Illustration of Mimivirus: A Giant Virus Infecting Amoebae
Credit: Science Photo Library / Alamy
Viruses exploit host cell machinery to produce proteins, with certain large viruses encoding essential components within their genomes to instruct host cells to generate viral proteins. This phenomenon emphasizes how giant viruses challenge the distinction between living and nonliving entities.
Since the discovery of the mimivirus in Bradford, England in 2003, which infects amoebas, biologists have increasingly focused on these giant viruses. Some exhibit sizes larger than typical bacteria, complex shapes, and possess numerous genes.
Among these genes are those that code for components involved in translation—the biological process that turns genetic information into proteins. In cellular biology, translation occurs through ribosomes, initiated by molecular assemblies known as initiation complexes.
To investigate whether giant viruses possess a similar system, Max Fells and his team from Harvard Medical School explored the dynamics within infected amoebas and the manipulations by mimivirus post-infection.
The researchers isolated ribosomes from infected cells and identified the viral proteins linked to them. “This was our initial clue that these might be the elements we were seeking,” said Fells.
Subsequently, they knocked out the gene responsible for the viral complex by substituting it with a modified DNA sequence, resulting in a virus that could not synthesize the corresponding protein. This intervention decreased virus production by up to 100,000-fold and severely inhibited the formation of new infectious particles.
These findings collectively indicate that during an infection, viral complexes potentially redirect the protein synthesis machinery of the host to significantly boost the production of viral structural proteins, even under extreme conditions like nutrient scarcity and oxidative stress, which typically hinder protein synthesis in host cells.
This discovery introduces a profound evolutionary inquiry: how did these viruses acquire such capabilities? Some researchers propose that giant viruses may descend from ancient cellular life forms, while others suggest they evolved from typical viruses through gene acquisition from their hosts.
“Giant viruses have acquired a diverse array of cellular machinery from their eukaryotic hosts over evolutionary time,” stated Frank Aylward from Virginia Tech, who was not part of the study. Genetic exchange can occur during viral infection, allowing natural selection to favor advantageous genes over extended evolutionary periods.
Many of the largest viruses dominate the internal environment of single-celled organisms, which presents more variability than the relatively stable environments of multicellular hosts. Consequently, this flexible control over protein synthesis may confer a significant evolutionary advantage, Aylward noted.
This research also raises critical questions. The mimivirus genome comprises approximately 1,000 proteins, the majority of which remain functionally enigmatic. It remains unclear how these viruses intricately control protein production throughout a single infection cycle.
“Viruses have traditionally been regarded as passive participants in the evolution of living systems,” stated Hiroyuki Ogata from Kyoto University, Japan. “This study demonstrates that giant viruses can reconfigure molecular systems that are fundamental across the spectrum of life.”
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Credit: Dr. Gavin Leroy/Professor Richard Massey/COSMOS-Webb Collaboration
In a groundbreaking study, scientists leveraged subtle distortions in the shapes of over 250,000 galaxies to construct the most detailed dark matter map to date, paving the way for insights into some of the universe’s greatest enigmas.
Dark matter, elusive by nature, does not emit any detectable light. Its existence can only be inferred through its gravitational interactions with normal matter. Researchers, including Jacqueline McCreary from Northeastern University, utilized the James Webb Space Telescope (JWST) to map a region of the sky larger than the full moon.
“This high-resolution image depicts the scaffold of a small segment of the universe,” noted McCreary. The new map boasts double the resolution of previous ones created by the Hubble Space Telescope, encompassing structures much farther away.
The researchers studied approximately 250,000 galaxies, noting that their shapes, while interesting, serve primarily as a backdrop for understanding gravitational distortions. As Liliya Williams from the University of Minnesota explained, “These galaxies merely act as the universe’s wallpaper.” The critical component is the way dark matter’s gravitational pull warps the light from these distant galaxies—a phenomenon known as gravitational lensing. The more distorted the shape of these galaxies is from a perfect circle, the greater the amount of dark matter situated between us and them.
By analyzing these optical distortions, the team was able to derive a map illustrating massive galaxy clusters and the cosmic web filaments linking them. Many of these newly identified structures deviate from prior observations of luminous matter, suggesting they are predominantly composed of dark matter. “Gravitational lensing is one of the few and most effective techniques for detecting these structures across vast regions,” Williams stated.
This research is significant, considering that dark matter constitutes about 85% of the universe’s total matter, crucial for the formation and evolution of galaxies and clusters. Understanding its distribution could shed light on its behavior and composition, according to Williams.
“This achievement is not just observational but also paves the way for various analyses, including constraints on cosmological parameters, the relationship between galaxies and their dark matter halos, and their growth and evolution over time,” McCreary highlighted. These parameters include the strength of dark energy, the enigmatic force driving the universe’s accelerating expansion.
While initial findings from the JWST map align with the Lambda CDM model of the universe, McCreary emphasizes that a thorough analysis of the data is still required to unearth new insights. “At first glance, it appears consistent with Lambda CDM, but I remain cautious. A final assessment will depend on complete results.”
For over 165 years, the enigmatic prototaxite has stood as one of the earliest giants to rise from Earth’s barren landscapes, defying simple classification. These towering, columnar organisms dominated the terrestrial environment over 400 million years ago, reaching impressive heights of 8 meters (26 ft), long before the advent of trees. A recent study conducted by paleontologists from the University of Edinburgh and the National Museums of Scotland posits that this mysterious entity was not merely a giant fungus, as often presumed, but rather belonged to an entirely extinct lineage of complex life.
Prototaxites dominated terrestrial ecosystems 410 million years ago as the largest living organisms. Image credit: Matt Humpage.
The prototaxite marks the first giant life form on Earth’s surface, emerging during the late Silurian to late Devonian periods, approximately 420 to 370 million years ago.
Recognized for their pillar-like fossils that can reach up to 8 meters, they played a crucial role in early terrestrial ecosystems well before the emergence of trees.
These organisms were widely distributed across ancient terrestrial environments and were likely consumed by arthropods, marking a pivotal stage in land colonization and holding significant ecological importance.
Despite over 165 years of inquiry, the biological identity of prototaxite remains a topic of heated debate among paleontologists, who contest whether it is a fungus or belonged to a distinct, entirely extinct lineage of complex eukaryotes.
In a groundbreaking study, Dr. Corentin Rollon and colleagues examined Prototaxites Taichi, found preserved in remarkable three-dimensional detail within the 407-million-year-old Rhynie Chert in Aberdeenshire, Scotland.
“The Rhynie Chert is a remarkable treasure trove,” noted Dr. Rollon, the lead author of the study published in this week’s edition of Scientific Progress.
“This site represents one of the oldest fossilized terrestrial ecosystems, and its well-preserved biodiversity enables innovative approaches like machine learning applied to fossil molecular data.”
“Numerous other specimens from the Rhynie Chert are preserved in museum collections, contributing vital context to our findings.”
The research team investigated new specimens of Prototaxites Taichi, identifying the largest known example of this species at the site, facilitating detailed anatomical and molecular comparisons with fossil fungi found in the same deposits.
Microscopic imaging revealed a complex internal structure that diverges significantly from any known fungi.
The fossil comprises three distinct types of tubes, including large, thick-walled tubes featuring annular stripes and dense spherical regions known as medullary points.
These intriguing features form a complex 3D network of interconnected tubes, suggesting a branching pattern unheard of in fungal biology.
Researchers employed infrared spectroscopy and machine learning techniques to classify molecular fingerprints from prototaxite alongside those of fossil fungi, arthropods, plants, and bacteria found in Rhynie Chert.
Fossilized fungi from this location maintain characteristic chemical signatures linked to chitin-rich cell walls, which were intriguingly absent in ancient prototaxite.
The team also searched for perylene, a biomarker associated with pigment compounds produced by specific fungi, previously detected in other Rhynie Chert fossils. However, no such compounds were found in the prototaxite sample.
Collectively, the structural, chemical, and biomarker findings imply that prototaxite does not align with any known fungal group, including the earliest forms of modern fungi.
“This research marks a significant advancement in a 165-year-long discussion,” stated Dr. Sandy Hetherington, the senior author of the paper.
“These organisms represent life forms distinct from those we currently recognize, displaying different anatomical and chemical characteristics from fungi and plants, thereby belonging to a unique, now-extinct lineage of complex life.”
“Our study combines chemical analysis and anatomical insights into prototaxite, revealing that it cannot be classified within any known fungal group,” explained co-author Laura Cooper.
“As earlier researchers have discounted classifications to other large and complex life forms, we conclude that prototaxite belonged to an entirely distinct lineage of extinct complex life.”
“Thus, prototaxite symbolizes independent evolutionary experiments in constructing large and complex organisms, known to us only through exceptionally preserved fossils.”
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Corentin C. Rollon et al. 2026. Prototaxites fossils are structurally and chemically distinct from both extinct and extant fungi. Scientific Progress 12(4); doi: 10.1126/sciadv.aec6277
In the 1920s, renowned physicist Albert Einstein believed he had identified a fundamental flaw within quantum physics. This led to extensive investigations revealing a pivotal aspect of quantum theory, one of its most perplexing features.
This intriguing property, known as Bell nonlocality, describes how quantum objects exhibit cooperative behavior over vast distances, challenging our intuitions. I’ve accepted this understanding for over 21 years—a remarkable insight for the 21st century.
To illustrate this phenomenon, consider two hypothetical experimenters, Alice and Bob, each possessing a pair of “entangled” particles. Entanglement enables particles to correlate, even when separated by distances that prevent any signal from transmitting between them. Yet, these correlations become apparent only through the interaction of each experimenter with their respective particles. Do these particles “know” about their correlation beforehand, or is some mysterious connection at play?
Einstein, alongside Nathan Rosen and Boris Podolsky, sought to refute this eerie connection. They proposed that certain “local hidden variables” could explain how particles understand their correlated state, making quantum physics more relatable to everyday experiences, where interactions happen at close range.
In the 1960s, physicist John Stewart Bell devised a method to empirically test these concepts. After numerous attempts, groundbreaking experiments in 2015 provided rigorous verification of Bell’s theories, earning three physicists the 2022 Nobel Prize. “This was the final nail in the coffin for these ideas,” says Marek Zhukowski from the University of Gdańsk. Researchers concluded that hidden variables could not maintain the locality of quantum physics. Jacob Valandez at Harvard University adds, “We cannot escape from non-locality.”
Embracing delocality offers substantial advantages, as noted by Ronald Hanson from Delft University of Technology, who led one of the groundbreaking experiments. For him, the focus was never on the oddities of quantum mechanics; rather, he viewed the results as a demonstration of “quantum supremacy” beyond conventional computational capabilities. This intuition proved accurate. The technology developed for the Bell Test has become a foundation for highly secure quantum cryptography.
Currently, Hanson is pioneering quantum communication networks, utilizing entangled particles to forge a near-unhackable internet of the future. Similarly, quantum computing researchers exploit entangled particles to optimize calculations. Although the implications of entanglement remain partially understood, the practical application of entangling quantum objects has transformed into a valuable technological asset, marking a significant evolution for a leading figure in discussions about the quantum nature of reality.
Using high-resolution images, NIRCam, a near-infrared camera aboard the NASA/ESA/CSA James Webb Space Telescope, has led astronomers to discover COSMOS-74706, one of the earliest known barred spiral galaxies. This discovery is pivotal in shaping our understanding of cosmic evolution.
COSMOS-74706: Unsharp mask overlaid on F200W, F277W, and F356W filter configurations. The white lines represent logarithmic spirals along the galaxy’s arm structure while the lines indicate the north-south bar structure. Image credit: Daniel Ivanov.
The barred spiral galaxy COSMOS-74706 existed approximately 11.5 billion years ago.
“This galaxy developed its bar just two billion years after the universe’s inception,” stated Daniel Ivanov, a graduate student at the University of Pittsburgh.
“Stellar bars are linear features found at the centers of galaxies, confirming their namesakes.”
COSMOS-74706’s bar comprises a dense collection of stars and gas, appearing as a bright line bisecting the galaxy when viewed perpendicularly to its plane.
Stellar bars significantly influence a galaxy’s evolution, funneling gas from the outskirts into the center, which feeds the supermassive black hole and can inhibit star formation within the galactic disk.
While previous reports identified barred spiral galaxies, their analyses were inconclusive due to the less reliable optical redshift methods compared to the spectroscopy used for COSMOS-74706 verification.
In some instances, a galaxy’s light was distorted by a massive object, leading to a phenomenon known as gravitational lensing.
“Essentially, COSMOS-74706 is the most redshifted spectroscopically confirmed lensless barred spiral galaxy,” Ivanov noted.
“We were not surprised to find barred spiral galaxies so early in the universe’s timeline.”
“In fact, some simulations suggest the bar formed at redshift 5, or roughly 12.5 billion years ago.”
“However, I believe we shouldn’t expect to find many of these galaxies just yet.”
This discovery helps refine the timeline for bar formation, making it a significant finding.
Artist’s Impression of BepiColombo Spacecraft Near Mercury
Source: ESA/ATG Media Lab
In 2026, the highly anticipated BepiColombo spacecraft is set to orbit Mercury, promising to unlock the planet’s long-standing mysteries.
BepiColombo is a collaborative mission involving the European Space Agency (ESA) and the Japan Aerospace Exploration Agency (JAXA). This intricate mission includes the Mercury Planetary Orbiter (MPO) and the Mercury Magnetospheric Orbiter (Mio), tethered to the Mercury Transport Module (MTM).
Since its launch in 2018, the MTM has made six flybys of Mercury, skillfully utilizing the planet’s gravity to facilitate its descent into orbit, a method pioneered by Giuseppe “Bepi” Colombo.
This mission has already gathered crucial scientific insights, including data about the solar wind and high-resolution imagery of Mercury’s surface. However, the MPO’s advanced instruments, including X-ray spectrometers, remain inactive due to obstructions by the MTM.
In September 2026, the MPO and Mio will detach from the MTM, embarking on their final descent into orbit, completing this phase by November when their focus will shift to detailed studies of Mercury.
According to Charlie Feldman, a researcher at the University of Leicester who contributed to the MPO’s instruments, “We’re hopeful that our equipment will function as intended. With the extensive time invested in building it, the excitement comes with a degree of anxiety.”
Alongside capturing intricate details of Mercury’s magnetosphere, the MPO will extensively map and analyze the planet’s surface using its spectrometer and other tools. “This represents the first X-ray imagery of an extraterrestrial surface,” Feldman noted.
Such observations may unravel enigmas surrounding the significant X-ray emissions detected from Mercury’s night side in prior missions. Additionally, the spacecraft will assess X-rays emitted from the sun-facing side, unearthing new insights into Mercury’s geological composition and evolution. “Deciphering how planets formed gives us a broader understanding of solar system dynamics,” Feldman stated.
