A groundbreaking study proves that Alzheimer’s disease symptoms can be induced in healthy animals through gut microbiome transmission, highlighting the gut-brain connection and suggesting early treatment and treatment of Alzheimer’s disease. New avenues for personalized interventions have been opened.
Researchers have discovered a link between the gut microbiome and gut bacteria. Alzheimer’s disease disease.
For the first time, research has demonstrated that symptoms of Alzheimer’s disease can be transmitted to healthy young organisms through the gut microbiome, confirming its role in Alzheimer’s disease.
The research was led by Professor Yvonne Nolan from APC Microbiome Ireland, the world’s leading SFI-funded research center based at University College Cork (UCC), and Professor Yvonne Nolan from UCC’s Department of Anatomy and Neuroscience. Professor Sandrine Thure, King’s College London, and Dr. Annamaria Cattaneo, IRCCS Fatebenefratelli, Italy.
Scientists have discovered a link between Alzheimer’s disease and the gut microbiome. Pictured are Dr. Stephanie Grabracer and Professor Yvonne Nolan. Credit: UGC
This study confirms that the gut microbiome is emerging as an important research target for Alzheimer’s disease, given its sensitivity to lifestyle and environmental influences.
was announced on brainThis study shows that memory impairment in Alzheimer’s patients can be transferred to younger animals through gut microbiota transplantation.
Alzheimer’s disease, memory impairment, gut microbiome
Patients with Alzheimer’s disease had greater abundance of pro-inflammatory bacteria in their fecal samples, and these changes were directly correlated with the patients’ cognitive status.
Professor Yvonne Nolan said: “The memory test we investigated relies on the growth of new neurons in the hippocampal region of the brain. Animals with the gut bacteria of Alzheimer’s patients produced fewer new neurons and had impaired memory. I found out that it is true.”
“Alzheimer’s patients are typically diagnosed at or after the onset of cognitive symptoms, which may be too late, at least with current treatments. “Understanding the role of gut bacteria could pave the way for the development of new treatments and even personalized interventions,” Professor Nolan said.
Implications for treatment strategies and research collaborations
Alzheimer’s disease is the most common cause of dementia and is a general term for memory loss and other cognitive impairments severe enough to interfere with daily life. As the population ages, one in three people born today could develop Alzheimer’s disease. Funded by Science Foundation Ireland, scientists at UCC are leading the way in healthy brain aging by investigating how the gut microbiome responds to lifestyle influences such as diet and exercise. We are working to develop strategies to accelerate and advance the treatment of Alzheimer’s disease.
Professor Sandrine Thuret, Professor of Neuroscience at King’s College London and one of the study’s senior authors, said: ‘Alzheimer’s disease is an insidious disease and there is still no effective treatment. , represents an important advance in the understanding of this disease, confirming that the composition of our gut microbiota is causally linked to the development of the disease. This collaboration will help future research in this field. We hope that this will lead to potential advances in therapeutic interventions.”
Professor. John F. Cryan, vice president of research and innovation at UCC, who also worked on the study, said: He conducts research into related diseases such as Alzheimer’s disease, and with UCC he recognizes APC Microbiome Ireland as a leading institution in microbiome and brain health research. This research is consistent with our UCC Futures Framework and the University’s strategic plans in the areas of food, microbiome, health and, soon to be launched, Future Aging and Brain Sciences. “
Reference: “The microbiota of Alzheimer’s patients induces defects in cognition and hippocampal neurogenesis” Stephanie Grubrucker, Moira Marizzoni, Edina Silajzic, Nicola Lopizzo, Elisa Mombelli, Sarah Nicolas, Sebastian Dom-Hansen, Katia Scacellati, Davide Vito Moretti, Melissa Rosa, Carina Hoffman, John F. Cryan, Olivia F. O’Leary, Jane A. English, Aongus Lovell, Cora O’Neill, Sandrine. Ture, Annamaria Cattaneo, Yvonne M. Nolan, October 18, 2023; brain.
DOI: 10.1093/brain/awad303
The research was carried out by Dr Stephanie Grubrucker, a postdoctoral researcher in collaboration with Professor Nolan, in collaboration with postdoctoral colleagues Dr Edina Siladzic from King’s College London and Dr Moira Marizzoni from IRCCS Fatebenefratelli in Italy. It was carried out. UCC collaborators were Professor Cora O’Neill, Dr Olivia O’Leary, Dr Sarah Nicholas, Dr Jane English, Mr Sebastian Dohm Hansen and Dr Aongus Lovell.
Source: scitechdaily.com
