Prior to 2020, few had ever heard of the antiparasitic drug ivermectin. However, interest surged during the Covid-19 pandemic as unfounded claims emerged about its potential to prevent or treat viral infections. Notably, popular podcast host Joe Rogan stated he used it in 2021 while recovering from Covid. That same year, Robert F. Kennedy Jr., a prominent public health figure in the U.S., petitioned the FDA regarding its use in treating Covid-19.

Despite numerous studies disproving ivermectin’s efficacy against Covid-19, the buzz around it persists. While criticized as a quack remedy during the pandemic, ivermectin is still a legitimate medicinal drug, with researchers believing it contains potential yet to be fully explored.

What is ivermectin?

Ivermectin is an antiparasitic agent that was developed in 1975 by the pharmaceutical company Merck. It effectively eliminates a wide array of parasites and is FDA-approved for the treatment of two conditions caused by human parasites: onchocerciasis (river blindness) and intestinal strongyloidiasis. Additionally, in some regions, it is used to treat lymphatic filariasis and cutaneous larva migrans.

These parasitic infections are uncommon in high-income nations but pose significant threats to millions in low-income countries globally. As a result, over 300 million individuals take ivermectin annually, making it one of the most impactful global health interventions to date. Its discoverer was awarded the Nobel Prize in 2015.

The FDA has also approved various topical formulations of ivermectin for conditions such as head lice and rosacea. Furthermore, the drug is widely utilized in veterinary medicine to prevent and treat parasitic infections, including heartworms and roundworms. The FDA cautions against the consumption of veterinary formulations by humans, as they differ from those specified for human use.

Can ivermectin treat or prevent COVID-19?

Ivermectin was initially thought to be a promising treatment for Covid-19. Early studies suggested it might aid recovery and prevent viral replication; however, larger studies have indicated otherwise.

For instance, a 2022 study involving over 3,500 Covid-19 patients showed no difference in hospitalization rates between those treated with ivermectin and those given a placebo. Similarly, a 2023 study, involving more than 1,400 adults, found no significant benefit of ivermectin in accelerating recovery compared to placebo.

Can ivermectin treat cancer?

Ivermectin is not approved for cancer treatment and has not undergone thorough clinical trials. However, preliminary studies have indicated that it may have potential as an adjunct cancer therapy.

A decade ago, Peter P. Lee at a lab in Los Angeles discovered that ivermectin could induce cancer cell death through a process known as immunogenic cell death, thus prompting immune cells to recognize and attack cancer cells. Lee and his team searched the National Cancer Institute database to assess the effects of all FDA-approved drugs on various cancer cells, finding that ivermectin notably enhanced signs of immunogenic cell death in several cancer types.

“At that moment, I’d never heard of ivermectin,” Lee remarked. “I had to investigate, and upon learning it was a parasitic drug, I found it rather astonishing.”

In 2021, Lee and associates tested ivermectin in a mouse model of metastatic triple-negative breast cancer, a notably aggressive and challenging condition to treat. They found that 40% of mice treated with a combination of ivermectin and immunotherapy survived beyond 80 days, contrasted with none of the mice given immunotherapy alone surviving past 50 days. Mice solely administered ivermectin did not fare better than untreated counterparts.

“Ivermectin itself isn’t inherently a cancer treatment,” Lee clarified. “But it seems beneficial when used alongside immune-based therapies.”

A clinical trial is currently evaluating the use of ivermectin in conjunction with cancer immunotherapy for metastatic triple-negative breast cancer, with anticipated results expected next year. Other studies also suggest that pancreatic cancer therapies are more effective when combined with ivermectin, and Lee is exploring similar effects on colon cancer cells.

While these findings are encouraging, they do not confirm ivermectin as an effective cancer treatment for humans. “Many therapies that show promise in animal studies do not translate to humans,” Lee pointed out.

What are the side effects of ivermectin?

Ivermectin is generally regarded as safe, but can be toxic when taken in high doses. Possible side effects may include nausea, vomiting, diarrhea, low blood pressure, and dizziness. In severe cases, ivermectin usage might lead to seizures, coma, or even death, especially if combined with other medications like blood thinners.

“Individuals should not take [ivermectin] on their own or without the guidance of a knowledgeable medical professional. I genuinely hope to utilize ivermectin in ways that provide benefits to numerous patients, but its use is more complex than simply self-administering a medication,” he advised.