A device designed for facial and neck massage suggests it might enhance the brain’s waste removal system and alleviate symptoms associated with conditions like Alzheimer’s disease.

Cerebrospinal fluid (CSF) envelops the brain and inflates it before moving through a network of delicate tubes known as grinft blood vessels. Research on mice indicates that this fluid clears waste produced by brain cells, including proteins linked to diseases like Alzheimer’s and Parkinson’s, such as beta-amyloid.

This has prompted researchers to consider whether increasing CSF flow could promote brain health. However, they note that the grinft vessels, previously only discovered deep within the neck, are difficult to access. Gou Young Koh, from the Advanced Science and Technology Research Institute in Korea, remarks on this challenge.

Recently, Koh and his team identified a network of grinft vessels located just five millimeters beneath the skin on the faces and necks of mice and monkeys. They made this breakthrough by administering fluorescent dyes that label the CSF and imaging the subjects under anesthesia. “We utilized a different kind of anesthesia than was applied in earlier studies. The previous anesthetic blocked the visualization of vessels close to the skin,” Koh explains.

In their effort to determine if massaging these vessels could boost CSF flow, the researchers developed a device with small rods attached to a 1 cm cotton ball. They used it to gently stroke down the face and neck of a 2-year-old mouse for a few months, applying strokes for one minute on younger mice. “A gentle facial and neck massage can compress the liquid and enhance the CSF flow,” Koh states.

After 30 minutes of massage, CSF flow was observed to increase nearly threefold in the brains of the mice compared to their flow prior to the massage. Furthermore, this process seemed to reverse age-related decreases in CSF flow. “After stimulation, the CSF flow in older mice appeared comparable to that of younger mice [who hadn’t received the massage],” Koh elaborates.

In their unpublished findings, the team observed similar outcomes in monkeys. They also identified glymphetic blood vessels in human cadavers, implying that massage could stimulate CSF flow in humans, as suggested by Koh.

However, due to anatomical differences between mice, monkeys, and humans, further investigations are necessary to confirm this, remarks Vesa Kiviniemi from Uru University in Finland. “It’s a slightly different scenario.”

Moreover, it remains uncertain whether increased CSF flow can genuinely mitigate brain aging or offer protection against neurodegenerative conditions like Alzheimer’s. Stephen Prucks of the University of Bern in Switzerland stated that Koh’s team aims to investigate this with mice that exhibit Alzheimer-like traits.