Tag Archives: Cell

CAR-T Cell Therapy: A Natural Approach to Revitalizing Aging Intestinal Health

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The Importance of a Strong Intestinal Lining for Optimal Health

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As we age, the cells that line our intestines gradually lose their ability to regenerate, impacting our immune health. However, recent research has successfully reversed this decline in older mice using genetically modified immune cells.

This innovative approach, known as CAR T-cell therapy, is primarily used to target specific blood cancers. It entails collecting a patient’s T cells, reprogramming them in a laboratory to identify and eliminate cancerous cells, and then reintroducing them into the bloodstream. Emerging variations of this therapy show promise not only in combatting solid tumors but also in preventing arterial blockages and treating autoimmune diseases like lupus.

In a groundbreaking study, Cemil Beyaz and his team at Cold Spring Harbor Laboratory, New York, explored the application of this therapy for revitalizing the aging gut. They focused on targeting damaged cells, known as senescent cells, which accumulate over time, fail to proliferate, and secrete substances that exacerbate inflammation and promote further aging. The researchers aimed their intervention at a protein called uPAR, prevalent on aging cells.

“The decline in gut health we observe with aging is linked to diminished stem cell fitness responsible for renewing the intestinal lining every three to five days,” Beyaz states. “We posited that eliminating these ‘unfit’ senescent cells would enhance the regenerative ability and overall functionality of stem cells in older mice.”

To validate this hypothesis, the researchers engineered CAR T cells from older mice to specifically recognize and eliminate uPAR on senescent cells. Upon reintroducing these modified cells, the researchers noted a significant increase in both the activity and number of stem cells maintaining tissue function, reaching levels comparable to those observed in younger mice. The treated older mice also exhibited marked improvements in intestinal barrier integrity and reduced inflammation compared to a separate cohort that received CAR T-cell therapy targeting different mechanisms.

“By removing senescent cells, we not only inhibited the aging process but also witnessed a reversal, with tissues displaying characteristics similar to those of young mice,” said team member Corina Amor, also from Cold Spring Harbor Laboratory.

“This therapy could potentially reverse age-related declines in bowel function, decreasing vulnerability to diseases such as intestinal infections, compromised intestinal integrity, and even cancer,” explained Tuomas Tammera from Memorial Sloan Kettering Cancer Center, who was not part of the study. However, he emphasized that ensuring the treatment’s effectiveness and safety in humans remains crucial.

Onur Eskiokaku, a researcher at Cold Spring Harbor Laboratory, highlighted the importance of determining the optimal dosage before advancing to human trials. “While uPAR is abundant in aged, defective cells, it may also be present in healthy tissues under certain conditions,” he noted.

It’s important to remember that senescent cells aren’t all detrimental; they play roles in tumor suppression and wound healing. “We are investigating the implications of depleting uPAR expression in other tissues,” mentioned Jesse Poganic from Harvard Medical School.

Additionally, treating aging in otherwise healthy individuals is not commonplace. The complexity and expense associated with CAR-T therapy, coupled with ongoing safety concerns, suggest that widespread application for reversing aging effects is not imminent, according to Joanna Neves at the Center at King’s College London. “Safety standards for preventative treatments must be more stringent than those for oncology.”

Beyaz asserts that addressing the age-related decline in intestinal function has long posed a challenge, with no effective solutions currently available, especially when the intestinal barrier’s regenerative capability is compromised. This research marks a significant step forward, indicating that the removal of unfit cells can restore crucial functions.

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Source: www.newscientist.com

Man Surprises Doctors with HIV Cure Following Stem Cell Transplant

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Human Cells Infected with HIV

Steve Gschmeisner/Science Photo Library

A man has become the seventh individual to rid himself of HIV after receiving a stem cell transplant for blood cancer. Notably, he was the second case among seven to receive stem cells that weren’t resistant to the virus, reinforcing the idea that resistant cells may not be essential for HIV treatment.

“Understanding that treatment can occur without this resistance offers us additional avenues for combating HIV,” remarks Christian Gabler at the Free University of Berlin.

So far, five individuals have been cleared of HIV following transplants from donors possessing mutations in both copies of a gene responsible for CCR5, a protein that HIV targets to infect immune cells. Scientists have drawn conclusions that having two copies of a mutation that eradicates CCR5 from immune cells is crucial for eliminating HIV. “It was previously thought that the use of HIV-resistant stem cells was key,” states Gabler.

However, last year, a sixth instance emerged, known as the Geneva patient, who was declared free of the virus. His infection persisted for over two years after receiving stem cells that lacked the CCR5 mutation, indicating that CCR5 might not be the complete narrative, though many scientists suggest that two years without viral infection may not suffice to confirm an actual cure, Gabler notes.

The recent cases bolster the hypothesis that the Geneva patient has indeed been cured. The research includes a male who received stem cells in October 2015 to address leukemia, a blood cancer characterized by uncontrolled growth of immune cells. At the time, the patient was 51 years old and was infected with HIV. During the treatment, he underwent chemotherapy to eliminate a majority of his immune cells, allowing the donor’s stem cells to generate a healthier immune system.

Ideally, the man would have received HIV-resistant stem cells; however, these were unavailable, leading doctors to use cells with one typical and one mutated copy of the CCR5 gene. During this time, the patient was undergoing conventional HIV care known as antiretroviral therapy (ART), a regimen of medications that suppress the virus to undetectable levels, preventing transmission and reducing the likelihood of donor cells becoming infected.

Approximately three years post-transplant, he opted to discontinue ART. “He felt that he had waited long enough after the stem cell transplant and believed his cancer was in remission, so he anticipated a positive outcome from the transplant,” Gabler explained.

Shortly thereafter, tests revealed no traces of the virus in the man’s blood samples. Since then, he has remained free of the virus for seven years and three months, qualifying him as “cured.” He holds the record for the second-longest duration HIV-free amongst the seven declared cases, achieving this status longer than some by around a dozen years. “It’s astonishing that a decade ago he was very likely facing death from cancer, and now he has conquered a terminal diagnosis of a lingering viral infection without any medication. He is in good health,” Gabler remarked.

This discovery challenges our perceptions of what it entails to treat HIV through this method. “We once believed that transplantation required a donor without CCR5, but now it seems that’s not the case,” points out Ravindra Gupta from the University of Cambridge, who was not part of the study.

It’s generally assumed that the success of such treatments hinges on the inability of the virus to hide within remaining immune cells of the recipient after chemotherapy, thus preventing infection or replication in the donor’s cells. “Essentially, you deplete the pool of host cells that the virus can infect,” argues Gabler.

