Itching is a dominant symptom of dermatitis (eczema), and scratch promotes skin inflammation, which deteriorates the disease. However, it is almost unknown whether scratching can make the spots and the lord benefit the mechanism that worsens inflammation. New research conducted in the mouse reveals the double nature of scratching. It can worsen skin inflammation, but can also increase immunity against bacterial infections at the site of injury.
Scratch is synergistic with the activation of FCεRI mast cells and promotes inflammation of allergic skin. Image credit: LIU et al。 , Doi: 10.1126/Science.adn9390.
Scratch is an attractive, typical, evolved behavioral reaction to the sensation of itching of the skin.
In many common skin diseases such as dermatitis, prolonged itching is a dominant symptom, indicating a substantial source of affection.
In response to itching, scratch is well -clinically recognized to worsen dermatitis, and some diseases are pathogenic.
However, itching is often a fun feeling and does not cause evasion behavior. This suggests that it can have some benefits to the host.
“Scratch is often fun. This suggests that this behavior must be a profit to evolve,” said Professor Daniel Kaplan of Pittsburgh University.
“Our research helps solve this paradox by providing evidence that scratches also provide bacterial defense against skin infections.”
How to use a new genetic modification mouse model to eliminate the function of neurons that senses itching, called non -peptide giku 2 (NP2), is in the relationship between scratches, injuries, and inflammation. We investigated whether it will affect.
They discovered that they revitalized neurons that sensed the pain that releasing a substance P (SP) when scratched.
However, scratch can worsen problems such as dermatitis, but reducing bacteria can help you to use immune protection. Staphylococcus aureusInfection.
Furthermore, the wound affects the microorganisms in the skin at the damaged site, and can prevent the imbalance of microorganisms, but chronic conditions such as atopic dermatitis complicate this.
The survey suggests that scratching functions as a pathological factor in inflammation and as an evolved mechanism to strengthen protection against infections.
“Discover that scratch improves defense Staphylococcus aureus It suggests that some context may be useful, “said Professor Kaplan.
“But if the itch is chronic, the damage caused by the skin will probably exceed this advantage.”
Survey results It will be displayed in the journal Science。
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Andrew W. Rue et al。 2025. Scratch promotes allergic inflammation and host defense through the activation of nerve gesturing mast cells. Science 387 (6733); DOI: 10.1126/Science.adn9390
Source: www.sci.news
