In a worrying trend, U.S. hospitals are receiving unusual requests from patients needing blood transfusions: they desire blood from donors who have not been vaccinated against COVID-19. This has, in some instances, delayed urgent treatments and even caused life-threatening reactions.

“These requests stem largely from misinformation surrounding vaccine safety and blood supplies rather than grounded health concerns about blood transfusions,” stated Jeremy Jacobs from Vanderbilt University Medical Center in Nashville, Tennessee. “It’s critical to note that local blood supplies are highly regulated, meticulously tested, and there’s no evidence to suggest that unvaccinated blood reduces transfusion risks.”

Jacobs and his team conducted an analysis of blood donations at the Vanderbilt Center from January 2024 to December 2025. They discovered that 15 patients, or their caregivers, expressed a desire to directly donate blood if the source was a selected individual, often a relative, instead of being sourced from a blood bank.

While direct donations in the UK and Australia are only permitted under rare circumstances—such as when an individual’s blood type is uncommon—the practice is more common in the United States yet often discouraged due to inconsistent policies across facilities.

Researchers noted that all 15 patients specifically requested blood from a donor who was unvaccinated, a direct response to the COVID-19 vaccination. It’s important to mention that blood banks do not record or communicate the vaccination status of anonymized donors.

Such requests have not only caused delays in treatment but also elevated risks for patients. In severe cases, dangerously low hemoglobin levels can result in organ damage or dysfunction. Another patient suffered from anemia as a consequence.

“Direct blood donations introduce operational complexities that routine blood supply usage does not entail,” Jacobs states. “These involve additional logistics, collection processes, tracking, and timing.”

Although blood is rigorously tested before transfusion, direct blood donation may carry an increased risk of infection. This is primarily due to one-time donors being less likely to maintain consistent infection control measures compared to repeat donors known to the blood bank.

The uptick in direct donations mirrors the trends observed during the HIV/AIDS epidemic of the late 20th century and resurfaced with the advent of mRNA COVID-19 vaccines. These vaccines work by introducing a segment of SARS-CoV-2’s genetic material into the body, prompting cells to produce specific proteins and activating the immune response during actual infection.

Extensive studies have affirmed the safety and efficacy of these vaccines, yet misinformation mistakenly ties them to infertility concerns and other health issues. Conspiracy theories falsely assert that these vaccines contain microchips and alter DNA.

Research conducted in 2025, as noted in a study, confirms the safety of blood donations from vaccinated individuals. “The demand for unvaccinated blood reflects significant vaccine hesitancy among portions of the population, rather than genuine transfusion-related risks,” stated Dr. Ash Toye from the University of Bristol, UK.

This issue extends beyond the Vanderbilt Center. Last year, the Welsh Blood Service reported an increase in inquiries regarding donors’ vaccination statuses. A petition to the British government addressing this was also dismissed. Additionally, in Oklahoma, there are legislative proposals pushing for patients to have access to unvaccinated blood.

“These requests illustrate how misinformation creates a significant operational burden for patients, hospitals, and blood donors,” Jacobs stated. “Simultaneously, it highlights the necessity of addressing patient anxieties with respect and empathy, even when those concerns lack scientific support.”