Newly discovered tardigrade species using genome, transcriptome and proteome analysis Hypsibius henanensis scientists investigated the molecular basis that contributes to radioresistance in these small invertebrates.
Schematic diagram of the mechanism conferring radiation resistance Hypsibius henanensis. Image credit: Li others., doi: 10.1126/science.adl0799.
Tardigrades, also known as tardigrades or moss piglets, are a diverse group of microscopic invertebrates famous for their ability to withstand extreme conditions.
First discovered in 1773, these organisms can live for up to 60 years, grow up to 0.5 mm in size, and are best seen under a microscope.
They can survive in temperatures as low as -272 degrees Celsius (-457 degrees Fahrenheit) or as hot as 150 degrees Celsius (302 degrees Fahrenheit), and temperatures as low as -20 degrees Celsius for several minutes, and for up to 30 years without food or water. Masu. Minus 4 degrees Celsius (minus 4 degrees Fahrenheit) continues for decades.
It can withstand pressures from virtually 0 atmospheres in outer space to 1,200 atmospheres at the bottom of the Mariana Trench.
They also exhibit excellent resistance to ionizing radiation, withstanding doses of gamma rays as high as 3,000 to 5,000 grays (Gy), approximately 1,000 times the lethal dose for humans.
The mechanism of radioresistance in tardigrades remains largely unknown.
Previous studies investigating how they do this have shown that tardigrades have powerful DNA repair abilities.
They also express tardigrade-specific proteins called damage suppressors (Dsup), when expressed in human cells, protects DNA from radiation damage.
In a new study, Lei Li and colleagues at Qingdao University describe a new species of tardigrade. Hypsibius henanensis.
Through detailed morphological and molecular analyses, they also investigated the basis of radioresistance in this species.
The researchers evaluated how exposure to heavy ion beams changes the molecular profiles of animals. They found that 285 stress-related genes were upregulated.
They further uncovered three molecular mechanisms that contribute to radioresistance in organisms.
First, the horizontally transferred bacterial gene DOPA dioxygenase 1 (Doda 1) enhanced radiation resistance by producing betalains (pigments with powerful free radical scavenging properties commonly found in plants, fungi, and bacteria).
Second, proteins unique to tardigrades, TDP1promotes DNA double-strand break repair.
Finally, mitochondrial chaperone genes BCS1Proliferated during the evolution of tardigrades, it is uniquely upregulated in response to radiation and protects cells from radiation-induced mitochondrial damage.
“The extreme environmental tolerance of extremophiles such as tardigrades provides a treasure trove of unexplored molecular mechanisms of stress tolerance,” the authors write.
“Functional studies of these radioresistance mechanisms may further expand our understanding of cell survival under extreme conditions and provide inspiration for promoting human health and fighting disease.”
of result Published in the Journal on October 25, 2024 science.
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Ray Lee others. 2024. The multi-omic landscape of tardigrades and the molecular basis of radioresistance. science 386 (6720);doi: 10.1126/science.adl0799
Source: www.sci.news
