Colossal Biosciences, a US biotech startup, has announced the birth of what is called the “wool mouse.”
The company says gorgeous hair rodents are living evidence that their mission to restore wool mammoths from extinction within a few years is progressing.
To make mice, scientists have introduced eight simultaneous editing into the genome of experimental mice using modern genetic techniques. These include the addition of genes that make fur grow up to three times longer than usual, as well as other genes that make hair wavy and golden.
Other editing targets target genes associated with fat metabolism, which are thought to help increase mammoth size.
Mice are the result of years of hard work by scientists to reconstruct important parts of the mammoth genome. The last wool mammoth is believed to have died about 3,000 years ago, and scientists are stitching together mammoth DNA, which has been decomposed from relics that range from 35 to 1.2 million years ago.
This is the first time that some of the important genes identified throughout the study have been expressed in living animals.
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Mammoth 2.0
Colossal's ambitious long-term plan is to add many of these mammoth genes to modern elephant embryos to create a mammoth-like hybrid.
Despite claiming to be revived wool mammoth, the original Mammuthus Primigeniuswith all the original genetic complexity and population diversity, it has not been brought back to life. Creatures are more accurately referred to as “cold-resistant elephants.”
The Mammoth's return was repeated by various groups and dates back to 2011. The group is generally privately funded, and the exact details of their work are rather opaque.
However, these lifestyle, breathing, and rather cute wool mice show that scientists have made impressive advances in reconstructing some of the key genes that have made mammoths unique. Colossal's Chief Scientist Dr. Beth Shapiro The mouse says it is a “critical step in examining an approach to revive the properties lost to extinction.”
A huge task
There's still a lot to do before you see mammoth-like creatures crossing the tundra or walking through the zoo.
Initially, it is much easier to create gene-edited mice than elephants. Mice have been a staple of genetic experiments for decades and can be quickly raised in a huge number.
Elephants, on the other hand, are rarely used in laboratory experiments, and live mammals happen to have longer gestation periods of over 18 months.
Colossal has made impressive advances by manipulating elephant cells into stem cells.
However, even if Colossal could create a viable elephant mammoth embryo, it would not be able to be used as a large number of surrogates, if any, because both Asian and African elephants are at risk of extinction.
This means that Colossal must develop its own artificial uterus to develop experimental embryos until birth. This has never been done before. Such a system should not only replicate all the complexity of the placenta, but also support calves that are as heavy as Asian elephant calves, exceeding at least 100 kg (220 lbs).
But perhaps the biggest question remaining is simply, why? Colossal says other similar tasks to revive mammoths and revive dodos and tylacine will lead to biotechnology that will help save other species from environmental changes.
The company claims to stimulate interest and investment so that they can't do anything else, starting with these iconic extinct creatures.
Certainly, the project has attracted a lot of media attention and has attracted more than $200 million (£157 million) of investments that probably wouldn't have made it to a traditional conservation project.
And there are already examples of the technology being used to support species facing extinction today. For example, in Australia, gene editing is used to provide resistance to the poison of cane toads, an invasive species that kill many animals in the region (adorable, endangered marsupials).
In the US, scientists used similar biotechnology to increase the genetic diversity of ferrets with black feet, but it had dipped to a population size that was essentially involved.
More broadly, Colossal's research could help scientists produce eggs, sperm and embryos of a variety of endangered species, including Asian and African elephants, which help to increase numbers.
We can ask questions
But do these lofty ambitions justify? Jurassic Park– Blatant use of genetic engineering? Many people are particularly intelligent social animals like elephants, and feel uneasy about corrections, not to mention a complete overhaul of the genome.
And what is the life of the first artificial wool elephant like? Where do they live and are they introduced to herds and families?
Are they healthy or tired of genetic problems? And shouldn't we focus our efforts on saving habitats and ecosystems, not individual species?
In recent years, genetic engineering has gained greater acceptance among the public, and is generally considered an important way to produce new drugs and disease-resistant crops.
Does the creation of a large, shaggy elephant make people feel that biotechnology is going too far? Or, as a huge hope, will it serve as an inspiring symbol of how technology can save thousands of species that are at risk of extinction each year?
This is a question that biologists, ethicists and biotechnology regulators need to carefully consider the work of scaling up from mice to mammoths.
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Source: www.sciencefocus.com
