Nobel Prize in Chemistry Honors Breakthroughs in Molecular Architecture

The 2025 Chemistry Award recognizes Beijing U, Richard Robson, and Omar Yaghi for their innovative work on materials featuring cavities that can absorb and release gases like carbon dioxide, also known as metal-organic frameworks.

Heiner Linke, chair of the Nobel Committee on Chemistry, stated, “A small sample of such material can function like Hermione’s bag from Harry Potter.”

Tens of thousands of metal frameworks are currently in exploration. These materials present various potential applications, from capturing CO₂ emissions to permanently purifying chemicals and extracting water from the atmosphere.

In the late 1980s, Richard Robson from the University of Melbourne pioneered the first metal-organic framework, drawing inspiration from the structural organization of diamonds. He discovered the feasibility of using metal ions as junctions connected by carbon-based or organic molecules.

When metal ions and organic compounds combine, they naturally form an organized framework. While the cavity in the diamond structure is petite, metal framework cavities can be significantly larger.

Robson’s metal-organic framework was initially filled with water. Kitagawa from Kyoto University in Japan was the first to devise a framework robust enough to retain stability when dried, allowing for gas to occupy the empty cavities.

“He demonstrated that gas could be absorbed, retained, and released by the material,” remarked Olof Ramström of the Nobel Committee on Chemistry.

Kitagawa also developed an organic-metal framework that changes form depending on gas absorption and release.

Omar Yaghi, from the University of California, Berkeley, achieved a more stable framework using clusters of zinc and oxygen metal ions along with linkers featuring carboxylate groups.

“This framework was remarkable due to its stability, enduring temperatures up to 300 degrees Celsius,” Ramström noted. “What’s even more impressive is that it possesses a vast surface area. Just a few grams of this porous material equate to the surface area of a large soccer field, similar to that of a small sugar cube.”

Yaghi also revealed that the cavities within these materials can be enlarged merely by extending their lengths.

Following these significant advancements, the field has seen rapid growth, as Ramström stated, “We are witnessing the development of new metal-organic frameworks almost on a daily basis.”