A recent study brings hope for adults living with severe peanut allergies, revealing that they can develop tolerance in just a few weeks.
Researchers gradually introduced 21 adults with severe allergies to peanut products.
By the conclusion of the trial, 14 participants could safely consume a handful of peanuts without experiencing any allergic reactions.
This method, known as oral immunotherapy, has shown success in previous studies involving children and infants, marking the first instance it has been tested in adults.
Chief Investigator Professor Stephen Till, a leading adult allergy expert from King’s College London, expressed satisfaction with the results, stating he was “very pleased.”
“The constant fear of potentially life-threatening reactions places a significant burden on individuals with peanut allergies,” he commented. “Currently, the only management strategy for these allergies is strict avoidance and the treatment of reactions, including the use of adrenaline.”
Peanut allergies affect around 2% of the population in Western countries. According to a 2021 survey, this condition appears to be on the rise.
The trial indicated “preliminary evidence” that adults with severe allergies could achieve desensitization, thereby enhancing their quality of life.
Participants in the study were aged 18 to 40 and diagnosed with severe peanut allergies through the Guy and St Thomas’ NHS Foundation Trust.
They began with small amounts of peanut flour mixed into food, monitored closely. The initial dose was 0.8 mg, equivalent to less than 0.3% of a peanut.
If tolerated, the participants moved on to 1.5 mg after 30 minutes, and then 3 mg after another 30 minutes, representing 1% of a peanut.
Those who could handle 1.5 or 3 mg continued consuming that amount daily for two weeks before returning to the clinic for supervision while attempting higher doses.
Participants prepared peanut flour each day, gradually increasing the dosage until they could tolerate 50 mg to 1 g of peanut protein, which translates to 2-4 peanuts.
Once they reached this level, they transitioned to real peanuts, peanut butter, or other peanut products.
Chris, a 28-year-old participant in the study, remarked: “My entire life was consumed by the fear associated with peanuts. I started with a little peanut flour in yogurt. By the end of the trial, I could sit down and eat four peanuts.”
Chris now includes four peanuts in his breakfast daily to maintain his immunity, stating: “Although minor mistakes can have grave consequences, I no longer fear collapsing or dying during takeout.”
Professor Adam Fox, chairman of the National Allergy Research Group and professor of pediatric allergy at King’s College London, called the study “important evidence of the principle,” which could be beneficial in treating adult allergies, although he was not involved in the research.
He cautioned, however: “This treatment must be conducted under careful medical supervision and should never be attempted independently.”
This study was published in the scientific journal Allergy.
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Source: www.sciencefocus.com
