Innovative treatments may transform the management of lower back pain by addressing the root causes associated with inflammatory “zombie” cells. Recent research conducted using mice.
A group of scientists, led by researchers from McGill University in Canada, found that a combination of two medications, O-Vanillin and RG-7112, effectively eliminates zombie cells from mouse spinal tissues, alleviating pain and inflammation symptoms.
“Our results are promising because they indicate that by eliminating cells that not only obscure pain but also contribute to issues, we can approach lower back pain treatment in a novel manner,” stated the senior author, Professor Lisbet Haglund from McGill’s Ministry of Surgery.
Zombie cells, also referred to as senescent cells, do not function like typical cells. Rather than undergoing division and death to make way for new cells, they persist in the body.
As we age, these zombie cells can build up, leading to inflammation, pain, and spinal damage.
For the hundreds of millions of adults globally suffering from back pain, the impact of zombie cells is often masked and inadequately addressed by current medications.
This new treatment, however, aims to alleviate back pain by targeting and eliminating these lingering zombie cells, thereby addressing the underlying issues.
Aging or zombie cells accumulate in the shock-absorbing discs between each spinal vertebra, releasing inflammatory molecules that damage discs – Credit: Nemes Laszlo/Science Photo Library via Getty
The McGill research team discovered this promising new treatment while working with mice genetically engineered to develop spinal injuries and lower back pain over seven months.
The researchers administered varying doses of O-Vanillin and RG-7112 to these mice. Some received only one of the drugs, while others received a combination of both.
RG-7112 is a medication already established to remove zombie cells in various contexts, though it hasn’t been applied to lower back pain treatment until now.
O-Vanillin, a natural compound sourced from turmeric, is recognized for its anti-inflammatory benefits, but had not been previously tested against zombie cells.
After 8 weeks of treatment, mice receiving both drugs at higher doses exhibited the lowest levels of zombie cells, inflammation, and pain.
Those treated with a single drug showed some improvement, but the results were not as significant as those achieved with the combination therapy.
“The pressing question now is whether these medications can produce the same effects in human subjects,” Haglund remarked.
“It’s 19 feet ahead,” announced the robotic voice from an iPhone held by Moshfik Ahmed, as he navigated through London’s Road Cricket Field in search of a seat.
“Up the stairs,” directed Ahmed, an English cricketer with visual impairment, as he tapped a white cane on his way to the Edrich Stand without any external assistance. “There’s one landing. We’re positioned at 9 o’clock at the base of the stairs. We’ve reached the fifth row.”
Ahmed was among the first to test the newly installed Wayfinding technology at Lord’s, designed for blind and partially sighted individuals, enabling disabled fans to enjoy live sports.
Waymap, the company behind this app-based navigation tool, asserts that the 31,000-seat cricket stadium is the first sports venue worldwide to offer personal GPS, specifically tailored to manage traffic in stadiums, shopping centers, and transportation systems.
Utilizing a £50,000 camera, Waymap meticulously mapped stairs, corridors, inclines, entrances, and concourses to develop a digital twin of this historic cricket ground, allowing the app to navigate users by meter precision.
This technology was implemented ahead of next month’s Test match between England and India. The Marylebone Cricket Club, which manages the venue, believes it can assist other cricket enthusiasts in discovering the most accessible routes throughout the premises.
“The concept is fantastic for the visually impaired,” said Ahmed, who tried the app upon the Guardian’s invitation after participating in a showcase match on Wednesday. “If it functions flawlessly, I can navigate to the station independently, cross the street by myself, arrive at the stadium, and find my way using the app. I know many sports enthusiasts who are visually impaired. This will make it completely accessible for them.”
Moshfik Ahmed at the cricket grounds on the road. Photo: Sean Smith/Guardian
It was Ahmed’s first experience with the app, which had some initial hiccups. At times, it mistakenly suggested he head in the wrong direction, pointing him to temporarily closed stairs, and even guided him to row 20 of the Edrich Stand instead of column 5.
However, it seemed that both the app and the user were still in the adaptation phase. For instance, the app should be customized to reflect the individual user’s walking pattern, which could clarify the misdirection he experienced.
“It must be precise and dependable,” stated Ahmed, who lost most of his vision in 2017.
“We’re dedicated to delivering an exceptional experience,” said Celso Zuccollo, CEO of WayMap. “WayMap represents a novel navigation approach. It usually requires multiple visits to fully grasp how to use the app effectively.”
“The objective is likely to extend this technology to venues like Wembley, various football stadiums, and we are in discussions with horse racing tracks,” he added.
Existing apps available for users of the Washington, DC public transport system do not adequately alert users to the movements of people around them, particularly those whom Ahmed noted can pose significant challenges in maneuvering safely and comfortably.
Known as Verve-102, this treatment could revolutionize heart attack prevention and significantly lower LDL cholesterol levels (often referred to as “bad” cholesterol) with a single injection.
While statins can achieve similar cholesterol reductions, they typically require daily administration.
“This is the future,” stated Professor Riyaz Patel, an academic from the University of London and a doctor at Barts Health NHS Trust involved in the trial – BBC Science Focus.
“This is not a fantasy; it’s reality. We are actively implementing it. I was providing this treatment to my patient during the exam.”
Unlike statins, which gradually lower cholesterol, Verve-102 aims for a one-time alteration by “turning off” a specific gene called PCSK9 in the liver. This gene is crucial in managing the levels of LDL cholesterol that the liver can detect and eliminate from the bloodstream.
In simpler terms, a reduction in PCSK9 means less LDL in the bloodstream.
“The results are stunning,” Patel remarked. “This drug disables a small segment of your DNA, and your LDL cholesterol will be permanently 50% lower thereafter. That’s a game-changer!”
Cholesterol builds up in blood vessel walls, leading to plaque formation that can obstruct blood flow.
Elevated LDL cholesterol levels heighten the risk of this buildup, prompting millions (over 40 million in the US and over 7 million in the UK) to take daily medications like statins for cholesterol management.
The VERVE-102 clinical trial included 14 participants with familial hypercholesterolemia, a genetic disorder that heightens the risk of heart disease, heart attacks, and strokes due to extremely high LDL cholesterol levels.
Initial outcomes from Verve-102 injections show that all participants reacted positively to the treatment with no severe side effects.
Responses varied by dosage. The lowest dose group experienced an average LDL reduction of 21%, while the intermediate group showed a 41% reduction, and the high-dose group saw a 53% reduction.
Remarkably, one individual in the high-dose group achieved a 69% reduction in LDL cholesterol after receiving Verve-102.
Dr. Eugene Braunwald, a distinguished medical professor and Hershey’s professor of medicine at Harvard Medical School who did not take part in the study, noted that the preliminary data is “promising” and indicates “the potential for a new era in cardiovascular disease treatment.”
Verve is actively recruiting participants for further stages of clinical trials involving even higher Verve-102 doses in the UK, Canada, Israel, Australia, and New Zealand. The final results are expected to be revealed in the latter half of 2025.
Read more:
About our experts
Professor Riyaz Patel is a consultant cardiologist and clinical academic scholar at University College London (UCL) and Barts Health NHS Trust. He is a fully funded clinician scientist with the British Heart Foundation and serves as a professor of cardiology at UCL, where he investigates the causes of heart disease, focusing on cardiovascular risks and the genetics of coronary heart disease. He has established and led new cardiovascular prevention services at Barts Heart Center.
Treatment offers protection to mice against venom from common taipans and various other snakes
Matthijs Kuijpers/Alamy
Antibodies derived from inflammatory men exhibit effectiveness against a range of snake bites, suggesting that a universal treatment may soon be achievable.
The use of non-human antibodies, however, can lead to serious adverse effects, including potentially fatal allergic reactions. Additionally, it necessitates the identification of the specific snake responsible for the bite before administering the anti-venom.
Jacob Granville from Centivax, a biotechnology firm in San Francisco, California, is exploring broadly neutralizing antibodies that could be developed into anti-venoms effective against multiple or all venomous snakes. “There are 650 venomous snake species, but their venoms involve just 10 common classes of toxins,” Granville explains.
