A study by researchers from the University of Florida, Texas State University, and the United States Department of Agriculture suggests that an extract of the polar fraction of orange peel, which contains a compound called feruloylputrescine, may reduce cardiovascular disease.
Lee othersThe inhibitory effects of orange peel polar fraction (OPP) and orange peel non-polar fraction (OPNP) on the production of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) in response to L-carnitine treatment were compared. In vivo and In vitro.
Recent studies have shown that some gut bacteria may contribute to the development of cardiovascular disease.
During digestion, gut bacteria produce trimethylamine N-oxide (TMAO) when certain nutrients are ingested, and levels of TMAO can help predict future cardiovascular disease.
In a new study, Dr. Yu Wang from the University of Florida and colleagues investigated the potential of orange peel extract to reduce the production of TMAO and trimethylamine (TMA).
They tested two types of extracts: a polar fraction and a non-polar fraction.
To obtain the polar fraction, they extracted orange peels using polar and non-polar solvents.
“Think of a salad dressing. The things that are in the water and vinegar section are polar compounds. The things that are in the oil section, away from the water, are non-polar compounds,” says Dr. Wang.
“The solvents we used are not exactly the same as water and oil, but they have a similar polarity.”
The authors found that extracts of the non-polar fraction of orange peel effectively inhibited the production of harmful chemicals.
The researchers also identified a compound in the polar fraction extract of orange peel called feruloylputrescine, which also significantly inhibited the enzyme involved in TMA production.
“This is a novel discovery that highlights a previously unrecognized potential health benefit of feruloylputrescine in reducing the risk of cardiovascular disease,” Dr Wang said.
“The discovery regarding orange peel is significant because five million tonnes of orange peel are produced annually in orange juice production nationwide.”
“About 95 percent of Florida oranges are used for juice. About half of the peels are used to feed cows. The rest are discarded.”
“But the FDA considers natural orange peel extract to be safe for human consumption, so we're looking to get more out of the peel.”
“These findings suggest that orange peels, which are often discarded as waste in the citrus industry, could be repurposed into valuable health-promoting compounds, such as ingredients in dietary supplements and foods,” Dr Wang said.
“Our study paves the way for the development of functional foods enriched with these bioactive compounds, providing a new therapeutic strategy for heart health.”
of result Appears in Journal of Agricultural and Food Chemistry.
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Hana Lee others2024. Discovery of novel bioactive compounds from the polar fraction of orange peel and their inhibition of trimethylamine and trimethylamine N-oxide by a metabolomic approach. In vitro and In vivo Assay: Feruloylputrescine inhibits trimethylamine by suppressing the cntA/B enzymes. Journal of Agricultural and Food Chemistry 72(14):7870-7881; doi:10.1021/acs.jafc.3c09005
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