Exploring Space and Astronomy in Japan: The Land of the Rising Sun
Experience Japan’s unique blend of astronomy and culture, featuring cutting-edge research institutes and breathtaking starry skies. Explore prestigious locations like JAXA Tsukuba Space Center, the Nobeyama Radio Observatory, and the Tanegashima Space Center, while marveling at the celestial beauty above the Japanese Alps and Yakushima.
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Domestic cats trace their lineage back to North African wildcats
Maria Boyko/Alamy
Research indicates that domestic cats originated in North Africa, subsequently dispersing to Europe and East Asia over the last 2000 years, a timeline earlier estimates had not suggested.
The domestic cat (Felis catus) has its roots in the African wildcat (Felis lybica lybica) and is now present on every continent apart from Antarctica.
Prior studies proposed that domestic cats might have first appeared in the Levant, potentially arriving in Europe around 9600 BC.
Claudio Ottoni, a professor at Tor Vergata University in Rome, along with his team, examined 225 ancient cat remains from around 100 archaeological sites across Europe and present-day Turkey. This research yielded 70 ancient genomes that spanned over 10,000 years, dating from the 9th millennium BC to the 19th century AD. They also investigated museum specimens and 17 modern ocelot genomes from Italy, Bulgaria, Morocco, and Tunisia.
The oldest genetically identified cat from this research was sourced from Sardinia and dated to the second century AD, categorized as an African wildcat or domestic cat. All early European specimens were genetically determined to be European wildcats (Felis silvestris).
This research implies that the spread of domestic cats occurred significantly later than previously believed.
Ottoni emphasized that Mediterranean civilizations during the first millennium BC played a crucial role in the relocation of African wildcats, involving at least two genetically distinct populations. One group likely consisted of wildcats introduced to Sardinia from northwest Africa, establishing the current wildcat population on the island, while the other formed the genetic basis of modern domestic cats.
“Initially, during the domestication phase, cats likely adapted well to human surroundings,” he explains. “Their ecological flexibility enabled them to thrive. They have coexisted with humans in various urban and suburban areas and even traveled with them over great distances, showcasing their evolutionary success.”
Leopard cats (Prionailurus bengalensis) cohabited with humans in ancient China
Tuchart Duando/Getty Images
In a related study, Luo Shujing and her team from Peking University investigated 22 sets of feline remains from China, dating back over 5,000 years, while analyzing genomes from 130 modern and ancient Eurasian cat specimens. They identified a different wildcat species, the leopard cat (Prionailurus bengalensis), which is native to East Asia.
“These cats were likely drawn to human settlements due to the abundance of rodents, but they were never genuinely domesticated,” states Luo.
The findings show that true domestic cats made their way to China significantly later, around 1,300 years ago during the Tang Dynasty. Genomic data connects these cats to those originating from the Middle East and Central Asia, suggesting they arrived in China via the Silk Road through traders.
Despite a relationship that lasted over 3,500 years, leopard cats were ultimately never domesticated and reverted to their natural habitats, according to Luo.
“We often get inquiries from the public about whether it’s feasible to keep these adorable ocelots as pets, particularly if raised from youth,” she remarks. “My straightforward response is: Forget it. Our ancestors tried for over 3,000 years and didn’t succeed.”
Cairo and Alexandria, the forerunners of ancient science: Egypt
Set off on an extraordinary journey through Cairo and Alexandria, two of Egypt’s hallmark cities, where the allure of ancient history intertwines with modern vibrancy.
TThere’s an enduring saying that history is penned by the victors, and this is just as true for video games as it is for any other arena. It’s easy to think of the Nintendo Entertainment System (NES) as the sole gaming console of the mid-to-late 1980s. For those who grew up in Nintendo’s key markets of Japan and North America, this bulky device was essentially the only option available, especially with its iron grip on third-party developers that crafted a monopoly on prominent titles. However, in Europe, where home computers thrived, the NES struggled against superior competitors.
The Sega Master System first made its debut in Japan in the fall of 1985, originally branded as the Sega Mark III. Powered by the renowned Z80 CPU (which was also utilized in home computers like the Spectrum, Amstrad, and TRS-80) and a robust Sega-designed video display processor, it comes equipped with 8kb of RAM, boasts a 64-color palette, and can render 32 sprites on-screen simultaneously, making the NES (which uses the antiquated 6502 processor) look like an antiquity.
Initially marketed in Japan as an extension of Sega’s SG-1000 series, this device resembled a budget-friendly home computer rather than a pure gaming console, complete with optional keyboard and printer. Nonetheless, as the NES surged in popularity across Japan and the United States, Sega reassessed its strategy, stripping away some computer functions before reintroducing the Mark III as the Master System in 1986. This sleek, angular console stood in stark contrast to the beige Betamax aesthetic of the NES.
Sega Master System titles were available in two formats: cartridges and Sega cards for shorter, more affordable games. Photo: booksR/Alamy
Included with the Master System was a light gun, and Sega also introduced 3D glasses compatible with specific games. “We refer to it as a 3D version of Outrun,” says programmer Chris White, who later developed the Master System emulator for Sega’s PlaySega website. “It definitely gave me a headache, and the flashing lenses caused mild disorientation, but it was a reflection of Sega’s willingness to experiment boldly.”
Initially, Sega managed the distribution of the Master System in the U.S., but they sought local partners to navigate the more fragmented European market. In the UK and France, later expanding to Spain, Virgin Mastertronic took on that role. “Sega’s partners had a stronger marketing position in Europe,” noted Nick Alexander, Virgin Mastertronic’s managing director during that time. “They also established better retail and distribution relationships compared to Nintendo. There was a running joke in Computer Trade Weekly, a video game trade magazine, stating that Nintendo viewed Europe as a land of dragons. They were out of touch and concerned, which is why they focused primarily on the U.S.”
Alexander, who led Virgin Games since 1983, embraced the company’s innovative, youth-oriented marketing approach. “We envisioned video games as equivalent to a band on tour,” he shared. “Thus, we procured a double-decker bus and traveled across the country, visiting school playgrounds and shopping centers. This garnered significant press attention. While Nintendo targeted family entertainment, we understood that in Europe, it resonated primarily with Germany. We aimed at teenagers, knowing that if we won them over, their younger siblings would also be drawn to the Master System. That was our formula for overshadowing Nintendo in Europe.”
While Nintendo had Mario, Sega possessed a significant asset: arcade heritage. The company ported many of its popular arcade hits to the console, including Space Harrier, Outrun, Golden Ax, and Afterburner, marketing it in the West as a home arcade experience. Even though these weren’t perfect conversions of the original games, they were notably faster and more vibrant than those previously available on home computers. For teenage arcade enthusiasts at the time, this felt revolutionary.
“Game center in my living room”… Shinobu of Sega Master System. Photo: ArcadeImages/Alamy
“Thanks to the impressive hardware of the Master System, games visually surpassed other Z80-based systems,” White asserts. “It gives developers the ability to create scrollable tilemaps and dynamically position sprites, which makes programming straightforward and alleviates a lot of processing demands from the CPU. This design shared numerous similarities with Sega’s arcade technology; in fact, it was originally derived from the graphics chip used in Sega’s arcade machines, the TMS9918. ”
For European developers, mastering the hardware was a dream. “We had been developing for the Spectrum and Amstrad, and our titles were being ported to the C64,” recalls Andrew Oliver, who, along with his brother Philip, created Dizzy games for Codemasters. “I vividly remember attending the CES show in Las Vegas, where Sega had an extensive booth that stood alongside Nintendo, promoting their message of ‘speed.’ Back then, computers were all about vibrant visuals and rapid execution. Ultimately, Codemasters signed a licensing agreement and obtained a development kit for the console. It operates on a Z80, similar to the Spectrum, yet the graphics chip is reminiscent of the C64, resulting in fast performance with impressive parallax scrolling and sprites. The programming process was quite straightforward.”
Additionally, British developers believed that Sega offered a more useful platform than Nintendo. Mike Simpson, a programmer at the British publisher Personal Software Services, later acquired by MirrorSoft, shared, “We established a small in-house studio in Coventry, employing around 20 people to port various titles.” He continued, “Someone approached us about porting Xenon 2, a top-tier 16-bit Amiga game, to the Master System. It seemed like an impossible task, but we had to give it a shot. I was even invited to Japan for training in programming. I spent a week at Sega in Tokyo, getting insights from Mark Cerny,” [the later lead architect of PlayStation 4 and 5]. “I recall rows of tightly packed desks and conference room chairs being used as makeshift beds.”
A classic console… Sonic the Hedgehog. Photo: Sega
Even with the arrival of the Mega Drive, the Master System maintained its popularity in Europe (and later in Brazil) and continued to be supported with simplified versions of Mega Drive hits like Sonic the Hedgehog. Sonic Chaos, a beloved offshoot developed for both the Master System and Sega’s handheld devices (which shared the same hardware), stands out as a highlight of the series. Subsequently, Sega released a revamped Master System 2 at a budget-friendly price of £50, bundled with Sonic.
However, the Master System offered more than just ports and arcade classics. It has a rich legacy with iconic platformers like Wonder Boy III: The Dragon’s Trap, Psycho Fox, Fantasy Zone, Alex Kidd’s Miracle World, the groundbreaking role-playing adventure Phantasy Star, and the excellent Zelda-like Golbelius: Valley of Fate. These titles, as well as many often overlooked from the NES era, remain true gems. Unlike many classic Nintendo games, Master System titles are now more accessible to modern collectors.
Indeed, while the NES dominated in America to the point where “Nintendo” became synonymous with gaming, the Master System emerged victorious in Europe, Brazil, and elsewhere. Historical accounts may be harsh, but for those of us who lived through it, who read European gaming magazines or flipped through Sega catalogs in the annual Argos and Grattan Christmas sales, the Master System was more than a console; it was an arcade experience that foretold the future of gaming. A promise that the Mega Drive would continue to uphold.
Francis Crick (right) and James Watson modeling DNA in 1953
A. Barrington Brown, Gonville, Caius College/Scientific Photography Library
Click: The Moving Mind – From DNA to the Brain Matthew Cobb profile book, England. Basic Books
Francis Crick missed a crucial seminar in 1951, likely because he was occupied with his partner. James Watson attended but failed to take proper notes, leading to inaccuracies in their initial DNA model.
This anecdote is just one of many compelling elements in Click: The Moving Mind – From DNA to the Brain, a biography by zoologist and author Matthew Cobb. If you’re curious about the discovery of DNA’s structure and subsequent developments, this is the must-read book.
Crick, raised as a shopkeeper’s son, struggled academically at first and didn’t gain admission to Oxbridge. He eventually earned a second-class degree and a rather dull PhD on the viscosity of water. After serving in WWII, he entered civil service, but his marriage faltered and his son lived with relatives. However, his readings nurtured a passion for the molecular foundations of life and consciousness. He re-entered research, working in an independent lab in Cambridge.
In 1949, he began exploring biomolecule structures through X-ray diffraction. His notes detail various mishaps: spills, misplaced films, and sample errors. Crick once flooded his boss’s hallway twice and incessantly conversed with Watson, irritating their co-workers. The two were ultimately separated to different rooms.
By 1952, Crick had a new family but faced bankruptcy and potential job loss under his boss, Lawrence Bragg. Competing biochemist Linus Pauling falsely claimed to have deduced DNA’s structure—this drove Bragg to allow Crick and Watson to pursue the DNA research unhindered. By March 1953, they had successfully unraveled it.
“
Part of Crick’s success lay in his willingness to fail, proposing multiple ideas that eventually proved incorrect. “
While chemist Rosalind Franklin’s data was indeed significant, Cobb asserts that Crick and Watson did not misappropriate it. He also highlights that Franklin, Watson, and Wilkins collaborated more than previously recognized.
It’s often overlooked that Crick and Watson acknowledged Franklin and Wilkins in their renowned publication, Nature. A paper by Franklin and Wilkins coincided with their work, and she developed a friendship with Crick and his second wife, Odile, often staying with them during her recovery from cancer surgery, which ultimately claimed her life. This untimely death is why she wasn’t a recipient of the 1962 Nobel Prize.
Crick later played an instrumental role in decoding how DNA encodes proteins, contributing many vital insights to the process. While the biography remains engaging at this point, it loses some momentum as it shifts focus to Crick’s life, rather than Cobb’s narrative. Following the genetic code’s unveiling in the 1960s, Crick published several poorly received papers and likely faced depression in 1971.
In 1977, he relocated to California and shifted his focus to consciousness research. Cobb posits that his contributions in this field were as groundbreaking as his molecular biology achievements, including efforts to define the brain’s connectome.
This biography paints Crick as a multifaceted individual. He was anti-religious and anti-monarchy, celebrated his remarriage openly, championed cannabis legalization, experimented with acid, and occasionally hosted wild gatherings where adult films were shown. There are also allegations of unwanted advances towards several women.
Moreover, Crick corresponded with individuals expressing racist views regarding IQ and genetics but ultimately recognized that the matters were more nuanced than he once believed. Since the 1970s, he notably refrained from discussing this topic, especially in stark contrast to Watson, who passed away last week at 97.
It’s evident that Crick’s triumph stemmed not only from his brilliance but also from his readiness to fail and his willingness to propose and publish many ideas that did not pan out. For instance, one Saturday, after reviewing a paper outlining X-ray results for proteins, he, with a colleague’s assistance, was able to determine its structure by noon.
As I read, I reflected that perhaps Crick’s qualifications might not align with the current scientific standards. Today’s researchers might be astonished to learn that he had no formal education and only submitted one grant proposal. The legacy of geniuses like Crick may be struggling to thrive in a system that hasn’t nurtured their kind.
Beans from civet cat droppings possess distinct chemical properties that help explain their gourmet status.
The palm civet (Paradoxulus hermaphroditus), resembling a mongoose, is indigenous to South and Southeast Asia. Civet coffee, or kopi luwak, stands out as one of the most extraordinary luxury drinks, fetching over $1,000 per kilogram of beans that have undergone digestion by a civet.
Kopi luwak is primarily produced in Indonesia, the Philippines, and Vietnam, with minor production in other nations like India and Timor-Leste. However, animal rights organizations are advocating for consumers to avoid this industry. They allege that many civets are kept in deplorable cage conditions.
To investigate how coffee beans transform during a civet’s digestive process, Parati Aresh Shinu and their research team from the Central University of Kerala in India gathered coffee samples from five farms near Kodagu in the Western Ghats of India.
These farms are home to civets that roam freely, and workers regularly collect beans from their droppings to blend with the harvest of tree-grown coffee beans. “At our site, civets and planters interacted harmoniously,” Sinu mentions. “We aim to educate farmers regarding the chemical composition.”
