Having low levels of “bad” cholesterol in your blood can decrease the risk of developing dementia, according to recent Korean studies published in the Journal of Neurology, Neurosurgery and Psychiatry. While the connection between low-density lipoprotein cholesterol (LDL-C) and heart health is well-known, its impact on brain health and dementia is still being studied.
Scientists analyzed data from 11 university hospitals in Korea, studying 571,000 adults without dementia. Participants were divided into two groups based on their cholesterol levels, with one group having high LDL-C levels above 3.4 mmol/L or 130 mg/dL, and the other group having low LDL-C levels below 1.8 mmol/L or 70 mg/dL.
The study found that individuals with low LDL-C were at a lower risk of developing dementia, with a 26% lower likelihood of being diagnosed with any type of dementia and a 28% reduced risk of Alzheimer’s disease compared to the high LDL-C group. However, extremely low LDL-C levels below 1.4 mmol/L or 55 mg/dL did not show a significant decrease in dementia risk.
Additionally, the study observed that individuals in the low LDL-C group who took statins to lower their cholesterol levels had a 13% lower risk of dementia and a 12% lower risk of Alzheimer’s disease compared to those not taking statins.
While the study found a significant association between low LDL-C levels and reduced dementia risk, it had some limitations, such as being a retrospective study that did not consider other influencing factors like age, gender, genetic risk, and lifestyle. The study did not establish a causal link between LDL-C and dementia risk, emphasizing the need for further research.
Dr. Petra Proitsi, a genetic epidemiologist at Queen Mary University, London, acknowledged the complexity of the relationship between cholesterol and dementia, calling for more comprehensive studies involving diverse ethnic groups to explore this association further.
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About our experts:
Dr. Petra Proitsi is a genetic epidemiology specialist at the Preventive Neurology Centre at Queen Mary University, London. She leads themes of digital and health data science at the Wolfson Institute of Population Health and holds a PhD in Neuroscience from King’s College London.
Source: www.sciencefocus.com