Researchers began investigating individuals bitten multiple times by different snakes. “Perhaps a daring snake researcher,” remarks Granville. Media reports introduced the story of Tim Friede, who claims to have “self-administered escalating doses of venom from the world’s deadliest snakes over 700 times.”
“If anyone could yield a wide-ranging neutralizing antibody against snake venom, it would be Tim Friede,” Granville affirms.
From just 40 milliliters of Friede’s blood, the team “converted immune memory into a library of billions of antibodies,” he adds. They subsequently tested promising candidates against venom from 19 of the deadliest Elapidae family species, including several cobra varieties.
Ultimately, they treated two antibodies derived from Friede’s blood, known as LNX-D09 and SNX-B03, along with a toxin inhibitor named varespladib. In experiments on mice, this combination provided comprehensive protection against 13 species, including various cobras, the tiger snake (Notechis scutatus), and the general Thai bread snake (Oxyuranus scutellatus). It also offered partial protection against six additional species, including the notorious death adder (Acanthophis Antalcus).
The subsequent phase involves testing these treatments on animals brought into Australian veterinary clinics following a snake bite and identifying antibodies that can confer protection against vipers.
Tian Du from the University of Sydney emphasizes that “discovering two antibodies that can inhibit toxins makes for a universal treatment for closely related species.”
Additionally, after learning that the anticoagulant drug heparin can assist individuals in avoiding limb loss following a cobra bite, Du aims to determine whether their treatment can also avert skin and muscle necrosis.
Earlier this month, a mysterious spaceship named X-37B landed at Vandenburg Space Force base near Santa Barbara, California. This experimental project, shrouded in secrecy, has been ongoing for over a decade.
Details about the X-37B and its mission are scarce, but fragments of information have been gradually unveiled over the years, allowing us to piece together the puzzle of what is happening in space.
While the public eye is fixed on the race to the moon by private companies and national space agencies, a more secretive competition is taking place in the background.
The X-37B is just one of many clandestine experiments conducted by countries like the US, Russia, and China. Recent revelations shed light on the features of this mysterious spacecraft and give a glimpse into the future of military space operations.
The X-37B is seen here on the runway after a successful completion of the sixth mission. – Staff Sergeant Adam Shanks / US Space Force
What do you know about the X-37B?
The X-37B, built by Boeing, is a cutting-edge spacecraft born out of NASA’s X-37 program. It embarked on its first flight in 2010 and has since been managed by various US military entities, including the US Space Force.
The US Space Force, established in 2019, recognizes the importance of space in future conflicts and aims to achieve space superiority through operations like space control.
The X-37B, despite not being a weapon itself, plays a crucial role in preparing the US for potential space warfare scenarios. Its capabilities are key in collecting data and testing new technologies in the space domain.
Recent maneuvers like the “aero brake” operation have showcased the agility and versatility of the X-37B, hinting at its potential role in future defense strategies.
While the specifics of the X-37B’s missions remain classified, its significance lies in its contribution to the US military’s readiness for an evolving space landscape.
War in Space: Where does the X-37B fit?
As space becomes increasingly congested with satellites and new technologies, the X-37B’s role in collecting data and testing capabilities is vital for understanding the evolving space environment.
The spacecraft’s ability to operate autonomously and perform complex maneuvers like aero braking sets it apart as a valuable asset in modernizing US space defense strategies.
While countries like China and Russia are also developing secretive space capabilities, the X-37B represents the US’s commitment to maintaining a competitive edge in space while adapting to new threats.
Overall, the X-37B serves as a reminder that space is no longer just a realm of exploration, but a frontier where countries must prepare for defense and strategic advantage.
About our experts
Vivienne Machi: Military space editor at Aviation Week, with a decade of experience covering international military and space technology.
Todd Harrison: Senior fellow at the American Enterprise Institute specializing in defense strategy, budget, and space policy.
Measuring just 4cm square, Google has developed a computing chip with unprecedented speed. In just five minutes, this chip can complete tasks that would take conventional computers 10 billion years to finish – a mind-boggling number surpassing the age of our universe.
The chip, named Willow, is the size of an After Eight Mint and could revolutionize drug development by accelerating the experimental phase. Recent advancements suggest that within five years, quantum computing will transform research and development across various industries.
Willow boasts fewer errors, enhancing the potential of artificial intelligence. Quantum computing leverages matter existing in multiple states simultaneously to make vast calculations beyond previous capabilities, expediting advancements in medicine and technology.
However, concerns remain about security vulnerabilities posed by quantum computing – the ability to breach even the most robust encryption systems.
Google Quantum AI, alongside other entities like Microsoft, Harvard University, and Quantinum, is working on harnessing quantum mechanics for computing. Overcoming challenges in error correction has paved the way for significant speed enhancements and groundbreaking developments.
Quantum processors are evolving rapidly, surpassing traditional computers and unlocking new possibilities for quantum computations. The potential for quantum computers to exist in multiple states simultaneously promises remarkable capabilities across various fields.
Dr Peter Leake, Research Fellow at the University of Oxford’s Quantum Institute and founder of Oxford Quantum Circuits, acknowledges the rapid advancements in quantum computing technology. While applauding Google’s progress in error correction, he highlights the need for practical applicability in real-world scenarios.
As quantum computing approaches practical implementation, collaboration across various fields becomes crucial to navigate challenges and harness the full potential of this groundbreaking technology.
Recent respiratory disease epidemics have attracted a lot of attention, yet most respiratory monitoring is limited to physical signals. Exhaled breath condensate (EBC) is packed with rich molecular information that can reveal various insights into an individual's health. Now, Professor Wei Gao and colleagues at California Institute of Technology have developed EBCare, a mask-based device that monitors EBC biomarkers in real time. For example, the EBCare mask can monitor asthma patients for their levels of nitrite, a chemical that indicates airway inflammation.
This diagram shows how the smart mask detects breathed chemicals, such as nitrite, an indicator of airway inflammation. Images by Wei Gao and Wenzheng Heng, Caltech.
“Monitoring a patient's breathing is routinely done, for example to assess asthma and other respiratory diseases,” Prof Gao said.
“However, this method requires patients to visit a clinic to have a sample taken and then wait for the test results.”
“Since COVID-19, people have started wearing masks. We can leverage this increased use of masks for remote, personalized monitoring to get real-time feedback on one's health from the comfort of one's own home or office.”
“For example, we could use this information to evaluate how effective a medical treatment is.”
To selectively analyze the chemicals and molecules in your breath, you first need to cool them down and condense them into a liquid.
In a clinical setting, this cooling step is separate from the analysis: Moistbreath samples are cooled in a bucket of ice or a large refrigerated cooler.
The EBCare mask, on the other hand, is self-cooling, according to the team.
The breath is cooled by a passive cooling system that integrates hydrogel evaporative cooling and radiative cooling to effectively cool the breath on the facemask.
“This mask represents a new paradigm for respiratory and metabolic disease management and precision medicine because wearing it daily allows for easy collection of breath samples and real-time analysis of exhaled chemical molecules,” said Wen-zheng Heng, a graduate student at the California Institute of Technology.
“Breath condensate contains soluble gases as well as non-volatile substances in the form of aerosols and droplets, including metabolic products, inflammatory indicators and pathogens.”
Once the breath is converted into liquid, a series of capillaries in a device called bioinspired microfluidics immediately transports the liquid to a sensor for analysis.
“We learned how to transport water from plants, which use capillary action to pull water up from the ground,” Professor Gao said.
“The analysis results are then sent wirelessly to an individual's phone, tablet or computer.”
“The smart mask can be prepared at a relatively low cost. The materials are designed to cost just $1.”
To test the masks, the authors conducted a series of human studies, focusing primarily on patients with asthma or COPD.
The researchers specifically monitored the patients' breath for nitrite, a biomarker of inflammation in both diseases.
Results showed that the masks accurately detected biomarkers indicative of inflammation in patients' airways.
