with a bacterial species called Helicobacter pylori.
Researchers have found that diagnosing stomach cancer early is difficult, so many people with stomach cancer die within five years of diagnosis. As cancer grows, it moves from the stomach to other organs, such as the kidneys and liver, through a process called metastasis, which increases the severity even further. This problem has created a need for effective early diagnostic and therapeutic targets to combat gastric cancer before metastasis occurs.
Human cells contain molecules that carry genetic information essential for the development and function of organs and body systems. This molecule is DNA And it consists of a sequence of four nucleotide bases: adenine, guanine, cytosine, and thymine.
To carry out its role, DNA undergoes two transformations through biochemical reactions. First, it is transcribed into a slightly similar but less stable molecule. RNA It is a sequence of nucleotide bases that is almost identical to DNA, except that it has uracil instead of thymine. This RNA serves as a template for protein synthesis, and there are various types. Enzymes then convert some of these RNA molecules into in particular messenger RNA or convert mRNA into protein. Proteins allow organs to grow and function.
Not all RNA molecules become proteins. What does not become protein non-coding RNA or ncRNA. These ncRNAs interact with cells and other molecules to control various processes required to form proteins from DNA for cell growth and survival.
In the past, researchers discovered a type of ncRNA called long ncRNA, which affects the body’s immune system’s ability to fight cancer cells. However, there are no studies specific to their activity in gastric cancer. Therefore, a group of Chinese biomedical researchers investigated how these ncRNAs influence the development of gastric cancer and how scientists can use their ncRNAs to predict the survival of gastric cancer patients. did.
Researchers found that normal and gastric cancer sample from global cancer database called cancer genome atlas. The normal samples were from patients without gastric cancer and served as the standard or reference point for comparison. Using the R programming language and a software package developed for biological data, they investigated which groups of ncRNAs were expressed at different levels in these patients. They used information from a genome browser called ensemble Identify protein-encoding genes located within and around differentially expressed ncRNA regions.
The researchers found that the expression levels of thousands of ncRNAs were different in gastric cancer compared to normal sample tissue. they again, 15 genes surrounding ncRNA regions that influence gastric cancer progression. They found that about 8 out of 10 ncRNAs were expressed at levels higher than those required in normal cells, and the rest were expressed at lower levels.
Additionally, the researchers investigated the time period during which ncRNAs interact with other ncRNAs and mRNAs to influence tumor growth and patient outcomes. They identified five long ncRNAs that interact with mRNA; microRNA. These long ncRNAs caused abnormal increases and decreases in protein levels within cells, influencing differences in tumor development and progression, as well as patient outcomes. They reported one microRNA that could inhibit tumor growth and serve as a potential target during therapy.
They used a statistical method called , to analyze the proportion of cells that fight infections and harmful substances. immune cellswere investigated in cancer and normal samples to determine how each cell interacts with ncRNAs and influences patient survival. The study highlighted that certain immune cells were higher depending on the age of the patient and the stage of gastric cancer in which the data was obtained. They confirmed the relationship between immunity and long ncRNA regulatory networks in gastric cancer. They identified specific immune cells whose presence increases a patient’s chance of surviving stomach cancer, and immune cells whose presence reduces survival.
With this study, the authors believe that by identifying new potential targets of specific immune cells and ncRNAs, we can assess patients’ chances of recovery and develop effective treatments for them. They concluded that further insight into the biological processes involved in gastric cancer was gained. However, the size of the cancer data is much larger than the regular data used for comparison, which may have influenced the results, the researchers reported. They emphasized the need for further research, especially laboratory analysis, to validate the findings.
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Source: sciworthy.com
