New Research Identifies Additional Dog Breeds at Elevated Risk for Respiratory Diseases

Pekingese and Japanese Chin Dogs

Pekingese and Japanese Chin dogs are at an increased risk for respiratory diseases.

Michael Schultze, Catamount/Alamy

Dog owners are urged to consider a broader spectrum of breeds when seeking a puppy, as recent studies indicate that serious breathing issues are more common than once believed.

Brachycephalic breeds—dogs with short snouts and flat faces—have surged in popularity, according to Francesca Tomlinson from Cambridge University.

However, along with their rising popularity, these breeds face increasing health concerns, primarily Brachycephalic Obstructive Airway Syndrome (BOAS), which can present as noisy or labored breathing. This condition severely hampers activities like exercise, sleep, and managing heat and stress.

While concerns about BOAS frequently focus on breeds like English bulldogs, French bulldogs, and pugs, research led by Tomlinson explored 898 dogs from 14 breeds including the Affenpinscher, Boston Terrier, Boxer, and Pekingese.

All subjects underwent comprehensive respiratory evaluations and detailed body and facial measurements.


Findings revealed that Pekingese and similar breeds are exceptionally vulnerable to BOAS, with over 80% affected. Breeds like the Cavalier King Charles Spaniel, Shih Tzu, and others showed moderate risk, while only the Maltese and Pomeranian showed no significant health concerns.

Three major factors contribute to breathing issues: excess weight, narrow nostrils, and extreme facial flattening. Other traits, such as short or screw-shaped tails, may also be linked to BOAS-related anatomical changes. “It’s not solely flatness that influences risk; various factors play a role,” explains Tomlinson.

Prospective dog owners should seek puppies from health-tested parents and familiarize themselves with the potential health consequences of extreme physical traits, particularly those affecting the face.

“Our goal isn’t to eliminate defining breed characteristics but to support breeding that promotes function over mere appearance,” Tomlinson emphasizes.

She adds that the severity of physical trait exaggeration is crucial in determining health outcomes. “This suggests a practical approach: opting for less extreme physical traits may help lower disease risk.”

Anna Quine from the University of Sydney highlights that “cute” flat-faced dogs are more susceptible to chronic respiratory distress and heat stress.

Breeding dogs for a flat face is akin to “designing a car without a radiator,” she warns. “If we’re introducing dogs into the world, our first priority should be their welfare, not merely satisfying human aesthetic preferences.”

Paul McGreevey, also from the University of Sydney, concurs that the study validates what many veterinarians already suspect: compromised airways are common in flat-faced dogs, with variations across and within breeds.

“For dogs struggling with airway issues and carbon dioxide expulsion, breed labels become irrelevant,” he states, noting that classifications are human decisions.

Yet, he raises concerns regarding the study’s methodology, pointing out the subjective nature of classifying respiratory sounds. “This raises questions about consistency across the 14 distinct breeds,” McGreevy states. “Moreover, the authors admit that athletic assessments depend on individual speed and temperament.”

Tomlinson countered that the evaluation incorporates objective measures, including abnormal breath sound detection, following a standardized protocol. “The intention of the exercise test is not to assess exercise capacity but to observe how airways react to mild exertion,” she clarifies.

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Source: www.newscientist.com

Early Findings Indicate Elevated Risk of Colon Cancer in Long-Distance Runners

Researchers may have identified a potential connection between extreme endurance running and colorectal cancer, as nearly half of marathon and ultra-marathon participants have undergone screening.

Initial research assembled 100 long-distance runners aged 35-50 for colonoscopy, though these findings have not yet been peer-reviewed.

Close to 50% were found to have polyps (growths), with 15% diagnosed with advanced adenomas—growths that are likely to progress to cancer.

In contrast, recent studies indicate that only about 4.5 to 6 percent of adults in their late 40s from the general population have these advanced adenomas. However, it’s important to note that these studies included significantly larger sample sizes.

“I was quite concerned when I observed a group of ultra-marathon runners in their 30s diagnosed with stage 4, very advanced colorectal cancer,” said Dr. Timothy Cannon, who led the study at the Inova Schar Cancer Institute in Virginia. BBC Science Focus.

“They reported experiencing bleeding and convulsions post-race. At least one or two mentioned that they were told this was normal following their runs.”

Such symptoms can result from ischemic colitis, where blood flow is diverted from the colon to supply oxygen to the legs and other muscles during intense activity. This can lead to swelling and bleeding but typically resolves spontaneously.

Dr. Cannon speculated whether repeated cycles of damage and healing could create conditions conducive to cancer development.

Blood flow to the legs deprives the intestines of oxygen.

“There is currently no evidence that ischemic colitis directly causes cancer,” he stated. “However, it’s not difficult to imagine the potential outcomes. When numerous cells die and regenerate chaotically, there are ample chances for DNA replication errors.”

Alternative explanations exist as well. Endurance athletes are known to possess distinct gut microbiota compared to non-runners, and they often consume considerable amounts of ultra-processed foods, such as bottled energy drinks.

Dr. Cannon’s team is preparing to compare the gut bacteria of runners with and without adenomas to that of non-runners.

The findings were presented at the American Society of Clinical Oncology’s annual meeting, yet researchers cautioned that these are merely preliminary results, necessitating further investigation. They also highlighted that the screening study lacked a control group of non-runners.

“This leans more toward hypothesis than definitive answers,” Cannon remarked.