In a separate experiment, the masks demonstrated that they could accurately detect subjects' blood alcohol levels, suggesting that they could potentially be used for field DUI checks and other alcohol consumption monitoring.
We also explored how the mask can be used to assess blood urea levels in the monitoring and management of kidney disease.
As kidney function declines, by-products of protein metabolism, such as urea, accumulate in the blood.
At the same time, the amount of urea in saliva increases, which breaks down into ammonia gas, leading to high ammonium concentrations in the breath condensate.
The study showed that the smart mask could accurately detect ammonium levels, closely reflecting the urea concentration in blood.
“Our smart mask platform for EBC collection and analysis represents a major advancement in the potential for real-time monitoring of lung health,” said Professor Harry Rossiter, director of the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center.
“This concept, with the potential to add biosensors for a wide range of compounds in the future, highlights the groundbreaking potential of smart masks in health monitoring and diagnostics.”
No turning point in the history of the universe surpasses the birth of the first stars. As stars flickered into existence some 200 to 400 million years after the Big Bang, the energy they emitted ripped apart the atoms of the gas that had cooled the universe, reheating it in a process called reionization. Then, as the stars burned out and died, they created a cocktail of chemical elements that prepared the universe to give rise to galaxies, planets, and eventually life itself.
It's no wonder astronomers are itching to get a glimpse of this first generation of stars. To start with, they were spectacular: huge and blisteringly bright, thought to be 300 times more massive and 10 times hotter than the Sun. But observing them could also tell us a lot about the mysterious early stages of the Universe, particularly how the universe came to be flooded with supermassive black holes in an incredibly short space of time.
Now we may finally be on the brink. Earlier this year, astronomers reported that the James Webb Space Telescope (JWST), by fixing its excellent field of view on the outer edges of very distant galaxies, may already have seen evidence of the first stars. “The observations we can now make really expand our knowledge,” says Hannah Ubler of the University of Cambridge.
The signal may turn out to be a false alarm, but what's interesting right now is that other researchers are starting to look at different features of the light from the early universe, even suggesting that it might be the first stars.
I’ll be 60 in just over 5 years, which is a big deal. I already have an age-related disease (high blood pressure), and the odds are good that I haven’t been diagnosed with at least one more by then. After that, the symptoms of age will pile up and bring me to my inevitable end. Many of you will no doubt be in a similar situation. We are living longer than ever before, but those extra years don’t necessarily come with good health.
But judging by recent trends, my sons may be even luckier. Instead of facing a long list of common diseases in their 70s and 80s, they may be able to immunize themselves against them. They may be able to celebrate middle age with vaccinations that immunize them against Alzheimer’s, cancer, and hypertension. What’s more, they may even have access to an anti-aging panacea that vaccinates against all of these and more, allowing them to enter old age in better health than most of us today could hope to achieve.
Suddenly, an ancient medical technique looks set to become a game changer in the fight against diseases associated with age. Vaccines, the most commonly used injections for infectious diseases like COVID-19 and measles, are now showing promise for treating non-infectious diseases, particularly those associated with age. The field is advancing rapidly, and there are signs that, in the right winds, I and others my age might be able to benefit from these vaccinations. It’s so…
Humanity has always dreamed of traveling beyond our solar system to the stars, but the vastness of the universe has kept us grounded. Our closest star, Proxima Centauri, is a staggering 4.24 light years away, which is too far for us to wait patiently.
Recently, on April 23, NASA launched the Advanced Composite Solar Sail System from New Zealand, a system that uses lightweight sails to propel spacecraft instead of traditional rockets. This development has excited both experts and science fiction fans, as it opens up possibilities for long-distance space travel.
How solar sail works
Instead of using thrusters and fuel like traditional spacecraft, solar sail systems use reflective sails to absorb momentum from photons emitted by the sun. This technology enables spacecraft to gain acceleration without the limitations of fuel. In space, where there is no air resistance, a slight push from the sun is all that’s needed for propulsion.
Solar sails operate similar to sailing ships, utilizing the momentum of photons for movement. By harnessing the sun’s energy, spacecraft can travel far distances at manageable speeds.
How fast can an interstellar probe travel with a solar sail?
The speed of a solar sail system depends on factors like the size of the sail, spacecraft mass, and distance from the sun. With creative maneuvers like slingshot maneuvers and potential laser boosts, spacecraft using solar sails can achieve speeds close to 20% of the speed of light.
Future solar sail systems could reach speeds up to 20 percent of the speed of light. – Image credit: NASA/Aero Animation/Ben Schweighart
Will humanity ever be able to sail to another planet?
Potentially, solar sail technology could pave the way for human interstellar travel in the future. However, there are challenges, such as sustaining long-term missions for generations and addressing relativistic effects caused by near-light speed travel.
What exactly is NASA's solar sail mission?
NASA’s Advanced Composite Solar Sail System is a demonstration of solar sail technology that aims to test a new lightweight boom made of flexible materials. The mission involves a CubeSat deploying an 80 square meter sail in orbit to gather data for future solar sail missions.
About our experts
patrick johnson is an associate professor at Georgetown University with expertise in quantum mechanics. He authored the book “Star Wars Physics” and has contributed to scientific journals like Physical Review.
Twenty years ago, scientists announced the creation of a new miracle substance that would revolutionize our lives. They named it graphene.
Graphene is made up of a single layer of carbon atoms arranged in a hexagonal pattern, making it one of the strongest materials ever produced. It is more resistant to electricity than copper and has excellent heat conductivity.
The potential applications of graphene seemed limitless, with predictions of ultra-fast processors, quicker battery charging, and stronger concrete. It was even proposed as a solution for potholes in roads.
Professor Andre Geim (left) and Professor Konstantin Novoselov from the University of Manchester discovered graphene. Photo: John Super/AP
The scientists behind the discovery, Andre Geim and Konstantin Novoselov, received the Nobel Prize in Physics in 2010 for their work. The National Graphene Institute was established at the University of Manchester.
Despite the initial hype, the graphene revolution has not materialized as expected. Challenges in scaling up production have hindered its widespread adoption.
Sir Colin Humphreys, a materials science professor at Queen Mary University of London, pointed out that the main issue lies in the difficulty of producing graphene on a large scale.
He explained that the original method of creating graphene was not conducive to mass production and that significant investments by companies like IBM, Samsung, and Intel have been made to develop scalable production methods.
Recent advancements in manufacturing techniques show promise for the resurgence of graphene technology. Companies like Paragraph are now producing graphene-based devices in large quantities.
Graphene-based devices are being used for various applications, including sensors for detecting magnetic fields and differentiating between bacterial and viral infections.
Additionally, graphene devices are expected to be more energy-efficient than current technologies, offering a promising future for the material.
While the graphene revolution may have been delayed, it holds the potential to address pressing global challenges and significantly impact modern life.
Graphene “has the potential to make a real difference to modern life,” says Sir Colin Humphreys, professor of materials science.
Photo: AddMeshCube/Alamy
The hyped science failed to make the grade.
nuclear power “Our children will have immeasurably cheap electrical energy in their homes.” – Louis Strauss, then chairman of the U.S. Atomic Energy Commission, in 1954.
Sinclair C5 “This is the future of transportation” – promotional materials for the 1985 Sinclair C5 electric scooter/car. Sales in the first year were predicted to be 100,000 units, but only 5,000 units were sold. Project has been abandoned.
medical advances “The time has come to close the book on infectious diseases and declare that the war on epidemics has been won” – in the words of Dr. William H. Stewart, Surgeon General of the United States from 1965 to 1969.
Living a healthier life can be achieved in many ways. Simple activities like daily walks, healthy eating, and brain-boosting puzzles like Sudoku can keep your mind and body active. For a unique approach, consider trying neuromodulation, which involves sending electric shocks to the brain.
Neuromodulation is an innovative method that uses a stimulator placed on the head to deliver electrical shocks directly to the nervous system. This non-invasive technique offers numerous health benefits and has gained traction as a cutting-edge technology for enhancing well-being.