The researchers retrieved around 70 pieces of civet dung containing coffee beans and subsequently hand-harvested the coffee from the Robusta trees on the plantation, performing tests to analyze crucial chemical elements like fat and caffeine.
The fat content of civet beans was notably higher than that of beans directly from trees, while levels of caffeine, protein, and acid were marginally lower. This decrease in acidity is likely a result of fermentation during digestion.
Significant differences were also found in the volatile organic compounds present in civet coffee versus regular coffee beans. Some of these compounds can be found in conventional coffee, while civet beans either lack them altogether or possess only trace amounts.
The research team proposes that the elevated fat content in civet coffee may enhance its distinctive aroma and flavor, while reduced protein levels could lessen bitterness.
Sinu criticized the practice of confining civet cats for kopi luwak production, expressing hope that further studies could lead to the development of an artificial fermentation process mirroring the coffee’s natural chemical composition.
“We believe that the gut microbiome might play a role in the fermentation process,” Sinu explains. “Understanding the enzymes involved in digestion and fermentation could enable us to produce civet coffee artificially.”
In the upcoming year, Formula 1 (F1) is set to undertake one of its most ambitious transformations yet, shifting from fossil fuels to a fully sustainable fuel mixture. This initiative is part of a broader strategy to adhere to new environmental regulations and demonstrate that the sport can, as F1 puts it, “continue without the need for new car production”.
Nonetheless, skepticism remains. As F1 contributes over 1% of the total carbon footprint in sports, experts argue that there are far more significant environmental issues that F1 must address. What are these challenges and how can we overcome them?
Switch Gears
In 2020, F1’s governing body, the Fédération Internationale de l’Automobile (FIA), established a timeline for race car engines to transition to 100% sustainable fuel by 2026 and achieve carbon neutrality by 2030.
From 2023 to 2024, Formula 2 and Formula 3, F1’s supporting racing series, will start utilizing 55% ‘sustainable bio-based fuels’, transitioning to 100% ‘advanced sustainable fuels’ by 2025.
F1 has developed its own ‘sustainable’ fuel for 2026, designed specifically for the hybrid engines currently used in F1 cars, which consist of both an internal combustion engine (ICE) and two electric motor generators.
Images from the Japanese Grand Prix, which was rescheduled from autumn to spring to minimize carbon emissions related to equipment transport between races (Source: Formula 1) – Formula 1
According to F1, the new fuel will not raise the overall carbon levels in the atmosphere. The carbon used in these new fuels will be sourced from existing materials, such as household waste and non-food biomass, or it will be captured directly from atmospheric carbon dioxide.
This will enable the production of synthetic fuels, which are man-made fuels aimed at replacing the fossil fuel-based gasoline currently in use. In the long term, the FIA asserts that F1, 2, and 3 will all eventually adopt this “fully synthetic hybrid fuel”.
Moreover, this new fuel will be classified as “drop-in”, indicating that it will be compatible with existing internal combustion engines as well as the current fuel distribution infrastructure. This means the fuel powering F1 cars in 2026 will be the same fuel you could purchase at your local gas station today.
Is it Truly Sustainable?
However, as the term “sustainable” has gained popularity, experts have started to challenge F1’s assertions.
Dr. Paula Pérez-López, an expert in environmental and social sustainability at the MINES ParisTech Center for Observation, Impacts, and Energy (OIE), articulates that for a product to qualify as “sustainable”, it must fulfill certain environmental, social, and economic criteria, with each segment of the supply chain considering these factors.
“The term ‘sustainable’ should not be confused with ‘low carbon’. A product or process may exhibit low carbon emissions but still produce high levels of other pollutants, thus rendering it ‘unsustainable’. “
The FIA’s collaboration with the Zemo partnership, a UK-based nonprofit organization, has led to the introduction of the Sustainable Racing Fuel Assurance Scheme (SRFAS). This third-party initiative ensures that sustainable racing fuels comply with FIA regulations.
The certification mandates that the fuel comprises “at least 99 percent Advanced Sustainable Components (ASC)” that are certified to be derived from renewable energy sources such as non-biological origin (RFNBO), municipal waste, or non-food biomass.
Essentially, this means that the new fuel must be synthetic, produced from waste, or derived from materials not intended for human or animal consumption, such as specially engineered algae.
Fraser Browning, the founder of Curve Carbon, which advises companies on minimizing their environmental footprints, indicates that these new fuels can indeed facilitate genuine decarbonization efforts if managed appropriately.
“The overarching question pertains to F1’s complete impact,” he notes. “Is F1 pursuing synthetic fuels as a vital component of their sustainability goals, or is it merely a procedural formality?”
Browning emphasizes that advancements in motorsport have historically contributed to significant innovations in sustainable transportation. For instance, in 2020, Mercedes announced that hybrid technology would be utilized in road cars. Earlier this year, they also revealed a new battery technology capable of extending the range of electric vehicles by 25 percent.
“Without the innovations deriving from motorsport, hybrid vehicles wouldn’t have evolved at the present speed,” he contends. “However, this needs to be executed transparently and responsibly.”
Cutting Carbon
Beyond the transition to synthetic fuels, F1 is also making strides to reduce carbon emissions in other areas. Travel and logistics account for roughly two-thirds of F1’s carbon emissions, as teams, heavy machinery, and fans travel considerable distances between races each year.
To mitigate this, adjustments have been made to the F1 calendar for 2024 to lessen freight distances between events, as stated in F1’s latest Impact Report. For example, the Japanese Grand Prix has been synchronized with other Asia-Pacific races and moved to April.
Formula 1 has unveiled that DHL’s new fleet of biofuel-powered trucks minimizes carbon dioxide emissions by an average of 83% compared to traditional fuel-powered trucks during the European segment of the 2023 season (Source: F1) – Formula 1
Additionally, F1 has broadened the adoption of biofuels for the trucks used to transport equipment throughout Europe, resulting in a 9% reduction in logistical carbon emissions.
By the conclusion of 2024, total carbon emissions are projected to decrease by 26% from 2018 levels, although F1 acknowledges there remain “key milestones to achieve, including further investments in alternative fuels and updates to our logistics system to enhance efficiency”.
Synthetic Fuels vs. Electric Vehicles
What does it mean when F1 claims that its new synthetic fuel is a drop-in solution suitable for everyday vehicles? Could it serve as a more sustainable alternative to electric vehicles (EVs)?
Critics warn that producing synthetic fuels for internal combustion engines (ICE) is energy-intensive, costly, and may require five times the renewable electricity compared to operating a battery-powered electric vehicle.
“Obtaining pure and concentrated CO₂ poses a considerable challenge,” states Gonzalo Amarante Guimarantes Pereira, a professor at the State University of Campinas in São Paulo, Brazil, and co-author of a study comparing biofuels with pure electric vehicles.
“There is a technology known as direct air capture that can achieve this, but attaining 100% concentration comes with substantial energy costs. The estimated expense varies between $500 to $1,200 (approximately £375 to £895) per tonne, rendering e-fuels at least four to eight times more costly than operating an electric vehicle.”
Browning concurs that EVs represent a more favorable low-carbon choice for the future. “Their emissions during use and maintenance are significantly lower,” he states.
“While synthetic fuels might yield a lesser overall impact if managed wisely, we still lack a comprehensive lifecycle assessment across multiple sustainability metrics to definitively address this issue.”
In simpler terms, as long as the entire system producing synthetic fuels cannot be reliably demonstrated to have a positive environmental impact, the jury remains out on the actual extent of their effects.
The undeniable truth is that SXSW Sydney, now in its third year, continues to be a hub for technology, music, and film in Austin, Australia, surrounded by brands. On Saturday, families attending a complimentary children’s concert navigated through the vibrant yellow CommBank Tour Zone, while queues formed at the enormous L’Oréal tent. Yet, just a short distance away in the gaming hall of the International Convention Center, the brand’s presence was noticeably subdued.
As the global gaming sector grapples with an ongoing recession, major studios remain cautiously distant from Australia due to the high cost of living. Even amidst a conference buzzing with brand synergy, indie developers took the spotlight. Large development teams were scarce; the majority of projects showcased were from solo creators or small partnerships. Reflective of the broader Australian gaming landscape, these indie developers were impressively ambitious.
A still from Mixtape, the new game developed by Melbourne’s Beethoven and Dinosaur and published by Annapurna Interactive. Photo: Beethoven and Dinosaurs/Annapurna Interactive
Australia’s two standout titles in the showcase, though still feeling somewhat subdued, gained significant attention. SXSW’s Game of the Year, Mixtape, from veteran developers Beethoven and Dinosaur (who brought us the delightful psychedelic adventure The Artful Escape in 2021) and the mid-sized American publisher Annapurna Interactive, tells a humorous ’90s coming-of-age story blending Edgar Wright-type comedy with the animation style of Spider-Man: Into the Spider-Verse.
Set to release later this year, the game promises a nostalgic journey through the joy of youth. Imagine Devo downhill skating on a lazy afternoon with cassette tapes playing in the background. Think of headbanging to Silverchair on a road trip or sneaking booze into parties while evading cops with erratic shopping carts. My 20-minute demo left me beaming, with at least one standout joke causing a fit of laughter.
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In contrast, the concept behind Pro Jank Footy emerges. Co-creators David Ashby and Tyler Roach, known from the series Danger 5, have cautiously ventured into gaming with support from film distributor Umbrella. This game offers a whimsical, arcade-style take on AFL reminiscent of SNES-era sports titles. After each goal, the losing team selects one of three comical power-ups (like attacking seagulls, oversized players, or resetting the score to zero) before the game resumes. During a live demonstration at Tumbalone Park, hosted by Aunty Donna’s Broden Kelly, who also features in the game, a small audience of families gathered, while a few brave souls took to the stage, risking embarrassment for the chance to win a scarf and seemed to enjoy themselves.
Aunty Donna’s Broden Kelly engaging with the audience during Pro Jank Footy’s live stage demo at SXSW Sydney. Photo: Samuel Graves/SXSW Sydney
Highlights emerged even from games featuring less ambitious concepts. One standout was the dynamic shooter Hyper Primate, where you embody a monkey, armed with various makeshift wooden guns, battling other animals in pursuit of a colossal floating banana. While the game has an intentionally rough aesthetic, the movement mechanics felt incredibly refined as you zoomed through jungle arenas.
Another impressive title was a solo project called Huedini, an exhilarating top-down game where you swiftly match colors to evade and consume enemies and obstacles. Even a brief gameplay session revealed that its seemingly simple mechanics could evolve into mind-bending complexity.
The Victorian Government’s strong backing for indie developers continues to yield benefits, with several projects funded by VicScreen, including Huedini. Other notable selections from this group included Way to the Woods, a stunning adventure game where you guide a deer and fawn endowed with light powers through a verdant city, and a captivating puzzle game, Letters to Arralla, where you decipher photo-based addresses in a serene island community populated entirely by root vegetables. South Australia also showcased a robust lineup, including Pro Junk Footy and a satisfying minimalist cube-rolling puzzle game, Toya, which felt like a serene reprieve amidst a bustling exhibition floor.
A still from Way to the Woods by Melbourne developer Onepixel.dog. Photo: Onepixel.dog
Even international participations largely embraced the grassroots ethos of the showcase. While most games, except for Sony’s Ghost of Yourei, weren’t playable, the discussions garnered good attendance. Exceptional projects from small teams included A Week in the Life of a Non-Social Giraffe, a point-and-click puzzle game centered on social anxiety from the U.S., Abyss X Zero, a 3D action game akin to Zelda from Brazil, and Crescent County, a pastel-themed broom racing simulator from a UK developer.
A recurrent critique of SXSW Sydney has been its pricing, with the least expensive one-week access pass costing over $100. This year, however, the final day’s exhibition entry was free, resulting in a vibrant crowd of families and children. Highlights included party games like Cow Chess, a project by a Sydney-based duo that bore no resemblance to cows or chess and felt like a fusion of Terry Gilliam’s Worms and Super Smash Bros., and Chained Beasts, a co-op Roman gladiator game where all players are interconnected by chains.
In truth, the plethora of indie games presented made it impossible to experience them all in a single day. While SXSW Sydney might be marked by corporate branding efforts, the indie spirit undeniably thrives, particularly in the realm of video games.
Researchers have shown that hypercompressed water can undergo various freeze-thaw processes to convert into ice VI at room temperature, facilitated by a previously unidentified metastable ice form known as ice XXI.
Small ice crystals XXI formed through a nucleation and slow melting process. Image credit: Lee et al., doi: 10.1038/s41563-025-02364-x.
Water consists of only two elements, yet it has numerous polymorphs ranging from Ice Ih to Ice XX, along with four amorphous phases.
The exploration of formation and migration pathways for various water phases has captivated scientists for a century, especially in high-pressure physics and the quest for extraterrestrial life on icy moons.
“Water exhibits remarkable complexity in its solid forms,” stated Dr. Lee Geun-woo from the Korea Institute of Standards and Science and the National University of Science and Technology.
“Most phases are typically found under conditions of high pressure and low temperature.”
“When water is compressed rapidly, it can remain in a liquid state even under high pressures where it would normally crystallize into ice VI.”
“Ice VI is particularly fascinating, as it is believed to exist within icy moons like Titan and Ganymede.”
“Its highly distorted structure may facilitate intricate transition pathways that lead to metastable ice forms.”
“Most ice variants can only be observed under extreme conditions; hence, we utilized a diamond anvil cell to create these high-pressure conditions.”
“In this setup, the water sample is positioned between two diamonds, which can withstand and apply immense pressure.”
“The water was subjected to pressures as high as 2 gigapascals, roughly 20,000 times greater than typical atmospheric pressure.”
“This allows for ice formation even at room temperature, with molecules packed more tightly than in conventional ice.”
To examine ice formation under varied pressure conditions, researchers initially produced high pressures of 2 gigapascals in just 10 milliseconds.
They then took 1 second to release the anvil cell and repeated this procedure.
During these cycles, the scientists utilized Europe’s XFEL’s X-ray flashes to capture images of the sample every microsecond.
With extremely high X-ray pulse rates, they could even create videos illustrating the formation of ice structures.
Using PETRA III’s P02.2 beamline, the researchers confirmed that ice XXI possesses a tetragonal crystal structure composed of unusually large repeating units known as a unit cell.
“The unique X-ray pulses from Europe’s XFEL revealed multiple crystallization pathways in rapidly compressed and depressurized water over 1,000 times using a dynamic diamond anvil cell,” Dr. Lee explained.
“In this specialized pressure cell, the sample is squeezed between the tips of two opposing diamond anvils, following a defined pressure trajectory,” said Dr. Cornelius Strom from the Deutsche Electron Synchrotron.
“The crystallization structure of liquid water is influenced by the degree of supercompression,” added Dr. Lee.
