The ‘fountain of youth’ isn’t locked away in a philosopher’s stone or a mythical body of water, according to new research. In fact, US scientists say the key to slowing aging is hidden within our bodies.
It was announced in new research that: The secret to anti-aging lies in white blood cells known as T cells. The researchers behind the study discovered that these cells can be reprogrammed into senescent cell-killing machines known as CAR (chimeric antigen receptor) T cells.
When they tested this treatment on mice, they lost weight, improved their metabolism and glucose tolerance, increased physical activity, and led healthier lives. Moreover, there is no tissue damage or toxicity.
“If you give this to old mice, it rejuvenates them. If you give this to young mice, it slows down the aging process. There are currently no other treatments that can do this.” Corina Amor Vegas is an assistant professor at Cold Spring Harbor Laboratory (CSHL) in the United States and one of the authors of the paper.
Researchers call this treatment a “living drug.” That’s because when CAR T cells are genetically modified, they become more aggressive in attacking a group of cells known as senescent cells.
Senescent cells are responsible for many of the conditions and diseases that develop as we age, such as obesity and diabetes. As the years go by, we accumulate more and more of them, and this causes a buildup of harmful inflammation. However, CAR T cells may be able to eliminate them and slow the effects of aging.
This treatment is already approved in the United States to treat blood cancers. But this is the first time scientists have shown that CAR T cells can slow or even reduce the effects of aging.
There are already drugs that can eliminate senescent cells, but these must be taken repeatedly. The effects of CAR T cells, on the other hand, are long-lasting. If he takes one dose when he is young, he will be protected for life.
“With CAR T cells, you could potentially get away with just one treatment. For chronic diseases, this is a big advantage. Think about the patients who need treatment,” said Amor Vegas. If administered intravenously, it will be fine for several years. ”
Scientists will then investigate whether the cells not only make you healthier for the rest of your life, but also help you live longer.
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Source: www.sciencefocus.com
