A serum aimed at reversing hair loss has shown promising outcomes within a two-month period. This topical treatment, formulated with plant extracts and proteins that stimulate cellular activity, demonstrated notable enhancements in hair density compared to a placebo.

Hair loss affects approximately: 50% of men and 40% of women by the time they reach 50. Various treatments, such as finasteride and minoxidil, also known as Rogaine, may be effective; however, their success can vary based on genetics and the degree of hair loss.

Researchers are exploring innovative techniques for hair regeneration, including stem cell applications. Investigations into fibroblast manipulation, a cell type crucial for connective tissue formation, and a drug aimed at revitalizing dormant hair follicles are underway.

In a unique approach, researchers from Schweitzer Biotech in Taiwan have developed a serum enriched with caffeine, commonly found in health products, alongside two proteins known to enhance cellular growth: Insulin-like growth factor-1 (IGF-1) and Fibroblast growth factor-7 (FGF-7), both displaying potential for hair follicle regeneration. Additionally, extracts from Centella asiatica, a tropical herb widely used in skincare, appear to support hair follicle health.

To evaluate efficacy, an international research team enlisted 60 adults aged 18 to 60 without severe hair loss. Participants were divided into five groups; the first group received a placebo serum devoid of active ingredients, while the second group was provided with a basic preparation of 0.1% caffeine and vitamin B5, known for its moisturizing properties. The remaining groups used this base formulation, with the third group incorporating IGF-1 and FGF-7, the fourth group including IGF-1 and FGF-7 with C. asiatica, and the fifth group receiving all components.

All participants were instructed to apply 1 milliliter of serum to their entire scalp nightly for 56 days. Improvements were observed in all groups across various measured outcomes, including hair density, thickness, and reduced hair loss. The most significant increase in hair density was found in Group 5, which saw nearly a 25% improvement—almost double that of the placebo group.

Researchers propose that C. asiatica extracts may enhance hair root strength and boost blood circulation around hair follicles. “This plant has been recognized for its anti-aging, reparative, and anti-inflammatory properties,” explains Christos Tziotsios from King’s College London. “It could be somewhat of a miracle plant. There’s stronger evidence for some of the other components in this study. For instance, IGF-1 and FGF-7 are both known to influence hair cycle dynamics.”

Both Tziotsios and the research team emphasize that while the study’s scale is noteworthy, extended trials are essential before a treatment utilizing this formulation can be deemed available. “This doesn’t negate its potential interest, but it’s clear that further investigation is required,” says Tziotsios. “The more we comprehend the molecular mechanisms linked to hair loss and hair biology, the closer we will be to achieving a definitive treatment.”