“Our results hint at the potential existence of more high-temperature metastable ice phases and the related transition pathways, offering new insights into the compositions of icy satellites,” remarked Dr. Rachel Husband, also from the Deutsche Electron Synchrotron.
These findings were published in a magazine on October 10th in Nature Materials.
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YH. Lee et al. Multiple freeze-thaw paths of dense ice through the ice XXI phase at room temperature. Nat. Mater. published online on October 10, 2025. doi: 10.1038/s41563-025-02364-x
Neural networks (white) and eggs (green) in a mouse ovary (left) and a fragment of a human ovary (right). Growing follicles containing eggs are depicted in magenta
Eliza Gaylord and Diana Laird, UCSF Laird Laboratory
A novel imaging technique has uncovered an unexplored ecosystem within the ovaries that could affect the aging process of human eggs. This breakthrough may pave the way for strategies to slow ovarian aging, maintain fertility, and enhance health after menopause.
Women are born with millions of immature eggs, with one maturing each month post-puberty. However, after the late 20s, fertility declines sharply, typically attributed to diminishing egg quantity and quality.
To gain insights into this decline, Eliza Gaylord and her team at the University of California, San Francisco, developed a 3D imaging method that visualizes eggs without the need for slicing the ovaries, a traditional technique.
These newly captured images revealed that eggs cluster in pockets, rather than being uniformly distributed, indicating that the ovarian environment may significantly influence egg aging and maturation.
By integrating this imaging with single-cell transcriptomics, which identifies cells by their gene expression, researchers examined over 100,000 cells from both mouse and human ovaries. Samples were taken from mice aged 2 to 12 months and four women aged 23, 30, 37, and 58.
Through this approach, the team identified 11 major cell types and uncovered some surprises. One unexpected finding was the presence of glial cells—typically associated with the brain—that nourish and repair nerve cells, alongside sympathetic nerve cells that manage the fight-or-flight response. In mice lacking sympathetic nerves, fewer eggs matured, suggesting these nerves may influence when eggs develop.
Moreover, the researchers observed that fibroblasts, crucial for structural support, decrease with age, potentially leading to inflammation and scarring in the ovaries of women in their 50s.
This research indicates that ovarian aging is influenced beyond just the eggs; it involves the surrounding ecosystem, as noted by Diana Laird, also affiliated with UCSF. Importantly, she highlights the similarities discovered between aging ovaries in mice and humans.
“These similarities provide a basis for using laboratory mice to model human ovarian aging,” states Laird. “With this roadmap, we can start to explore the mechanisms that dictate the pace of ovarian aging to devise treatments that might slow or reverse the process.”
One potential avenue is to adjust sympathetic nerve activity to slow egg loss, thereby extending the reproductive time frame and delaying menopause.
Whole eggs (green) and a subset of developing eggs (magenta) in the ovaries of 2-month-old (left) and 12-month-old (right) mice.
Eliza Gaylord and Diana Laird, UCSF Laird Laboratory
Theoretically, this approach not only preserves fertility but may also diminish the risk of common postmenopausal conditions, including heart disease. “While later menopause could increase the risk for some reproductive cancers, this pales in comparison to the 20-fold higher risk of death from cardiovascular disease post-menopause,” explaines Laird.
However, such interventions are likely still far in the future. Evelyn Telfer, a researcher at the University of Edinburgh—known for being the first to successfully culture human eggs outside the ovary—points out that the limited age range and samples from just four women restrict the applicability of the findings. “Though intriguing, this study’s results are too preliminary to support treatment strategies aimed at altering follicle utilization or slowing egg loss,” she notes.
Ever find yourself gazing at adorable things until they start to seem a bit creepy? Think of garden gnomes, baby dolls, kids dressed as princesses, and all cats. Well, there’s one more addition to this peculiar list.
The tufted ground squirrel (Rheithrosciurus macrotis) may appear cute with its bright eyes and bushy tail, but the Dayak hunters of Borneo view it as a cold-blooded killer.
This ruthless rodent, nicknamed “Vampire Alice,” is infamous for allegedly flipping deer onto their backs, using its razor-sharp teeth to sever their jugular veins, causing the animals to bleed out.
Those who discovered the remains of a deer in the woods suspect that the squirrel returns to the scene to feast on the deer’s heart, liver, and stomach.
In villages bordering the forest, tufted ground squirrels are also known to prey on domestic chickens and consume their hearts and livers.
The squirrel gained notoriety in 2014 thanks to a paper written by 15-year-old Emily Meyard, titled Academic Paper, which revealed folk tales about animals with a bloodthirsty reputation.
The paper was published in Taprobanica: Journal of Biodiversity in Asia and has since made these once-overlooked creatures go viral. Articles have been written, videos shared, perhaps making Beatrix Potter reconsider her legacy.
In 2015, footage of one caught on camera went viral for the first time, however, it did not catch any herbivores in the act.
Instead, they were seen foraging in Gunungparun National Park in West Kalimantan, where action from the killer critter remained elusive, but new revelations emerged.
The tufted ground squirrel shares its native Borneo habitat with Prevost’s squirrel, a fluffy creature with a black, reddish-brown, and white coat that prefers life among the trees. – Credit: Richard McManus via Getty
In 2020, researchers discovered that the unusual teeth of these squirrels—long incisors with intricate ridges—are adapted for cracking open tough nuts.
Tufted ground squirrels are highly specialized seed predators, with a strong preference for canarium tree nuts.
It turns out the perception of tufted ground squirrels as fearsome creatures is a misconception. They truly have bright eyes and fluffy tails.
In fact, their bushy tails are among the largest proportionally of any mammal, being 30% larger than their bodies.
The reason for this unusual trait remains uncertain. Since they spend most of their time on the forest floor seeking food, it’s not for warmth, as it rarely gets cold in Borneo.
This could be related to attracting mates, deterring predators, or perhaps serving a mysterious form of camouflage. Their tail, which features a charcoal hue with frosty accents, helps them blend into the forest floor.
Regardless, I’ve stopped disparaging tufted ground squirrels and have learned to appreciate them as genuinely fascinating creatures.
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The narrative of Earth is one of transformation. Over 4.5 billion years, our planet has evolved from a scorching mass of molten rock and poisonous gases into a temperate and vibrant habitat teeming with diverse life forms. This evolution was punctuated by pauses, restarts, and cataclysmic events, as the intricate biogeochemical processes shaped the most extraordinary phases in Earth’s history.
Our understanding of this vast tale is largely thanks to rocks. They preserve the chronology of events that contributed to the surface’s stratification through various deposits. This intricate ordering is understood through hierarchies, and the scientific discipline dedicated to interpreting them is known as stratigraphy.
In Strata: A Story from Deep Time, journalist Laura Poppick delves into this nuanced science of rock interpretation, offering insights on how planets respond to and recover from periods of upheaval. “Through these layers, we glimpse ancient versions of our planet, gaining contextual awareness as we traverse through the present,” she observes.
Poppick highlights several transformative periods in Earth’s history, selecting four key episodes. The first examines the development of oxygen-rich atmospheres, tracking the evolution of photosynthesizing microorganisms and significant oxidative events that led to mass extinctions around 2.4 billion years ago.
The second segment discusses “Snowball Earth,” a period approximately 720 million years ago when many regions are believed to have frozen over. Following this, she explores the advent of mud and the subsequent rise of vegetation. Finally, the Mesozoic era, dominated by dinosaurs, records atmospheric carbon dioxide levels much higher than today’s due to volcanic activity, offering a framework to understand planetary responses to climate shifts.
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Sedimentary rocks maintain a distinct layer system that clearly records the events that have shaped our planet’s surface. “
Throughout each episode, Poppick introduces geologists working to unravel the numerous unanswered questions regarding the timing and causes of these changes. She visits significant geological sites, from Newfoundland to the Australian Outback, where one can observe the strata that articulate these narratives.
The recurring theme emphasizes the importance of paying attention to rocks. To an untrained observer, they may appear ordinary; however, Poppick reminds us that “a trained eye discerns physical and chemical indicators—proxies—that reveal the characteristics of our planet during the formation of these rocks.” She underscores the value of geologists’ expertise.
This book is a remarkable attempt to make stratigraphy engaging. At times, it falters, and Poppick’s fragmented writing style led me to lose the thread of the narrative.
Her comparisons of geological transformations to human-centric changes sometimes felt uneasy. For instance, she likens the Mesozoic greenhouse climate to modern carbon emissions, though the historical era’s temperatures were so extreme that such analogies may be misleading, even at optimistic emission projections.
Another limitation lies in the currently incomplete nature of geoscience. Some of the pivotal questions raised by Poppick—including the true cause of Snowball Earth—remain unresolved or are subject to debate among different factions. By the end, I was left with a sense of uncertainty about what can be definitively stated. Yet, that unpredictability might be intrinsic to geology itself. “Nothing is immutable in stone as our understanding of geology continues to evolve, just like the rocks,” Poppick states.
Nevertheless, the book effectively captures the grandeur of the story embedded in rocks. It does so particularly well by showing how seemingly mundane observations about rocks can lead directly to profound insights into Earth’s history. Such revelations illuminate the stratigraphic process as Poppick examines overlooked outcrops, encouraging us to perceive the rocks in our surroundings with renewed appreciation.
“Hierarchies are, in many ways, love letters from a maturing Earth,” she argues. This book abundantly reveals the reasons to uncover the secrets they hold.
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sIX years ago, Melbourne-based filmmaker Christina Kraskov was inspired by an article about the international Microsoft Excel competition. Her first thought was, “What on Earth, this isn’t the real deal.” Her second thought: “I need a film about this. I want to see it desperately.”
With no existing films on competitive spreadsheet use, Kraskov resolved to create her own. The topic intrigued her as it showcases “a unique inner world that often goes unnoticed.”
The documentary “Spreadsheet Champions,” which will premiere at the Melbourne International Film Festival, follows six young competitors from various countries as they prepare for the 2023 Microsoft Office Specialist World Championship. Introducing their skills, it may seem trivial, but Excel is an incredibly sophisticated tool. The documentary reveals that the average user taps into only 10-15% of its capabilities, whereas competitors must master around 70%.
Organized by Certiport, a performance-based assessment provider endorsed by Microsoft, the competition consists of two parts. The first assesses proficiency in formulas, functions, and overall knowledge through complex questions judged on both accuracy and speed. The second part emphasizes a more creative use of these skills. As Kraskov puts it, “It’s about understanding the narrative behind data or grasping the essence of what it conveys.”
“It helped me a lot”… Carmina, a teenage competitor from Guatemala, spreadsheet champion. Photo: Presented by Melbourne International Film Festival
The championship has been held since 2002 and is open to students aged 13 to 22. Participants must first achieve the highest qualification in their home nations. Despite the niche focus, the stakes are remarkably high, as each competitor can only participate in the MOS Championship once.
“In most sports, there’s a returning champion, creating a defined rivalry; however, here, you can only compete once.”
“This creates unique challenges as competitors qualify in their home countries at vastly different times. Once everyone is qualified, we communicate via Zoom and navigate from there.”
The six featured competitors include Arkimini, 20, from Greece; Braydon, 16, from Australia; Carmina, 16, from Guatemala; Dela Pikes, 19, from Cameroon (who has to study in school due to lacking a laptop or WiFi); Mason, 15, from the United States; and Nam, 21, from Vietnam. Each contestant adds their unique personality to the film, varying from the shy, stereotypical “nerd” to the enthusiastic and outgoing. “Our aim is to showcase how extraordinary this competition is. We’re not here to mock or belittle anyone,” Kraskov explains.
Dela Pikes from Cameroon lacks a laptop or WiFi, so he has had to prepare for the competition through school. Photo: Presented by Melbourne International Film Festival
Kraskov and producer Anna Charalambus spent about a week with each competitor in their respective countries, immersing themselves in their daily lives at home, school, and with families and friends.
“If you observe their lives closely, people naturally reveal their true selves,” Kraskov remarks. “Adolescents are still developing, thus they often don’t connect aspects of their identities – they simply exist in the moment. The insights provided by their parents were invaluable.”
Many contest details were kept secret, adding another layer of challenge for the filmmakers. This competition exemplifies the concept of nominal determinism, overseen by someone deeply invested in security.
“The level of security is extremely high,” notes Kraskov. “Eventually, Microsoft entrusted us and asked us important questions. Ultimately, he must conduct a rigorous, secure global evaluation next year.”
By participating in the MOS Championship, these young individuals are stepping closer to adulthood. Carmina, now 18, is pursuing a degree in mechatronics engineering at university. The film captures her vibrant spirit as a teenager passionate about exploring new things (which remains true).
Watching the documentary allowed Carmina to reflect on her past competition experiences and her younger self, realizing the insights gained. “Even though I knew the outcome, watching it again felt a bit suspenseful,” she shares. “[Competing taught me to engage and explore… it was extremely beneficial.]”
“Spreadsheet Champions” had its world premiere at SXSW in Texas earlier this year, with five out of the six participants attending MIFF. Kraskov takes pride in showcasing these individual stories – ordinary people engaging in something slightly different from the norm.
“Celebrities, musicians, and models tend to hog the spotlight,” she reflects. “But it’s those dedicated to pursuits that many overlook that I find even more compelling.”
Antiparasitic drugs gained significant attention during the Covid-19 pandemic, though their applications are unrelated to the virus.
HJBC/ShutterStock Source: ShutterStock
Prior to 2020, few had ever heard of the antiparasitic drug ivermectin. However, interest surged during the Covid-19 pandemic as unfounded claims emerged about its potential to prevent or treat viral infections. Notably, popular podcast host Joe Rogan stated he used it in 2021 while recovering from Covid. That same year, Robert F. Kennedy Jr., a prominent public health figure in the U.S., petitioned the FDA regarding its use in treating Covid-19.
Despite numerous studies disproving ivermectin’s efficacy against Covid-19, the buzz around it persists. While criticized as a quack remedy during the pandemic, ivermectin is still a legitimate medicinal drug, with researchers believing it contains potential yet to be fully explored.
What is ivermectin?
Ivermectin is an antiparasitic agent that was developed in 1975 by the pharmaceutical company Merck. It effectively eliminates a wide array of parasites and is FDA-approved for the treatment of two conditions caused by human parasites: onchocerciasis (river blindness) and intestinal strongyloidiasis. Additionally, in some regions, it is used to treat lymphatic filariasis and cutaneous larva migrans.
These parasitic infections are uncommon in high-income nations but pose significant threats to millions in low-income countries globally. As a result, over 300 million individuals take ivermectin annually, making it one of the most impactful global health interventions to date. Its discoverer was awarded the Nobel Prize in 2015.
The FDA has also approved various topical formulations of ivermectin for conditions such as head lice and rosacea. Furthermore, the drug is widely utilized in veterinary medicine to prevent and treat parasitic infections, including heartworms and roundworms. The FDA cautions against the consumption of veterinary formulations by humans, as they differ from those specified for human use.
