Lab Mouse witnessed him cheering for his unconscious companion

In a new laboratory experiment, scientists at the University of Southern California showed that when mice encountered a social partner familiar with the unconscious state caused by anesthesia, they escalated to powerful behaviors such as biting or pulling their partner’s mouth and tongue, showing clear and consistent behavior.

Mice have their own “first aid” practices to help other mice in need. Image credits: Sun et al. , doi: 10.1126/science.adq2677.

“There are many factors that determine mammals’ empathy and social bonds,” says Professor Li Zhang, a researcher at the University of Southern California.

“However, this is the first time this study has seen first responder-like behavior in mice.”

New research shows that mice tend to help other mice they know to be unconscious.

Their responses range from mild sniffing and grooming to more powerful actions such as mouth and tongue biting, and eventually escalates to pulling the tongue out of the unconscious mouse.

“The behavior was particularly unique because it was similar to how humans behave in emergency responses. Dr. Wenzian Sang, PhD of the University of Southern California, said:

Interestingly, scientists were first witnessed rehabilitation behavior in mice paired together in an unrelated study.

When humans encounter unconscious individuals, emergency response changes, such as assessing the situation, checking for responsiveness, seeking help and performing cardiopulmonary resuscitation (CPR) for the individual.

The urgent “helper mice” target the unconscious companion’s mouth and tongue appears to improve their companion’s airways and lead to faster recovery,” said Huizhong Tao, professor at the University of Southern California.

“We learned in this study that tongue pulling between mice cannot be interpreted as an offensive gesture.”

“Social behavior in this study was significantly more pronounced among familiar mouse pairs, and was rarely seen when one of the paired mice was simply sleeping or active.”

“And also, after the unconscious mice regained consciousness, they regularly used their tongues.”

https://www.youtube.com/watch?v=r5dzd4dpvio

In this study, the authors utilized advanced neuroimaging and optogenetics to investigate the neural mechanisms behind social behavior in helper mice.

“One of the most interesting aspects of our neurologic observations was the discovery of the activation of oxytocin neuropeptides,” Professor Chan said.

“Oxytocin is widely known as a hormone that plays an important role in social bonds.”

“Oxytocin is sometimes called love hormone because it is linked to trust, bonding and affection.”

“This was the first study showing that oxytocin is an important factor in social ties in mice.”

“Our findings not only enhance our understanding of animal behavior, they also highlight the important role of the oxytocin system.

result It will be displayed in the journal Science.

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Wenjian Sang et al. 2025. Prosocial behaviors like resurrection in response to the unconscious or dead homologue of rodents. Science 387 (6736); doi:10.1126/science.adq2677

Source: www.sci.news

Mouse providing first aid to unconscious companions

Mouse tends to become an unconscious peer by pulling its tongue

Wenjian Sun et al. 2025

When they unconsciously find another mouse, it appears that some mice are trying to revive their companions by stepping into them and biting them and pulling their tongues aside to clean their airways. This finding suggests that caregiving behavior may be more common in animal kingdoms than we thought.

There have been rare reports of large social mammals trying to help such types of incapacitated members. Wild chimpanzee touching and licking injured companion, Dolphins who try to push their suffering podmates into the surface can breathe and Elephants provide support to sick relatives.

now, Lee Chang The University of Southern California (USC) and his colleagues filmed what happened when they introduced a familiar cagemate who was active or anesthetized and unresponsive to a laboratory mouse.

In a series of tests, on average, animals spent about 47% of the 13-minute observation window to interact with their unconscious partners, showing three different behaviors.

“They start with sniffing, then grooming, and very intensive or physical interactions,” says Zhang. “They really open their mouths and pull out their tongues.”

These more physical interactions included licking the eyes and chewing on the area of the mouth. After focusing on the mouth, the mice pulled the tongue of their unresponsive partner in more than 50% of cases.

In another test, the researchers gently placed a non-toxic plastic ball in the mouth of an unconscious mouse. In 80% of cases, the support mouse successfully removed the object.

“If you extend the observation window, your success rate can be even higher,” says team members. Huizhong Taoeven at USC.

The awakened mouse began walking again earlier than it was unharmed for the mouse. Then, as their responsibility moved and responded, the caregiver’s mouse slowed down and stopped the caregiving behavior.

Additionally, caregiver mice spent more time when they were familiar with unconscious mice than they had previously met.

Restoration behavior is not an analog of CPR that requires specialized training, Zhang says. It’s like awakening someone using a strong smelly salt or slapping, or doing basic first aid so that the unconscious person can breathe. It is also important during surgery to place the tongue of anesthetized patients to prevent airway blockage, he says.

Zhang and his colleagues found that behavior is driven by oxytocin-releasing neurons in the amygdala and hypothalamic regions of the brain. The hormone oxytocin is involved in other compassionate behaviors in a wide range of vertebrate species.

Similar behavior has been reported in lab mice Along with research papers Also explained by another team By the third team last month.

