Research Indicates Omega-6 Fatty Acids Do Not Elevate Inflammation Markers

In an extensive community-based investigation, researchers from the Fatty Acid Institute identified a weak yet statistically significant inverse relationship between various inflammatory biomarkers and omega-6 fatty acids.

This image features Oenothera biennis, plants that produce oils with a high linolenic acid content. Image credit: Georg Slickers/CC by-sa 4.0.

“Chronic inflammation is acknowledged as a significant risk factor for various health disorders,” stated President William Harris of the Fatty Acid Institute and his colleagues.

“Omega-6 fatty acids, especially linoleic acid (LA) and arachidonic acid (AA), have been identified as either anti-inflammatory or pro-inflammatory agents. Researchers have considered both positions regarding dietary intake.”

The researchers utilized data from the Framingham Offspring study, a prominent cohort study in the Boston region.

This groundbreaking longitudinal research initiative began in 1971 and follows children from the original Framingham Heart Study, examining genetic and lifestyle factors influencing cardiovascular and metabolic health.

It has yielded valuable insights into chronic disease risks and prevention for decades, establishing itself as one of the most dependable sources for understanding long-term health trends.

This investigation is cross-sectional, meaning LA and AA levels were evaluated alongside 2,700 inflammation-related biomarkers in the same blood samples.

We statistically analyzed the association between the levels of these two omega-6 fatty acids and the levels of 10 blood and urine biomarkers related to inflammation and oxidative stress.

After statistically controlling for several potential confounding variables (such as age, race, gender, smoking status, blood pressure, and weight), researchers discovered that elevated LA levels were significantly linked to lower levels of five out of the 10 biomarkers.

For AA, higher levels were associated with reduced concentrations of four markers; however, there was no statistically significant relationship with higher inflammation/oxidation levels, unlike LA.

“These new findings clearly indicate that individuals with the highest LA (and AA) levels in their blood exhibit less inflammation than those with lower levels,” Dr. Harris remarked.

“This result contradicts the expectation if omega-6 fatty acids were deemed ‘pro-inflammatory.’ In fact, they seem to exhibit anti-inflammatory properties.”

“Amidst discussions in the media about the dangers of seed oils—the primary source of LA in diets—numerous voices advocate for reducing LA consumption.”

“This recommendation lacks a scientific basis, and this study, along with others, suggests the opposite: rather than decreasing LA intake, increasing it may be the healthier choice.”

“These findings diverge from the prevailing narrative but are consistent with earlier studies.”

“Numerous studies within medical literature support the findings presented here.”

The study was published in the journal Nutrients on June 22nd.

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Heidi T.M. Lai et al. 2025. Erythrocyte omega-6 fatty acids and biomarkers of inflammation in the Framingham offspring study. Nutrients 17 (13): 2076; doi: 10.3390/nu17132076

Source: www.sci.news

Research finds that consumption of cranberries enhances performance markers in well-trained runners

Cranberries have the highest polyphenol and antioxidant capacity of any fruit or vegetable, which may help prevent the production of free radicals during exercise, which in turn may improve performance. In a new study, scientists investigated the effects of polyphenol-rich cranberry extract on time trial performance and post-exercise lactic acid response.

Consuming cranberries for 28 days seemed to improve running speed as well as aerobic performance in trained runners. Image credit: Michael Reichelt.

Polyphenols, such as proanthocyanidins, anthocyanins, flavonols, and flavonols, are secondary plant compounds found in fruits and vegetables.

Cranberries have the highest total polyphenol content of the most consumed fruits in the American diet and the highest antioxidant capacity of any fruit and vegetable.

In addition, its polyphenol content is notable due to its high concentration of rare A-type proanthocyanidins, which are believed to be the main contributors to its beneficial effects.

The use of nutritional supplements is increasing among athletes, and many are turning to natural health products to improve athletic performance.

Intense exercise significantly increases the production of reactive oxygen species due to high oxidative metabolic demands.

As a result, polyphenols may provide a natural antioxidant defense against exercise-induced free radical production.

“For elite athletes, any advantage can make the difference between finishing fifth or reaching the podium,” said study lead author Dr. Andreas Bergdahl, a researcher at Concordia University.

For this study, Dr. Bergdahl and his colleagues recruited 14 high-level runners who did at least five hours of endurance training per week.

The athletes ran two time trials during their three visits, one running 1,500 meters and one running 400 meters.

The first visit was used as the baseline. The second time, they administered a single large dose of cranberry extract two hours before the run.

The athletes were then instructed to consume a small amount of cranberry extract every day for 28 days before repeating their third run.

“We chose these distances to test the effects of cranberry extract on different energy systems,” said Dr. Francis Parenteau, lead author of the study. candidate at Concordia University.

“The 400m is short and intense and requires an anaerobic system. The 1,500m uses an aerobic system, but is shorter than what athletes typically run.”

“They weren’t training to run that distance, so we were able to isolate the effect of training as a variable.”

In addition to running time, the researchers also measured post-exercise blood lactate levels, a marker of potential muscle fatigue and oxygen deprivation.

They also fitted the runners with a portable near-infrared spectroscopy device to measure muscle oxygenation levels before, during and after a run.

After analyzing the data, the scientists found that consuming cranberry extract for 28 days showed a trend towards increased speed in the 1,500 meter time trial, but not in the 400 meter.

However, compared to baseline, they found that lactic acid accumulation decreased after 400 meters, but not after 1,500 meters.

Data also showed that cranberry extract promoted better oxygen extraction by muscles, improved lactate clearance, and slowed muscle deoxygenation.

“The benefit of this is that it’s all natural,” Dr. Bergdahl said.

“It’s an ergogenic aid, meaning it enhances performance, but it’s not an anabolic steroid.”

“Athletes can significantly improve their performance simply by consuming more cranberries.”

of study It was published in the magazine physical activity and nutrition.

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Francis Parenteau other. 2023. Cranberry supplements improve physiological markers of performance in trained runners. physical activity and nutrition 27 (4): 8-14; doi: 10.20463/pan.2023.0032

Source: www.sci.news