When it comes to weight loss, one universal truth stands out: losing body fat is challenging, and keeping it off can be even more difficult. A recent study may shed some light on why this is the case: adipose tissue, or body fat, retains a sort of “memory” even after cells have become obese.
“This discovery potentially helps explain the changes that occur in adipose tissue during weight fluctuations,” explained Dr. Ferdinand von Mayen, an assistant professor at ETH Zurich’s Faculty of Health Sciences and Technology, in an interview with BBC Science Focus.
Dr. von Mayen and his team observed transcriptional changes in human cells, which are responsible for regulating genetic material, in individuals’ adipose tissue before and after a 25 percent reduction in BMI. “We found that even after weight loss, the genetic regulation in adipose tissue did not fully return to normal, indicating that the body is programmed to regain lost weight,” he added.
While this news may be disheartening for those on a weight loss journey, Dr. von Mayen hopes that this study will help destigmatize weight fluctuations. “There is a molecular mechanism at play that influences weight regain, and it’s not simply a matter of willpower,” he emphasized.
He also stressed the importance of prevention in addressing the global obesity epidemic. “Early intervention is key, as it is much harder to lose weight once it has been gained. Implementing healthier lifestyle choices at a societal level is crucial in combating this issue,” Dr. von Mayen noted.
About our experts
Dr. von Mayen: I specialize in researching obesity and metabolic diseases at the Nutritional and Metabolic Epigenetics Laboratory at ETH Zurich.
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Source: www.sciencefocus.com