The concept of neuromodulation has been around for some time, but companies like Parasin and gamma core have reignited interest in recent years. These companies claim to improve mental performance and overall health with their devices that can be used conveniently at home.
Research from reputable institutions like UCL, Harvard University, and University College London supports the effectiveness of neuromodulation. Even tech entrepreneurs like Brian Johnson have shown interest in this technology.
What is neuromodulation and how does it work?
Neuromodulation is a technique that alters neural activity by delivering electrical signals to specific areas. Imagine it as a dimmer switch that can increase or decrease nerve or brain activity. This method can excite or inhibit nerves to alleviate pain and modify neural patterns associated with various conditions like epilepsy and Parkinson’s disease.
Companies like Parasym use “auricular vagal neuromodulation therapy” to deliver electrical signals through the ear to target the vagus nerve, which plays a crucial role in connecting the brain, heart, and digestive system.
How technology can slow aging
Neuromodulation can help slow down the aging process by combating chronic inflammation, enhancing cognitive function, and improving cardiovascular health. Research shows promising results in addressing age-related issues like Alzheimer’s disease and heart conditions.
While neuromodulation offers benefits like improved heart rate variability and reduced fatigue and depression, it remains in the early stages of development. Safety concerns and experimental results underscore the need for further research and validation.
Is neuromodulation safe?
Neuromodulation has evolved since its inception in the 1960s, with modern devices providing safer options for users. Implantable devices offer more effective treatment but come with higher risks, including infections and other complications.
Non-invasive wearable devices like those from Parasym are considered safer, with minor side effects like skin irritation being the main concern. These devices require consistent use to deliver optimal results, making them a more accessible but less durable alternative to implantable devices.
While neuromodulation technology shows promise in improving health and well-being, users should weigh the benefits against the costs and potential risks before investing in these innovative devices.
Noland Arbor can play chess using Neuralink implant
Neuralink
Neuralink, the brain-computer interface company founded by Elon Musk, has revealed the identity of its first patient who says its implant “changed his life.” But experts say it’s not yet clear whether Neuralink has done more than replicate existing research efforts.
Who was Neuralink’s first patient?
Musk announced in January that the first human patient had received a Neuralink implant, but few details were released at the time. We now know from something. Live stream video by company – Who is that person and how will the test be done?
Noland Arbaugh explains in the video that an accident eight years ago dislocated his fourth and fifth vertebrae, leaving him a quadriplegic. He previously controlled the computer with a mouth interface, and is shown moving the cursor with just his thoughts, apparently using a Neuralink implant.
“Once I started imagining the cursor moving, it became intuitive,” Arbaugh says in the video. “Basically, it was like using ‘force’ on the cursor, and I was able to move the cursor anywhere I wanted. I could just look anywhere on the screen and the cursor would move where I wanted it. It was a very wild experience.”
He uses the device for reading, language learning, and computer games such as chess, and claims he uses it for up to eight hours at a time, at which point he needs to charge the device. “It’s not perfect, I’ve run into some problems. But it’s already changed my life,” he says.
What does the implant contain?
Neuralink did not respond to requests for an interview, but its website says the current generation coin-sized implant, called N1, generates neural activity through 1,024 electrodes distributed across 64 threads that extend into the user’s brain. It is said that it records. These are so fine that they must be placed by a surgical robot.
In a livestream video, Arbaugh said he was discharged from the hospital the day after his implant surgery, and that from his perspective the surgery was a relatively simple process.
The implant uses a small battery that is charged through the skin by an inductance charger and communicates wirelessly with an app on your smartphone.
Does this mean the first human trials were successful?
Reinhold Scherrer Researchers at the University of Essex in the UK will decide whether Neuralink’s first human trial was a success because the company “has not released enough information to form an informed opinion” He said it was too early.
“While the video is impressive and there is no doubt that it took a lot of research and development work to get to this stage, it is unclear whether what is being shown is new or groundbreaking,” he said. Masu. “Although control appears to be stable, most of the studies and experiments presented so far are primarily replications of past studies. Replication is good, but major challenges still remain. ”
Who else is working on brain implants?
Neuralink isn’t the only group exploring this idea. A number of academic organizations and commercial startups have already conducted human experiments that have successfully interpreted brain signals and produced some sort of output.
A team at Stanford University in California placed two small sensors just below the surface of the brain of a man who was paralyzed from the neck down. Researchers may be able to interpret the brain signals when a man decides to put pen to paper and translate them into text that can be read on a computer.
When will Neuralink be available and how much will it cost?
It’s too early to tell, as this has a long way to go before it becomes a commercial product, with much testing and certification to come. But Musk has made it clear that he intends to commercialize the technology.of The first product planned was named Telepathy.allows users to take control of their mobile phones and computers.
○On Sunday, January 22, 1984, the Los Angeles Raiders defeated the Washington Redskins 38-9 in Super Bowl XVIII. With the exception of a few older Raiders fans, we all remember him that night 40 years ago with one ad that set the tone for the techno-optimism that would dominate the 21st century. did.
Advertisement showed an auditorium full of zombie-like figures watching a projection of an elderly leader resembling the Emperor from 1980's The Empire Strikes Back. A young, athletic woman wearing red and white (the colors of the flag of Poland, which waged a massive labor uprising against the Soviet-controlled communist state) spins a hammer and frames the face of her leader. He threw it across the screen. As armored police rush in to stop her.
The ad explicitly referenced George Orwell's dystopian novel 1984. Meanwhile, then-President Ronald Reagan began his re-election campaign with the audacity to confront the threat of the totalitarian Soviet Union, increasing the risk of global nuclear annihilation.
That same month, Apple began selling personal computers. This will change the way we think about computing technology in our lives and will lead to many of the ideological changes that will drive the 21st century. In many ways, the long 21st century began 40 years ago this week for him.
From a garage-based startup in Cupertino, California, we have steadily grown to where we are today. The most valuable company in the history of the world, Apple has changed the way we experience culture and each other. While not the only force to do so, if you look at other ruling forces that left their mark in 1984, such as Reagan, Apple is a key player in how we view and govern ourselves over the next 40 years. It was part of a larger change. Years later, it still impacts daily life in ways few could have imagined at the time.
Before the Macintosh debuted, Apple created high-quality computers like the Apple II (1979) that ran programs using the standard operating system at the time, the Apple Disc Operating System (which was similar to the Apple Disc Operating System). was highly regarded among computer enthusiasts for producing innovative desktop computers. MS-DOS was provided by a small then-starting company called Microsoft and could be programmed in languages such as Basic.
Companies like Texas Instruments and Atari had brought user-friendly computers to homes before the Macintosh, and IBM and Commodore had made desktop computers for businesses, but the Macintosh was something different. I was promised something.
The Macintosh created a mass market for usable computers that looked more like magic than machines. The Macintosh is a sealed box that hides the board and cables and presents a sleekly designed box, similar to the MacBook and the iPhone, which was released in 2007 and was the most influential and profitable of Apple's products. We have established design standards for what will become.
The iPhone represents much of what's appealing and loathsome about 21st century life. This is a device that does things that no other device or technology can do. It just provides all of that in its own controlled environment that masks all of the actual technology and the human agency that created it. There may be a little elf in there.
Billions of people now use such equipment, but few people ever look inside or think about the people who mined the metals and assembled the parts in dangerous conditions. plug. There are now cars and appliances designed to feel like an iPhone, all glass, metal, curves, and icons. None of them provide any clues for humans to build or maintain them. Everything seems like magic.
The shift to magic by design has blinded us to the real situation of most people working and living in the world. Gated devices are similar to gated communities. What's more, the sealed boxes are equipped with ubiquitous cameras and location devices, and when connected through invisible radio signals, serve as a global surveillance system that Soviet dictators never dreamed of. . We have also entered a world of soft control beyond Orwell's imagination.
Gated communities began to grow in popularity in the United States during the Reagan administration. It was to provide the illusion of safety against imagined but undefined invaders. They also resembled private states, with exclusive membership and strict rules of etiquette.
