Astronomers Uncover Direct Evidence of Supermassive Stars in the Early Universe

Astronomers utilizing the NASA/ESA/CSA James Webb Space Telescope have identified the chemical signature of a protostar with a mass between 1,000 and 10,000 times that of the Sun in GS 3073, an early galaxy with a redshift of 5.55 (approximately 1 billion years post-Big Bang).



A primordial supermassive star in the early universe. Image credit: Gemini AI.

In 2022, it was suggested by astronomers that supermassive stars formed naturally within turbulent flows of rare cold gas during the early universe, thus accounting for the existence of quasars less than a billion years after the Big Bang.

“Our recent finding helps to unravel a cosmic enigma that has persisted for two decades,” stated Dr. Daniel Whalen of the University of Portsmouth.

“GS 3073 offers the first observational proof of these colossal stars.”

“These astronomical behemoths would have radiated intensely for a brief period before collapsing into enormous black holes, leaving behind chemical imprints detectable billions of years later.”

“Much like Earth’s dinosaurs, they were massive and rudimentary, with lifespans spanning just 250,000 years—an ephemeral moment in cosmic time.”

The cornerstone of this discovery involved assessing the nitrogen-to-oxygen ratio in the GS 3073 galaxy.

This galaxy presents a nitrogen-to-oxygen ratio of 0.46, significantly exceeding what can be accounted for by any known type of star or stellar explosion.

“Chemical abundances serve as the universe’s fingerprints, and the pattern from GS 3073 is unlike that produced by typical stars,” remarked Dr. Devesh Nandal, an astronomer at the University of Virginia, Harvard University, and the Smithsonian Center for Astrophysics.

“This unprecedented nitrogen concentration aligns with a single known source: protostars that are thousands of times more massive than the Sun.”

“This suggests that the first generation of stars included genuine supermassive objects that contributed to the creation of early galaxies and may have planted the seeds for contemporary supermassive black holes.”

The researchers performed modeling of stars with masses between 1,000 and 10,000 solar masses to predict their evolution and the elements they would produce.

They identified a specific mechanism for generating substantial nitrogen. (i) These colossal stars fuse helium, forming carbon in their cores. (ii) Carbon seeps into the outer shell, where hydrogen is undergoing fusion. (iii) Carbon merges with hydrogen, resulting in nitrogen through the carbon/nitrogen/oxygen (CNO) cycle. (iv) Convection disseminates nitrogen throughout the star. (v) Eventually, this nitrogen-rich material is expelled into space, enriching the surrounding gas.

This mechanism spans millions of years during the star’s helium burning phase, leading to the excess nitrogen observed in GS 3073.

The team’s models predict that upon demise, these massive stars do not explode. Instead, they collapse directly into gigantic black holes with masses reaching thousands of solar masses.

Interestingly, GS 3073 harbors an actively feeding black hole at its core, which could potentially be the remnant of one of these supermassive first stars.

If validated, this would simultaneously clarify two mysteries: the origin of nitrogen and the formation of black holes.

The study also revealed that this nitrogen signature is exclusive to specific mass ranges.

“Stars below 1,000 solar masses or above 10,000 solar masses do not generate chemical patterns suitable for this signature, indicating a ‘sweet spot’ for such enrichment,” scientists noted.

of study Published in Astrophysics Journal Letter.

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Devesh Nandal others. 2025. A protostar between 1000 and 10,000 MSun created a nitrogen surplus in GS 3073 at z = 5.55. APJL 994, L11; doi: 10.3847/2041-8213/ae1a63

Source: www.sci.news

Astronomers Capture Direct Images of Brown Dwarfs Orbiting Nearby Red Dwarfs

Astronomers utilized the Subaru Telescope, W.M. Keck Observatory, and ESA’s Gaia mission to capture images of the brown dwarf companion orbiting the M dwarf star LSPM J1446+4633.



NIRC2 image of J1446 taken in August 2023. The white arrow indicates the location of the new companion J1446B. Image provided by: Uyama et al., doi: 10.3847/1538-3881/ae08b6.