“I definitely don’t want people to walk away thinking exercise is harmful because it is beneficial overall. The inquiry is whether high levels of exercise could elevate the risk of colon cancer—and I believe they might.”

Read more:

  • Running slowly may be essential for a healthier, longer lifespan. Here’s why
  • What are the limits of human endurance?
  • The astonishing truth about how running can alter one’s perception of time

Source: www.sciencefocus.com

Simple indicators of elevated cortisol levels

Cortisol, a hormone produced by adrenal glands located on top of the kidneys, plays a crucial role in various body functions such as metabolism regulation, inflammation reduction, and stress response promotion. While essential for health, chronically elevated cortisol levels can lead to numerous problems.

Increased cortisol levels can occur due to factors like Cushing’s syndrome from long-term use of synthetic cortisol-containing steroid drugs or tumors in the brain or adrenal glands causing excessive cortisol production.

There are several indicators of elevated cortisol levels:

Weight Gain

High cortisol levels can lead to weight gain, particularly around the abdomen. Cortisol influences fat storage, causing more fat to accumulate in that area. While this is true for both genders, hormonal variations can affect distribution.

Other factors like diet, lifestyle, genetics, and hormonal imbalances such as insulin resistance also contribute to increased abdominal fat. Signs may include fat accumulation in the neck and shoulders (buffalo hump) and a rounded, swollen face.

Fatigue and Insomnia

Despite feeling tired, individuals with high cortisol levels often experience sleep disturbances, leading to chronic fatigue. Disrupted cortisol circadian rhythm affects sleep patterns negatively.

Man fighting fatigue while lying on the sofa – Credit: Catherine Falls Commercial

High Blood Pressure and Blood Sugar Levels

Elevated cortisol levels can increase blood pressure and blood sugar levels over time, raising the risk of hypertension and diabetes.

Mood Changes

Cortisol, known as the stress hormone, can induce anxiety, depression, and irritability by affecting brain neurotransmitters like serotonin and dopamine.

Bone Weakness

Prolonged high cortisol levels can cause muscle atrophy, loss of bone density, and increase the risk of osteoporosis, especially in postmenopausal women.

Other Symptoms

Additional symptoms may include bruising-prone skin, large purple stretch marks, low sex drive, and fertility issues.


This article addresses the query (sent by Stephen Donnelly): “How do I know if my cortisol levels are high?”

To submit questions, email questions@sciencefocus.com or message us on our Facebook, Twitter, or Instagram Page (include name and location).

For more fascinating science facts, visit our Ultimate Fun Facts page.


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Source: www.sciencefocus.com

Discovery of a direct correlation between elevated insulin levels and pancreatic cancer by scientists

A new study has proven a direct link between high insulin levels and increased risk of pancreatic cancer in people with obesity and type 2 diabetes. This landmark study shows how excess insulin overstimulates pancreatic acinar cells, leading to inflammation and precancerous cells, particularly in the case of pancreatic ductal adenocarcinoma (PDAC). These findings highlight the importance of maintaining healthy insulin levels and may lead to new strategies for cancer prevention and treatment, including lifestyle interventions and targeted therapies.

For the first time, we explain in detail why people with obesity and type 2 diabetes have an increased risk of pancreatic cancer.

A recent study conducted by scientists at the University of British Columbia’s Faculty of Medicine revealed a direct relationship between high blood pressure and high blood pressure. insulin This level is frequently observed in patients with obesity, type 2 diabetes, and pancreatic cancer.

This study cell metabolismprovides the first detailed explanation of why people with obesity and type 2 diabetes are at increased risk of pancreatic cancer. This study shows that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This excessive stimulation causes inflammation and transforms these cells into precancerous cells.

“In addition to rapid increases in both obesity and type 2 diabetes, we are also seeing an alarming increase in the incidence of pancreatic cancer,” said co-senior author and professor in the Department of Cellular Physiology Sciences and co-senior author of the study. said Dr. James Johnson, interim director of the agency. UBC’s Institute of Life Sciences. “These findings help us understand how this is happening and highlight the importance of keeping insulin levels within a healthy range. can be achieved through medication.”

Dr. James Johnson is a professor in the Department of Cellular and Physiological Sciences and interim director of the UBC Life Sciences Institute. credit:
UBC Faculty of Medicine

The study focused on pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer and a highly aggressive disease with a five-year survival rate of less than 10 percent. The incidence of pancreatic cancer is on the rise. By 2030, PDAC is expected to become the second leading cause of cancer-related deaths.

Role of insulin in pancreatic cancer

Although obesity and type 2 diabetes were previously established as risk factors for pancreatic cancer, the exact mechanisms by which this occurs remained unclear. This new study sheds light on the role of insulin and its receptor in this process.

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Reference: “Hyperinsulinemia causes pancreatic cancer through acinar insulin receptors by increasing digestive enzyme production and inflammation” (Anni MY Zhang, Yi Han Xia, Jeffrey SH Lin, Ken H Chu, Wei Chuan K. Wang, Titine JJ Ruiter, Jenny) CC Yang, Nan Chen, Justin Choa, Shilpa Patil, Haoning Howard Sen, Elizabeth J. Rideout, Vincent R. Richard, David・F. Shafer, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson, Janelle L. Kopp, October 31, 2023. cell metabolism.
DOI: 10.1016/j.cmet.2023.10.003

This study was funded by the Canadian Institutes of Health Research and the Lustgarten Foundation.

Source: scitechdaily.com