Nevertheless, Gabler speculates that the latest cases imply a potential cure can be achieved as long as non-resistant donor cells can eliminate the recipient’s remaining original immune cells before the virus has a chance to spread. Such immune responses often arise from variations in the proteins that the two cell sets display. These, he notes, enable donor cells to recognize the remaining recipient cells as a threat that must be eradicated.

The findings indicate a wider array of stem cell transplants might offer the possibility of curing HIV than previously believed, including those that do not exhibit two copies of the CCR5 mutation, according to Gabler.

However, for this to be effective, several factors must align, such as the genetic compatibility between the recipient and donor to ensure the donor’s cells can swiftly eradicate the recipient’s cells. Additionally, in the most recent case, the man possessed one copy of the CCR5 mutation, which may have modified his immune cell dynamics throughout his body, aiding in the eradication of the virus, Gabler noted.

This suggests that most individuals undergoing stem cell transplants for HIV or blood cancers should ideally receive HIV-resistant stem cells, as emphasized by Gabler.

It’s crucial to recognize that individuals with HIV who do not have cancer will not gain from stem cell transplants, as these procedures are highly risky and prone to life-threatening infections, Gabler warns. Most experts agree that adhering to ART (typically taken in pill form daily) is substantially safer and more practical for halting HIV’s spread. This approach allows many to lead longer, healthier lives. Moreover, a newly available medication, lenacapavir, offers nearly complete protection against HIV with just two injections annually.

Despite this, research continues on treating HIV through gene editing of immune cells and exploring preventive vaccines.

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Source: www.newscientist.com

How Ancient Viruses Pack into Every Cell

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Our personal genome (an organism’s genetic information) contains remnants of viruses that once infected our ancestors.

No need to worry though. These viruses aren’t contagious like those that cause COVID-19 or the common cold; instead, they are sequences that have been integrated into our DNA over millions of years.

Most of these sequences come from a specific group of viruses known as retroviruses, which invade host cells and manipulate them into producing replication-required proteins.

Sometimes, a retrovirus can insert itself into a sperm or egg cell, which allows it to propagate across subsequent generations.

While this occurrence is rare, its frequency increases over extensive periods of evolution. Currently, about 8 percent of our DNA is comprised of these viral remnants.

Viruses have subtly merged into our DNA over millions of years – Image credit: Science Photo Library

For many years, scientists believed these viral sequences were mostly insignificant, referring to them as “junk DNA” that merely existed within cells without serving any important purpose.

However, recent research has shifted this perspective. Modern iterations of these viral proteins have been found to play crucial roles in functions such as memory retention, the development of the placenta, and enhancing our immune system’s ability to combat harmful microorganisms.

Nonetheless, it’s not all positive. Certain viral DNA fragments are linked to various human diseases, including amyotrophic lateral sclerosis (ALS), certain cancers, and type 1 diabetes.

While they may not directly cause disease, they could play a role in the intricate biological processes that researchers are exploring.

This article addresses the question (submitted by Nick Conley via email): “Can a virus alter my DNA?”

If you have any inquiries, please reach out to us at: questions@sciencefocus.com or send us a message facebook, ×or Instagram Page (remember to include your name and location).

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Source: www.sciencefocus.com

Stem Cell Therapy Lowers Heart Failure Risk Following Heart Attack

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Mesenchymal stem cells tagged with fluorescent markers

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The largest trial conducted so far indicated that individuals who received a stem cell infusion right after a heart attack had a lower risk of developing heart failure compared to those who underwent standard treatment. This finding offers compelling evidence that stem cells may aid in the heart’s self-repair mechanisms.

Following a heart attack, the heart muscle sustains permanent damage and weakness, rendering the organ unable to adequately pump blood to meet the body’s needs, frequently resulting in heart failure. Presently, the only available treatments are heart transplants or pumps that can restore heart function.

To explore solutions, researchers turned to stem cells, which possess the remarkable capability to transform into various cell types. Nonetheless, prior studies evaluating their application post-heart attack have yielded inconsistent results. A 2020 study with 375 participants showed that bone marrow-derived cells, which include stem cells that evolve into blood cells, did not notably decrease mortality compared to standard therapies such as cardiac rehabilitation and medications aimed at lowering blood pressure, preventing blood clots, and managing cholesterol levels.

Armin Attar and colleagues from Shiraz University in Iran explored a different strategy. They employed mesenchymal stem cells capable of differentiating into structural cells such as cartilage and adipose tissue. These stem cells are also known to release substances that mitigate inflammation and promote tissue regeneration.

The researchers collected mesenchymal stem cells from umbilical cord blood and administered them into the hearts of 136 patients within three to seven days following their first heart attack. While these stem cells can also be extracted from the individual’s own adipose or bone tissue, the cultivation process can take up to a month. By utilizing umbilical cord blood samples, the team can provide treatments more swiftly and potentially enhance their efficacy, Attar explained. Another group of 260 participants received standard post-heart attack treatments.

After three years, individuals who received the stem cell therapy were, on average, 57% less likely to develop heart failure and 78% less likely to be hospitalized for heart failure compared to those receiving standard treatment. Furthermore, they exhibited significant improvements in cardiac function, suggesting that the therapy aids in the regeneration of heart tissue post-injury.

“This represents a significant advancement,” Attar remarked. Although the therapy did not lower mortality risk during the study period, the reduction in hospitalizations is still significant, according to Hina Chowdhury from the Icahn School of Medicine at Mount Sinai in New York. “Heart failure is the predominant cause of hospital admissions in the U.S.,” she pointed out.

However, it should be noted that 80% of participants were male, leading Chaudhry to caution that it is uncertain how the therapy would affect women, who are more prone to heart failure post-heart attack. Attar’s team did not observe any gender differences in a separate analysis. This study was also restricted to young adults, with all participants aged between 18 and 65. “It’s beneficial to see distinctions among age groups, as younger individuals typically have enhanced regenerative abilities and recover better from cardiac injuries,” Chaudhry noted.

This research provides the most robust evidence to date that stem cells can aid in restoring heart function post-heart attack. Nevertheless, this treatment does not fully heal the heart. “There is no medication or treatment that can replace lost heart muscle cells,” Chaudhry emphasized. Still, she added, “This ongoing work is expanding our understanding of the heart’s regeneration process and how to achieve it.”

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Source: www.newscientist.com

Breastfeeding Triggers Immune Cell Surge and May Offer Cancer Protection

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Immune-related changes occur in the breast after breastfeeding

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Breastfeeding has long been linked to lowering the risk of breast cancer. However, the precise mechanisms behind this effect remain elusive. Recent studies reveal that women who breastfeed possess a higher presence of specialized immune cells in their breasts that might inhibit malignant immune cells.

