Scientists sequenced and analyzed the genomes of seven people who lived between 42,000 and 49,000 years ago in Ranis, Germany, and Zlatiks, Czech Republic. As a result, the Ranis and Zlati Kush were linked by distant kinship ties, and that they were part of the same small, isolated group, representing the deepest known split from lineages outside Africa. was shown. The Ranis genome contains a Neanderthal component derived from a single admixture event common to all non-Africans, which the authors date back 45,000 to 49,000 years ago. This means that all non-African ancestors sequenced so far existed in a common population during this time, and further The human remains suggest that they represent a distinct non-African population.
Illustration of the Zlati Kush, who belonged to the same group as the Ranis and had close relationships with two of them. Image credit: Tom Björklund / Max Planck Institute for Evolutionary Anthropology.
Dr. Alev Schumer of the Max Planck Institute for Evolution said, “After modern humans left Africa, they met and interbred with Neanderthals, and as a result, approximately 2 to 3 percent of Neanderthal DNA is present in all areas outside Africa.'' It's in people's genomes.” Anthropology and its colleagues.
“However, little is known about the genetics of Europe's first settlers or the timing of interbreeding between Neanderthals and non-Africans.”
“An important site in Europe is Zlaty Kush in the Czech Republic, where the complete skull of a single individual who lived about 45,000 years ago was discovered and previously genetically analyzed.”
“However, due to the lack of archaeological context, we were unable to link this person to an archaeologically defined group.”
“Ilsenhöhle, located in Ranis, Germany, about 230 km from the nearby site Zlatiks, is known for a particular type of archeology, Rincombi-Ranissian-Jersmanovičian (LRJ), dating back about 45,000 years. ”
“It has long been debated whether the LRJ culture was created by Neanderthals or early modern humans.”
“Although most small bone fragments have been preserved at Ranis, previous research was able to analyze mitochondrial DNA from 13 of these remains, indicating that they belong to modern humans rather than Neanderthals. It turns out.”
“However, because mitochondrial sequences represent only a small portion of genetic information, their relationship to other modern humans has remained a mystery.”
In the new study, the authors analyzed the nuclear genomes of 13 specimens taken from Ranis and found that they represented at least six individuals.
Based on the size of the bones, it was determined that two of the children were infants, and that three were genetically male and three were female.
Interestingly, these individuals included mothers and daughters as well as more distant biological relatives.
The researchers also sequenced more DNA from the female skull found in Zlati Kush, producing a high-quality genome for this individual.
“To our surprise, we discovered that there is a fifth or sixth degree genetic relationship between the two people from Zlati Kush and Ranis,” Dr. Schumer said.
“This means that Zlati Kush is genetically part of an extended family of Ranis and likely created LRJ-type tools as well.”
Of the six Ranis bones, one bone is particularly well preserved, in fact, it is the best preserved modern human bone from the Pleistocene for DNA searches.
This allowed the research team to obtain a high-quality genome from this male individual, called Ranis13.
Together, the Ranis13 and Zlatý kůň genomes represent the oldest high-quality living human genome sequenced to date.
Analyzing genetic variation associated with phenotypic traits, scientists found that Ranis and Zlati Kush individuals carried mutations associated with dark skin and hair color, as well as brown eyes. I did. This reflects the recent African origins of this early European population.
By analyzing parts of the genomes of Ranis and Zlati Kush inherited from the same ancestor, the authors found that their populations consisted of at most a few hundred individuals and were spread over a larger area. We estimate that there is a possibility.
They found no evidence that this small early modern human population contributed to later European or other world populations.
The Zlati Kush/Ranis people coexisted with Neanderthals in Europe, raising the possibility that Neanderthals were among their recent ancestors after they migrated to Europe.
Previous studies of modern humans dating back more than 40,000 years have found evidence of recent admixture between modern humans and Neanderthals.
However, no such evidence for recent Neanderthal admixture was detected in the genomes of Zlati-Kush/Ranis individuals.
Illustration by Zlatý kůň/Ranis group. Image credit: Tom Björklund / Max Planck Institute for Evolutionary Anthropology.
“The fact that no such Neanderthal ancestry remains in Ranis and Zlati Kush, while modern human populations that may have later arrived in Europe inherited such Neanderthal ancestry. is an older Zlati Kush/Ranis lineage This could mean that they entered Europe by a different route or may not have overlapped with the areas inhabited by Neanderthals.''Also Max Planck. said Dr. Kay Pruefer of the Institute for Evolutionary Anthropology.
The Zlati Kush/Ranis population represents the earliest divergence from modern human groups that migrated from Africa and later dispersed across Eurasia.
Despite this early separation, the Neanderthal ancestry of Zlatikush and Ranis derives from the same ancient admixture event that can be detected in all peoples outside Africa today.
By analyzing the length of Neanderthal-contributed segments in the high-coverage Ranis13 genome and using direct radiocarbon dating of this individual, researchers found that this common Neanderthal admixture dates back to 45,000 years ago. It was estimated to be 49,000 years old.
Since all modern non-African populations share this Neanderthal ancestry with the Zlati Kush and Ranis, this means that approximately 45,000 to 49,000 years ago, non-African populations of consistent ancestry still existed. It means you must have done it.
Dr Johannes Kraus, a researcher at the Max Planck Institute for Evolutionary Anthropology, said: “These results provide a deeper understanding of the early pioneers who settled in Europe.”
“They also suggest that the remains of modern humans more than 50,000 years old found outside Africa have interbred with Neanderthals and are part of the general non-African population now found in many parts of the world. This indicates that it may not have been the case.”
of findings Published in today's magazine nature.
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AP Sumer others. The genomes of the earliest modern humans constrain the timing of admixture with Neanderthals. naturepublished online on December 12, 2024. doi: 10.1038/s41586-024-08420-x
This article is adapted from the original release by the Max Planck Institute for Evolutionary Anthropology.
Source: www.sci.news
