The pandemic might have accelerated brain aging, even before we contracted Covid-19.

The Covid-19 pandemic may have hastened brain aging, even prior to infection. Studies indicate that early in the outbreak, the brain may have undergone changes equivalent to 5.5 months of aging, potentially attributed to stress and shifts in lifestyle.

Many individuals suffering from long Covid report experiencing brain fog. However, the wider neurological implications of the pandemic are not completely understood a few years post-Covid-19’s emergence.

To investigate this, Ali-Reza Mohammadi-Nejad at the University of Nottingham, along with his team, trained machine learning models using 15,000 brain scans to analyze structural changes related to aging.

A model was then applied to brain scans from 996 volunteers participating in the UK Biobank Study. This comprised 564 individuals who underwent both scans prior to March 2020, which acted as the control group. The remaining 432 volunteers had one scan before March 2020 and another later, with scans averaging three years apart and a minimum gap of two years.

The research revealed that the pandemic may have induced an acceleration of brain aging by 5.5 months, as evidenced by structural changes in both white and gray matter. This effect was also observed in individuals who had recorded Covid-19 infections as part of the Biobank project.

This accelerated aging effect was notably more significant among men and those from lower socioeconomic backgrounds. However, the results may not be generalizable, as biobank participants typically exhibit better health, higher income, and less ethnic diversity than other demographics within the UK.

Researchers propose that these alterations might have been driven by the isolation and stress of lockdowns, alongside changes in lifestyle factors like physical activity and alcohol use during that period.

In their study, the authors indicate that these structural brain changes could be “at least partially reversible,” while also acknowledging limitations stemming from the study’s UK-based participant pool, suggesting that the findings may not accurately represent lockdowns’ impact elsewhere. “Our conclusions may actually underestimate the pandemic’s effects on more vulnerable populations,” Mohammadi-Nejad asserts.