Previous findings indicate that the risk of breast cancer, which is the second most prevalent cancer globally, decreases by 4.3% for each year of breastfeeding. This preventive effect appears to be particularly advantageous for older mothers.

The exact reasons remain partially understood, but are believed to involve alterations in breast tissue and hormonal exposure. To investigate further, Shereen Roy and colleagues at the Peter McCallum Cancer Center in Victoria, Australia, examined breast tissue from 260 women from diverse ethnic backgrounds, aged 20 to 70. These women varied in their maternal status and breastfeeding experiences, with none having previously been diagnosed with breast cancer.

“We discovered that breastfeeding mothers have a greater quantity of specialized immune cells known as CD8+ T cells, which can persist in breast tissue for decades after childbirth,” says Roy. “These cells serve as local defenders, poised to combat abnormal cells that may lead to cancer.” In certain instances, these cells remained present for up to 50 years.

The researchers also investigated mice, some of which underwent a complete cycle of pregnancy, lactation, and breast recovery during the weaning of their pups. Their mammary tissue was analyzed 28 days later, by which point the mammary glands had reverted to their pre-pregnancy state. Other mice had their pups taken away shortly after birth, or they were not pregnant at all.

The study revealed that completing a full lactation cycle significantly increased the accumulation of specialized T cells in mammary tissue, a phenomenon not observed in the other mice. When triple-negative breast cancer cells, known for their aggressive nature, were transplanted into the mammary gland tissue, tumors developed much more slowly in mice that had experienced lactation. However, depleting these T cells led to rapid tumor growth.

The researchers also analyzed clinical data from over 1,000 women diagnosed with triple-negative breast cancer post at least one full-term pregnancy. They found that women who breastfed exhibited tumors with a higher density of CD8+ T cells. “This indicates that the body’s immune response against breast cancer is active and ongoing,” notes Roy.

After considering other risk factors linked to breast cancer mortality, such as age, the researchers noted that women who breastfed had substantially longer overall survival. However, the variability in the data made it challenging to determine whether the duration of breastfeeding impacted this outcome.

The research team believes that T cells accumulate during breastfeeding to fend off infections that can lead to mastitis. Additionally, the relationship between pregnancy and breast cancer is complex, with studies indicating the risk being mitigated primarily for pregnancies occurring at younger ages.

“These findings have significant implications for understanding why certain women possess a more inherent protection against aggressive breast cancer and how we might develop targeted prevention and treatment strategies in the future,” Roy explains. However, she emphasizes that the choice to breastfeed is personal, not feasible for everyone, and may not always prevent breast cancer development.

Daniel Gray, along with researchers from the Walter and Eliza Hall Medical Research Institute in Victoria, highlighted that one of the study’s strengths was the analysis of multiple groups of women. “This lays the groundwork for future research that may elucidate how CD8+ T cells retain ‘memory’ of breastfeeding,” he comments.

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Source: www.newscientist.com

Research Indicates Space Travel May Accelerate Stem Cell Aging by Up to 10 Times

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Transitioning to space poses significant challenges for the human body.

Astronauts can experience loss of bone density, swollen nerves in their brains and eyes, and alterations in gene expression. Research indicates that time spent in space can accelerate aging.

Groundbreaking research by NASA’s twin astronauts Mark and Scott Kelly monitored aging indicators in both siblings, with Mark remaining on Earth while Scott spent 340 days in space.

Six months later, several changes in Scott persisted, including DNA damage, cognitive decline, and telomere shortening that affects chromosome protection. This was highlighted in the Journal Science.

Recent research published in Cell Stem Cell reveals that stem cells also show signs of aging due to stress from space flight.

According to Dr. Catriona Jamieson, director of the Sanford Stem Cell Institute at UC San Diego, these cells are “aging ten times faster in space than on Earth.”

Stem cells are unique cells capable of differentiating into various tissue types. Their accelerated aging poses a concern as it diminishes the body’s natural ability to repair tissues and organs.

This new research comes at a time of increasing interest in space exploration, with government plans for long-term lunar missions and private companies sending consumers and celebrities into space. Understanding these health risks is crucial for safer space travel. Additionally, studying the acceleration of intracellular aging aids researchers in comprehending biological processes at a slower pace.

Astronauts and twin brothers Scott and Mark Kelly at NASA’s Johnson Space Center in 2016.
Houston Chronicle /Hurst Newspaper /Houston Chronicle by Getty Image

Researchers utilized bone marrow stem cells sourced from individuals who underwent hip replacement procedures. These cells were cultivated in “nanobioreactors,” essentially small, clear blood bags no larger than an iPhone that facilitate biological processes. The nanobioreactor was housed in a monitored environment known as cubelabs.

Samples from each patient were divided into two cubelabs; one was sent to space, while the other remained on Earth.

The samples intended for space travelled aboard the International Space Station across four commercial resupply missions conducted by SpaceX. Overall, the samples experienced microgravity for 32-45 days, the weightlessness found in orbit. For comparison, the Earth-bound cells were maintained in a cube lab setup.

Cubelabs monitored cell conditions throughout the journey and terrestrial duration, capturing daily images using a microscope. Upon the return of the space-stressed stem cells to Earth, researchers conducted comparisons against ground controls, sequenced the genome, and performed additional analyses.

Source: www.nbcnews.com

Revolutionary Zombie Cell Killers: The Ultimate Solution to End Your Back Pain for Good

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Innovative treatments may transform the management of lower back pain by addressing the root causes associated with inflammatory “zombie” cells. Recent research conducted using mice.

A group of scientists, led by researchers from McGill University in Canada, found that a combination of two medications, O-Vanillin and RG-7112, effectively eliminates zombie cells from mouse spinal tissues, alleviating pain and inflammation symptoms.

“Our results are promising because they indicate that by eliminating cells that not only obscure pain but also contribute to issues, we can approach lower back pain treatment in a novel manner,” stated the senior author, Professor Lisbet Haglund from McGill’s Ministry of Surgery.

Zombie cells, also referred to as senescent cells, do not function like typical cells. Rather than undergoing division and death to make way for new cells, they persist in the body.

As we age, these zombie cells can build up, leading to inflammation, pain, and spinal damage.

For the hundreds of millions of adults globally suffering from back pain, the impact of zombie cells is often masked and inadequately addressed by current medications.

This new treatment, however, aims to alleviate back pain by targeting and eliminating these lingering zombie cells, thereby addressing the underlying issues.

Aging or zombie cells accumulate in the shock-absorbing discs between each spinal vertebra, releasing inflammatory molecules that damage discs – Credit: Nemes Laszlo/Science Photo Library via Getty

The McGill research team discovered this promising new treatment while working with mice genetically engineered to develop spinal injuries and lower back pain over seven months.

