Covid-19 Affects Blood Vessel Aging, Particularly in Women

Covid-19 seems to speed up the aging of blood vessels, particularly in women.

The virus has been linked to cardiovascular issues such as heart disease, although the exact mechanisms remain unclear. For further insights, see Rosa Maria Bruno from the University of Parisite and her research team, who studied 2,390 individuals with an average age of 50 across 16 nations, including the UK and US, from September 2020 to February 2022.

Participants included those testing positive for Covid-19 viruses or for antibodies without vaccination, alongside others who were negative for both without past infections.

The health of their arteries was evaluated by measuring the speed of pressure wave transmission between the carotid artery in the neck and the femoral artery in the foot. This assesses arterial stiffness, which naturally increases with age and elevates heart disease risk.

Findings indicated that confirmed SARS-CoV-2 infections were related to increased arterial stiffness in women. This correlation appeared to grow with infection severity; for instance, women hospitalized for Covid-19 showed an average arterial age roughly five years greater than their uninfected peers, rising to 7.5 years among those who needed intensive care.

Researchers accounted for other factors influencing arteriosclerosis, such as smoking and obesity.

However, no similar findings were present in men. Earlier studies indicate that women tend to have stronger responses to infections than men, and an inability to modulate immune responses can result in inflammatory damage. Bruno expressed hope for observable gender differences but noted that this study didn’t yield significant ones.

The results also shed light on long Covid, which is more prevalent among women. After six months, arterial stiffness in women showed slight improvement, yet remained notably high in patients with ongoing Covid-19 complications. “Our study demonstrated measurable changes in blood vessels correlating with the symptoms of long Covid patients,” said Bruno.

Some individuals in the uninfected group may have experienced mild infections unbeknownst to them, potentially influencing the study’s validity.

Regardless, Vassilios Vassilio from the University of East Anglia highlighted the study’s robustness, asserting it could aid in identifying individuals affected by long Covid. “This research marks the first large, international multicenter investigation confirming an association between COVID-19 and accelerated vascular aging,” he noted. “The findings enhance comprehension of mechanisms post-Covid-19 syndrome and may pave the way for targeted pharmaceutical approaches.”