Innovative research indicates that the optimal time for labor induction is early in the morning. This approach aligns with our natural circadian rhythms, potentially shortening labor duration and decreasing the likelihood of C-sections.

“This cost-effective strategy enhances the birthing experience for mothers, newborns, and healthcare providers alike,” notes Hanne Hoffman from Michigan State University.

Across the UK, US, and Australia, approximately one-third of all births are induced, utilizing medication or artificial methods instead of allowing labor to commence spontaneously. Induction generally mitigates the risk of stillbirth, especially when the baby is overdue or facing developmental issues. Another indication for induction is when the water breaks prematurely, heightening the risk of infection.

However, induced labor can often be longer than natural labor. “I know individuals who underwent labor induction and endured two lengthy days of it; I was astonished by their prolonged and painful experiences,” Hoffman shares.

This prompted Hoffman, who investigates circadian rhythms—our body’s natural oscillations—to contemplate whether a specific time of day is ideal for labor induction. “We observe that natural childbirth follows a circadian rhythm, with uterine contractions peaking in the late evening and deliveries primarily occurring at night,” she adds. This timing may have evolved as it offers a safer environment, reducing predator threats.

To further explore this, Hoffman and her team analyzed data from over 3,000 induced deliveries at Michigan hospitals from 2019 to 2022. They discovered that the shortest labor duration was for those induced between 3 a.m. and 9 a.m. For instance, inductions at 5 a.m. averaged 15 hours, while those at 11 p.m. took around 21 hours—an extension of six hours. Those induced in the morning also faced lower chances of emergency C-sections.

The early morning advantage may stem from heightened uterine receptor sensitivity to oxytocin during this timeframe, a crucial hormone that stimulates uterine contractions during childbirth. For inductions, a synthetic oxytocin is typically administered. “When a doctor initiates labor with a substantial dose of oxytocin, you may, in essence, be capitalizing on your body’s internal morning oxytocin boost and intensifying labor,” explains Satchidananda Panda from the Salk Institute for Biological Studies in San Diego, California.

The findings suggest that women with a higher BMI or first-time mothers benefit significantly from early morning inductions. The research team now aims to delve into the biological mechanisms behind these outcomes.

While organizing all labor inductions between 3 a.m. and 9 a.m. may not be feasible for all hospitals, prioritizing first-time mothers and patients with higher BMI could be beneficial, Hoffman posits.

Crucially, this study indicated no medical complications arising from early morning inductions. “We observed no rise in NICU admissions,” emphasizes Rene Cortese from the University of Kansas Medical Center. “This study sends a vital message: while one risk is diminished, no new risks are introduced.”

The research team is eager to conduct additional studies to validate that assigning early morning delivery actually enhances outcomes. “We need to establish a proof-of-concept study to replicate this finding,” shares Hoffman.

Other chronotherapy approaches, which adjust medical interventions based on circadian rhythms, are being explored across oncology, cardiology, and psychiatry, with recent findings indicating that administering cancer treatments before 3 p.m. can improve patient survival rates.