Transitioning to space poses significant challenges for the human body.

Astronauts can experience loss of bone density, swollen nerves in their brains and eyes, and alterations in gene expression. Research indicates that time spent in space can accelerate aging.

Groundbreaking research by NASA’s twin astronauts Mark and Scott Kelly monitored aging indicators in both siblings, with Mark remaining on Earth while Scott spent 340 days in space.

Six months later, several changes in Scott persisted, including DNA damage, cognitive decline, and telomere shortening that affects chromosome protection. This was highlighted in the Journal Science.

Recent research published in Cell Stem Cell reveals that stem cells also show signs of aging due to stress from space flight.

According to Dr. Catriona Jamieson, director of the Sanford Stem Cell Institute at UC San Diego, these cells are “aging ten times faster in space than on Earth.”

Stem cells are unique cells capable of differentiating into various tissue types. Their accelerated aging poses a concern as it diminishes the body’s natural ability to repair tissues and organs.

This new research comes at a time of increasing interest in space exploration, with government plans for long-term lunar missions and private companies sending consumers and celebrities into space. Understanding these health risks is crucial for safer space travel. Additionally, studying the acceleration of intracellular aging aids researchers in comprehending biological processes at a slower pace.

Researchers utilized bone marrow stem cells sourced from individuals who underwent hip replacement procedures. These cells were cultivated in “nanobioreactors,” essentially small, clear blood bags no larger than an iPhone that facilitate biological processes. The nanobioreactor was housed in a monitored environment known as cubelabs.

Samples from each patient were divided into two cubelabs; one was sent to space, while the other remained on Earth.

The samples intended for space travelled aboard the International Space Station across four commercial resupply missions conducted by SpaceX. Overall, the samples experienced microgravity for 32-45 days, the weightlessness found in orbit. For comparison, the Earth-bound cells were maintained in a cube lab setup.

Cubelabs monitored cell conditions throughout the journey and terrestrial duration, capturing daily images using a microscope. Upon the return of the space-stressed stem cells to Earth, researchers conducted comparisons against ground controls, sequenced the genome, and performed additional analyses.