In an extensive community-based investigation, researchers from the Fatty Acid Institute identified a weak yet statistically significant inverse relationship between various inflammatory biomarkers and omega-6 fatty acids.
This image features Oenothera biennis, plants that produce oils with a high linolenic acid content. Image credit: Georg Slickers/CC by-sa 4.0.
“Chronic inflammation is acknowledged as a significant risk factor for various health disorders,” stated President William Harris of the Fatty Acid Institute and his colleagues.
“Omega-6 fatty acids, especially linoleic acid (LA) and arachidonic acid (AA), have been identified as either anti-inflammatory or pro-inflammatory agents. Researchers have considered both positions regarding dietary intake.”
The researchers utilized data from the Framingham Offspring study, a prominent cohort study in the Boston region.
This groundbreaking longitudinal research initiative began in 1971 and follows children from the original Framingham Heart Study, examining genetic and lifestyle factors influencing cardiovascular and metabolic health.
It has yielded valuable insights into chronic disease risks and prevention for decades, establishing itself as one of the most dependable sources for understanding long-term health trends.
This investigation is cross-sectional, meaning LA and AA levels were evaluated alongside 2,700 inflammation-related biomarkers in the same blood samples.
We statistically analyzed the association between the levels of these two omega-6 fatty acids and the levels of 10 blood and urine biomarkers related to inflammation and oxidative stress.
After statistically controlling for several potential confounding variables (such as age, race, gender, smoking status, blood pressure, and weight), researchers discovered that elevated LA levels were significantly linked to lower levels of five out of the 10 biomarkers.
For AA, higher levels were associated with reduced concentrations of four markers; however, there was no statistically significant relationship with higher inflammation/oxidation levels, unlike LA.
“These new findings clearly indicate that individuals with the highest LA (and AA) levels in their blood exhibit less inflammation than those with lower levels,” Dr. Harris remarked.
“This result contradicts the expectation if omega-6 fatty acids were deemed ‘pro-inflammatory.’ In fact, they seem to exhibit anti-inflammatory properties.”
“Amidst discussions in the media about the dangers of seed oils—the primary source of LA in diets—numerous voices advocate for reducing LA consumption.”
“This recommendation lacks a scientific basis, and this study, along with others, suggests the opposite: rather than decreasing LA intake, increasing it may be the healthier choice.”
“These findings diverge from the prevailing narrative but are consistent with earlier studies.”
“Numerous studies within medical literature support the findings presented here.”
The study was published in the journal Nutrients on June 22nd.
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Heidi T.M. Lai et al. 2025. Erythrocyte omega-6 fatty acids and biomarkers of inflammation in the Framingham offspring study. Nutrients 17 (13): 2076; doi: 10.3390/nu17132076
Source: www.sci.news