LSPM J1446+4633 (J1446) is a nearby mid-M dwarf, situated 17 parsecs (55 light-years) away.

The newly identified brown dwarf orbits its parent star at a distance approximately 4.3 times that of the Earth from the sun, completing an orbit every 20 years.

This object, designated J1446B, has a mass ranging from 20 to 60 times that of Jupiter.

“The success of this discovery was due to the combination of three complementary observational methods: (i) radial velocity (RV) measurements via long-term infrared spectroscopic monitoring by Subaru’s IRD instrument, (ii) high-resolution near-infrared imaging with advanced adaptive optics at the W.M. Keck Observatory, and (iii) precise astronomical acceleration measurements from ESA’s Gaia mission,” stated California State University astronomer Taichi Uyama and his team.

“By integrating these datasets and applying Kepler’s laws, we were able to determine the dynamic mass and orbital parameters of J1446B with unprecedented precision.”

“Radial velocity data by itself cannot differentiate between mass and orbital inclination, but the addition of direct imaging and Gaia data resolves this ambiguity.”

“The Subaru IRD-SSP program provided crucial RV data, while Keck’s cutting-edge adaptive optics allowed for the direct detection of the companion star at very close distances from the host star.”

“Previous studies have shown that astronomical acceleration from Hipparcos and Gaia can be combined with direct imaging to detect and analyze companion objects.”

“However, Hipparcos was unable to measure faint red dwarf stars like J1446.”

“Our study is the first to apply Gaia-only acceleration data to such a system, successfully constraining the orbit and dynamical mass of a brown dwarf companion.”

Near-infrared observations of J1446B indicated a brightness variation of about 30%, hinting at dynamic atmospheric phenomena such as clouds or storms.

“This finding serves as a significant benchmark for testing brown dwarf formation theories and atmospheric models,” the astronomers noted.

“Future spectroscopic studies may enable researchers to map the weather patterns on this intriguing object.”

“This achievement highlights the efficacy of combining ground-based and space-based observatories in discovering hidden worlds beyond our solar system.”

The team’s paper was published in Astronomy Magazine.

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Taichi Uyama et al. 2025. Direct Image Exploration for Companions with Subaru/IRD Strategic Program II. A brown dwarf companion star was discovered around the nearby medium-M dwarf LSPM J1446+4633. A.J. 170, 272; doi: 10.3847/1538-3881/ae08b6

Source: www.sci.news

Major Direct Action on Actor Image Use in AI Content Poses Fairness Concerns

The performing arts union Equity has issued a warning of significant direct action against tech and entertainment firms regarding the unauthorized use of its members’ likenesses, images, and voices in AI-generated content.

This alert arises as more members express concerns over copyright violations and the inappropriate use of personal data within AI materials.

General Secretary Paul W. Fleming stated that the union intends to organize mass data requests, compelling companies to reveal whether they have utilized members’ data for AI-generated content without obtaining proper consent.

Recently, the union declared its support for a Scottish actor who alleges that his likeness contributed to the creation of Tilly Norwood, an “AI actor” criticized by the film industry.

Bryony Monroe, 28, from East Renfrewshire, believes her image was used to create a digital character by the AI “talent studio” Xicoia, though Xicoia has denied her claims.

Most complaints received by Equity relate to AI-generated voice replicas.

Mr. Fleming mentioned that the union is already assisting members in making subject access requests against producers and tech firms that fail to provide satisfactory explanations about the sources of data used for AI content creation.

He noted, “Companies are beginning to engage in very aggressive discussions about compensation and usage. The industry must exercise caution, as this is far from over.”

“AI companies must recognize that we will be submitting access requests en masse. They have a legal obligation to respond. If a member reasonably suspects their data is being utilized without permission, we aim to uncover that.”

Fleming expressed hope that this strategy will pressure tech companies and producers resisting transparency to reach an agreement on performers’ rights.

“Our goal is to leverage individual rights to hinder technology companies and producers from binding collective rights,” Fleming explained.

He emphasized that with 50,000 members, a significant number of requests for access would complicate matters for companies unwilling to negotiate.

