Labradors with a mutation that causes starvation tend to easily gain weight

Labradors and flat-coated retrievers, two dog breeds, may be more susceptible to being overweight because they carry mutations that cause them to feel hungry between meals and slow their metabolic rates. “It's a double whammy,” he says. Eleanor Laffan at Cambridge University.

mutations that affect genes called POMCwhich affects about a quarter of Labradors and two-thirds of flat-coated retrievers, but does not affect other breeds.

Discovered in 2016, it was found to alter pathways in the brain associated with weight regulation, but it was unclear exactly how it affected eating habits.

To find out, Laffan's team conducted a “boxed sausage” test on 87 pet Labradors. In this test, dogs were able to see and smell sausages in an impenetrable container. The Labrador dog, in which he had one copy of the mutation, continued to try to open the box much longer than the dog without it.

However, in another test in which dogs were given a can of food every 20 minutes until they ran out of food, all dogs ate the same amount of food, regardless of whether they had the genetic mutation or not. This shows that the mutation affects appetite in a specific way, by increasing hunger levels between meals, Laffan says.

The researchers also measured the resting metabolic rates of flat-coated retrievers while they slept and found that dogs with two copies of the mutation had metabolic rates that were about a quarter lower than other dogs.

Laffan said the effect would be expected to be the same in both breeds, but in a second experiment flat-coated retrievers were more likely to carry both of the mutations than Labradors. He wanted to find out.

Laffan said many other genes probably influence dog weight, just as they do in humans.

Dan O'Neill Researchers from the Royal College of Veterinary Medicine say owners of overweight dogs should avoid giving treats as a way to show affection and instead give their dogs other forms of attention. “You can also replace that snack with a walk,” he says.