Can ivermectin treat or prevent COVID-19?
Ivermectin was initially thought to be a promising treatment for Covid-19. Early studies suggested it might aid recovery and prevent viral replication; however, larger studies have indicated otherwise.
For instance, a 2022 study involving over 3,500 Covid-19 patients showed no difference in hospitalization rates between those treated with ivermectin and those given a placebo. Similarly, a 2023 study, involving more than 1,400 adults, found no significant benefit of ivermectin in accelerating recovery compared to placebo.
Can ivermectin treat cancer?
Ivermectin is not approved for cancer treatment and has not undergone thorough clinical trials. However, preliminary studies have indicated that it may have potential as an adjunct cancer therapy.
A decade ago, Peter P. Lee at a lab in Los Angeles discovered that ivermectin could induce cancer cell death through a process known as immunogenic cell death, thus prompting immune cells to recognize and attack cancer cells. Lee and his team searched the National Cancer Institute database to assess the effects of all FDA-approved drugs on various cancer cells, finding that ivermectin notably enhanced signs of immunogenic cell death in several cancer types.
“At that moment, I’d never heard of ivermectin,” Lee remarked. “I had to investigate, and upon learning it was a parasitic drug, I found it rather astonishing.”
In 2021, Lee and associates tested ivermectin in a mouse model of metastatic triple-negative breast cancer, a notably aggressive and challenging condition to treat. They found that 40% of mice treated with a combination of ivermectin and immunotherapy survived beyond 80 days, contrasted with none of the mice given immunotherapy alone surviving past 50 days. Mice solely administered ivermectin did not fare better than untreated counterparts.
“Ivermectin itself isn’t inherently a cancer treatment,” Lee clarified. “But it seems beneficial when used alongside immune-based therapies.”
A clinical trial is currently evaluating the use of ivermectin in conjunction with cancer immunotherapy for metastatic triple-negative breast cancer, with anticipated results expected next year. Other studies also suggest that pancreatic cancer therapies are more effective when combined with ivermectin, and Lee is exploring similar effects on colon cancer cells.
While these findings are encouraging, they do not confirm ivermectin as an effective cancer treatment for humans. “Many therapies that show promise in animal studies do not translate to humans,” Lee pointed out.
What are the side effects of ivermectin?
Ivermectin is generally regarded as safe, but can be toxic when taken in high doses. Possible side effects may include nausea, vomiting, diarrhea, low blood pressure, and dizziness. In severe cases, ivermectin usage might lead to seizures, coma, or even death, especially if combined with other medications like blood thinners.
“Individuals should not take [ivermectin] on their own or without the guidance of a knowledgeable medical professional. I genuinely hope to utilize ivermectin in ways that provide benefits to numerous patients, but its use is more complex than simply self-administering a medication,” he advised.
Devi Sridhar argues that we have misaligned health priorities. Many of us obsess over personal choices like diet and exercise while ignoring the crucial role of government in health outcomes. This crucial factor: effective governance.
Public health initiatives—including universal healthcare, access to clean drinking water, breathable air, and safe transportation—actually have a far greater effect on longevity than individual commodities like gym memberships or health food. As a professor of global public health at the University of Edinburgh, Devi has authored a new book titled How Can I Not Die (Too Early), which builds a compelling case that emphasizes both personal endeavors and public health as keys to a long, healthy life.
In her interview with New Scientist, she tackles the illusion of personal responsibility for health, discusses how to elevate public health appeal, and shares her vision if she were in a position of authority.
Graham Lawton: Are you suggesting that focusing on our own health is futile?
Devi Sridhar: Not at all! Personal health initiatives can be highly effective if resources, time, and education are available. However, placing sole responsibility for health on individuals ignores the broader societal factors at play. The environment and circumstances you reside in profoundly impact your lifespan. Society often forgets the systemic issues tied to health, where individuals’ agency is critical. Yet, large-scale health improvements typically originate from governmental initiatives.
How did we come to believe that health is solely our responsibility?
This belief is empowering. People think, “What can I do today?” and “If I’m disciplined enough, I can succeed!” However, broader structural barriers often limit their ability to make changes. We’re inundated with self-help narratives while less attention is paid to systemic factors, which many perceive as not directly relevant to their own lives. Additionally, there’s significant skepticism about politicians, with a prevailing notion that nothing will change.
What’s the right balance between personal and public health measures?
The answer varies by the specific issue. Individual efforts can influence areas like diet and exercise, but for critical areas such as air quality and water safety, individuals are often at the mercy of governmental decisions.
Are celebrity diets and social media influencers further skewing this balance?
Absolutely. It’s all about marketing. We tend to believe that products with the right branding are more effective. Public health struggles with marketing challenges. Recent years have not helped, as public health messaging often comes across as oppressive rather than liberating.
How can we reshape perceptions of public health?
We need to shift the narrative around public health. It shouldn’t just be about societal benefits, but also about simplifying life. People want to understand, “How does this benefit me?” This may sound cynical, but it’s the reality we operate within.
Vaccinating children for measles is a lifesaver, but social media influencers may spread doubts
Morwan Ali/EPA/Shutterstock
Given the misinformation surrounding vaccinations, why do many people fall prey to such fallacies?
A lot of this is rooted in social media culture, where popularity seems to supersede accuracy. For example, when Joe Rogan discusses his experiences with measles on his podcast—where he asserts it was commonplace during his childhood—this message carries more weight than that of actual health experts. Despite being neither a medical professional nor a public health authority, his influence is substantial. If I claimed that the secret to longevity was gin and tonics, it would go viral, posing a significant challenge for credible health messaging.
Implementing effective public health policies seems complicated, isn’t it?
Change often meets resistance. Consider the initial pushback against smoking bans in pubs or seat belt laws. Though there’s resistance early on, over time, people adapt, and these measures become normalized.
Your book presents various instances of successful government interventions. Which one stands out to you?
As someone in Scotland, I have to mention the Dunblane gun laws enacted following a tragic school shooting in 1996. The resistance to these laws was fierce, yet they have effectively prevented mass shootings in British schools, saving countless lives and establishing a model for other nations.
In high-income countries, 20% of deaths are preventable. What insights can we draw from nations with lower preventable mortality rates?
Countries like Japan, which have high cancer survival rates and low chronic disease prevalence, serve as models for what can be achieved. In Japan, preventable mortality rates are estimated at about 10%, showcasing the potential for better outcomes.
Our objective should be to extend life expectancy, ideally reaching ages of 80, 90, or even 100. If one can age successfully and die of natural causes, that signifies a healthy approach to living.
However, longer lifespans mean an older population. How should we respond to this shift?
Aging should be perceived as a strength, not a detriment. The focus should be on encouraging healthy aging, allowing individuals to maintain independence without overwhelming healthcare systems.
How realistic is it to align preventable mortality rates with those of Japan?
It will likely take a decade or two, as changing urban design and reversing childhood obesity cannot be done overnight. Nevertheless, the return on investment can be considerable over time. A significant challenge is the current governmental tendency to prioritize short-term headlines over long-term planning.
Typically, there is initial resistance to new public health regulations, such as the essential use of seat belts, but people will adapt over time.
CrackerClips Stock Media/Alamy
If you were in charge of the UK National Health Service (NHS), what reforms would you prioritize?
I believe there’s a strong need for focus on preventive care. Currently, the UK invests significantly in acute care while neglecting prevention. The emphasis right now is on addressing hospital and ambulance waiting times, which will worsen as the population ages. My approach would be to prioritize preventive measures. Identify and invest in cost-efficient strategies to detect health issues early. What are the prevalent reasons behind hospital admissions, and how can we tackle them?
For instance, hypertension is known as a silent killer. Regular annual blood pressure checks could lead to early detection. Though the initial costs may be higher, savings can accumulate over the years. Regular assessments of waist circumference, abdominal fat, blood sugar, cholesterol levels, and grip strength should also be incorporated.
I interviewed you during the COVID pandemic, when you mentioned that it was an opportunity to address long-standing public health challenges. Did we capitalize on that?
No, quite the opposite. If anything, there has been a backlash against public health and government intervention. Strict lockdowns and mask mandates led to significant pushback. Rather than seizing the opportunity for systemic change, the focus has shifted back to individual responsibility.
Do you feel we’ve learned valuable lessons from the pandemic, and is the world better prepared for the future?
It depends on the perspective. In terms of public health, I would say no; we’ve regressed. The UK’s testing infrastructure has been dismantled. However, in terms of scientific advancement, yes, we’re now better equipped for vaccine development and more efficient research processes. If a bird flu strain spreads among humans, the UK government already has a vaccine ready for distribution.
A quote from your book resonates: “We don’t need to conduct any more studies.” Is that your position?
Yes. We have a wealth of knowledge already. Perhaps 90% of what we need to know to improve population health is already available. While there’s always room for further research, repeating studies that confirm what we already know can become a distraction and delay necessary actions.
Are we evolving positively on a global level regarding public health?
Overall, yes. Life expectancy is increasing, and quality of life is better than it was a century ago. Progress may not be rapid or uniform, and in some regions, there are setbacks, but the overall trend shows significant advancement.
What message do you want readers to take from your book?
Politicians have the power to effect change. Take the NHS, for example; its establishment was a deliberate decision, not a coincidence. Everything we have today is the result of policy choices made decades ago, and we are currently reaping the benefits. While the improvements from today’s decisions may not be immediate, future generations will benefit from them. My aim is to inspire hope for what is possible.
In the last decade, quantum computing has evolved into a multi-billion dollar sector, attracting investments from major tech firms like IBM and Google, along with the U.S. military.
However, Ignacio Cirac, a trailblazer in this field from Germany’s Max Planck Institute for Quantum Optics, provides a more measured assessment: “Quantum computers are not yet a reality,” he states, because creating a functional and practical version is exceedingly challenging.
This article is part of our special feature that delves into how experts perceive some of science’s most intriguing concepts. Click here for more information.
These quantum systems utilize qubits to encode data, in contrast to the traditional “bits” of conventional computers. Qubits can be generated through various methods, ranging from small superconducting circuits to ultra-cold atoms, yet each method presents its own complexities in construction.
The primary advantage lies in their ability to leverage quantum attributes for performing certain calculations at a speed unattainable by classical computers.
This acceleration holds promise for various challenges that traditional computers face, such as simulating complex physical systems and optimizing passenger flight schedules or grocery deliveries. Five years ago, quantum computers appeared poised to tackle these and numerous other computational hurdles.
Today, the situation is even more intricate. Certainly, the progress in creating larger quantum computers is remarkable, with numerous companies developing systems exceeding 1000 qubits. However, this progress also highlights the formidable challenges that remain.
A significant issue is that as these computers scale up, they tend to generate increased errors, and developing methods to mitigate or correct them has proven more challenging than anticipated. Last year, Google researchers made notable strides in addressing this problem, but as Cirac emphasizes, a fully functional useful quantum computer remains elusive.
Consequently, the list of viable applications for such machines may be shorter than many previously anticipated. Weighing the costs of construction against the potential savings reveals that, in many scenarios, the economics may not favor them. “The most significant misconception is that quantum computers can expedite all types of problems,” Cirac explains.
So, which issues might still benefit from quantum computing? Experts suggest that quantum computers could potentially compromise the encryption systems currently employed for secure communications, making them appealing to governments and institutions concerned with security. Scott Aaronson from the University of Texas at Austin notes this.
Another promising area for quantum computers is in modeling materials and chemical reactions. Because quantum computers operate within a framework of quantum objects, they are ideally suited for simulating other quantum systems, such as electrons, atoms, and molecules.
“These are simplified models that don’t accurately reflect real materials. However, if you appropriately design your system, there are numerous properties of real materials you can learn about physics.” Daniel Gottesman from the University of Maryland adds.
While quantum chemical simulations might seem more specialized than flight scheduling, the potential outcomes (such as discovering room-temperature superconductors) could be groundbreaking.
The extent to which these ambitions can be realized heavily relies on the algorithms guiding quantum computations and methods for correcting those pesky errors. This is a complex new domain, as Vedran Dunjko of Leiden University in the Netherlands points out, prompting researchers like himself to confront fundamental questions about information and computation.
“This creates a significant incentive to investigate the complexity of the problem and the potential of computing devices,” Dunjko asserts. “For me, this alone justifies dedicating a substantial portion of my life to these inquiries.”
Explore more articles in this series by using the links below:
The genus Tyrannosaurus had its direct ancestors migrate from Asia over 70 million years ago, according to a groundbreaking study conducted by researchers at University College of Paleontologists in London.
Tyrannosaurus Rex evolved in North America, while its direct ancestors originated from Asia. Image credit: Pedro Salas/Sergey Krasovskiy.
This research, led by Cassius Morrison, a Ph.D. student at University College London, indicates that the rapid increase in the size of tyrannosaur dinosaurs and their close relatives, the Megaraptors, coincided with a global climate cooling that followed a temperature peak 92 million years ago.
This finding suggests that Tyrannosaurus Rex and its relatives may have been better adapted to cooler climates compared to other dinosaur groups at the time, likely due to their feathers and warmer physiology.
The geographical origins of Tyrannosaurus Rex have been a topic of intense debate,” stated Morrison.
“Paleontologists remain divided over whether their ancestors originated from Asia or North America.”
“Our modeling indicates that the “grandparents” of Tyrannosaurus Rex likely migrated to North America from Asia, crossing the Bering Strait between modern-day Siberia and Alaska.”
“This aligns with prior research showing that Tyrannosaurus Rex shares a closer relation to Asian relatives like Turbosaurus than to North American relatives such as Daspletosaurus.
“Numerous Tyrannosaurus Rex fossils have been found in North America, but our findings imply that the direct ancestors of this group may not yet have been unearthed in Asia.”
Paleontologists concluded that Tyrannosaurus Rex actually evolved in North America, particularly in Lalamidia, and was widely distributed across the region.
This conclusion contradicts last year’s findings suggesting that Tyrannosaurus mcraeensis, discovered in New Mexico, could be North American ancestors of Tyrannosaurus Rex from 3 to 5 million years ago. The team argued that the fossils of Tyrannosaurus mcraeensis were not properly dated.
For this study, researchers examined the migratory patterns of Tyrannosaurus and its relatives across the globe.
They employed mathematical models that represented fossils, dinosaur evolutionary trees, as well as the geography and climate of the era.
Importantly, the model addressed gaps in the fossil record and factored in uncertainties in the calculations.
Megaraptors are considered one of the most enigmatic large carnivorous dinosaurs.
In contrast to Tyrannosaurus Rex, they evolved slender heads and limbs as long as human height, with claws measuring up to 35 cm (14 inches).
Scientists conclude that Megaraptors were more widely distributed than previously thought, first appearing in Asia around 120 million years ago, spreading to Europe, and likely reaching Gondwana (encompassing regions of present-day Africa, South America, and the Southwest).