Under data protection laws, individuals have the right to request all information held about them by an organization, which typically responds within a month.

“This isn’t a perfect solution,” Fleming added. “It’s no simple task since they might source data elsewhere. Many actors are behaving recklessly and unethically.”

Ms. Monroe believes that Norwood not only mimics her image but also her mannerisms.

Monroe remarked, “I have a distinct way of moving my head while acting. I recognized that in the closing seconds of Tilly’s showreel, where she mirrored exactly that. Others observed, ‘That’s your mannerism. That’s your acting style.'”

Liam Budd, director of recorded media industries at Equity UK, confirmed that the union takes Mr. Monroe’s concerns seriously. Particle 6, the AI production company behind Xicoia, claimed it is collaborating with unions to address any concerns raised.

A spokesperson from Particle 6 stated, ‘Bryony Monroe’s likeness, image, voice, and personal data were not utilized in any way to create Tilly Norwood.’

“Tilly was developed entirely from original creative designs. We do not, and will not, use performers’ likenesses without their explicit consent and proper compensation.”

Budd refrained from commenting on Monroe’s allegations but said, “Our members increasingly report specific infringements concerning their image or voice being used without consent to produce content that resembles them.”

“This practice is particularly prevalent in audio, as creating a digital audio replica requires less effort.”

However, Budd acknowledged that Norwood presents a new challenge for the industry, as “we have yet to encounter a fully synthetic actor before.”

Equity UK has been negotiating with UK production industry body Pact (Film and TV Producers Alliance) regarding AI, copyright, and data protection for over a year.

Fleming mentioned, “Executives are not questioning where their data originates. They privately concede that employing AI ethically is nearly impossible, as they are collecting and training on data with dubious provenance.”

“Yet, we frequently discover that it is being utilized entirely outside established copyright and data protection frameworks.”

Max Rumney, deputy chief executive of Pact, highlighted that its members must adopt AI technology in production or risk falling behind companies without collective agreements that ensure fair compensation for actors, writers, and other creators.

However, he noted a lack of transparency from tech firms regarding the content and data used for training the foundational models of AI tools like image generators.

“The fundamental models were trained on our members’ films and programming without their consent,” Rumney stated.

“Our members favor genuine human creativity in their films and shows, valuing this aspect as the hallmark of British productions, making them unique and innovative.”

Source: www.theguardian.com

Astronomers Capture Direct Image of Betelgeuse’s Stellar Companion

Utilizing the speckle imager Alopeke from the Gemini North Telescope, part of the NSF’s International Gemini Observatory, astronomers captured direct images of Betelgeuse.

Betelgeuse (right) and its remarkable companions (left). Image credits: International Gemini Observatory/Noirlab/NSF/Aura/M. Zamani, Noirlab of NSF.

Betelgeuse is an 8-million-year-old red supergiant located about 724 light years away on the shoulder of the Orion constellation.

It ranks among the largest known stars, with a radius approximately 1,400 times greater than that of the Sun.

Also referred to as Alpha Orionis or Alpha Ori, Betelgeuse is one of the brightest stars in the sky, radiating more light than 100,000 suns.

The star is nearing the end of its life cycle, and when it eventually explodes, the event will shine brightly, becoming visible for weeks even during daylight.

Betelgeuse experiences a major variability period of roughly 400 days, accompanied by a longer secondary period of about six years.

In 2019 and 2020, a significant drop in Betelgeuse’s brightness occurred, known as the “big dimming” event.

This led to speculation about an imminent supernova explosion, but astronomers later found that a large cloud of dust ejected during the dimming was the true cause.

Although the “big dim” mystery has been resolved, it rekindled interest in studying the red supergiant, prompting new analyses of existing archival data.

One analysis suggested that the presence of companion stars might be responsible for Betelgeuse’s six-year brightness fluctuations.

However, searches conducted by the NASA/ESA Hubble Space Telescope and the NASA Chandra X-ray Observatory did not detect these companions.

