Maternal Voice Enhances Language Development in Premature Infants

Premature babies may face language challenges later, but simple interventions can assist.

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The first randomized controlled trial of this straightforward intervention suggests that playing recordings of a mother’s voice to premature infants could expedite their brain maturation processes. This method may eventually enhance language development in babies born prematurely.

Premature birth alters brain structure, leading to potential language disorders and affecting later communication and academic success. A mother’s voice and heartbeat can foster the development of auditory and language pathways. Unfortunately, parents may not always be able to physically be with their infants in the neonatal units.

To explore whether this absence could be compensated for through recordings, Katherine Travis and her team at Weill Cornell Medicine in New York conducted a study with 46 premature infants born between 24 and 31 weeks gestation, all situated in the neonatal intensive care unit.

We recorded mothers reading from children’s books, including selections from A Bear Named Paddington. Half of the infants listened to a ten-minute audio segment twice every hour overnight between 10 PM and 6 AM, increasing their daily exposure to their mother’s voice by an average of 2.7 hours until they reached their original due date. The other infants received similar medical care but were not exposed to recordings.

Upon reaching their due date, these infants underwent two MRI scans to evaluate the organization and connectivity of their brain networks. The results indicated that those who heard their mother’s voice at night exhibited more robust and organized connections in and around the left arcuate fasciculus, a crucial area for language processing. “The structure appeared notably more developed,” said Travis. “The characteristics matched what one might expect to find in older, more mature infants.”

The scans also suggested that this maturation could be linked to increased myelination— the creation of a fatty sheath that insulates nerve fibers, enhancing the speed and efficiency of signal transmission within the brain. “Myelination is crucial for healthy brain development, especially in pathways that support communication and learning,” noted Travis.

Previous studies have indicated that delayed development of these brain areas correlates with language delays and learning challenges. The latest findings imply that targeted speech exposure could improve these outcomes.

However, is it truly vital for infants to hear their mother’s voice rather than others? While this study did not address that, earlier research explains the phenomenon. Babies start hearing around the 24th week of pregnancy, and continue to recognize their mother’s voice after birth due to early exposure in the womb. Travis explained, “This voice is biologically significant and may be especially appealing to the developing brain.”

Nonetheless, Travis emphasizes that language exposure from other caregivers is also critical for language development, and future studies will explore this aspect further.

The intervention is straightforward and can easily be integrated into care protocols. However, David Edwards from Evelina London Children’s Hospital cautioned against overinterpreting the findings. “Given the small sample size, additional control groups, including different audio sources and forms of auditory stimulation, should be evaluated,” he suggested.

Travis and her research team aim to validate these results in larger trials involving medically vulnerable infants. They will continue to monitor current participants to determine if the observed brain differences result in tangible improvements in language and communication skills as these infants grow.

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Source: www.newscientist.com

Philip Sunshine, 94, Passes Away; Doctors Innovate Treatments for Premature Infants

Philip Sunshine, a physician at Stanford University, significantly advanced neonatal theory as a medical specialty, transforming the care for premature and severely ill neonates, who previously faced little hope of survival. He passed away on April 5 at his home in Cupertino, California, at the age of 94.

His daughter, Diana Sunshine, confirmed his death.

Before Dr. Sunshine and a few other dedicated doctors took an interest in caring for infants in the late 1950s and early 1960s, more than half of these incredibly vulnerable patients died shortly after birth, often without insurance coverage for their treatment.

As a pediatric gastroenterologist, Dr. Sunshine believed that with proper attention, many premature babies could be saved. At Stanford, he assembled a multidisciplinary team to treat these infants in specialized intensive care units. Alongside his colleagues, he developed innovative feeding methods and breathing assistance techniques using ventilation.

“We managed to keep babies alive who would have otherwise not survived,” Dr. Sunshine recounted during an interview in 2000 with the Pediatric History Center at the American Academy of Pediatrics. “And now, this progress is often taken for granted.”

The early 1960s marked a pivotal moment for the care of premature babies.

As noted by the Oxford English Dictionary, the term “Neonatology” first appeared in the 1960 book “Isises of Newborn” by pediatrician Alexander J. Schaffer from Baltimore. By that time, Stanford’s Neonatology School, one of the nation’s earliest schools for this field, was already functional.

In 1963, Patrick Bouvier Kennedy, the second son of President John F. Kennedy, was born nearly six weeks prematurely and sadly passed away just 39 hours later. This tragic event captured the attention of newspapers across the nation and spurred federal health officials to begin funding research focused on newborns.

“Kennedy’s situation was a significant turning point,” Dr. Sunshine remarked in 1998 to Aha News, a publication of the American Hospital Association.

