Blood donation may not be purely altruistic
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Frequent blood donors may be gaining more than a warm, ambiguous feeling from altruism, as giving blood can increase their ability to produce healthy blood cells and potentially reduce the risk of developing blood cancer.
Hector Huerga Encabo The Francis Crick Institute in London and his colleagues analyzed genetic data extracted from blood cells donated from 217 German men aged 60 to 72 years old. They also looked at samples from 212 men of similar age who donated their blood less than 10 times and found that frequent donors were likely to have blood cells with specific mutations in the genes called. dnmt3a.
To understand this difference, the team added genetically engineered human blood stem cells that produce all blood cells in the body along with these mutations, along with unmodified cells, to the lab dish. To mimic the effects of blood donation, they also added a hormone called EPO. This was the body produced it later and added it to part of the dish.
After 1 month, cells with frequent donor mutations grew 50% faster than cells without mutations, but only in dishes containing EPO. Without this hormone, both cell types would have grown at similar rates.
“It suggests that all blood donation, you have a burst of EPO in your system, and this will support the growth of these cells dnmt3a Mutations,” Encabo says.
To investigate whether it would be beneficial to enable more effectiveness of these mutated blood cells, the team mixed with cells with mutations that cause the risk of leukemia, and again discovered that in the presence of EPO, frequent don cells can effectively lay other blood cells. this is, dnmt3a Mutations are beneficial and may inhibit cancer cell growth, Encabo said.
“It appears that blood donations provide selection pressure to improve stem cell fitness and capacity to fill up.” Ash Toy At the University of Bristol, UK. “It may not only save someone’s life, it may also increase fitness in the blood system.”
I say it needs more work to see if this is really true Markman Soor University College London provides a very simplified picture of what happens in the body of a lab experiment. “This should be examined across much larger cohorts, different ethnicities, women and other age groups,” Mansour says. He also points out that there is no donor. dnmt3a Mutations may not see this benefit.
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Source: www.newscientist.com