Dr. Steve Howell and his colleagues at NASA’s Ames Research Center investigated potential companions of Betelgeuse, referred to as Alpha Ori B or The Betelbuddy, using the Speckle Imager ‘Alopeke at the Gemini North Telescope.

“Speckle Imaging is an astronomical technique that employs very short exposure times to mitigate image distortion caused by Earth’s atmosphere,” they explained.

“This method allows for high resolution, and when combined with the light-gathering power of Gemini North’s 8.1m mirror, it enables the direct detection of faint companions of Betelgeuse.”

Analyzing the light from the companion stars allowed astronomers to identify their characteristics.

The companions appear to be A or B-type main-sequence stars, approximately six magnitudes fainter than Betelgeuse, with an estimated mass of around 1.5 solar masses.

The companion is situated relatively close to Betelgeuse, at about four times the distance between the Earth and the Sun.

This discovery marks the first detection of a close stellar companion orbiting a supergiant star.

Even more remarkably, the companions are within the extensive outer atmosphere of Betelgeuse, demonstrating the exceptional resolution capabilities of “Alopeke.”

“The speckle capabilities provided by the International Gemini Observatory prove to be a vital tool for astronomers across a wide range of applications,” stated Dr. Martin, NSF Program Director at the International Gemini Observatory.

“Providing solutions to the Betelgeuse mystery, which has persisted for centuries, is an exciting achievement.”

Survey results will appear today in the Astrophysical Journal Letters.

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Steve Howell et al. 2025. Possibility of direct imaging discovery of the stellar companion to Betelgeuse. apjl in press; doi: 10.3847/2041-8213/adeaaf

Source: www.sci.news

Hubble Captures Direct View of Intermediate Spiral Galaxy

A stunning new image from the NASA/ESA Hubble Space Telescope captures the beauty of the Spiral Galaxy NGC 3596.



This Hubble image showcases NGC 3596, a mid-spiral galaxy roughly 90 million light years from Earth in the constellation Leo. The color image features observations from Hubble’s Wide Field Camera 3 (WFC3), taken in the ultraviolet, near-infrared, and optical spectra. The colors result from assigning varying hues to each monochromatic image linked with individual filters. Image credits: NASA/ESA/Hubble/D. Thilker.

NGC 3596 is situated approximately 90 million light years away in the constellation Leo.

This galaxy was first discovered by German and British astronomer William Herschel on April 8, 1784.

Also recognized as Leda 34298, UGC 6277, or Hipass J1115+14, NGC 3596 belongs to the Leo II Group, a collection of galaxies within the Virgo supercluster.

“NGC 3596 is nearly perfectly oriented face-on relative to Earth, revealing the galaxy’s beautifully wound spiral arms,” stated the Hubble astronomer.

“The bright arms are densely packed with stars, gas, and dust.”

“Star formation is particularly vigorous in the spiral arms, as indicated by the vibrant pink regions of star formation and the young blue stars tracing the arms of NGC 3596 in this image.”

“What triggers the formation of these spiral arms? Given the vast variety of spiral galaxies, it’s a complex question,” they noted.

“Some galaxies exhibit clear spiral arms, while others have more erratic feathered arms.”

“Some display prominent bars at their centers, whereas others have compact circular cores.”

“Some galaxies are surrounded by neighbors, while others stand alone.”

“Early theories about the formation of spiral arms were complicated by what they termed a convoluted problem,” the researchers explained.

“If the spiral arms are a coherent feature, they would be tightly wrapped as the galaxy rotates, eventually rendering them invisible.”

Currently, researchers think that spiral arms represent patterns of varying density rather than fixed structures.

“Material such as stars, gas, and dust flows in and out of the spiral arms as they orbit within the galaxy’s disc,” they added.

“Much like vehicles encountering traffic jams, these materials decelerate as they enter the spiral arms, become gravitationally bound, and continue their journey through the galaxy.”

Source: www.sci.news

Webb captures direct image of a temperate superjupiter orbiting Epsilon Indi A

Astronomers Webb’s MIRI (Mid-Infrared Instrument) The image was taken of Epsilon Indi Ab, a gas giant several times the mass of Jupiter, located about 12 light years from Earth.