The researchers administered varying doses of O-Vanillin and RG-7112 to these mice. Some received only one of the drugs, while others received a combination of both.

RG-7112 is a medication already established to remove zombie cells in various contexts, though it hasn’t been applied to lower back pain treatment until now.

O-Vanillin, a natural compound sourced from turmeric, is recognized for its anti-inflammatory benefits, but had not been previously tested against zombie cells.

After 8 weeks of treatment, mice receiving both drugs at higher doses exhibited the lowest levels of zombie cells, inflammation, and pain.

Those treated with a single drug showed some improvement, but the results were not as significant as those achieved with the combination therapy.

“The pressing question now is whether these medications can produce the same effects in human subjects,” Haglund remarked.

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Source: www.sciencefocus.com

Life-Saving Treatments for Fatal Genetic Disorders Through Brain Immune Cell Replacement

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Microglia are specialized immune cells in the brain

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The process of replacing immune cells in the brain halts the advancement of a rare and terminal brain disorder known as ALSP. This also paves the way for future clinical trials targeting other neurological ailments.

Extensive research indicates that impaired microglia—specialized immune cells within the brain—play a role in various neurological disorders, including Alzheimer’s disease and schizophrenia. The term ALSP stands for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia, characterized by mutations in genes responsible for the survival of these cells, resulting in a reduced number of microglia and leading to progressive cognitive decline. Currently, no effective treatment exists for this fatal illness.

To address this, Bo Peng from Fudan University in China and his team employed a novel treatment called microglia replacement therapy. Prior experiments in rodents have shown that implanted stem cells—capable of developing into different cell types—can effectively replace microglia. However, it is necessary to first eliminate existing microglia in the brain to facilitate this. This can be achieved using drugs that target protein microglia.

Pursuing this avenue, Peng and his colleagues conducted initial tests on five mice with genetic mutations analogous to those associated with ALSP. As the mutations already impacted protein microglia, the researchers did not need to deplete these proteins with medication. Subsequently, they transplanted stem cells from healthy mice into the affected mice. Fourteen months later, treated mice exhibited approximately 85% more microglia in their brains compared to six untreated mice harboring the same mutation. Notably, these treated mice also demonstrated improvements in motor function and memory.

Encouraged by these promising findings, the researchers extended the treatment to eight individuals diagnosed with ALSP, using donor stem cells without preconditions. One year post-treatment, brain scans revealed minimal changes in participants compared to scans taken before the procedure. In contrast, four untreated individuals displayed significant brain deterioration and lesions over the same period. This implies that microglial replacement therapy effectively halted the progression of the disease.

At the study’s outset, all participants underwent cognitive assessments using a 30-point scale, where a decrease in score indicated cognitive decline. Reassessments a year later showed that, on average, scores remained stable for those who received the microglia replacements.

These results point to microglial replacement therapy being a potentially effective solution for ALSP. However, since this represents the inaugural human trial, “we remain unaware of any potential side effects,” comments Peng. “Given the rapidly progressive and lethal nature of this disease, prioritizing benefits over possible side effects might be crucial.”

Chris Bennett from the University of Pennsylvania cites the historical use of stem cell transplants for treating neurological disorders. “It has demonstrated effectiveness, particularly through microglia replacement,” he states. Recent FDA approvals for two similar therapies addressing other rare brain conditions further support this. “While prior studies may not have used this exact terminology, they effectively addressed similar conditions,” Bennett elaborates. “I’d describe this as a smart and innovative application of stem cell transplants. Nonetheless, microglia replacement therapy has been evolving for decades.”

Despite this, the results underscore the broader implications of microglial replacement therapy. Experts believe this strategy could one day address more prevalent brain disorders. For example, certain genetic mutations significantly heighten Alzheimer’s disease risk and affect microglial function. Replacing these malfunctioning cells with healthy human equivalents could offer a promising avenue for treatment.

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Source: www.newscientist.com

Challenging Thermal Radiation Limits May Lead to Improved Solar Cell Technology

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By manipulating fundamental physics, researchers can enhance energy-harvesting devices like solar cells

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Researchers have challenged long-standing principles of physics, paving the way for more efficient energy harvesting technologies, such as solar cells.

Linxiao Zhu from Penn State University has aimed to break Kirchov’s law of thermal radiation for nearly ten years. Established in the 1800s, this law states that the amount of thermal radiation emitted by an object is proportional to the heat it absorbs, linking to the fundamental principles of thermodynamics. Historically, it was believed that these constraints were absolute.

“In standard physics literature, it’s indicated that Kirchov’s law is a fundamental requirement of the second law of thermodynamics. However, this is not entirely accurate,” explains Zhu.

Previous breaches of this law were seen, but only concerning specific wavelengths of radiation. Zhu and his team have achieved a more significant departure from the norm.

This breakthrough required two significant elements: precisely structured materials and magnetic fields. Both the arrangement of the material and the magnetic environment play crucial roles in the behavior of the particles making up the radiation, like photons, and the energy they carry.

The researchers developed thin-layered semiconductors from indium, gallium, and arsenides, meticulously organizing the atoms. They positioned this setup near a strong electromagnet, illuminating it with lights of various colors at distinct temperatures, angles, and magnetic field strengths.

This combination of material structure and ongoing magnetic influence led to a significant disparity between the radiation absorbed and emitted—up to 43% more radiation was released than was originally absorbed. Zhu attributes this phenomenon to the presence of multiple colors of light. This characteristic is particularly beneficial since sunlight comprises a mixture of colors when hitting solar cell devices.

Aaswath Raman from UCLA indicates that this trial is a major advancement toward turning previously theoretical concepts into reality. He remarks that the stark difference between absorbed and emitted radiation is “a significant breakthrough.”

While novel materials can enhance the efficiency of light and heat-absorbing devices, the requirement for magnetic fields presents challenges. However, Raman remains optimistic about the emergence of new materials that display magnetic properties without requiring proximity to magnets, which could resolve these issues through innovative electromagnetic techniques.

Source: www.newscientist.com

New brain cell discovery may regulate when you should stop eating

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Manipulating neuron types can make snacks more likely to resist

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Neurons in the mouse brain tell them to stop eating when they have enough food. And since people probably have the same cells, they may one day manipulate them to help treat obesity.

“The main question we were trying to answer was how our brains sense and respond to different signals.” Alexander Nectau At Columbia University in New York.

To learn more, he and his colleagues used a kind of molecular profiling to distinguish between different cell types in the mouse brain. In the dorsal trunk nucleus, part of the brainstem associated with functions such as feeding, mood, and sleep, we encountered cells that produce a hormone called cholecystokinin, which helps regulate appetite.