Reagan won reelection in a landslide in the November 1984 election. His Reagan victory established a nearly unwavering commitment to market fundamentalism and technological optimism that was largely adopted by Reagan's critics and even his successors like Bill Clinton and Barack Obama. . Outside the United States, ostensibly left-wing 20th century leaders such as Greece's Andreas Papandreou, France's François Mitterrand, and Britain's Tony Blair limited the vision of change that the growing neoliberal consensus allowed. was.
By the beginning of this century, questioning the techno-optimism imposed by Apple and the faith in neoliberalism secured by Reagan's hold on the world's political imagination seems like a fit of sulking or sulking. Probably. Does anyone doubt the democratizing and liberating potential of computer technology and free markets?
Now, a quarter of the way through this century, it's clear that the only promises kept were to Apple's shareholders and the descendants of Reagan's politicians. Democracy is in tatters around the world. Networked computers rob relationships, communities, and society of the joy and humanity. The economy is more stratified than ever before. Politics excludes any positive vision of a better future.
Of course, you can't blame Apple or Reagan. They simply distilled, harnessed, and sold back to us what we longed for: a simple story of inevitable progress and liberation. If we had heeded the warnings in Orwell's book instead of Apple's ads, we might have learned that simple stories never have happy endings.
We have all experienced vomiting at some stage in our lives. Whether it’s due to a nasty bout of food poisoning or the well-known norovirus that infects the population episodically. And we can all agree that it’s scary.
But imagine what it would do to you physically, mentally, and emotionally if you were to expect constant nausea and vomiting at a critical stage in your life.this is the reality for them 4 in 5 women experience nausea and vomiting during pregnancy. Even mild cases can cause unpleasant symptoms such as nausea, loss of appetite, and vomiting.
According to the Office for National Statistics, in 2022 this will result in: 20,000 women hospitalized.
But until recently, little was known about the causes of nausea and vomiting during pregnancy. Anecdotal evidence suggests that the more nausea and vomiting you have, the healthier your pregnancy, and even suggests that it is related to the number of babies you have.
However, real-world evidence shows this is not true. In fact, nausea and vomiting can vary widely in severity and pattern during pregnancy.
Often referred to as “morning sickness,” nausea and vomiting during pregnancy can occur at any time of the day or night. Usually it’s worse for the first 12 weeks, then it calms down. However, for many women, it lasts throughout the pregnancy.
Read more about women’s health:
However, after more than 20 years of research in this field, a breakthrough has been made that identifies a causal relationship. This was promoted by Dr. Malena Fezo, a geneticist at the Keck School of Medicine at the University of Southern California.
Fezo was inspired to pursue this career after suffering from severe nausea and vomiting during her second pregnancy in 1999. She was unable to eat or drink without vomiting, and she rapidly lost weight and became so weak that she could no longer stand or walk.
However, doctors were skeptical that she might be exaggerating her symptoms to get attention. Fezo was eventually hospitalized and she miscarried at 15 weeks.
Fezo will conduct genetic research on previously pregnant women in collaboration with 23andMe, a private company that allows individuals to send samples of their DNA to determine health status and insights into their ancestry. did.
She identified a link with a woman who suffered from severe nausea and vomiting during pregnancy (requiring an intravenous fluid). and a variant of the gene encoding a protein named GDF15, a hormone that acts on the brain stem.
This association pinpointed the need for further research to understand the role of GDF15 protein in pregnancy.
GDF15 is secreted by the placenta during the first two trimesters of pregnancy. It also likely plays a role in preventing the mother from biologically rejecting the baby, which is essential to allowing the pregnancy to continue. However, GDF15 has been shown to regulate physiological body weight and appetite through the brain. This substance is produced in excess in cancer patients who suffer from severe appetite and weight loss.
In addition to previous research, research led by Fejzo and the University of Cambridge Professor Stephen O'Rahilly We found that the level of GDF15 was high. Seen in women with severe nausea and vomiting during pregnancy. However, the effects of this hormone appear to depend on the woman's susceptibility and her exposure to GDF15 before pregnancy. Women who received higher levels of exposure before pregnancy had higher levels of the GDF15 hormone but did not have symptoms of nausea or vomiting.
It has been hypothesized that long-term exposure to GDF15 before pregnancy may have a protective effect and reduce a woman’s sensitivity to the hormonal surge caused by fetal development.
This exposure relationship is very unique and provides more understanding and knowledge as well as the potential that women may be desensitized by increasing their exposure to hormones before pregnancy. It also suggests possible treatments. Just like some people treat food allergies with controlled exposure therapy.
Many of the common symptoms affecting women, such as nausea and vomiting during pregnancy, are poorly understood despite their very high incidence. Women’s healthcare is not a niche, and there is much to understand and learn through this type of research.
Illustration of Sierra Space’s first dream chaser, DC#1 (Tenacity). The Dream Chaser spacecraft developed by Sierra Space for NASA is gearing up for a demonstration mission to the ISS in 2024, with a focus on cargo delivery and in-orbit certification. .Credit: Sierra Space
NASA Sierra Space’s Dream Chaser spacecraft is scheduled for a demonstration flight to the ISS in 2024, carrying cargo transport and various on-orbit tests to ensure operational readiness for future missions. be exposed.NASA and Sierra Space are making progress toward the maiden flight of the company’s Dream Chaser spacecraft. international space station. The unmanned cargo spaceplane is scheduled to begin demonstration missions to orbital complexes in 2024 as part of NASA’s commercial resupply services.
Dream chaser and shooting starManufactured by Sierra Space, Louisville, Colorado, the Dream Chaser cargo system consists of two main elements: the Dream Chaser spacecraft and the Shooting Star cargo module. As a lifting body spacecraft, Dream Chaser is designed to be reused up to 15 times. HL-20 spacecraft It was developed at NASA’s Langley Research Center in Hampton, Virginia.Shooting Star, a spaceplane cargo module companion, is designed to support the transportation and disposal of pressurized and unpressurized cargo to the space station. The cargo module can only be used once and is disposed of before reentry.
The Dream Chaser system will be mounted on a ULA (United Launch Alliance) Vulcan Centaur rocket from Space Launch Complex 41 at Cape Canaveral Space Force Station in Florida, inside a 5-meter fairing. It can be launched by folding its wings. Fairing panels protect the spacecraft during ascent, but are discarded once it reaches orbit. Dream Chaser’s cargo module and wing-mounted solar arrays will be deployed during an autonomous rendezvous with the space station. In the event of disaster, Dream Chaser is designed to be ready for launch within as little as 24 hours.
NASA and Sierra Space are making progress toward the company’s Dream Chaser spacecraft’s maiden flight to the International Space Station. The unmanned cargo spaceplane is scheduled to begin demonstration missions to orbital complexes in 2024 as part of NASA’s commercial resupply services.Credit: Sierra SpaceMission overview
During the first flight, Sierra Space will conduct an in-orbit demonstration to qualify Dream Chaser for future missions. Teams from NASA Kennedy Space Center in Florida, NASA Johnson Space Center in Houston, and Dream Chaser Mission Control Center in Louisville, Colorado will monitor the flight. Sierra Space flight controllers will control the Dream Chaser spacecraft at the launch pad until it is handed over to NASA Kennedy’s Sierra Space ground operations team after landing.
The far-field demonstration will be conducted outside the vicinity of the space station before the spacecraft enters the invisible 2.5-by-1.25-by-1.25-mile (4-by-2-by-2-kilometer) boundary around the ellipsoid. . Rotating laboratory. These demonstrations are required before Dream His Chaser enters joint operations with his NASA team at Mission Control Center in Houston. These include demonstrating postural control, translational movements, and aborting functions.
Near-field demonstrations must be performed in close proximity to the space station, and include activation and use of light detection and ranging (LIDAR) sensors, responding to commands sent from the space station, retreating from the station in response to commands, and initially This includes maintaining proximity. 1,083 feet (330 meters) from the station, then 820 feet (250 meters), and finally 98 feet (30 meters). After the successful completion of the demonstration, Dream Chaser will move towards the space station.
