A new study from Cornell University reveals that the visual system, not just chemoreceptors, has a major influence on the social behavior of male fruit flies. The study found that enhanced visual input can override normal social inhibition, and suggests similar mechanisms in the human brain, particularly related to conditions such as autism and schizophrenia. It has meaning in understanding.
Drosophila males typically exhibit antisocial behavior toward other males and prefer to identify females through chemoreceptors. However, recent research by Cornell University biologists shows that the fruit fly visual system plays an important role in social interactions.
The findings provide new insights into the potential roots of a variety of human social behaviors, including those associated with conditions such as bipolar disorder and autism.
This paper recently current biology.
Visual system and social behavior
many seed Many animals use vision to regulate social behavior, but the underlying mechanisms remain largely unknown. In Drosophila, vision is thought to be used explicitly to detect and follow movement rather than to regulate social behavior, but researchers have found that this may not be the case. .
“In our study, hyperactivation of the visual system overcomes the inhibition produced by chemical signals emitted by male flies, telling other males, ‘Okay, I know, I’m another male, don’t interfere. ”’ said senior author Nirey Yapisi, assistant professor of neurobiology and behavior. “Surprisingly, visual enhancement in the brain somehow overrides chemosensory inhibition and attracts male flies to other males.”
Researchers found that changing GABARAP/GABA;a Receptor signaling in visual feedback neurons in the male brain influenced social inhibition in flies. When GABARAP is knocked down in the visual system, males unexpectedly exhibit increased courtship behavior towards other males.
Researchers discovered that genes similar to those in the human brain control visual neurons in fruit flies. Decreased GABA signaling in the human brain is associated with traits of social withdrawal in conditions such as autism and schizophrenia.
“Our results provide a promising avenue to investigate how these proteins regulate social behavior in the mammalian brain and their potential contribution to human mental state.” said lead author Dr. Yuta Mabuchi. ’23.
Reference: “Visual feedback neurons fine-tune Drosophila male courtship through GABA-mediated inhibition”, Yuta Mabuchi, Xinyue Cui, Lily Xie, Haein Kim, Tianxing Jiang, Nilay Yapici, September 2023 5 Day, current biology.
DOI: 10.1016/j.cub.2023.08.034
Source: scitechdaily.com