To study what these cells feel to make them work, researchers measured their activity as mice spent the day. “Every time an animal eats a bite, activity has risen and then it has become corrupted,” says Nectow. “These neurons sense and use information such as food smells and sights, food tastes, food sensations in the intestines, and neurohormones released in response to intestinal foods and so on. You can actually finish your meal.

Next, researchers used a technique called optogenetics. This involves engineering neurons so that they can turn them on and off with light. The mice slowed their diet when they used light to activate them. The more intense the activation, the slower and stopped the animal.

Neurons sit in the brainstem and are similar ancestor characteristics across vertebrates, so Nectow probably thinks we have them too. “We didn’t confirm that, but my guess is that humans have these neurons.”

The team also discovered that mouse neurons can be activated by compounds called glucagon-like peptide-1 (GLP-1) agonists. Brand names such as Ozempic and Wegovy.

If these neurons have the same function in people, theoretically, they can either control the feeding habits of obese people or combine this approach with GLP-1-based drugs to increase greater weight loss. They can be adjusted to achieve, says Nectau.

“Understanding the circuits governing meal halts is particularly important in an environment of near-ubiquitous food availability,” he says. Jeff Davis At Swansea University, UK. “The authors used elegant methods to identify these important cell populations.”

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Source: www.newscientist.com

Postponing the gift of a cell phone annually offers significant advantages: Managing screen time for children everywhere.

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Despite the availability of affordable cell phones, parents have new ways to stay connected with their children. However, this development has also sparked debates on screen time, safety, and social media.

As worries about phone usage rise and the age at which children get their first mobile phone decreases, countries worldwide are considering ways to address this issue in schools and homes.

While there’s no single solution, various action plans and suggestions are being explored, ranging from strict laws to grassroots initiatives.

Our correspondent delves into some of the noteworthy solutions to screen time as Australia and Spain gear up to implement stringent laws to combat the problem.

Australia: “Ensuring our children have a good childhood.”

In a significant move, Australia recently passed a law prohibiting social media use for under-16s, although specifics regarding its implementation and application are unclear.

While some Australian states already ban mobile phones in schools, a new federal ban aims to completely restrict social media usage for children under 16 by year-end. The law grants the communications minister authority to determine which platforms are restricted, likely including Snapchat, Instagram, Facebook, and TikTok.

YouTube is expected to be exempt due to its claimed educational benefits.

The legislation mandates platforms to verify users’ ages and take necessary steps to ensure compliance, with penalties of up to A$50m for non-compliance. Trials for age verification technology are ongoing, including facial age estimation and other authentication methods.

Australian Prime Minister Anthony Albanese emphasized that the ban aims to offer children “a childhood”, encouraging them to engage in outdoor activities and sports instead of being glued to their phones.

Josh Taylor, Melbourne

Spain: “You can use ours.”

Spain’s government is proposing a bill to raise the minimum age for social media account registration from 14 to 16, along with mandatory age verification measures for tech companies.

Additionally, the bill suggests default parental controls on smartphones and a national education campaign to educate children and teens on responsible social media usage.

An expert panel has recommended including warning labels on digital devices sold in Spain to inform consumers of the health risks associated with social media and technology.

In Barcelona’s Poblenou district, parents initiated a campaign to delay children’s access to mobile phones until age 16. This movement quickly spread across Catalonia, emphasizing the importance of holding off on phone ownership until a later age.

Major project spokesperson Nuria González Rojas noted the significant impact of delaying mobile phone ownership, with over 72% of Spanish children owning smartphones by age 12.

In another initiative, Basque parents’ organization Archa Brua is piloting schemes to delay mobile phone ownership with support from schools, families, and local businesses.

Sam Jones, Madrid

France: “Take back control of your screen”

French President Emmanuel Macron commissioned a report urging a reassessment of screen usage to safeguard children’s well-being and democracy’s future.

The report advocates for delaying smartphone usage until age 13, restricting access to social media until 18, and banning mobile phones with internet access until after school hours.

Experts stress the need to shield children from profit-focused tech influences due to adverse effects on vision, sleep, and overall health.

Macron urges ministers to consider and implement the report’s recommendations.

Angelique Chrysafis (Paris)

Italy: school ban

Italy has issued a blanket ban on smartphones and tablets in primary and middle school classrooms, citing disruptive incidents like physical altercations between students and teachers.

Education Minister Giuseppe Valditara supports efforts to ban mobile phones for children under 14 and social media profiles for those under 16.

Angela Giuffrida (Rome)

Germany: “The longer we can delay children from using smartphones, the better.”

German schools can’t outright ban cellphones, but restrictions on their use in classrooms and during breaks are in place.

Efforts to enhance digital literacy among youth are encouraged, with calls in some regions for total bans on mobile phones in elementary schools.

Pediatric experts advocate delaying smartphone ownership until age 11 to protect children’s development, noting adverse effects on mental health and well-being from early exposure to social media.

Despite concerns surrounding smartphones, Germany’s decentralized governance system means a national policy remains elusive.

Deborah Cole, Berlin

Source: www.theguardian.com

The upcoming advancements of 3D cell culture in biomedical research

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For more than a century, scientists have studied how cells grow and develop to aid medical research and drug development. They grow plant and animal cells in laboratory equipment such as Petri dishes, glass plates, and various media, producing collections of newly grown cells called “cells.” cell culture. Scientists carefully maintain cell cultures for research, providing the cells with the nutrients and environmental conditions they need to survive and reproduce. By studying them, researchers have advanced the scientific community’s understanding of cellular life and developed new drugs and vaccines against diseases such as cancer.

Currently, scientists grow most cell cultures in dishes or flasks. 2D culture. Two-dimensional or 2D cell culture confines cells to an unnatural flat space, limiting their growth and range of movement. These obstacles lead to less than optimal precision in 2D cell culture experiments, so scientists have invented new three-dimensional approaches to address these limitations.

This new approach consists of growing cells in three-dimensional systems such as spherical plates, gel-like materials that provide structural and biochemical support. hydrogelor specialized equipment that creates a controlled environment to regulate the delivery of nutrients. bioreactor. These systems allow cells to grow in all directions, just as they do in nature and in the human body. Scientists call these devices: three dimensional or 3D cell culture. 3D cell culture provides a more realistic environment in which cells can migrate, interact, mature, and organize into complex structures that resemble organ tissues.

The team of scientists wanted to assess the current state of 3D cell culture technology and how it is being adopted in the field of microbiology. Researchers have discovered that scientists are effectively using 3D cell cultures to develop vaccines, model tumors, and develop patient-specific cancer treatments. They explained that 3D cell culture is superior to 2D cell culture in these areas because artificially flat conditions limit the amount of cell growth. This limitation allows drugs and treatments aimed at killing cells or slowing their growth to appear to work, when in fact the cells are simply responding to the shape of their environment. This may create an illusion.