As Dream Chaser approaches the orbiting laboratory, it will eventually park approximately 38 feet (11.5 meters) from the space station, where the station’s crew will use the Canadarm2 robotic arm to maneuver the spacecraft in front of the team on the ground. Hold on to the cargo module fixtures. Attach the cargo module to the earth-facing port of the Unity or Harmony module.
Dream Chaser will carry more than 7,800 pounds of cargo on its first flight to the International Space Station. On future missions, Dream Chaser is designed to remain on station for up to 75 days and deliver up to 11,500 pounds of cargo. Cargo can be loaded onto the spacecraft up to 24 hours before launch. Dream Chaser can return more than 3,500 pounds of cargo and experimental samples to Earth, and more than 8,700 pounds of trash can be disposed of during reentry using its cargo module.return to earthDream Chaser will remain on the space station for approximately 45 days before being uninstalled using Canadarm2. After departure, the spacecraft can land within 11 to 15 hours at the earliest, with the possibility of landing daily if weather conditions permit.
Dream Chaser’s landing weather criteria typically require crosswinds of less than 17.2 mph (15 knots), headwinds of less than 23 mph (20 knots), and tailwinds of less than 11.5 mph (10 knots). Thunderstorms, lightning, or rain within a 20-mile radius of the runway or 10 miles along the approach path are not acceptable conditions for landing. Detailed flight rules help controllers determine whether a landing opportunity is favorable.
A combination of Dream Chaser’s 26 Reaction Control System thrusters ignites, sending the spacecraft out of orbit. Dream Chaser re-entered Earth’s atmosphere and glided in the style of NASA’s Space Shuttle to a runway landing at Kennedy Launch and Landing Facility, becoming the first spacecraft to land at the facility since the Space Shuttle’s last flight in 2011. becomes.Once Dream Chaser is powered down after landing, the Sierra Space ground operations team will transport Dream Chaser to the Space Systems Processing Facility for necessary inspections, unload remaining NASA cargo, and prepare for the next mission. let’s start doing ….Sierra Space (formerly Sierra Nevada Corporation) was selected in 2016 as NASA’s third commercial cargo replenishment spacecraft to service the International Space Station.
UCLA researchers have unveiled a new solid-state thermal transistor that uses electric fields to effectively control the movement of heat in semiconductors. This represents a major advance in the thermal management of computer chips and potential applications in understanding the thermal regulation of the human body. An illustration of a UCLA-developed solid-state thermal transistor that uses electric fields to control heat transfer. Credit: H-Lab/UCLA
New electronic devices precisely and quickly control turning heat on and off.
A team of UCLA scientists has unveiled the first stable, fully solid-state thermal transistor of its kind that uses electric fields to control thermal movement in semiconductor devices.
Group research recently published in journals scienceLet’s take a closer look at how the device works and its potential uses. With the highest speed and performance, this transistor could break new ground in thermal management in computer chips through atomic-level design and molecular engineering. This advance could also improve our understanding of how the human body regulates heat.
A leap forward in thermal management technology
“Precise control over how heat flows through materials has long been a dream of physicists and engineers, but an elusive dream,” said co-author of the study, a professor of mechanical and aerospace engineering. Professor Yongji Hu said. DOI: 10.1126/science.abo4297
Other authors on the paper, all from UCLA, include Man Li, Huan Wu, Erin Avery, Zihao Qin, Dominic Goronzy, Huu Duy Nguyen, and Tianhan Liu. Hu and Weiss are also affiliated with the California NanoSystems Institute and UCLA Samueli’s Department of Bioengineering and Department of Materials Science and Engineering.
Groundbreaking research has identified a molecular photoswitch that can improve solar energy storage. Researchers used quantum computing to analyze large databases to find the best molecules for the technology, taking an important step in harnessing emissions-free solar energy. Credit: SciTechDaily.com
Optimization of molecular photoswitches for solar power generation.
Molecular photoswitches that can both convert and store energy could potentially make harvesting solar energy more efficient. The research team quantum computing A method of finding molecular structures that is particularly efficient for this purpose.As the team explained in the journal Angewante ChemieTheir procedure was based on a dataset of more than 400,000 molecules that were screened to find the best molecular structures for solar energy storage materials.
MOST project: new solar energy pathways
Currently, solar energy is used directly to generate electricity or indirectly through energy stored in thermal storage. A third route could involve first storing energy from the sun in a photosensitive material and then releasing it when needed. The EU-backed project MOST (‘Molecular Solar Thermal Energy Storage’) is researching molecules such as photoswitches that can absorb and store solar energy at room temperature, in order to make the use of completely emission-free solar energy a reality. Masu.
A research team led by Kurt V. Mikkelsen of the University of Copenhagen, Denmark, and Kasper Moss Poulsen of the Polytechnic University of Barcelona-Catalunya, Spain, took a closer look at the photoswitches that are ideal for this task. They studied molecules known as bicyclic dienes, which switch to a high-energy state when exposed to light. The most prominent example of this bicyclic diene system is known as norbornadiene quadricyclane, but a vast number of similar candidates exist. The researchers explain: “The resulting chemical space consists of approximately 466,000 bicyclic dienes that we screened for potential applicability to MOST technology.”
Innovative screening methods and promising discoveries
Screening a database of this size is typically done as follows: machine learning, But this would require large amounts of training data based on real-world experiments, which the team didn’t have. Screening and evaluation of database molecules using previously developed algorithms and the new evaluation score “Eta” yielded clear results. All six of his top-scoring molecules differed from the original norbornadienequadricyclane system in important structural respects. The researchers concluded that this structural change, an enlargement of the molecular bridge between the two carbon rings of the bicyclic moiety, allowed the new molecule to store more energy than the original norbornadiene.
The researchers’ work demonstrates the potential for optimizing solar energy storage molecules. However, new molecules must first be synthesized and tested under real conditions. “Even if systems can be prepared synthetically, there is no guarantee that they will be soluble in the relevant solvents and will actually photoswitch in high yields, as we envisioned with Eta, or “There is no guarantee that there will be any optical switching at all,” the authors caution.
Impact and prospects
Nevertheless, the team developed a new large-scale training data set for machine learning algorithms, shortening difficult pre-synthetic research steps for chemists working on such systems in the future. The authors envision that this much larger reservoir of bicyclic dienes could be exploited to study photoswitches for a variety of applications, making it easier to tailor molecules to specific requirements. doing.
References: “Bicycles for Molecular Solar Energy Storage Candidates” by Andreas Arbus Hillers Bentsen, Jacob Linge Erholm, Oskar Berlin Ober, Helen Herzel, Kaspar Moss Poulsen, and Kurt V. Mikkelsen. Exploring the chemical space of formula dienes”, July 25, 2023, Angewante Chemie International Edition. DOI: 10.1002/anie.202309543
A breakthrough assay to detect acute myeloid leukemia (AML) through a KMT2A gene fusion promises to enhance diagnosis and treatment and represents a major advance in leukemia research.
The researchers Accuracy
Detecting specific molecular markers within leukemia cells has the potential to significantly improve the assessment of measurable residual disease. This advancement will enable better-informed treatment decisions and ultimately improve patient outcomes.
A new assay that detects unique molecular markers in patients with acute myeloid leukemia (AML) could revolutionize how the disease is detected and treated, according to a recently published new report. Molecular Diagnostic Journal Published by Elsevier. This assay may improve the detection of AML due to factors such as: Kuomintang 2A Gene fusions can impact treatment decision-making, assessment of response to treatment, and long-term monitoring.
AML is a rare, aggressive blood cancer that is diagnosed in approximately 120,000 people worldwide each year. Detecting residual disease during treatment is essential to determine prognosis and guide treatment decisions.Currently, methods to detect measurable residual disease (MRD) during treatment of AML include bone marrow morphology, multiparameter flow cytometry (MPFC), and DNA Sequencing.