Serving as the Newborn Dean at Stanford from 1967 to 1989, Dr. Sunshine played a crucial role in training hundreds, if not thousands, of doctors who went on to work in neonatal intensive care units worldwide. Upon his retirement in 2022 at the age of 92, the survival rate for babies born at just 28 weeks had surpassed 90%.

“Phill is one of the pioneers in neonatology—an exceptional neonatologist and one of the finest in our field’s history,” stated David K. Stevenson, the head of the neonatology division at Stanford, who succeeded Dr. Sunshine, in a 2011 graduate journal.

Dr. Sunshine understood that providing care for young children involves both technical skills and personal connection. He advocated for allowing parents to visit the neonatal intensive care unit to hold their newborns, noting that skin-to-skin contact was highly beneficial.

He also encouraged nurses to exercise their judgment and express concerns when they felt something was amiss.

“Our nurses have always been invaluable caregivers,” Dr. Sunshine recounted in oral history. “Throughout my career, I collaborated with nursing staff who often recognized baby issues before the doctors did, and they continue to do so.”

A newborn nurse who worked alongside Dr. Sunshine for over 50 years shared in a blog post for Stanford Medicine, “Phil exuded a deep kindness—towards the babies, us, and everyone around him.”

“He viewed everyone as equally important,” she commented.

It was a challenging journey, and the pressure was immense.

“He had a calming, encouraging presence and was completely unflappable,” Dr. Stevenson said in an interview. “He would often say, ‘If you’re going to be up all night in the hospital, what better way to spend your time than by giving someone 80 or 90 years of life?'”

Philip Sunshine was born in Denver on June 16, 1930, to parents Samuel and Molly (Fox) Sunshine, who owned a pharmacy.

He earned his bachelor’s degree from the University of Colorado in 1952 and graduated from medical school in 1955.

After his first year of residency at Stanford, he was drafted into the US Navy, where he served as a physician. Upon returning to Stanford in 1959, he trained under pediatrician Louis Gulac, later developing a modern neonatal intensive care unit at Yale University.

“He inspired my passion for caring for newborns and made the field so fascinating,” Dr. Sunshine recalled. He stated.

Since there was no neonatal fellowship available at the time, Dr. Sunshine pursued advanced training in pediatric gastroenterology and pediatric metabolism fellowships.

“This was a really thrilling period,” he commented in a Stanford Medicine Children’s Health blog post. He remarked. “People from diverse backgrounds were contributing valuable skills for newborn care—like neonatal specialists, cardiologists, and those with interests in gastrointestinal issues with infants. I learned a wealth of information and enthusiasm from them.”

Dr. Sunshine married Sarah Elizabeth Vryland, dubbed Beth, in 1962.

He is survived by his wife, daughter Diana, four other children—Rebecca, Samuel, Michael, and Stephanie—and nine grandchildren.

In many ways, Dr. Sunshine’s surname aptly captured his essence; it resonates perfectly with his profession and approach.

“Beyond being a pioneer in neonatology, he truly brought light to every environment he entered,” Susan R. Hintz, a neonatologist at Stanford University, shared in an interview. “He was a soothing presence, especially during incredibly stressful times. Nurses frequently remarked, ‘He is someone everyone remembers.’

Source: www.nytimes.com

Research shows that specific genetic alterations could lead to premature menopause

New research has identified four genes that, if altered, could impact the age at which menopause occurs. These genes (ETAA1, ZNF518A, PNPLA8, and PALB2) were found to cause women to experience menopause two to 5.5 years earlier if they have only one functioning copy. The study, conducted by scientists from the Universities of Exeter, Cambridge, and Wellcome, was published in Nature.

Understanding these genetic changes is crucial for potential therapies to extend reproductive lifespan and plan for the impact of menopause on women’s career and life plans. The study also found links between these genetic changes and cancer risk, highlighting the importance of further research in this area.

These genetic changes can lead to the DNA damage of eggs, affecting the age at which menopause occurs. The study analyzed data from 106,973 postmenopausal women and found that rare genetic changes have a significant impact on the age at menopause. These changes not only shed light on menopause but also provide insight into disease risks.

Dr. Stasha Stankovic, Dr. Hilary Martin, and Professor John Perry, members of the research team, emphasized the importance of understanding ovarian function for reproductive health and disease prevention. They hope that further research in this area will lead to new treatments for ovarian-centered diseases and help predict age at menopause more accurately.

The study also revealed that changes in a mother’s DNA can impact the DNA passed on to her child, showing a link between genetic mutations and the rate of DNA changes. This discovery is significant in understanding the biological mechanisms behind infertility, reproductive disorders, and disease predisposition.

About our experts

Dr. Stasha Stankovic is a reproductive geneticist with a PhD in Reproductive Genomics from the University of Cambridge. Her research has been published in top scientific journals such as Nature, Nature Medicine, Nature Genetics, and Cell Genomics.

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Source: www.sciencefocus.com