This image of Epsilon Indi Ab was taken with a coronagraph on Webb’s MIRI instrument. Image courtesy NASA / ESA / CSA / Webb / STScI / E. Matthews, Max Planck Institute for Astronomy.

Of the 25 planets that have been directly imaged to date, all are less than 500 million years old, and all but six are less than 100 million years old.

The newly imaged planet orbits Epsilon Indi A (HD 209100, HIP 108870), a K5V type star that is roughly the age of the Sun (3.7 to 5.7 billion years).

“Previous observations of this system have been more indirect measurements of the star, which gave us advance knowledge that there is likely to be a giant planet in the system tugging at the star,” said Dr Caroline Morley, an astronomer at the University of Texas at Austin.

“That’s why our team chose this system as our first observational system at Webb.”

“This discovery is fascinating because the planet is very similar to Jupiter – it’s a little warmer and more massive, but it’s more similar to Jupiter than any other planet imaged so far,” said Dr Elizabeth Matthews, astronomer at the Max Planck Institute for Astronomy.

“The cold planet is very dark and most of its radiation is in the mid-infrared. Webb is ideal for mid-infrared imaging, but it’s very difficult to do from the ground.”

“We also needed good spatial resolution to distinguish planets from stars in the images, and the large Webb mirror helps a lot in this regard.”

Epsilon Indi Ab is one of the coolest exoplanets ever directly detected, with an estimated temperature of 2 degrees Celsius (35 degrees Fahrenheit). This makes it the coolest planet ever imaged outside the solar system, and cooler than all but one free-floating brown dwarf.

The planet is only about 100 degrees Celsius (180 degrees Fahrenheit) warmer than the gas giants in our solar system.

This provides astronomers with a rare opportunity to study the atmospheric composition of a true solar system analogue.

“Astronomers have imagined there could be planets in this system for decades, and fictional planets orbiting Epsilon Indi have been the setting for Star Trek episodes, novels and video games such as Halo,” Dr Morley said.

“It’s exciting to actually see the planet out there and start measuring its properties.”

Epsilon Indi Ab is the 12th closest exoplanet currently known to Earth and the closest planet with a mass greater than Jupiter.

Astronomers chose to study Epsilon Indi A because the system suggested the possibility of planets, using a technique called radial velocity, which measures the back and forth wobble of the host star along the line of sight.

“We expected there to be a planet in this system because the radial velocity suggested its presence, but the planet we found was different to what we expected,” Dr Matthews said.

“It’s about twice as massive, it’s a little farther from its star, and its orbit is different from what we would expect. We don’t yet know what causes this discrepancy.”

“The planet’s atmosphere also seems to differ slightly from what the models predict.”

“So far, only a few atmospheric photometry measurements have been made, making it difficult to draw any conclusions, but the planet is fainter than expected at shorter wavelengths.”

“This could mean that there is a lot of methane, carbon monoxide and carbon dioxide in the planet’s atmosphere, absorbing shorter wavelengths of light. It could also suggest a very cloudy atmosphere.”

a paper The findings were published in the journal. Nature.

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E.C. Matthews othersA temperate superjupiter photographed in mid-infrared by JWST. NaturePublished online July 24, 2024, doi: 10.1038/s41586-024-07837-8

This article has been edited based on the original NASA release.

Source: www.sci.news

CERN researchers direct attention towards theoretical magnetic monopole

American theoretical physicist Joseph Polczynski once said that the existence of magnetic monopoles is “one of the safest bets you can make about physics that has yet to be seen.” In the search for these particles that have magnetic charges and are predicted by several theories that extend the standard model, Moedal (Monopole and Exotic Detectors at the LHC) Although the collaboration has yet to prove Polczynski correct, its latest discovery represents a major advance. The new results narrow the search window for these hypothetical particles.

Generation of monopole pairs by Schwinger mechanism. Image credit: MoEDAL Collaboration / CERN.

