In a groundbreaking discovery, researchers sequenced the complete genome of an ancient Egyptian individual for the first time. The DNA was sourced from the remains of an elderly man, possibly a potter, who lived over 4,500 years ago.

The analysis revealed that this ancient Egyptian had inherited roughly 20% of his DNA from ancestors residing in the fertile crescent, situated more than 1,000 kilometers east of Egypt. This indicates a connection between Egyptian and Mesopotamian cultures, despite the considerable distance.

The remains were unearthed in the early 1900s from Nuweyrat, a necropolis located near Beni Hasan, Egypt. They were discovered within a ceramic vessel placed in the tomb of Iwage. Currently, these remains are housed at the World Museum in Liverpool, England.

“We successfully dated this individual’s remains using radiocarbon analysis,” states Adeline Morez Jacobs from Liverpool John Moore University. He lived between 2855 and 2570 BC, making him one of the earliest individuals from ancient Egypt, whose history spans from 3150 to 30 BC.

Both the skeleton and DNA confirm that the individual was male. Signs of arthritis and other physical indicators suggest he was between 44 and 64 years old. “He was likely in his 60s at the time of death, which is quite advanced for that period,” says Joel Eilish at Liverpool John Moore University.

The man’s social status remains uncertain. “He might have been buried in a manner associated with the upper class,” observes Ireland. However, his skeletal structure indicates a struggle with physical activity. Evidence suggests he frequently looked down or leaned forward, and that he sat on hard surfaces for extended periods. Researchers speculate that his probable profession was as a potter, based on preserved representations of various ancient Egyptian occupations.

Using samples collected from his tooth roots, the team was able to sequence the entire male genome. Previously, only partial genomes from three ancient Egyptians who lived in the region over 1,000 years ago had been achieved.

“There are few genetic sequences available from ancient Egypt,” remarks Shirly Ben-Dor Evian from Haifa University, Israel.

This scarcity is largely attributed to the warm climate, which accelerates DNA degradation. “The conditions are simply too hot,” avers team member Pontus Skoglund from the Francis Crick Institute in London, referring to the sequence as a ‘long shot.’

“We speculated that pot burials would create a stable environment, complementing the rock-cut tombs where these burials occurred,” explains Linus Girdland-Flink from the University of Aberdeen, UK.

As expected, around 80% of the genetic lineage of this male individual corresponds to North African ancestry. However, the remaining 20% aligns with populations from the fertile crescent covering parts of modern-day Iraq, western Iran, Syria, and Turkey.

There are multiple theories regarding this finding, according to Ben-Dor Evian. “Explorers often speculate about these connections,” she comments. Even after agriculture became prevalent, “there always existed a segment of the population that remained nomadic or semi-nomadic,” which may account for DNA migration between the fertile crescent and Egypt.

Archaeological evidence has previously indicated a link between ancient Egypt and Mesopotamia. “A significant cultural connection existed between the two, sharing artistic motifs,” states Ireland, noting that items like Lapis Lazuli were traded between the regions.

This connection might also have influenced the inception of writing systems. “Initial writing appeared almost simultaneously in both areas,” he explains, “with the development of Mesopotamian and Egyptian hieroglyphics taking place just 300 years apart.”

“Was it a local invention originating in both regions? [or] Did they influence each other in some manner?” queries Ben-Dor Evian. “This theory could suggest interaction through the movement of individuals.”