“I have never observed these types of behavior when I run experiments in the lab, but have never left a recovery animal with my partner until I have fully awakened.” Christina Marquez at the Centre for Neuroscience and Cell Biology, Coimbra, Portugal. “The fact that three independent labs observe similar behaviors indicates that this is a robust finding, but we are observing what we observe in nonhuman species; We really need to be aware that we personify too many things that result from intentions that go beyond what is observed.”

Zhang and his colleagues believe that the behavior is innate, not learned. This is because all animals tested were only 2-3 months old and never saw this behavior or anesthetized cage companions.

He suggests that such instinctive behavior plays a role in strengthening group cohesion and may be more widespread among social animals than we have seen.

It may be difficult to see this behavior in wild mice, says Marquez. “Mouses are often prey animals that do not live in large groups, so they usually hide very well from us. However [the fact] That we haven’t seen it doesn’t mean they don’t do it. ”

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Source: www.newscientist.com

“Unconscious Brain Activity and Epileptic Seizures: The Role of Sleep Brain Waves”

A new study has found that the slow brain waves typical of sleep occur in epilepsy patients when they are awake, helping to prevent the brain from becoming more excited. These waves reduce epileptic activity while negatively impacting memory, suggesting a potential new therapeutic approach for epilepsy.

UCL researchers have found that slow brain waves commonly seen during sleep occur in epilepsy patients while they are awake, preventing seizures but affecting memory, suggesting a new potential treatment for epilepsy. are doing.
A new study led by researchers at University College London (UCL) has found that slow waves, which normally occur only in the brain during sleep, also occur when epilepsy patients are awake, and show that slow waves, which are associated with epilepsy symptoms, can also occur in the brain during sleep. It was found that there is a possibility of preventing increased excitement.

Methodology and findings

The study was published today (November 30) in the journal nature communications The National Institute for Health Research (NIHR) UCLH Biomedical Research Center also took part in conducting electroencephalogram (EEG) scans from electrodes in the brains of 25 patients with focal epilepsy (a type of epilepsy characterized by seizures originating from specific parts of the brain). was inspected. brain), they performed an associative memory task.
Electrodes were placed in the patient’s brain to localize abnormal activity and inform surgical treatment.
During the task, participants were presented with 27 pairs of images that remained on the screen for 6 seconds. The images are divided into nine groups of three, and each group contains photos of people, places, and objects. In each case, participants had to remember which images were grouped together. EEG data were recorded continuously throughout the task.
After reviewing EEG data, the researchers found that the brains of people with epilepsy produce slow waves lasting less than a second while they are awake and participating in tasks.
The occurrence of these “awakening” slow waves increased in response to increased brain excitability, reducing the influence of epileptic spikes on brain activity.
In particular, it reduces the “firing” of nerve cells, which the researchers say can prevent epileptic activity.

Implications and future research

Lead author Professor Matthew Walker (UCL Queen Square Institute of Neurology) said: “Sleep is crucial for repairing, maintaining, and resetting brain activity. When we are awake, our brains gradually become more excitable, which recovers during sleep.
“Recent research has shown that a specific form of brain activity, namely slow waves during sleep, plays an important role in these restorative functions. We believe that these ‘sleep’ slow waves , we wanted to consider whether this could occur during wakefulness in response to the abnormal increase in brain activity associated with epilepsy.
“This study reveals for the first time ‘arousal’ slow waves, a potential protective mechanism used by the brain to counter epileptic activity. This mechanism takes advantage of brain defense activity that normally occurs during sleep, but can also occur during wakefulness in epileptic patients. ”
As part of the study, the team also wanted to test whether the occurrence of “awake” slow waves had a negative impact on cognitive function.
Researchers found that during memory tasks, “awake” slow waves reduced neuronal activity, thus affecting cognitive performance and increasing the time patients needed to complete the task.
The researchers reported that for every additional slow wave per second, reaction time increased by 0.56 seconds.
Professor Walker said: “This observation suggests that the cognitive impairments experienced by epilepsy patients, particularly memory impairments, may be due in part to short-term impairments caused by these slow waves. “
The research team hopes that future studies will increase such activity as a potential new treatment for epilepsy patients.
Lead author Dr Laurent Sheibany (UCL Queen Square Institute of Neurology) said:
“Our study suggests that naturally occurring activity is utilized by the brain to offset pathological activity. However, slow waves of ‘wake’ may have no effect on memory performance. This comes at a cost because we know we give.
“From a purely neurobiological perspective, this study also supports the idea that sleep activity does not occur uniformly throughout the brain, but may occur in specific regions of the brain.”
Reference: “Awakening slow waves in focal human epilepsy affect network activity and cognition” November 29, 2023 nature communications.
DOI: 10.1038/s41467-023-42971-3
This research was funded by the Medical Research Council, Wellcome, UCLH Biomedical Research Center and the Swiss National Science Foundation.

Source: scitechdaily.com