New research shows that satiety-inducing molecules called bombesins are present not only in humans and other vertebrates, but also invertebrates such as starfish and their marine relatives.
Common starfish (Rubens of Asteria) Brofjorden is located in Govik, the Lysekil municipality in Sweden. Image credit: W. Carter.
Bombesin, a small peptide, plays an important role in regulating hunger by signaling when it is sufficient for us to eat.
That name is from Toad lit (Bombina Bombina) from its skin, the peptide was first isolated in 1971.
When injected into mammals, bombesin was found to reduce the size of the meal and increase the time between meals.
This has led scientists to believe that bombesin-like neurohormones produced in the brain and intestines are part of the body’s natural system to control food intake.
Furthermore, along with weight loss inducers such as Ozempic, compounds that mimic the action of bombesin are occurring for the treatment of obesity.
In a new study, Professor Maurice Elphick and colleagues at Queen Mary University in London explored the evolutionary history of bombesin.
By analyzing the genome of invertebrates, they discovered a gene encoding a bombesin-like neurohormone. Common starfish (Rubens of Asteria) other cerebral dermatosis, such as sea urchins and sea cucumbers.
“It was like searching for needles in a haystack, but eventually we discovered a gene encoding a bombesin-like neurohormones in the genome of a starfish and its parent,” Professor Elphick said.
Researchers then turned their attention to the function of the bombesin in this starfish, named Arbn.
Mass spectrometry was used to determine the molecular structure of ARBNs and to be chemically synthesized and tested.
They investigated how ARBN affects starfish feeding behavior. Starfish have a unique way of eating. The stomach is stretched out from the mouth to digest prey such as mussels and oysters.
“When I tested Arbn, I found that it caused a starfish stomach contraction,” said Dr. Weiling Huang, a researcher at Queen Mary University in London.
“This suggested that ARBN may be involved in stimulating stomach contractions when starfish stop feeding.”
“And this is exactly what I found. When I injected Albun into the starfish while pounding my stomach, it caused my stomach and returned it to my mouth.”
“In addition, it took longer to surround the mussels compared to those injected with ARBN, which also delayed the onset of feeding.”
The discovery of the ancient role of bombesin in appetite regulation sheds light on the evolutionary origins of animal feeding behavior.
“We can estimate that this function dates back 5 billion years to the common ancestors of starfish, humans and other vertebrates,” Professor Elphick said.
a paper Regarding the survey results, Proceedings of the National Academy of Sciences.
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Heiling Han et al. 2025. Discovery and functional characterization of bombesin-type neuropeptide signaling systems in invertebrates. pnasin press; doi: 10.1073/pnas.2420966122
Source: www.sci.news
