A new study has proven a direct link between high insulin levels and increased risk of pancreatic cancer in people with obesity and type 2 diabetes. This landmark study shows how excess insulin overstimulates pancreatic acinar cells, leading to inflammation and precancerous cells, particularly in the case of pancreatic ductal adenocarcinoma (PDAC). These findings highlight the importance of maintaining healthy insulin levels and may lead to new strategies for cancer prevention and treatment, including lifestyle interventions and targeted therapies.
For the first time, we explain in detail why people with obesity and type 2 diabetes have an increased risk of pancreatic cancer.
A recent study conducted by scientists at the University of British Columbia’s Faculty of Medicine revealed a direct relationship between high blood pressure and high blood pressure. insulin This level is frequently observed in patients with obesity, type 2 diabetes, and pancreatic cancer.
This study cell metabolismprovides the first detailed explanation of why people with obesity and type 2 diabetes are at increased risk of pancreatic cancer. This study shows that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This excessive stimulation causes inflammation and transforms these cells into precancerous cells.
“In addition to rapid increases in both obesity and type 2 diabetes, we are also seeing an alarming increase in the incidence of pancreatic cancer,” said co-senior author and professor in the Department of Cellular Physiology Sciences and co-senior author of the study. said Dr. James Johnson, interim director of the agency. UBC’s Institute of Life Sciences. “These findings help us understand how this is happening and highlight the importance of keeping insulin levels within a healthy range. can be achieved through medication.”
Dr. James Johnson is a professor in the Department of Cellular and Physiological Sciences and interim director of the UBC Life Sciences Institute. credit:
UBC Faculty of Medicine
The study focused on pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer and a highly aggressive disease with a five-year survival rate of less than 10 percent. The incidence of pancreatic cancer is on the rise. By 2030, PDAC is expected to become the second leading cause of cancer-related deaths.
Role of insulin in pancreatic cancer
Although obesity and type 2 diabetes were previously established as risk factors for pancreatic cancer, the exact mechanisms by which this occurs remained unclear. This new study sheds light on the role of insulin and its receptor in this process.
… (content continues) …
Reference: “Hyperinsulinemia causes pancreatic cancer through acinar insulin receptors by increasing digestive enzyme production and inflammation” (Anni MY Zhang, Yi Han Xia, Jeffrey SH Lin, Ken H Chu, Wei Chuan K. Wang, Titine JJ Ruiter, Jenny) CC Yang, Nan Chen, Justin Choa, Shilpa Patil, Haoning Howard Sen, Elizabeth J. Rideout, Vincent R. Richard, David・F. Shafer, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson, Janelle L. Kopp, October 31, 2023. cell metabolism.
DOI: 10.1016/j.cmet.2023.10.003
This study was funded by the Canadian Institutes of Health Research and the Lustgarten Foundation.
Source: scitechdaily.com