This suggests that Megaraptors inhabited regions like Europe and Africa, where no fossils had been found before.
They may have adapted differently from their Tyrannosaurus relatives, perhaps utilizing their claws for hunting instead of relying on powerful bites.
In South Gondwana, they could have preyed on small sauropods, while Tyrannosaurus Rex hunted large herbivores such as Triceratops, Edmontosaurus, and Ankylosaurus.
Both Tyrannosaurids and Megaraptors grew to enormous sizes nearly simultaneously as the climate cooled after the Cretaceous thermal peak 92 million years ago.
This rapid growth occurred following the extinction of other giant carnivorous dinosaurs, Carcharodontosaurids, which left a void at the top of the food chain.
The authors suggest that both Tyrannosaurus and Megaraptor could utilize cooler temperatures more effectively than their rival dinosaur groups.
By the end of the dinosaur age, Tyrannosaurus Rex weighed up to 9 tons (similar to very large African elephants and light tanks), while the Megaraptor reached lengths of up to 10 meters.
“Our findings illuminate the emergence of the largest tyrannosaurs in North and South America during the Cretaceous period and how they thrived by the end of the dinosaur epoch,” remarked Charlie Scheller of the University of London.
“They may have achieved their massive size to fill the ecological role left by the similarly large Carcharodontosaurid theropods that went extinct approximately 90 million years ago.”
“This extinction likely removed any ecological barriers that previously constrained the growth of tyrannosaurs.”
“Around 120 million years ago, Megaraptors were part of a diverse array of dinosaur species,” stated Dr. Mauro Alanciagaroland, a paleontologist at the Museum of Natural Sciences and the Bernardino Rivadavia Museum in Argentina.
“As the Cretaceous period progressed and the continents began to drift apart, these predators became increasingly specialized.”
“Such evolutionary shifts prompted them to adapt to more specific habitats.
“In areas like Asia, Megaraptors were ultimately replaced by Tyrannosaurus, but in regions like Australia and Patagonia, they became apex predators, dominating these ecosystems.”
This study is published in the journal Royal Society Open Science.
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Cassius Morrison et al. 2025. The Rise of the King: the origins of Gondwanan and the evolution of the Megaraptor dinosaurs. R. Soc. Open Sci. 12(5): 242238; doi: 10.1098/rsos.242238
The Euclidean Mission of the European Space Agency (ESA) has just released its first significant batch of research data, offering a fascinating glimpse into the vast cosmos.
This newly revealed image, covering a 63-square patch of the sky (over 300 times the size of a full moon), showcases millions of galaxies in intricate detail.
But this is just the beginning. The Euclidean mission, aimed at mapping the universe and unraveling the mysteries of dark matter and dark energy, which constitute 95% of the universe, has only just begun.
Launched in February 2024 and released in July 2023, Euclid is designed to survey a third of the sky, eventually capturing images of 1.5 billion galaxies. In just a week of observations, the mission has already spotted 26 million galaxies, some located an astounding 10.5 billion light years away.
Professor Carole Mandel, ESA’s director of science, described the release as “a treasure trove of information for scientists to delve into.” In an official statement, she highlighted Euclid’s role as the “ultimate discovery machine,” enabling astronomers to explore the grand structure of the universe with unparalleled precision.
The initial observations of the mission showcase Euclid’s capability to map the large-scale structures of the universe using high-resolution visible instruments (VIS) and near-infrared spectrometers (NISPs), capturing galaxies across vast distances and helping scientists track the intricate web-like structure of space.
This image shows not only light, gravity lenses within the cluster, but also a variety of huge galaxy clusters. The cluster near the center is called J041110.98-481939.3 and is almost 6 billion light years away. -ESA/EUCLID/EUCLID Image processing by CONSORTIUM/NASA, J.-C, Cuillandre, E. Bertin, G. Anselmi
“Euclid’s potential to unveil more about dark matter and dark energy from the massive structure of the Cosmic Web can only be realized once the entire survey is completed,” stated Dr. Clotilde Laigle, a scientist from the Euclidean Consortium.
“Nevertheless, this first data release offers a unique view into the vast organization of galaxies, providing insights into the formation of galaxies over time.”
With an immense data stream – sending back 100 GB of data to Earth per day – scientists are challenged with cataloging and analyzing an unprecedented number of galaxies. To tackle this, AI algorithms, in collaboration with thousands of citizen scientists, have categorized over 380,000 galaxies in their initial dataset.
The AI model known as “Zoobot” was trained over a month on the Galaxy Zoo platform with the help of nearly 10,000 volunteers to enhance their galaxy classification skills.
Dr. Mike Walmsley, an expert in astronomical deep learning at the University of Toronto, highlighted the significance of AI in processing Euclid’s vast datasets.
While scientists are still grappling with this first data release, many are already envisioning the future.
“Euclid will truly revolutionize our understanding of the universe,” stated Professor Christopher Conselice from the University of Manchester. He depicted the results as just “the tip of the iceberg,” foreseeing Euclid’s revelations about dark energy and a complete picture of galactic evolution throughout the ages.
The mission is still in its nascent stages, with the released data accounting for only 0.4% of Euclid’s final investigation scope. Setting the stage for even more profound discoveries, the initial data release indicates that Euclid is poised to offer a remarkable new perspective on the universe. In October 2026, ESA is expected to release Euclid’s first major cosmological dataset, covering larger research areas and multiple deep field paths.
If this initial glimpse is any indication, the coming years promise a deluge of data and discoveries that could redefine our understanding of the universe.
m
A favorite thing about Monster Hunter is that despite its name, it often feels more like a prey than a predator. Armed with swords several times with your own size and weight, you often go beyond time to become an incredible creature in this action game. The weather will often beat you at Monster Hunter Wild next week. As storm clouds gather, the daily hunt of relatively unthreatened creatures brings you a scary lightning dragon that will eat you for breakfast. The monsters intertwined with each other, tearing them with their teeth and claws as they turn their tails towards the hill.
Over the past few weekends, players have practiced Wilds in the Beta Test, trying out exquisite character creators and several hunts against the scary lions (doshaguma) and overgrown poisonous chickens (gypseros). As someone old enough to play these games on the PlayStation 2, I’ve been distorted uncomfortably with my fingers with my fingers as the PlayStation appeared in portable during the overseas grades of Japan. Ta. What was once a hard, dense game that hid all the thrills behind the barricades of a Mushroom Rally Quest, is now fluid, charming and globally popular. The 2018 entry, Monster Hunter World, broke Capcom records, reaching sales of 203 million people.
Ryozo Tsujimoto, the series producer and son of Capcom founder Kenzo Tsujimoto, has been with Monster Hunter since the early 00s, when Capcom’s online gaming designer. Obviously it still excites him. He is in front and center of many Wild promotions. “It’s really good to see our team play so many people playing games at the same time,” he told me at a recent Tokyo Game Show. “There are many things we can discover by watching players pick up and try out the game. It’s something we don’t see in our own tests. So we can see how players are responding. And we have some masks of the developer team at the booth.”
The main innovation in Wild is how monsters interact with each other. Previously, herbivores were Potter about herd grazing, but only the addition of the current generation consoles has been able to create a seamless ecosystem where teams meet each other and get caught up in the war on the grass. “To have the creatures travel together realistically is challenging in terms of making it look plausible,” says Wiles manager Yuya Tokuda. “If they all moved perfectly in sync, it would be a bit creepy and unconvincing as animal behavior in the pack. But if each monster was a complete wildcard like before, then it would be. It would be unacceptable to keep everything together. While each creature has personality, hitting the balance between herd and puck actions is a lot of work, and we do nothing I had to make sure not to do that.”
www.theguardian.com
The upcoming director of CERN stated that advanced artificial intelligence is revolutionizing basic physics and opening windows for the fate of the universe.
Professor Marktomson, a British physicist who will take on the leadership at CERN on January 1, 2026, envisions progress in particle physics comparable to the AI-driven prediction of protein structure that recently won Google Deepmind Scientists an award. Speculations suggest a potential Nobel Prize in October.
With the Large Hadron Collider (LHC) playing a key role, there is hope to unravel how particles obtained mass at the moment of the Big Bang and whether our universe is extraordinary. Professor Marktomson mentioned the adoption of a similar strategy to potentially avert a catastrophic collapse event.
Tomson emphasized, “These are not just incremental improvements, but rather significant strides achieved by embracing cutting-edge techniques.”
He also added, “The field will undergo a transformative change. Dealing with complex data like protein folding presents intricate challenges, and employing advanced AI technologies can lead to breakthroughs.”
CERN’s council anticipates a promising future with revolutionary advancements. Despite skepticism following the groundbreaking Higgs boson discovery in 2012, Professor Thomson believes that AI brings a fresh perspective to explore new frontiers in physics. The enhanced beam strength of LHC is expected to enable unprecedented observations of the Higgs boson, also known as the “God particle,” shedding light on other particles and the universe at large.
There is a particular focus on measuring the Higgs boson’s self-coupling, which plays a critical role in understanding how particles acquire mass and the evolution of the Higgs field post-Big Bang. Higgs’ self-coupling strength is crucial for determining the stability of the Higgs field and potential future transitions.
Dr. Matthew McCallow, a theoretical physicist at CERN, emphasized that the exploration of Higgs’ self-coupling is significant for advancing our understanding of the universe’s fundamental characteristics. Integrating AI into LHC operations has streamlined data collection and interpretation processes, enabling faster decision-making for experiments like the LHC ATLAS project.
Scientists have long sought to uncover dark matter using the LHC, considering it comprises a significant portion of the universe. With AI’s assistance, researchers hope to untangle this mystery. Thomson remarked, “AI allows us to pose more intricate and open-ended queries rather than merely searching for specific signals, hoping to uncover unexpected insights within the data.”
no, it wasn’t the “moment of SPUTNIK”. Last month’s release Deepseek R1 in China generated AI or chatbot has sparked conversations in the high-tech world, speculating on stocks, and suggesting that the United States is losing its edge in AI technology. However, the confusion caused by SPUTNIK doesn’t reveal much about Deepseek beyond American neurosis.
The original SPUTNIK moment occurred when the Soviet Union launched SPUTNIK 1 on October 4, 1957, shocking the world. In the famous words of Neil Armstrong, when he took a “small step” on the moon, it was an anachronistic phrase from a later, even more important milestone, the “Giant Leap for Mankind”.
Deepseek, backed by Chinese hedge funds, is a notable achievement. However, it doesn’t offer any technical advancements in large-scale language models (LLMs) that already exist. It lacks the speed and “wisdom” of Openai’s Chatgpt or Anthropic’s Claude.Vision-All LLMs tend to generate incorrect answers or fabricate facts to fill data gaps. NewsGuard’s evaluation system found that the DeepSeek chatbot made false claims in 30% of cases and failed to provide answers in 53% of cases.
DeepSeek’s high non-response rate may be attributed to censorship, avoiding sensitive issues for China or limiting information on topics like Tiananmen Square and Taiwan.
The true impact of DeepSeek lies in AI economy rather than its technology. It is a chatbot with strengths and weaknesses, like other major models, but it is built with lower costs and inferior technology. The ban on cutting-edge chips and chip manufacturing equipment to China by the Biden administration in 2022 has unintentionally spurred Chinese researchers to be more innovative.
DeepSeek is freely available and open-source, helping to democratize AI technology, especially outside the United States. While US companies create barriers to entry for competitors, it is ironic that China embraces openness.
The impact of DeepSeek goes beyond technology, unveiling the hype and geopolitical tensions surrounding AI. It challenges the notion of building larger AI models with massive computing capabilities and high costs.
The hype around DeepSeek mirrors the hyperbole around AI and reflects geopolitical tensions. If DeepSeek had originated from a US university, it might have gone unnoticed without causing global uproar. Amidst this panic, concerns about DeepSeek’s Chinese origin raise questions about privacy, censorship, and surveillance that affect AI technology as a whole.
Navigating between hype and fear around AI becomes crucial in times of trade wars and threats to democracy. It’s important to recognize the promises and challenges of technology without being swayed by political agendas.
It wouldn’t be Christmas without the smell of freshly baked gingerbread wafting through your home. A blend of warming spices and rich molasses, it’s a must-have snack on a winter’s day. And when I was a kid, it was always gingerbread that I fed Santa every Christmas Eve. In fact, gingerbread might be my favorite biscuit. It has the perfect balance of crunch and chewing power.
I’d like to think I know a thing or two about how to accomplish that. Participated in the 2023 series. Great British Bake Off He also received the notoriously difficult handshake from judge Paul Hollywood during Biscuit Week.
My success lies in the careful application of science to the art of baking. So let me share some key insights you need to bake gingerbread that will really turn heads, and the science behind why they’re so important. I’m a chemist by trade, so I eschew the traditional gingerbread house and instead assemble biscuits to create a stand-alone Christmas ‘chemistry’. Drool was already coming out of my mouth.
As with all biscuits, the first step is to prepare the dry ingredients. Flour, sugar, spices, and baking soda (see “Ingredients and Instructions” on the right) are required, and each has an important role to play. The flour acts as a binder and helps form the structure of the biscuit, while the sugar caramelizes to create sweetness, color, and texture.
Gingerbread’s flavor comes from a blend of spices, with ginger and cinnamon being the main ingredients.
aIn Valve’s Half-Life 2, the seminal first-person shooter that celebrates its 20th anniversary this month, taciturn scientist Gordon Freeman finds himself trapped in a dystopian cityscape. Armed soldiers patrol the streets while innocent civilians wander around dazed, without purpose or future. Dr. Wallace Breen, Freeman’s former boss at the scientific “research center” Black Mesa, looks down from a giant video screen and defends the virtues of humanity’s benefactors, an alien race known as the Combine.
Freeman stumbles through the first few levels of Half-Life 2, as players become accustomed to the terrifying future unfolding before them. It’s not the most cheerful atmosphere, but there are some friendly faces (guards Barney, Alix, and Eli Vance), and a beaked face named Lamar, Dr. Isaac Kleiner’s pet. There are even moments of humor, such as an eating alien running amok in a lab. I feel safe. It will make you feel happy. It feels nostalgic. There’s also a crowbar! And that omen. “That’s the old passageway to Ravenholm,” Alix Vance tweeted during a tour of Freeman’s Chapter 5 Black Mesa East facility. “We’re not going there anymore.” I feel a shiver run down my spine. you know You’ll end up going there.
“[Ravenholm] It was a completely different environment than anything players had ever been in before,” said level designer and member of the unofficial City 17 Cabal, a group within Valve that worked on Half-Life 2’s most famous levels, Dario Casali. “This is an outlier in the map set that survived from a very early build of the game, and was born out of the need to give the newly introduced Gravity Gun a place to shine.”
