Aquariums in the aquatic tail, called Newt, have a large genome with many repetitive factors. It is unknown how these elements form genome and relate to the unique playback ability of Newt. In the new research, scientists Carolinska Research Institute In other places, a chromosomal scale genomic sequence was generated. Newt with Iberia ribs (Pleurodeles Waltl)。
brown et al。 We present a chromosome scale assembly of 20.3 GB genome with Iberian ribs (Pleurodeles Waltl), It has an unprecedented continuity and integrity between giant genomes. Image credit: Brown et al。 , Doi: 10.1016/j.xgen.2025.100761.
Iberia's ribs, which are also known as gully parts or Spanish ribs, are a species of Newt. Climate disease To Spain, Portugal, Morocco.
This kind is known for its wide flat head and sharp RIB bone that can make a hole in its side.
Men measure up to 31 cm (12.2 inches) for men and up to 29 cm (11.4 inches) for women. North African specimens are smaller than European population specimens.
“Iberia's Ribbal Newt boasts an impressive playback roster that can reconstruct lost limbs and regenerate damaged organizations of complex organs, brain, heart, and eyes,” he said. A research institute professor Andas Simon and his colleagues said.
“The use of this model type is greatly enhanced by high -quality genomic assembly and annotation.”
“But this was a challenge for a considerable concentration of a large 20 GB genomal size and a repeated element sequence.”
The authors have discovered that repeated elements account for 74 % of Iberia's ribs of Newt genome content.
“This was a technical challenge, but I succeeded in a more detailed mapping that was more comprehensive than other species of similar genome size,” said Simon.
“We have determined the accurate position of both protein cord sequences and non -coded sequences of each chromosome,” said Karolinska Institute Ph.D. Student Ketan Michela.
“In addition, we have identified which protein corded gene is lacking in the genome of the newt, or has more copies than other species.”
“The result is an important resource for researchers in several fields, such as the evolution, regeneration and development of development of genome, and cancer biology.”
“The next step of the research is to focus on functional research. This is to manipulate the molecular process and determine how these will affect the regenerative ability.”
“In addition, we plan to conduct comparative research with other species to further understand these mechanisms.”
Survey results It will be displayed in the journal Cell genomics。
______
Thomas Brown et al。 The chromosome genome assembly reveals how the repetitive errors form a non -coding RNA landscape that is active during the rehabilitation of the neut limb. Cell genomicsReleased online on January 27, 2025. Doi: 10.1016/j.xgen.2025.100761
Source: www.sci.news