Morphological evaluation detects leukemic cells only with a detection limit of 5%. Although MPFC has a more sensitive detection limit of 0.01% to 0.001%, it is difficult to implement and interpret and is not standardized across laboratories. DNA sequencing approaches can identify leukemic cells by somatic mutation profiles, but are expensive and can be confounded by clonal hematopoiesis in nonleukemic blood cells.
Breakthrough progress in leukemia research
“We’ve seen a lot of research in this field,” explained lead researcher Dr. Grant A. Challen, of the Department of Oncology at Washington University School of Medicine in St. Louis. Normally absent in healthy cells. Other diseases such as chronic myeloid leukemia (CML) can already be tracked by standard BCR-ABL fusions, and sensitive detection of these fusions has revolutionized the way CML is treated. . For AML patients whose disease is caused by oncogenic fusions, the KMT2A fusion is a molecular marker that can be exploited for sensitive MRD detection. Therefore, we wanted to develop a platform for sensitive KMT2A fusion detection to improve detection and treatment methods for this disease. ”
Researchers have developed a new droplet digital PCR assay that allows for high sensitivity. Kuomintang 2A Fusion detection with the five most common fusion partners.At least 80 are known Kuomintang 2A There are fusion partners, but approximately 80% of fusions involve only 5 partners – AF9, AF6, AF4, Elleand English. They benchmarked the assay in human cell lines and patient samples and demonstrated sensitivity and specificity. Kuomintang 2A Fusion detection.
This assay detects these fusions by splitting cDNA molecules into microfluidic droplets and assaying them using primers and probes that generate a positive signal only when the fused transcript is present. Researchers were able to combine multiple primer/probe sets targeting different fusions into a pooled fusion detection reagent. they again, Kuomintang 2A Fusions in patient samples are known to be present Kuomintang 2A fusion.
Implications for AML treatment and future research
Dr. Challen said: This assay can be easily extended to include additional oncogenic fusions. This has potential implications for treatment decision-making and assessment of response to treatment. Knowing whether treatment is effective is critical to deciding when to escalate treatment or perform a hematopoietic stem cell transplant. ”
“This is a powerful new tool for highly sensitive KMT2A fusion detection and can be directly applied to disease detection in leukemia patients caused by these fusions. This fills a void in oncogenic fusion detection. , we offer several technical improvements. This assay is also highly scalable, and additional fusions can be easily added to the assay to expand coverage of other oncogenic fusions. We is improving blood cancer detection one drop at a time.”
Reference: “Droplet Digital PCR for Oncogenic KMT2A Fusion Detection” by Andrew L. Young, Hannah C. Davis, and Grant A. Challen, October 7, 2023. Molecular Diagnostic Journal. DOI: 10.1016/j.jmoldx.2023.09.006
This research was funded by: National Institutes of Health and the Leukemia and Lymphoma Society.
Stanford University engineers have created an injectable hydrogel depot technology that allows GLP-1 drugs to be administered once every four months, rather than requiring daily injections. This new hydrogel has the potential to revolutionize treatment for type 2 diabetes and weight management by significantly reducing the burden of daily injections.
The hydrogel drug delivery system was developed by materials engineers at Stanford University and turns daily or weekly injections of drugs like Ozempic, Maunjaro, Trulicity, and Victoza into a single injection every four months. This new system could greatly improve patient compliance and health outcomes for people with type 2 diabetes, as well as providing a more manageable treatment regimen.
The hydrogel contains GLP-1 drug molecules and slowly releases them over time, eliminating the need for frequent injections. This novel nanocomposite hydrogel is made of polymers and nanoparticles that dissolve over the course of several months, similar to how a sugar cube dissolves in water. Once the hydrogel is injected under the skin, it gradually releases the drug as it dissolves, providing sustained delivery over a four-month period.
Initial testing in laboratory rats has shown promising results, and future trials will be conducted on pigs to further validate the system’s effectiveness. The ultimate goal is to conduct human clinical trials within the next two years to evaluate the long-term administration of GLP-1-based treatments.
This research was supported by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases and a seed grant from the Stanford Diabetes Research Center.
Scientists have used environmental TEM to uncover atomic-level secrets about how water vapor interacts with metals, causing corrosion and passivation. Their research provides insights into improved corrosion management and clean energy solutions, with broad economic and environmental benefits. Credit: SciTechDaily.com
Groundbreaking research reveals new details about water vapor and metal interactions at the atomic level, with implications for corrosion control and clean energy development.
When water vapor comes into contact with metal, corrosion can occur and cause mechanical problems that negatively impact the performance of the machine. Through a process called passivation, a thin inert layer can also be formed that acts as a barrier against further degradation.
In any case, the exact chemical reactions are not well understood at the atomic level, but a technique called environmental transmission electron microscopy (TEM) allows researchers to directly observe interacting molecules on the smallest possible scale. Thanks to you, things are changing.
Innovative research in atomic reactions
Professor Guangwen Zhou, a faculty member in Binghamton University’s Thomas J. Watson College of Engineering and Applied Sciences, has been studying the secrets of atomic reactions since joining the Department of Mechanical Engineering in 2007. The national lab, along with collaborators at the University of Pittsburgh and Brookhaven University, has been studying the structural and functional properties of metals and the manufacturing process for “green” steels.
Their latest research, “Atomic Mechanism of Water Vapor-Induced Surface Passivation,” was recently published in a journal. scientific progress. Co-authors include his Binghamton doctoral students Xiaobo Chen, Dongxiang Wu, Chaoran Li, Shuonan Ye, and Shyam Bharatkumar Patel, MS ’21. Dr. Na Kai, 12 years. Dr. Zhao Liu, 2020. At the University of Pittsburgh, he is Weitao Shan, MS ’16, and Guofeng Wang. Sooyeon Hwang, Dmitri N. Zakharov, and Jorge Anibal Boscoboinik of Brookhaven National Laboratory;
Transmission electron microscopy images of aluminum oxide surfaces show that the passive oxide film formed in water vapor consists of an inner amorphous aluminum oxide layer and an outer crystalline aluminum hydroxide layer.Credit: Provided
In their paper, Chou and his team introduced water vapor to cleaned aluminum samples and observed the surface reactions.
“This phenomenon is well known because it occurs in our daily lives,” he says. “But how do water molecules react with aluminum to form this passive layer? [research] In the literature, how this happens at the atomic scale has not been well studied. If you want to use it for good, there is some way to control it and you need to know it. ”
They discovered something that had never been observed before. In addition to the aluminum hydroxide layer formed on the surface, a second amorphous layer developed underneath. This indicates that there is a transport mechanism that allows oxygen to diffuse into the substrate.
“Most corrosion research focuses on the growth of the passive layer and how it slows down the corrosion process,” Zhou says. “We feel that if we look at the atomic scale, we can fill in the gaps in knowledge.”
Guangwen Zhou is a professor of mechanical engineering in the Watson College of Engineering and Applied Sciences.Credit: Jonathan Cohen
Economic and Environmental Impact of Corrosion Research Economic and Environmental Impact of Corrosion Research
The cost of remediating corrosion worldwide is estimated at $2.5 trillion annually, which is more than 3% of global GDP. Therefore, developing better ways to manage oxidation would be an economic boon.
Additionally, understanding how the hydrogen and oxygen atoms in water molecules break down and interact with metals could lead to clean energy solutions, and the U.S. Department of Energy is excited about this research and Zhou’s past work. That’s why we funded a similar project.
“If you split water into oxygen and hydrogen, when they recombine, it’s just water again,” he says. “There is no fossil fuel pollution and no carbon dioxide production.”
Because of its impact on clean energy, the Department of Energy has periodically renewed Chou’s grant over the past 15 years.
“We are very grateful for the long-term support for this research,” said Zhou. “This is a very important issue for energy devices and systems because of the large amount of metal alloys used as structural materials.”
