Magnetic Gel: A More Effective Solution for Kidney Stone Removal

Devices utilizing magnets may offer a more efficient method for removing kidney stones compared to traditional techniques, potentially reducing the necessity for repeated surgeries.

Kidney stones form when minerals in urine crystallize. If they become lodged in the kidneys or move into the ureters, the tubes connecting the kidneys to the bladder, they can lead to significant discomfort.

Current treatments often involve breaking the stones into smaller pieces through methods such as guiding a thin tube with a laser through the bladder into the ureters and kidneys, or applying ultrasound waves externally.

Surgeons typically extract these fragments individually using a wire basket that passes in and out of the urethra. This repetitive retrieval process can result in tissue damage. About 40% of the time, residual debris is left behind, particularly if small particles evade the basket, increasing the risk of additional stones.

Seeking alternatives, Joseph Liao and his team at Stanford University in California previously engineered a magnetic gel designed to coat stone debris and a magnetic wire to capture it in lab settings.

Recently, they implemented this method in a study involving four pigs. They introduced various fragments of human kidney stones into the pigs’ kidneys before injecting the magnetic gel. By utilizing a magnetic wire inserted through the urethra, the researchers managed to extract multiple stone fragments simultaneously, unlike the traditional wire basket method that retrieves them one at a time. “It’s like using a stick to fish out a snot filled with stone debris, allowing for the removal of significant amounts of stone fragments at once,” explained Liao.

This technique appears to cause less tissue damage than conventional methods since fewer invasive procedures are necessary. Unlike wire baskets, the magnetic device effectively captures debris of varying sizes, permitting thorough removal of all remnants from the kidney, as noted by Rio. This not only decreases the chance of new stones forming but also curtails the need for additional surgeries.

“This is a very promising method,” states Veronica Magdanz from the University of Waterloo, Canada, who was not involved in the research. “Any advancement that enhances the success rate of stone collection and facilitates the removal of more pieces at once is advantageous.”

None of the pigs exhibited any adverse reactions to the gel. “This is excellent news. It is non-toxic and harmless,” Magdanz remarked. After refining the technique through further pig studies, Rio and his team aim to begin human trials within approximately a year.