Scientists mapped every nerve cell in this insect brain

This diagram shows every nerve cell (multicolor) in a baby fruit fly brain. Each sphere represents a cell body. The elongated tails show the branches that send and receive information between neurons. The connections between the cells, known as synapses, aren’t visible here.

The wiring of one insect’s brain is now pretty much mapped out.

Human brains, which are estimated to have more than 80 billion neurons, are very hard to study. But many animals have smaller brains with fewer neurons. That makes them useful for learning how brains work.

Until now, just three animals have had their brains diagrammed to this level of detail. One was a tube-shaped marine critter called a sea squirt. The two others were types of worms. But those creatures have at most about 1,500 neurons in their entire body. The scientists who did the new study wanted to understand much more complex animals, whose brains alone contain thousands of neurons.

The team started sketching out the larval fruit fly brain 12 years ago, says Marta Zlatic. She’s also a neuroscientist at the MRC Laboratory of Molecular Biology.

First, Zlatic, Cardona and their colleagues captured images of the entire larval fruit fly brain. They did this using a powerful tool for zooming in on tiny things called an electron microscope. The researchers stitched those images together using a computer. Then they manually traced each neuron to create a 3-D virtual model of all the cells.

In all, the 3-D model revealed more than 3,000 neurons and about 550,000 connections.

In the brain, collections of neurons called circuits work together to process information. So, the team explored how lots of neurons are connected to form circuits in fruit flies. The researchers examined neurons directly linked to one another. They also looked at distantly connected neurons that are not directly linked — kind of like finding connections between distant relatives in a family tree. Neural connections at this broader scale form what is called a connectivity pattern.

The connectivity patterns found in the fruit fly brain revealed 93 different types of neurons. Cells within each type share a similar pattern of connections to other cells. These groupings matched up with other features shared by the neurons, including shape and function.

Some neurons were extremely well-connected. They were directly linked with 20 or more other neurons. Nearly 75 percent of these neuron “hubs” were tied to the brain’s learning center — which goes to show how important learning is for these animals.

Although this work took 12 years, technology has vastly improved since the project began, Zlatic says. It would not take nearly as long if repeated today. But this whole-brain map may serve as a blueprint for other scientists studying brain circuitry, Zlatic says. “Now, we have a reference map.”

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Category: Technology

Source: Science News Explores