As part of their evaluation, the research team found that cells growing in all directions interact with their environment in ways that better mimic human tissues, forming structures like clusters of epithelial cells or the invasive patterns of cancer cells. I also discovered that. They explained that this realism will improve the accuracy of treatments, drug tests, and vaccine tests by more effectively replicating how treatments target cells and tissues in the body. . Although 3D cultures address many of the limitations of 2D systems, such as mechanical and biochemical relevance, they still face challenges such as reproducing the complexity of immune interactions.

One of the central problems with 3D cell culture that researchers have identified is that some researchers find it prohibitively expensive. Constructing a 3D cell culture can be 2 to 10 times more expensive than a 2D cell culture. Additionally, scientists have a hard time creating and maintaining them because they are very complex in design and require specialized equipment to maintain.

The researchers say these factors made adopting these practices a lengthy process for biomedical researchers. The researchers predicted that slow adoption could cause problems in the future, as researchers pioneering these unusual techniques may have trouble finding qualified reviewers to evaluate their experiments. . You will also have fewer colleagues qualified to reproduce your results.

Scientists concluded that 3D cell culture provides a more accurate model for drug testing, cancer research, and tissue engineering. Therefore, it could reduce researchers’ reliance on animal models, streamline drug development, and potentially lead to safer and more effective treatments. However, despite the many advantages of 3D cell culture, challenges such as high cost, technical complexity, and need for standardization continue to hinder its widespread adoption. The team’s proposed solution is to make 3D machining more accessible and improve overall efficiency. They also suggested that future researchers continue to use 3D cell cultures to push the boundaries of medicine by exploring applications in regenerative medicine and personalized cancer treatments.


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Source: sciworthy.com

Research: Protein from tardigrades found to inhibit human cell metabolism

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New research led by University of Wyoming Laramie provides additional evidence that tardigrade proteins could ultimately be used to provide life-saving treatments to people for whom refrigeration is not possible and to enhance storage of cell-based treatments.

Sanchez Martinez other. We provide insight into how tardigrades induce reversible biostasis through self-assembly of labile CAHS gels.

First discovered in 1773, tardigrades are a diverse group of microscopic invertebrates best known for their ability to survive in extreme conditions.

Also known as tardigrades or moss piglets, these creatures can live up to 60 years, grow to a maximum size of 0.5 mm, and are best seen under a microscope.

They can survive temperatures as low as -272 degrees Celsius (-457 degrees Fahrenheit) or as high as -150 degrees Celsius (-302 degrees Fahrenheit), and temperatures as low as -20 degrees Celsius for several minutes, and for up to 30 years without food or water. Masu. Minus 4 degrees Celsius (minus 4 degrees Fahrenheit) continues for decades.

Tardigrades can withstand pressures from nearly 0 atmospheres in space to 1,200 atmospheres at the bottom of the Mariana Trench, and radiation levels of up to 5,000 to 6,200 Gy.

They survive by entering a state of suspended animation called biostasis, using proteins that form gels within their cells and slow down life processes.

“Surprisingly, when you introduce these proteins into cells, they gel and slow down their metabolism, much like tardigrades do,” says researcher Sylvia Sánchez Martinez, Ph.D., of the University of Wyoming, Laramie.

“Furthermore, just like tardigrades, putting human cells with these proteins into biostasis makes them more resistant to stress, giving human cells some of the tardigrade's abilities.”

“Importantly, our study shows that the entire process is reversible,” said researcher Thomas Boothby, Ph.D., of the University of Wyoming, Laramie.

“When stress is reduced, the tardigrade gel dissolves and human cells return to normal metabolism.”

“Our findings provide an avenue to pursue technologies centered on inducing biostasis in cells and even whole organisms to slow aging and increase shelf life and stability.”

of findings appear in the diary protein science.

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S. Sanchez Martinez other. 2024. Unstable assembly of tardigrade proteins induces homeostasis. protein science 33 (4): e4941; doi: 10.1002/pro.4941

Source: www.sci.news

Feeling Anxious About Kids and Cell Phones is Normal, but Banning is not the Solution – Zoe Williams

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I I received a message from a former colleague, a once cheerful person who is now a provocateur of “alt-right” nostalgia to an aging society. Whatever he wanted, I would have told him to get on with it, but it just so happened that I didn't really agree with it: campaign to limit children's cell phone use. It is a bipartisan organization that

As surely as anything bad happens to children, people will blame it on phone use. Perhaps there is a crisis in their mental health, someone is being bullied online, someone is being threatened over an image they have sent, they are part of a criminal organization, part of a murderous enterprise, or they are committing self-harm. You may be doing this. Somewhere in the story, smartphones probably don't play a role. Those affected often wish they had limited their phone use, or at the very least, are keenly aware that they had little knowledge of what was happening to their children, who of course were constantly on their phones. is used. Then politicians and pundits get involved, exploiting the sorrows and trials of others to their discursive advantage, lecturing schools on the measures they are already frequently implementing and forcing parents back to “dumb phones”; Preaching to kids to ban devices completely.

And steadily, it becomes another indicator of reputable parenting. If you're doing it right, your kids will get a Nokia at age 14 and won't know about Instagram until they're 25. And all the kids who have had iPhones since age 6 and can operate them with one thumb, they texted with their eyes closed, well, they were clearly poorly raised. The main reason I dislike such campaigns is that they turn parents into jailers whose authority they must circumvent, which I can't help but think inhibits openness. Beyond hard work, respect, and responsibility, I like to instill the values ​​of “tell me what's going on” above all else. No information is too small. Beef is not trivial. No gossip is too far away. If someone from a completely different age texted another person a shrimp emoji and that person mistook it for a sombrero, I'd love to hear about it. Also, if I want to spend a significant amount of time every day engaging in a fierce battle with a teenager, I want it to be about something important: which is better, a dog or a cat? How many crunches should I eat in a day? – It's not about compulsive phone checking behavior that's just as good as mine, or even slightly better.

But I'd be lying if I said I didn't feel scared multiple times a day looking at the state of modern connectivity. TikTok is basically a never-ending reinforcement exercise. If your hobbies are K-pop or cafes with animals, there's no problem. All you see is a nicer young Korean woman and a piglet drinking a cappuccino. When I was 14, I was so obsessed with trench warfare that I regularly thought I was going crazy. I don't even want to think what my social feed would look like, a combination of self-diagnosed mental illness and military recruitment ads.