“Ravenholme was a completely different environment to anything the players had been in before.” Photo: Valve
The lack of ammunition for Freeman’s traditional weapons is what propels Ravenholm and Half-Life 2 into the realm of horror games. Ravenholm, an old mining town previously hidden from the Combine, is now a desolate place, shrouded in darkness and its inhabitants corrupted by the heavy bombardment of Headcrabs (face-eating aliens). “We used the confined space to slow down the zombies. [headcrab-afflicted people] It can actually get closer to you,” Casali reveals. And players will no longer be able to blow them away with machine guns or pistols. You will have to rely on your heavy gravity gun to pick up whatever is around and throw it at the monsters that are closing in on Freeman. Pots of paint, pieces of wood, and even corpses became ammunition for players.
Like most of Half-Life 2, Ravenholm is a cinematic experience, taking cues from horror films like Saw and 28 Days Later. When the Combine forces attack Black Mesa East, Freeman escapes through a dark tunnel leading to Ravenholm. Immediately, a sudden change in atmosphere hits the player like a chill. A gloomy set of dark buildings, faint and almost non-existent music, two crashed headcrab rockets, and the sound of something swinging from a barren tree. When I looked closely, I discovered the lower half of my body, which had been pecked by a crow.
A headcrab zombie appears out of nowhere and screams in pain. But soon, Freeman has little to worry about. Designed to fit within the map, Ravenholm’s “fast” zombies climb drainpipes and run across rooftops, leaving adventurous scientists with little safe haven. Freeman also has to contend with hunched creatures that throw poisonous headcrabs at him.
“A desolate place.” Photo: EA
Fortunately, Freeman is not without help. Soon, he encounters Father Grigori, responsible for Ravenholm’s saw-like traps, and passionately redeems his “flock” with a shotgun. Casali said: “In my opinion, this man was slowly losing his mind due to the Headcrab and the zombification of his followers. Ravenholm was so isolated that he didn’t even know about the Combine invasion. , I imagined they thought the devil had come to town. Father Grigori and the zombie horde were the perfect excuse to double down on the creepiness.”
Freeman follows Grigori throughout Ravenholm until the final climactic battle in a (appropriate) graveyard. “I thought Ravenholme really needed an action-packed ending, worthy of a horror movie,” says Casali. “What better place to do that than in a cemetery?”
The final encounter between Freeman and Grigori, besieged by an army of zombies and headcrabs, releases some of the tension built up while exploring the spooky streets of Ravenholm, but this level is difficult to play It still leaves a lasting impression on those who did it. Changes in tone and style. This segment has essentially been around since the beginning of Half-Life 2’s long development (a version appeared in Valve’s famous 2003 E3 demo), and evolved into the final game’s ammo-starved spooky fest.
One of the standout games of the past 20 years, Half-Life 2 defined the future of video games with its innovative visuals and excellent physics engine. As part of the City 17 cabal, the activities of Casali and his colleagues were instrumental. “The desire to surpass the original Half-Life was so strong that we were constantly motivated by the quality of work other teams were doing,” he recalls. “It was magic.”
TRussian-born tech entrepreneur Pavel Durov founded wildly popular social networks and cryptocurrencies, amassed a multi-billion dollar fortune, and found himself at odds with authorities in Russia and around the world.
The man, who is just a few months away from his 40th birthday and has been nicknamed “Russia’s Zuckerberg” after Facebook founder Mark Zuckerberg, has now been arrested in France after being detained at a Paris airport this weekend.
The St. Petersburg native rose to fame in Russia in his 20s when he founded VKontakte (VK), a social network that catered to the needs of Russian-speaking users and surpassed Facebook across the former Soviet Union.
After disputes with Russian authorities and an ownership battle, he sold VKontakte and founded a new messaging service called Telegram, which quickly became popular but also became controversial after being criticized for its lack of control over extremist content.
As this drama raged, Durov remained a mercurial and at times enigmatic figure, rarely giving interviews and limiting himself to the occasional cryptic statement on Telegram.
A self-described libertarian, Durov has promoted internet secrecy and message encryption.
He has steadfastly refused to allow moderation of messages on Telegram, where users can post videos, photos, and comments to “channels” that anyone can follow.
Durov, 39, had an arrest warrant out for him in France for allegedly conducting a wide range of criminal activities on Telegram, including fraud, drug trafficking, cyberbullying, and organized crime, including promoting terrorism and fraud.
The investigation has been entrusted to the French national police’s cyber unit and the national anti-fraud office. The suspect was still in police custody on Sunday, according to two sources familiar with the case. He has not been charged with any crime.
In 2006, Durov, a graduate of St. Petersburg University, founded VK, which captivated users despite its mysterious founder.
In an act that epitomized his unpredictable behavior, Durov in 2012 hurled large banknotes at passersby from VK’s headquarters on the roof of a historic bookstore on Nevsky Prospect in St. Petersburg.
ITonga was plunged into darkness in the aftermath of a massive volcanic eruption in the early days of 2022. The undersea eruption, 1,000 times more powerful than the Hiroshima bomb, sent tsunamis into Tonga’s neighbouring islands and covered the islands’ white coral sand in ash.
The force of the eruption of the Hunga Tonga Hunga Ha’apai volcano cut off internet connections to Tonga, cutting off communications at the very moment the crisis began.
The scale of the disruption was clear when the undersea cables that carry the country’s internet were restored weeks later. The loss of connectivity hampered restoration efforts and dealt a devastating blow to businesses and local finances that rely on remittances from overseas.
The disaster has exposed extreme vulnerabilities in the infrastructure that underpins how the Internet works.
Nicole Starosielski, a professor at the University of California, Berkeley and author of “The Undersea Network,” says modern life is inseparable from the running internet.
In that sense, it’s a lot like drinking water: a utility that underpins our very existence, and like water, few people understand what it takes to get it from distant reservoirs to our kitchen taps.
Modern consumers have come to imagine the internet as something invisible floating in the atmosphere, an invisible “cloud” that rains data down on our heads. Many believe everything is wireless because our devices aren’t connected by cables, but the reality is far more unusual, Starosielski says.
An undersea internet cable laid on the ocean floor. Photo: Mint Images/Getty Images/Mint Images RF
Nearly all internet traffic — Zoom calls, streaming movies, emails, social media feeds — reaches us through high-speed fibre optics laid beneath the ocean. These are the veins of the modern world, stretching for around 1.5 million kilometres beneath the surface of the ocean, connecting countries through physical cables that conduct the internet.
Speaking on WhatsApp, Starosielski explains that the data transmitting her voice is sent from her phone to a nearby cell tower. “That’s basically the only radio hop in the entire system,” she says.
It travels underground at the speed of light from a mobile phone tower via fibre optic cable on land, then to a cable landing station (usually near water), then down to the ocean floor and finally to the cable landing station in Australia, where The Guardian spoke to Starosielski.
“Our voices are literally at the bottom of the ocean,” she says.
Spies, Sabotage, and Sharks
The fact that data powering financial, government and some military communications travels through cables little thicker than a hose and barely protected by the ocean water above it has become a source of concern for lawmakers around the world in recent years.
In 2017, NATO officials reported that Russian submarines were stepping up surveillance of internet cables in the North Atlantic, and in 2018 the Trump administration imposed sanctions on Russian companies that allegedly provided “underwater capabilities” to Moscow for the purpose of monitoring undersea networks.
At the time, Jim Langevin, a member of the House Armed Services Committee, said a Russian attack on the undersea cables would cause “significant harm to our economy and daily life.”
Workers install the 2Africa submarine cable on the beach in Amanzimtoti, South Africa, in 2023. Photo: Logan Ward/Reuters
Targeting internet cables has long been a weapon in Russia’s hybrid warfare arsenal: When Russia annexed Crimea in 2014, Moscow cut off the main cable connection to the peninsula, seizing control of the internet infrastructure and allowing the Kremlin to spread disinformation.
Global conflicts have also proven to wreak unexpected havoc on internet cable systems: In February, Iran-backed Houthi militants attacked a cargo ship in the Red Sea. The sinking of the Rubimaa likely cut three undersea cables in the region, disrupting much of the internet traffic between Asia and Europe.
The United States and its allies have expressed serious concerns that adversaries could eavesdrop on undersea cables to obtain “personal information, data, and communications.” A 2022 Congressional report highlighted the growing likelihood that Russia or China could gain access to undersea cable systems.
It’s an espionage technique the US knows all too well: in 2013, The Guardian revealed how Britain’s Government Communications Headquarters (GCHQ) had hacked into internet cable networks to access vast troves of communications between innocent people and suspected targets. This information was then passed on to the NSA.
Documents released by whistleblower Edward Snowden also show that undersea cables connecting Australia and New Zealand to the US were tapped, giving the NSA access to internet data in Australia and New Zealand.
Despite the numerous dangers and loud warnings from Western governments, there have been few calls for more to be done to secure cable networks, and many believe the threat is exaggerated.
The 2022 EU report said there were “no published and verified reports suggesting a deliberate attack on cable networks by any actor, including Russia, China or non-state groups.”
“Perhaps this suggests that the threat scenarios being discussed may be exaggerated.”
One expert speaking to the Guardian offered a more blunt assessment, describing the threat of sabotage as “nonsense”.
TeleGeography map of undersea internet cables connecting the US, UK and Europe. Photo: TeleGeography/https://www.submarinecablemap.com/
The data bears this out, showing that sharks, anchors and fishing pose a bigger threat to the global Internet infrastructure than Russian espionage. A US report on the issue said the main threat to networks is “accidental human-involved accidents.” On average, a cable is cut “every three days.”
“In 2017, a vessel accidentally cut an undersea communications cable off the coast of Somalia, causing a three-week internet outage and costing the country $10 million per day,” the report said.
An Unequal Internet
But for many experts, the biggest risk to the internet isn’t sabotage, espionage or even rogue anchors, but the uneven spread of the globe-spanning cable infrastructure that ties together the world’s digital networks.
“There aren’t cables everywhere,” Starosielski said. “The North Atlantic has a high concentration of cables connecting the U.S. and Europe, but the South Atlantic doesn’t have as many.”
“So you’re seeing diversity in terms of some parts of the world being more connected and having multiple routes in case of a disconnection.”
As of 2023, there are more than 500 communication cables on the ocean floor. Map of the world’s submarine cable networks These are found to be mainly concentrated in economic and population centres.
The uneven distribution of cables is most pronounced in the Pacific, where a territory like Guam, with a population of just 170,000 and home to a U.S. naval base, has more than 10 internet cables connecting the island, compared with seven in New Zealand and just one in Tonga, both with a population of more than 5 million.
The aftermath of the 2022 Tonga eruption spurred governments around the world to act, commissioning reports on the vulnerabilities of existing undersea cable networks while technology companies worked to harden networks to prevent a similar event from happening again.
Last month, Tonga’s internet went down again.
Damage to undersea internet cables connecting the island’s networks caused power outages across much of the country and disruption to local businesses.
For now, economic fundamentals favor laying cables to Western countries and emerging markets where digital demand is surging. Despite warnings of sabotage and accidental damage, without market imperatives to build more resilient networks, there is a real risk that places like Tonga will continue to be cut off, threatening the very promise of digital fairness that the internet is based on, experts say.
I
When the COVID-19 pandemic hit in 2020, it forced Krista Castro and Bryan Shin to rethink their lives. The couple, an animation director and programmer, had been working for major studios but wanted to create their own games. They decided to quit their jobs in 2021 and form A cozy gaming companion. They also became parents around the same time.
They set a goal to create a game in two years. By 2023, they had completed Fear the Spotlight, a ’90s-style horror adventure game. Although it received positive reviews on Steam, they struggled to market it and considered moving on. Then, Blumhouse, the successful horror film production company, approached them.
Blumhouse saw potential in Fear the Spotlight and offered to help. The couple was thrilled to collaborate with them as they shared a passion for horror. Together, they worked on an expanded version of the game set to release soon.
Fear the Spotlight captures the essence of ’90s horror with its atmospheric design and slow pace. Inspired by classic horror games and movies, the game aims to appeal to all horror enthusiasts, even those not typically into gaming.
The couple’s love for horror shines through in the game, incorporating elements from various horror media. With Blumhouse’s support, they look forward to sharing their vision with a wider audience.
The rats in John Cryan's lab were withdrawn and anxious, behaving in ways that mirrored those who had been bullied at work and who feared they might encounter the bully again.
Believe it or not, the good news is that they fed some of these rodents a slurry of microbes extracted from their own feces. This may sound unpleasant, but it had a surprisingly positive effect on their behavior. “That was surprising,” says Cryan, a neurobiologist at University College Cork in Ireland. “We found that the behavioral changes that were induced by stress were normalized, and they started to behave like normal animals.”
Even more surprising, the mental changes weren't brought about by changes to gut bacteria, but by modifying another key aspect of the microbiome whose importance is only now being recognized: viruses.
After all, our bodies are full of these viruses – trillions of stowaways that do no harm to our health, but instead play a key role in nurturing a beneficial microbiome and making us healthier. Recent studies have found that the influence of this “virome” can be found throughout the body, from the blood to the brain. The hope is that tweaking it might lead to new ways of treating a variety of ailments, from inflammatory bowel disease and obesity to anxiety.
Microbiome Diversity
Over the past decade, there has been a surge in interest in the microbiome (all the tiny organisms that live on and in our bodies), but that interest has focused primarily on bacteria. Until recently, the assumptions were that…
TOny, who is in his 50s, recently did a quick calculation of how much time he’s spent watching porn in his life. “The results were horrifying,” he says. Eight years. “It’s hard to even think about. The frustration is intense.”
Tony saw his first “hardcore” movie on VHS in the 1980s, when he was 12 years old. It was in his 20s that he first got online, which turned his habit into a “full-blown addiction.” For the past 30 years, he’s managed to maintain a double life: he works in care, has friendships and relationships with men and women. But there’s one side of him he keeps completely secret.
“So far, I’ve only told three people about this: two therapists, and now you,” he says. “I’ve kept it a complete secret from everyone I’ve ever known. I’m very careful to cover my tracks, even in relationships. My lack of interest in sex with my partner might be the only thing that makes her wonder.”
Tony has tried many times to stop watching porn but has never been able to go more than a month without it. He’s tried cutting down, banned masturbation, blocked porn sites, and tried to quit completely. But “the addict’s brain is very cunning and manipulative,” he says. He also tried therapy, but found it difficult to keep up with the costs long-term.
Still, Tony is grateful for one thing: he was young before the internet. “At least I had a normal youth. Parties, shows, adventures with friends. I had a girlfriend. I had a sex life. A guy like me doesn’t have that chance now.”