At CERN's Large Hadron Collider (LHC), interactions between protons or heavy ions can produce pairs of magnetic monopoles.

In collisions between protons, protons can be formed from a single virtual photon (Dorrell-Yang mechanism) or from the fusion of two virtual photons (photon fusion mechanism).

Through a process called the Schwinger mechanism, pairs of magnetic monopoles can also be generated from the vacuum of huge magnetic fields produced by near-miss collisions of heavy ions.

Since starting data acquisition in 2012, MoEDAL has achieved several firsts, including conducting the first search for magnetic monopoles produced by photon fusion and Schwinger mechanisms at the LHC. Ta.

inside First part of the latest researchMoEDAL physicists explored monopoles and highly charged objects (HECOs) produced via the Dorell-Yang mechanism and the photon fusion mechanism.

This search was based on proton-proton collision data collected during Experiment 2 at the LHC using the complete MoEDAL detector for the first time.

The complete detector consists of two main systems that sense magnetic monopoles, HECO, and other highly ionizing virtual particles.

First, magnetic monopole and HECO trajectories can be permanently registered without background signals from standard model particles. The second system consists of an approximately 1-ton capture volume designed to capture magnetic monopoles.

Although the researchers did not find any magnetic monopoles or HECOs in their latest scan of the trapping volume, the masses and production rates of these particles were determined for different values ​​of particle spin, a unique form of angular momentum. limits have been set.

For magnetic monopoles, a mass limit of 1 to 10 times the Dirac charge (gD), the basic unit of magnetic charge, is set, excluding the existence of monopoles with masses as high as about 3.9 trillion electron volts (TeV). I did. .

For HECO, a mass limit was established for charges from 5e to 350e, where e is the electronic charge, and the presence of HECO with masses in the range up to 3.4 TeV was excluded.

“MoEDAL's search reach for both monopoles and HECOs allows the collaboration to explore vast swaths of the theoretical 'discovery space' for these hypothetical particles,” said a spokesperson for the MoEDAL collaboration. said Dr. James Pinfold.

in their second studyMoEDAL scientists focused on searching for monopoles produced via the Schwinger mechanism in heavy ion collision data collected during LHC Experiment 1.

In a unique effort, we scanned a decommissioned section of the CMS experimental beam pipe for trapped monopoles instead of the trapping volume of the MoEDAL detector.

Again, the team found no monopoles, but set the strongest mass constraints yet for Schwinger monopoles with charges between 2 gD and 45 gD, ruling out the existence of monopoles with masses up to 80 GeV. did.

“A crucial aspect of the Schwinger mechanism is that the production of complex monopoles is not suppressed compared to the production of elementary monopoles, as is the case with Dorell-Yang and photon fusion processes,” Pinfold said. Ta.

“Therefore, if monopoles are composite particles, this and the previous Schwinger monopole search may have been the first ever chance to observe monopoles.”

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Moedal collaboration. 2024. Searching for highly ionized particles in pp collisions in LHC Run-2 using the Full MoEDAL detector. arXiv: 2311.06509

B. Acharya other. 2024. MoEDAL explores magnetic monopoles generated by the Schwinger effect in CMS beam pipes. arXiv: 2402.15682

Source: www.sci.news

Physicists have successfully captured direct images of noble gas nanoclusters at room temperature

For the first time, physicists have directly imaged small clusters of noble gas atoms at room temperature. This result opens up exciting possibilities for fundamental research in condensed matter physics and applications in quantum information technology.

Xenon nanoclusters between two graphene layers. Sizes range from 2 to 10 atoms. Image credit: Manuel L'Engle.

“When I was researching the use of ion irradiation to modify the properties of graphene and other two-dimensional materials, I noticed something unusual. They can become trapped between the sheets,” the University of Vienna said. Dr. Jani Kotaski and his colleagues.

“This happens when noble gas ions pass through the first graphene layer fast enough to pass through, but not the second graphene layer.”

“Once trapped between the layers, the noble gases are free to move because they do not form chemical bonds.”

“But to accommodate the noble gas atoms, the graphene bends to form tiny pockets.”