Snapchat, on the other hand, works as if someone created the app out of a disturbing dream. What if everyone could see not only who you're talking to most of the time, but also who you're talking to? They are I was able to talk to the most people and rank entire circles by their asymmetrical loyalties and affiliations. Imagine if you could always see where everyone is with Snap Maps. But if you turn it off to avoid detection, you'll look suspicious and he'll probably start people gossiping about you on Snapchat. The level of hyper-surveillance that teens exert on each other is incredible. The last thing you want to do is rush in with an oar and make the situation worse.

But I think so, and I always say one thing: Whatever it is, it's not the end of the world. Today's social apocalypse will be tomorrow's boring anecdote. Yes, the internet has a very long memory, but it also has a lot going on at the same time. I don't have the strength to stay angry forever or even for two weeks. It's strange that no one has proposed a cross-party parenting campaign to help us all maintain a sense of balance. That should be our main job.

Zoe Williams is a columnist for the Guardian

Source: www.theguardian.com

Nerve cell overgrowth may be the cause of persistent pain following a UTI

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Urinary tract infections often cause you to need to urinate more often than usual

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Pain that persists even after a urinary tract infection appears to be cured may be caused by an overgrowth of nerve cells in the bladder.

Urinary tract infections (UTIs) are most commonly caused by bacteria. Escherichia coli From the feces, it reaches the urethra, bladder, and kidneys. Common symptoms include pain when urinating and an urge to urinate more frequently than usual. These infections primarily affect women, but About half of them will develop a urinary tract infection at some point in their lives.

“One of the big problems with urinary tract infections is that the recurrence rate is very high,” he says. Soman Abraham At Duke University, North Carolina. “However, after treatment, some people may experience the same symptoms of a urinary tract infection even if the infection is gone.”

To understand the root of the ongoing symptoms, Abraham and his colleagues reported persistent pelvic pain due to recurrent urinary tract infections, even though examination revealed no pain.8 analyzed bladder tissue biopsies taken from human women. Escherichia coli in their urine. They also collected biopsies from three women who were not known to have had urinary tract infections. The study did not include transgender people.

The researchers found that women with persistent UTI symptoms had an abnormal overgrowth of nerve cells in their bladders compared to other women. These nerve cells also contained high levels of a peptide called substance p, which causes pain and inflammation.

The researchers then gave the mice recurring urinary tract infections and found that they showed similar persistent signs of pain even after the infection had subsided. When the researchers looked closely at the mouse bladders, they found that immune cells called mast cells, which are located near nerve cells, were highly activated. Mast cells produce so-called nerve growth factors, which stimulate the production of nerve cells.

Antibiotics used to treat UTIs are often less selective for the bacteria they target, affecting beneficial bacterial strains around nerve cells. This damages nerve cells, causing mast cells to work overtime to help replace them, Abraham says.

In the final part of the experiment, the researchers induced urinary tract infections in another set of mice before treating them with a compound that suppresses the production of nerve growth factor. He then induced two more urinary tract infections and found that the mice showed no signs of lingering pain.

The research team hopes the results will help develop effective treatments to prevent ongoing symptoms in people. “You can actually prevent these nerves from growing, which can prevent pain and urinary frequency,” Abraham says.

topic:

Source: www.newscientist.com

AT&T customers across the U.S. experience major cell phone service disruption

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Early Thursday morning, cell phone outages affected cities across the United States, causing thousands of AT&T customers to experience service interruptions. These interruptions prevented them from sending text messages, accessing the Internet, making phone calls, and even calling 911.


Around 7 a.m. ET, more than 50,000 incidents were reported, and that number exceeded 70,000 by 9 a.m. ET. However, by 11 a.m. ET, reports of service failures had decreased to 60,000.

AT&T spokesperson Jim Greer stated, “Some customers are experiencing wireless service interruptions this morning. We are working urgently to restore service. He recommends using Wi-Fi calling until service is restored. I recommend it.”

AT&T, the largest U.S. mobile phone service provider with 240 million subscribers, did not offer a possible explanation for the outage. The company also did not provide a timeline for when full service would be restored. Despite intermittent outages in recent days, Thursday’s outage was much larger.

The most affected cities, according to the website, included San Francisco, Houston, Atlanta, and Chicago.

Users of other carriers such as Verizon, T-Mobile, Cricket, and UScellular also reported outages, but those were much smaller compared to AT&T. Verizon and T-Mobile confirmed that the outage did not affect their own customers, except when trying to contact customers of other carriers.

T-Mobile stated, “No outages occurred,” while Verizon’s statement said, “Verizon’s network is operating normally.”

The San Francisco Fire Department and the City of Chicago’s Office of Emergency Management and Communications were actively addressing the issues affecting AT&T Wireless customers.

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Atlanta Mayor Andre Dickens confirmed that calls with the city’s emergency services continued to work. However, Massachusetts State Police advised against using phone services and dialing 911 due to a flooding of concerned callers testing the service.

The police department stated, “Many 911 centers across the state are inundated with calls from people trying to see if 911 works from their cell phone. Do not do this. Call another number via your cell phone service. If you can make a non-emergency call, 911 service will also work.”

Source: www.theguardian.com

New UCLA study challenges traditional views of bioengineering and stem cell dynamics

