In a groundbreaking study, researchers identified the right inferior frontal gyrus (rIFG) as important in the brain’s inhibitory control circuits. Using dynamic causal modeling and fMRI in 250 participants, this study found high connectivity in this circuit that was influenced by gender and performance. The findings reveal hemispheric asymmetries and sex-related differences in brain processes and provide insights that may improve treatment strategies for psychiatric and neurological disorders associated with response inhibition.
Researchers have discovered a critical role for the right inferior frontal gyrus in the brain’s inhibitory control, revealing implications for the treatment of gender differences and related diseases.
Published in Volume 3 in 2023 psychoradiology A team of dedicated researchers from the University of Hong Kong and the University of Electronic Science and Technology of China has conclusively identified the right inferior frontal gyrus (rIFG) as a key input and causal regulator within the subcortical response inhibition node. This right-lateralized inhibitory control circuit is characterized by its important intrinsic connectivity, highlighting the critical role of rIFG in coordinating top-down cortico-subcortical control and supporting the brain in response inhibition. It emphasizes the complex dynamics of function.
Advanced research methods and results
In this comprehensive study, researchers used dynamic causal modeling (DCM-PEB) and functional magnetic resonance imaging (fMRI), a substantial sample size to investigate inhibitory circuits in the brain, with a particular focus on the right inferior frontal gyrus (rIFG), caudate nucleus (rCau), globus pallidus (rGP), and thalamus (rThal). (n = 250). This approach treated the brain as a nonlinear dynamical system and enabled the inference of directed causal relationships between these nodes, influenced by task demands and biological variables.
Brain activation map of general response inhibition at the whole-brain level (control: NoGo > Go; P < 0.05 FWE, peak level). L, left. Mr. R, that’s right. The color bar represents the t-value of the BOLD signal and reflects the significance level of the contrast.Credit: Psychoradiology
Our findings reveal high intrinsic connectivity within this neural circuit, with response inhibition markedly enhancing causal projections from rIFG to both rCau and rThal, particularly in the regulatory role of rIFG during such tasks. It has become clear that the role will be expanded. This study also revealed that gender and performance metrics significantly influence the functional architecture of the circuit. For example, females showed increased self-inhibition of rThal and decreased regulation to GP, whereas better inhibitory performance was associated with stronger transmission from rThal to rIFG.
Sex differences and hemispheric asymmetry
Interestingly, these communication patterns are not reflected in the left-lateralized model, which emphasizes hemispheric asymmetry. This study shows that different brain processes may mediate similar behavioral performance in response inhibition across genders, and that response inhibition may be higher in the thalamic loop in particular. Accuracy Associated with stronger information flow from rThal to rIFG.
(a) Location of the region included in the right model. A matrix: Intrinsic connectivity across all experimental conditions (b, f). B matrix: modulatory effects on effective connectivity between regions and self-inhibition from NoGo (c, g) and Go conditions (d, h). C matrix: Driving ROI inputs (e, i) in NoGo and Go conditions. The values ​​in the matrix reflect the connection parameters.Credit: Psychoradiology
Impact and future directions
These insights into the brain’s inhibitory control mechanisms have important implications for understanding a variety of psychiatric and neurological disorders characterized by response inhibition deficits. The results of this study may guide the development of targeted neuromodulatory strategies and personalized interventions to address these disorders, enhancing the treatment and management of such conditions..
Reference: “Right inferior frontal gyrus as an effective regulator of the cardinal node and basal ganglia thalamocortical response inhibition circuit” Qian Zhuang, Lei Qiao, Lei Xu, Shuxia Yao, Shuaiyu Chen, Xiaoxiao Zheng, Jialin Li, Meina Fu, Keshuang Lee, Deniz Vatancevar, Stefania Ferraro, Keith M. Kendrick, Benjamin Becker, October 13, 2023. psychoradiology.
DOI: 10.1093/psyrad/kkad016
Source: scitechdaily.com