Reference: “Atomic mechanism of water vapor-induced surface passivation” Xiaobo Chen, Weitao Shan, Dongxiang Wu, Shyam Bharatkumar Patel, Na Cai, Chaoran Li, Shuonan Ye, Zhao Liu, Sooyeon Hwang, Dmitri N. Zakharov, Jorge Anibal Boscoboinik Written by Wang Feng and Zhou Guangwen, November 1, 2023, scientific progress. DOI: 10.1126/sciadv.adh5565
Scientists have developed a promising treatment for sepsis, and clinical trials using sodium ascorbate, a vitamin C preparation, have shown effective results. The treatment has progressed into extensive clinical trials across Australia and demonstrated significant improvements in sepsis patients, including improved kidney function and reduced dependence on other drugs. This breakthrough, the result of decades of research, brings hope to a disease that is the leading cause of death in intensive care units around the world.
Flory Institute researchers, in collaboration with hospital intensivists, have demonstrated that sodium ascorbate, a pH-balanced formulation of vitamin C, is effective in treating sepsis.
Researchers at the Florey Institute have demonstrated that the formulation they have developed reduces deadly sepsis, and the next phase of clinical trials is set to begin across Australia next month.
Promising results from early clinical trial conducted at Melbourne’s Austin Hospital published in journal Critical carehave shown that sodium ascorbate, a pH-balanced formulation of vitamin C, is effective in treating sepsis.
Lead researcher Associate Professor Yugish Lankadeva said sepsis is notoriously difficult to treat and is often fatal.
LR Florey Professor Clive May, Austin Health Intensivist Professor Rinaldo Bellomo and Florey Associate Professor Yugish Rankadeva discovered that sodium ascorbate can be used to treat sepsis.Credit: Flory
Challenges in sepsis treatment
“Sepsis accounts for 35 to 50 percent of all hospital deaths. It is when the immune system is unable to fight the underlying infection, causing a life-threatening drop in blood pressure, multiple organ failure, and death. ,” said Associate Professor Lankadeva. In our clinical trial at Austin Hospital, sodium ascorbate was administered into patients’ bloodstreams, resulting in promising improvements in multiple organs. ”
Associate Professor Lankadeva, Florey’s research director for Systems Neuroscience, said of the next steps: $4.9 million government-funded research project Delivered in intensive care units in Adelaide, Melbourne, Perth, Brisbane, Alice Springs and Sydney.
“We will recruit 300 adult sepsis patients who will receive either our formulation or a placebo in addition to their usual hospital care. These results will provide additional data to determine the efficacy of the formulation. It will help in collection,” said Associate Professor Lankadeva.
Flory scientists have created a special formulation of sodium ascorbate to treat sepsis.Credit: Flory
Insights into previous trials
Professor Rinaldo Bellomo, director of intensive care research at Austin Hospital, said the first part of the trial at his department involved 30 adult sepsis patients between October 2020 and November 2022.
While in intensive care in the hospital, half of the patients were randomly assigned to receive sodium ascorbate, and the other half received a placebo.
This study found that patients with sepsis treated with sodium ascorbate:
Signs that more urine is produced and kidney function has improved
Less need for noradrenaline, a drug used clinically to restore blood pressure
He showed signs of improved function in multiple organs.
“Sepsis is the number one cause of death in intensive care units in Australia and around the world,” Professor Bellomo said. “In many cases, the disease progresses so rapidly that by the time patients reach us, they are already seriously ill. It will be a huge change.”
Decades of research bear fruit
Professor Clive May, Florey Senior Research Fellow on the project, has been researching how sepsis causes organ failure, particularly damage to the brain and kidneys, for more than 20 years.
“By showing decreased oxygen levels in the tissues of sepsis, we found that sodium ascorbate was a possible treatment.
“We have seen dramatic results in preclinical studies, where extremely high doses of sodium ascorbate caused complete recovery within just three hours with no side effects. It’s heartening to see that it’s paying off and bringing treatments into the hands of patients,” said Professor Clive May.
Surviving sepsis: The patient’s perspective
Longtime Flory staffer Brett Purcell serves as the consumer representative for the MEGASCORES research program, providing a valuable perspective from sepsis survivors.
“In 2011 I was taken to the hospital by ambulance with high fever and delirium. I was suffering from the early stages of sepsis. My condition gradually worsened and I was transferred to a larger hospital after 12 days. By that time My heart was severely infected and I was in septic shock. Six months ago I had a successful aortic valve replacement. Unfortunately the valve was infected.
“The surgical team repaired the damage in a six-hour operation, but my condition deteriorated to critical condition. I was told it would be an hour. It was the good decision-making of the surgical team and ICU intensivist that saved me. I was put on life support with an ECMO machine and dialysis, and my symptoms rapidly worsened. Improved.
“After almost eight weeks in the hospital, I’m home. I’m really lucky to be alive and hope this new research using sodium ascorbate is less invasive, faster, and extremely effective in fighting sepsis.” We hope to provide hospitals with a new and effective life-saving tool.”
Reference: “Ultra-dose sodium ascorbate: pilot, single-dose, physiological effects, double-blind, randomized, controlled trial” Fumitaka Yanase, Sofia Spano, Akinori Maeda, Anis Chaba, Thummaporn Naorungroj, Connie Pei Chen Ow , Yugeesh R. Rankadeva, Clive N. May, Ashenafi H. Betley, Darius JR Lane, Glenn M. Eastwood, Mark P. Plummer, Rinaldo Bellomo, October 12, 2023. Critical care. DOI: 10.1186/s13054-023-04644-x
The superabsorber becomes a liquid under ultraviolet light after absorbing enough water. It can then be reused. Credit: Ken Pekarsky, KIT
Water and UV light effectively and quickly break down the cross-linked polymers in diaper liners without the use of any chemicals. This process allows recycled plastic molecules to be reused for a variety of uses.
Superabsorbent materials such as sodium polyacrylate are important components of a variety of hygiene and medical products, including diapers, bandages, and dressings. These cross-linked polymers are typically insoluble in water, although they are known for their high absorbency. Recycling them traditionally required the use of strong acids.
It will not melt at high temperatures, it will only deteriorate. However, the acid “breaks” the chains and stabilizes the polymer after about 16 hours at 80 degrees. Celsius Therefore, recycling is now possible. Because this process is complex and expensive, superabsorbents are rarely recycled. Approximately 2 million tons of this waste is thrown away or incinerated each year.
Turns into liquid in 5 minutes instead of 16 hours
Researchers from KIT’s Institute of Biochemical Systems, Institute of Biointerfaces, and Institute of Chemical Technology and Polymer Chemistry have discovered that crosslinked sodium polyacrylate polymers degrade under ultraviolet light after uptake of water. .
“The chains that connect the polymers are broken by light, and they are so loose that they swim underwater and turn into liquid fibers,” explains Pavel Levkin, a professor at the Institute of Biochemical Systems. For the study, researchers cut liners from traditional diapers, wetted them with water and exposed them to a 1000 W lamp. After 5 minutes, the solid material turned into a liquid and fell into the collector. “This method using ultraviolet light is about 200 times faster than using acids,” Revkin says.
Recycled polymers can be used in a variety of ways
The team then used known processes to convert the liquid into new adhesives and dyes. “The observation that this substance is soluble and processable was very important. It could probably be turned into many other products,” explains the scientist.
In the test, the researchers used clean diapers. However, it is also possible to separate superabsorbents from used diapers. “Therefore, there is no reason why a near-realistic use should not be possible,” Revkin says. By using solar power, you can optimize recycling methods that are cost-effective and environmentally friendly. “We have discovered a promising strategy to recycle superabsorbents, which significantly reduces environmental pollution and contributes to a more sustainable use of polymers.”
Reference: “From diapers to thickeners and pressure-sensitive adhesives: recycling superabsorbents by UV degradation” by Shuai Li, Johannes M. Scheiger, Zhenwu Wang, Birgit Huber, Maxi Hoffmann, Manfred Wilhelm, Pavel A. Levkin , September 7, 2023 ACS Applied Materials & Interfaces. DOI: 10.1021/acsami.3c06999
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