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Confocal microscopy images show mesenchymal stem cells (green) captured within nanovials (pink). Nanovial technology was developed by Dino Di Carlo and colleagues at UCLA. Credit: Shreya Udani/UCLA
University of California Los Angeles Stem cell scientists have uncovered surprising genetic instructions for promoting protein secretion, with major implications for biotechnology and cell therapy.
Mesenchymal stem cells present in the bone marrow secrete therapeutic proteins that may help regenerate damaged tissue.
The UCLA study examining these cells challenges conventional understanding of what genetic instructions drive the release of these therapeutic proteins.
The discovery could help advance both regenerative medicine research and the laboratory production of biological therapeutics already in use.
Expanding the possibilities of antibody-based medicineToday, drugs based on antibodies (proteins that fight infection and disease) are prescribed for everything from cancer to disease. COVID-19 (new coronavirus infection) For high cholesterol. Antibody drugs are supplied by genetically engineered cells that act as small protein-producing factories in the lab.
Meanwhile, researchers are targeting cancer, internal organ damage, and many other diseases with a new strategy that involves transplanting similarly engineered cells directly into patients.
These biotechnological applications rely on the principle of causing cellular changes. DNA When a cell produces more genetic instructions to make a particular protein, it releases more of that protein.
Challenging established biological principlesBut a groundbreaking study from UCLA challenges this long-held belief, at least when it comes to certain types of stem cells.
The researchers looked at mesenchymal stem cells, which reside in the bone marrow and can self-renew and grow into bone, fat, and muscle cells. Mesenchymal cells secrete a protein growth factor called VEGF-A. Scientists believe this may play a role in blood vessel regeneration, repairing damage caused by heart attacks, kidney damage, arterial disease in the extremities, and other diseases.
Amazing discoveries in stem cell researchWhen the researchers compared the amount of VEGF-A released by each mesenchymal cell to the expression of the gene encoding VEGF-A in the same cells, the results were surprising. There was only a weak correlation between gene expression and actual growth factor secretion. Scientists have identified other genes that better correlate with growth factor secretion, including genes that code for proteins on the surface of some stem cells. The research team isolated stem cells with the protein on their surface, cultured a population that secreted large amounts of VEGF-A, and continued to secrete it even after several days.
Biotechnology and its impact on medicineThe findings were published Dec. 11 in the journal natural nanotechnologyco-author Dino Di Carlo said, suggesting that fundamental assumptions in biology and biotechnology may be worth reconsidering. UCLA Samueli School of Engineering.
“The central dogma is that there are instructions in DNA, and these instructions are transcribed. RNAThe RNA is then translated into protein,” said Di Carlo, who is also a member of UCLA. California Nanosystems Institute and Eli and Edythe Regional Center for Regenerative Medicine and Stem Cell Research. “Based on this, many scientists assumed that if you had more RNA, you would get more protein, and more protein would be released from the cell. I had doubts.”
It seems inconceivable that when a gene is expressed at a higher level, there is more secretion of the corresponding protein. We found a clear example where this does not occur, and many new questions arise.” Ta.
“The results could help make the production of antibody-based therapeutics more efficient and define new, more effective cell therapies. Knowing the right genetic switches to flip could enable the manipulation and selection of highly productive cells to create or deliver therapeutics.
Breakthrough in single cell analysisThe UCLA study was conducted using standard laboratory equipment enhanced with technology invented by Di Carlo and his colleagues. Nanovials, microscopic bowl-shaped hydrogel containers, each capturing a single cell and its secretions. By leveraging a new analytical method using nanovials, scientists were able to measure the amount of VEGF-A released by each of 10,000 mesenchymal stem cells compared to tens of thousands of genes expressed by that same cell. I was able to link it to the mapped atlas.
“The ability to link protein secretion to gene expression at the single-cell level holds great promise for the fields of life science research and therapeutic development,” said David, a member of the Broad Stem Cell Research Group and a professor of biology at the University of California, Los Angeles. said chemistry professor Kathryn Plath. Center and co-corresponding author of the study. “Without that, we would not have been able to reach the unexpected results found in this study. Now we have learned something new about the mechanisms that underpin the fundamental processes of life, and we have We have an incredible opportunity to leverage this to improve human health.”
A new path in therapeutic drug developmentAlthough activation of genetic instructions for VEGF-A showed little correlation with protein release, the researchers identified a cluster of 153 genes with strong associations with VEGF-A secretion. Many of them are known for their functions in blood vessel development and wound healing. For others, their functionality is currently unknown.
One of the top matches encodes the cell surface protein IL13RA2, but its purpose is poorly understood. Its outer location made it easy for scientists to use it as a marker and separate those cells from other cells. Cells with IL13RA2 showed 30% more VEGF-A secretion than cells lacking the marker.
In a similar experiment, the researchers kept isolated cells in culture for six days. At the end of that period, cells with the marker secreted 60% more VEGF-A compared to cells without the marker.
Potential impact on clinical applicationsMesenchymal stem cell-based therapies have shown promise in laboratory studies, but many of these new options are safe but not effective in clinical trials with human participants. It is shown that there is no. Her ability to use IL13RA2 to sort VEGF-A-rich cells could help change this trend.
“Identifying the subpopulations that produce more and the markers associated with that population means that they can be separated very easily,” Di Carlo said. “If we had very pure populations of cells that produced high levels of therapeutic proteins, we would have better treatments.”The nanovials are commercially available from Partillion Bioscience, a company co-founded by Di Carlo and founded in CNSI’s on-campus incubator. Expand.
Reference: “Correlating growth factor secretion in nanovials with single cell transcriptome using SEC-seq” Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath, Dino Di Carlo, December 11, 2023; natural nanotechnology.
DOI: 10.1038/s41565-023-01560-7The study’s lead author is Shreya Udani, who received her PhD from UCLA in 2023. Other co-authors, all at UCLA, are staff scientist Justin Langerman; Doyoung Koo, who received his Ph.D. in 2023. graduate students Sevana Bagdasarian and Chitradewi Somardi; undergraduate student Brian Chen; Simran Kang received her bachelor’s degree in 2023. and Joseph de Rutte, who completed his PhD in 2020 and is co-founder and CEO of Partillion.This research was supported by: National Institutes of Health It also won the Stem Cell Nanomedicine Program Award, jointly funded by CNSI and the Broad Center for Stem Cell Research.
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Source: scitechdaily.com

Common household products and cosmetics found to impact cell epigenetics

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New research has found that formaldehyde poses serious risks to epigenetics, interfering with gene activity and potentially causing cancer and other diseases. The study emphasizes the need for stricter policies to limit exposure to formaldehyde, given its prevalence in various household products, cosmetics, polluted air, architecture, and other industries.

The research, conducted by Dr. Manel Esteller and Dr. Lucas Pontel from the Josep Carreras Leukemia Research Institute and Dr. Christopher J. Chan from the University of California, Berkeley, focused on the effects of high formaldehyde concentrations in the body. The study revealed formaldehyde’s harmful impact on normal epigenetic patterns and its association with cancer, liver degeneration, and increased asthma risk.

Formaldehyde is commonly found in products used in architecture, furniture manufacturing, textiles, and hair products, as well as in polluted gases and the metabolism of certain food substances. It can also be produced in the body and has the potential to alter the epigenetic landscape of cells.

The study concluded that formaldehyde inhibits the production of S-adenosyl-L-methionine (SAM), a universal donor of the methyl chemical group that regulates genetic activity. This decrease in SAM content leads to a loss of methylation of histones, proteins that package DNA and control gene function, contributing to formaldehyde’s carcinogenic properties.

As such, the researchers stressed the need for environmental and health policies aimed at reducing exposure to formaldehyde in various industries and environmental sources. Despite restrictions by international health authorities, there are still areas of work where formaldehyde is used at high levels, necessitating further regulations to minimize exposure to this hazardous substance.

Reference: Vanha N. Pham, Kevin J. Bruemmer, Joel DW Toh, Eva J. Ge, Logan Tenney, Carl C. Ward, Felix A Dingler, Christopher L. Millington, Carlos A. Garcia Prieto, Mia C. Pross Holmes, Nicholas T. Ingoglia, Lucas B. Pontel, Manel Esther, Keetan J. Patel, and Daniel K.・Nomura, Christopher J. Chan, November 3, 2023, science. DOI: 10.1126/science.abp9201

Source: scitechdaily.com