“Here, two or more noble gas atoms can meet and form two-dimensional noble gas nanoclusters that are ordered and densely packed.”

The researchers' method overcomes the difficulty that noble gases do not form stable structures under experimental conditions at ambient temperatures.

“We observed these clusters using a scanning transmission electron microscope, and they are really fascinating and very fun to look at,” said Dr. Manuel L'Engle, a physicist at the University of Vienna.

“They rotate, jump, grow, and shrink as we imagine them.”

“Getting the atoms between the layers was the most difficult part of the job.”

“Achieving this gives us a simple system to study fundamental processes related to the growth and behavior of materials.”

“The next step is to study the properties of clusters containing different noble gases and how they behave at low and high temperatures,” Dr Kotasky added.

“With the use of noble gases in light sources and lasers, these new structures may enable future applications such as quantum information technology.”

a paper The findings were published in this week's magazine Natural materials.

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M. Langre other. Two-dimensional few atomic noble gas clusters within a graphene sandwich. nut.meter, published online on January 11, 2024. doi: 10.1038/s41563-023-01780-1

Source: www.sci.news

Discovery of a direct correlation between elevated insulin levels and pancreatic cancer by scientists

A new study has proven a direct link between high insulin levels and increased risk of pancreatic cancer in people with obesity and type 2 diabetes. This landmark study shows how excess insulin overstimulates pancreatic acinar cells, leading to inflammation and precancerous cells, particularly in the case of pancreatic ductal adenocarcinoma (PDAC). These findings highlight the importance of maintaining healthy insulin levels and may lead to new strategies for cancer prevention and treatment, including lifestyle interventions and targeted therapies.

For the first time, we explain in detail why people with obesity and type 2 diabetes have an increased risk of pancreatic cancer.

A recent study conducted by scientists at the University of British Columbia’s Faculty of Medicine revealed a direct relationship between high blood pressure and high blood pressure. insulin This level is frequently observed in patients with obesity, type 2 diabetes, and pancreatic cancer.

This study cell metabolismprovides the first detailed explanation of why people with obesity and type 2 diabetes are at increased risk of pancreatic cancer. This study shows that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This excessive stimulation causes inflammation and transforms these cells into precancerous cells.

“In addition to rapid increases in both obesity and type 2 diabetes, we are also seeing an alarming increase in the incidence of pancreatic cancer,” said co-senior author and professor in the Department of Cellular Physiology Sciences and co-senior author of the study. said Dr. James Johnson, interim director of the agency. UBC’s Institute of Life Sciences. “These findings help us understand how this is happening and highlight the importance of keeping insulin levels within a healthy range. can be achieved through medication.”

Dr. James Johnson is a professor in the Department of Cellular and Physiological Sciences and interim director of the UBC Life Sciences Institute. credit:
UBC Faculty of Medicine

The study focused on pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer and a highly aggressive disease with a five-year survival rate of less than 10 percent. The incidence of pancreatic cancer is on the rise. By 2030, PDAC is expected to become the second leading cause of cancer-related deaths.

Role of insulin in pancreatic cancer

Although obesity and type 2 diabetes were previously established as risk factors for pancreatic cancer, the exact mechanisms by which this occurs remained unclear. This new study sheds light on the role of insulin and its receptor in this process.

… (content continues) …

Reference: “Hyperinsulinemia causes pancreatic cancer through acinar insulin receptors by increasing digestive enzyme production and inflammation” (Anni MY Zhang, Yi Han Xia, Jeffrey SH Lin, Ken H Chu, Wei Chuan K. Wang, Titine JJ Ruiter, Jenny) CC Yang, Nan Chen, Justin Choa, Shilpa Patil, Haoning Howard Sen, Elizabeth J. Rideout, Vincent R. Richard, David・F. Shafer, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson, Janelle L. Kopp, October 31, 2023. cell metabolism.
DOI: 10.1016/j.cmet.2023.10.003

This study was funded by the Canadian Institutes of Health Research and the Lustgarten Foundation.

Source: scitechdaily.com