If you’re not a lipid researcher or a health podcast enthusiast, you may not be familiar with apolipoprotein B-100. This protein, produced in the liver, plays a crucial role in moving dietary fat and cholesterol within the body. It binds these substances to cells for utilization, storage, or elimination.
Despite its relative obscurity, ApoB has gained attention as a means to predict cardiovascular disease risk more accurately than traditional cholesterol tests. Recent studies, like the 2021 research published in Lancet Health and Longevity, have highlighted ApoB as an essential indicator in assessing cardiovascular health. The findings suggest that elevated levels of ApoB are linked to a higher risk of heart disease, stroke, and diabetes, leading to a shorter lifespan.
While LDL cholesterol testing is a common method to assess cardiovascular risk, measuring ApoB can provide a more detailed perspective. ApoB binds to various lipoproteins, including LDL, VLDL, IDL, and LP(a), which can accumulate in arteries and contribute to blockages. Experts like Dr. Katherine Ranken emphasize the importance of ApoB testing in evaluating atherogenic lipoproteins for a more precise cardiovascular risk assessment.
Although ApoB testing is not widely available through public healthcare systems, private options exist for individuals seeking more in-depth insights into their cardiovascular health. However, the utility of ApoB testing, particularly in relation to lifestyle interventions, remains an area of ongoing research and debate.
Ultimately, understanding ApoB scores and their implications can be valuable for individuals looking to take a proactive approach to their cardiovascular health. While private testing options may appeal to some, concerns persist regarding the potential exploitation of health anxieties and the need for adequate support for individuals with elevated ApoB scores.
About our experts
Dr. Katherine Ranken is a consultant at University College London Hospital specializing in diabetes, dyslipidemia, and cardiovascular risk prevention research.
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Source: www.sciencefocus.com