All statistics on pornography use in the UK and globally have skyrocketed due to the widespread use of mobile phones: in May 2023 alone, around 13.8 million people, a third of all internet-using adults, viewed pornography online. According to Ofcom
Of these, two-thirds were male. Although pornography companies do not report (or acknowledge) statistics on underage viewers, on average, children in the UK first see pornography at age 12. In a recent study, the Children’s Commissioner for England said: Much of what young people see is violent and extreme.
'TThe part where the mother and child get separated on the Red Mountain is a level fairly early in the game where you have to go back and find the mother. I was completing the sound design and music in the hospital. She was right next to my mother as she slept while she was recovering from open heart surgery. ”
Todd Baker pauses for a moment. He recalls the development process for Monument Valley 2, a 2017 indie puzzle game. Biggest success stories It will remain in the history of mobile games. The second game is more experimental than the first. The number of stories has increased and the atmosphere has changed. While the first title was all optical illusions and impossible objects, the sequel moves away from his MC Escher-inspired towers and spiers to non-Euclidean geometry and brutalism.
At the center of it all are a mother and daughter, wordlessly walking back and forth in each other's paths, desperately trying to stay together as the world heaves and undulates and does its best to tear them apart. It's about women's heritage and relationships, and for Todd there were parallels between fiction and reality. “The fact that this game is about a mother and a child, and the fact that I lost my mother at the end of the year when I was making this game, is very heartbreaking.”
“I wanted the music to speak and tell the story”…Monument Valley 2. Photo: ustwo
Monument Valley 2's soundtrack is the kind of music you want to listen to when you're not playing. Even when separated from the parent game, it's still very enveloping, very rich and textured, and provides a comfortable background for whatever you're doing. Waves of warm, organic tones and ambient, soothing sounds wash over you. This was always Baker's intention. Even before the unfortunate coincidence of fictional and real losses, Monument Valley 2's soundtrack was designed to be soothing, familiar, and gorgeous.
“Basically, what I was trying to do was create the sound of a really warm hug,” Baker said with a laugh, referring to one of the early stages of the game, when the child first comes to his mother. He described the moment he was held in his mother's arms. “At that moment, the kid comes in and I hug him, and there’s a lot of bass going on…I needed a really warm, fuzzy feeling, like this is where I want to be right now. .”
This moment in the game is very important. It's all about setting what's at stake. Yes, this story is abstract and minimalistic, but this moment has such power. Baker creates an impromptu acoustic guitar melody that he layered on three tracks and played on an EBow for a slightly supernatural sound, all backed up by an intoxicating supporting bass note, but it's not unlike the visuals here. I am doing a very important job. Establish everything that's at risk, Apple/iOS friendly, “bright on white”. If you don't watch the game to the end, you'll never see these two reunite.
That resonated with the audience, Baker said. “What's amazing is that now I get messages from people saying, 'This was the soundtrack of my childhood,'” Baker laughs. “They talked to me as adults now who were playing this game when they were 11 or 12 years old and said this is nostalgic and it's a safe space for them. It touches people's hearts. , they have a lot of nostalgia for it now.”
'It touched people's hearts'…Todd Baker performs music from Monument Valley 2 at London's V&A. Photo: ustwo
Baker was responsible for not only the music for Monument Valley 2, but also the entire sound design. Things like how a chime sounds when you swipe or tap on certain interactive elements, or how a little music plays as you explore a curious geometric world. It gets sucked in. This was an opportunity for him to emulate the approach Martin Stig Andersen took with Limbo and Inside. Both games had a huge influence on Monument Valley 2's audio, even though they couldn't be more different in tone.
“From the beginning, I was confident that I could do this. We were able to do the whole project holistically, including discussions about whether to license the music or use other artists for the trailer.” But for this one…I had to bring it myself. I wanted the music to speak and tell the story, and I wanted the rest of the development team to be really excited about it.”
As Baker says this, he imitates a hug and brings it around himself, recreating the hug he tried to evoke in the hearts and ears of players in the game's early moments. A decade after the original game was released, Apple still promotes both Monument Valley and the sequel on the App Store, with the latter installed on at least 30 million of his devices. There's no doubt that millions of people heard echoes of that hug and Baker's relationship with his mother. If you've never played this game with the sound on, find your headphones, head over to the App Store, and give it a try. I promise you, it's worth the effort.
A total solar eclipse is a great opportunity to learn about the sun
ESA/Royal Observatory of Belgium
A total solar eclipse occurs somewhere on Earth approximately every 18 months, and that has been the case throughout human history. Not surprisingly, people have been studying these dramatic events for just as long, with the first records of solar eclipses dating back more than 3,000 years. During that time, we learned an amazing amount about the Sun, Earth, and even the basic laws of physics from total solar eclipses.
For most of history, humans could only see the faint outermost layers of the sun during total days (periods when the moon covers the entire sun’s disc). This faint blanket of plasma, called the corona, has been central to the scientific advances resulting from the study of solar eclipses.
Solar eclipse in 2024
On April 8th, a total solar eclipse will pass over Mexico, the United States, and Canada. Our special series covers everything you need to know, from how and when to see a solar eclipse to the strangest solar eclipse experience of all time.
The corona is home to many of the sun’s most fascinating phenomena, including coronal mass ejections (CMEs), which occur when the sun’s swirling magnetic fields blast bundles or clumps of matter into space. If a CME were to hit Earth, it could damage satellites and power grids, and could be extremely dangerous to astronauts in space, beyond the protection of Earth’s atmosphere.
“The Sun’s magnetic activity changes over time and changes across the star’s surface.” meredith mcgregor at Johns Hopkins University in Maryland. Currently, there is no good way to predict this activity. But by studying the coronavirus, we may be able to start doing just that.
A total solar eclipse isn’t the only way to see the outermost layer of the sun. There is also a device called a coronagraph, which uses a shade to block the sun’s disk in a type of artificial solar eclipse. These instruments are used not only to study our own star, but also to study other stars that are more distant and look for planets around them that would otherwise be hidden in the glare of starlight. It is also important. “The idea of using coronagraphs to block out the light of other stars and look for extrasolar planets comes from natural solar eclipses,” MacGregor says.
The same dimness that makes the corona difficult to observe in totality also makes it an excellent target for spectroscopy. Spectroscopy works by splitting light into its constituent wavelengths. This allows researchers to determine which elements are present in a material by the unique pattern of wavelengths each element emits or absorbs. Helium was discovered using spectroscopy during a solar eclipse in 1868. This was the first time an element had been discovered by studying the sky.
Shortly thereafter, astronomers discovered what appeared to be another new element in the corona, which they named corona, but it turned out that it was simply iron heated to extraordinary temperatures of several million degrees. found. Even though it was not a new element, it was a puzzling discovery. The surface of the sun is only about 5,600 degrees Celsius, so why is the outermost layer so hot?
I said, “Imagine you’re at a campfire and you start walking away from the campfire. It’s supposed to be cold, but it’s much hotter.” Frederick Bartley at the Ohio State Science and Industry Center. “That’s what’s happening with coronavirus, but no one knows why.”
The eclipse also provided some of the first proofs of Albert Einstein’s theory of general relativity, which governs the behavior of large-scale gravity. One of the key predictions of general relativity is that massive objects should bend the trajectory of light as they pass by. Einstein first published the theory in his 1915, and evidence of its truth came in his 1919 when astronomer Arthur Eddington observed starlight bending around the sun during a solar eclipse.
As a total solar eclipse passes over Central and North America this month, astronomers will continue a long-standing tradition of using the totality to observe the sun and precisely how it affects the space around it. It turns out. The sun still has many secrets to unravel, and eclipses are one of the best times to study them.
It has been 100 days since the war in Gaza began, and it has become increasingly difficult to read the news. Her husband told me it might be time to talk to a therapist. Instead, on a cold winter morning, after fighting back tears as I read another tale of human tragedy, I turned to artificial intelligence.
“I’m pretty depressed about the state of the world,” I typed into ChatGPT. “It’s natural to feel overwhelmed,” the magazine responded, offering a list of practical advice, including limiting media exposure, focusing on the positive and practicing self-care.
I closed the chat. I was sure that I would benefit from doing all this, but at that moment I didn’t feel much better.
It may seem strange that an AI would even try to provide this kind of assistance. But millions of people have already turned to his ChatGPT, a professional therapy chatbot that provides convenient and inexpensive mental health support. Even doctors are said to be using AI to create more empathetic notes for patients.
Some experts say this is a boon. After all, AI may be able to express empathy more openly and tirelessly than humans, unhindered by shame or burnout. “We admire empathetic AI” by a group of psychological researchers I wrote recently.
But others are not so sure. Many people question the idea that AI can be empathetic and worry about the consequences if people seek emotional support from machines that can only pretend to care. Some even wonder if the rise of so-called empathic AI might change the way we think…
WWho is behind the most notorious ‘deepfake’ apps on the internet? The Guardian’s new podcast series ‘Black Box’ has been trying to answer that question for months now, as we explore a hall of mirrors. It was like wandering.
The app, ClothOff, has hundreds of thousands of followers and has already been used to generate dozens of images of underage girls in at least two cases. The photos have traumatized the girls, outraged their parents and left police at a loss as to how to stop it.
Producers Josh Kelly, Alex Atack and I followed Cross-Off’s footsteps to a nondescript, seemingly vacant address in central London. We’ve encountered fake businesses, distorted voices, and fake employee photos.
This was a frightening insight into the future we’re all heading into in our careers. In the age of artificial intelligence, is everything you see and hear on your screen real?
The search for ClothOff is just one story to tell about the times we live in. We’re in the first few years of AI infiltrating our lives, but it’s not yet deep enough that we can’t remember what life used to be.
We wanted to take a snapshot of this moment in time to explore the impact AI is already having on the world and look for clues about what’s to come. We met the scientists who pioneered AI software until they dramatically turned against it last year. We’ve heard stories of people reminiscing about their first dates with their boyfriends (smartphone chatbots), and stories of heartbreaks when the same lover turned cold due to system girlfriend updates. Ta.
We’ve been hearing about the prospect of AI systems that can detect cancer years before doctors and machines could offer desperate people what no one else has: humanity.
Everywhere we go, we encounter an even bigger mystery: people using AI. What has fascinated us again and again is the way in which we are already reshaping what it means to be human in a series about artificial intelligence that is not just about technology, but actually about us.
michael safi Presenters, today’s highlights
This week’s picks
Ash Sarkar, one of the hosts of If I Speak. Photo: Antonio Olmos/Observer
Hear Me Out Wide range of weekly episodes available Get to know some of the dramatic talents of multiple stars in this chatty theater podcast from actor Lucy Eaton. They each choose their favorite speech and act it out in a private chat, giving it a Desert Island Disc feel for the stage. In the first episode of the new series, hear Mark Gatiss perform Hamlet’s “Longing” and “Rage” “Speech the Speech” soliloquy from Jack Thorne’s Motives and Clues. Alexi Duggins
dead river Wide range of weekly episodes available This alarming story focuses on one of the most devastating environmental catastrophes in history: the 2015 Mariana Dam disaster in Brazil. The disaster led to the largest class action lawsuit in British history involving 700,000 claimants. It’s an emotional and worrying listen, packed with music that tugs at your heartstrings as you hear locals talk about their fears that the dam is sick. advertisement
The Blame of Fame: Milli Vanilli Wide range of weekly episodes available You may already know the story of Rob Pilatus and Fab Morvern, but Insecure’s Amanda Seales brings you the inside story in this fun podcast. When German producer Frank Farian asks the tight-trousered pop duo to make a deal with the devil, they are exposed as impostors, leading to exploitation and tragedy. Hannah Verdier
Time Capsule: Silver Chain Wide range of weekly episodes available The 1970s swing scene is the stuff of myth and legend, so when Paul Ditty heard that the secret club Silver Chain had kept a stash of newsletters in a safe deposit box, he couldn’t resist investigating. His brilliant unraveling of the mysterious Minnesota club begins with a simple question. How did they find the time to swap partners? HV
if i speak Wide range of weekly episodes available Novara Media journalists Ash Sarkar (above) and Moya Lothian-McLean have questions on their minds, including “Can I really be friends with my boss?” and “Are dating apps dead?” By grappling with questions, he swaps politics with personal (of sorts) issues. “Should I give my mom some money?” As Sarkar says, this is “the place where we can reveal our most free and nosy selves without judgment.” Holly Richardson
There’s a podcast for that
Comedian Paul Sinha hosts new podcast Pub Quiz. Photo: Martin Godwin/The Guardian
this week, robin winter choose the best five Comedy podcasts that actually teach you somethingfrom comedy quizzes with Chase star Paul Sinha to investigating urban legends in black culture.
Do Go On It’s surprising how little-known this Australian podcast is despite its longevity. Hosted by incredibly likeable Melbourne comedians Matt Stewart, Jess Perkins and Dave Warneke, each week one of them chooses a topic to report on. Recent episodes include History of Monopoly, Pirate Queen of Ireland, Eurovision, and more. Unlike many other long-running podcasts (Do Go On is entering its ninth year), the inside jokes are easy to follow and there’s a genuine, contagious enthusiasm from the trio.Rare podcasts that will make you laugh out loud and Full of fascinating stories.
Paul Sinha’s Perfect Pub Quiz The Chase’s Paul Sinha is also a popular touring comedian and combines these pursuits in this clever BBC Radio 4 podcast. If you can imagine him doing his set of tight 20-minute stand-up encyclopedias, you’ll be able to get pretty close to this vibrant show. In series two, Sinha takes his trivia skills to different parts of the country, testing Ipswich residents on their most famous politicians and Manchester’s tallest buildings. However, there is not much time to think, so the listener needs to respond quickly.
mom taught me Comedians Langston Carman and David Goboly explore black conspiracy theories, superstitions, urban legends, and, in their words, “the old lady’s story that your uncle told you about who wore jeans to the beach.” Dive deep into the world of “public pool. They often have hilarious guests to discuss reader suggestions. After almost 300 episodes, there’s no sign of running out of material.
big flop With only a handful of episodes to date, The Big Flop explores everything from the laughably bad movie Cats to the banned Four Loko, an alcoholic energy drink invented by a bunch of frazzled boys. It’s a show that focuses on events that didn’t go well. Hosted by actor, singer, and TikTok star Misha Brown, it was produced by pod giant Wonderly. Two weekly guests (mostly American stand-ups and performers) bring freshness to each episode, and thanks to an experienced behind-the-scenes team, it’s well-researched and well-produced.
That’s not true fish If you love comedy podcasts, you’ll be spoiled for choice with No Such Thing As a Fish, created by the writers of the long-running BBC quiz show QI. The authors started the podcast in 2014 after discovering interesting facts that weren’t aired during their research. Now his 500-episode podcast is the granddaddy of the genre, unapologetically nerdy but beautifully accessible even for non-Oxbridge fans. Winner of many well-deserved awards and published as a book, No Such Thing As a Fish is a must-listen for anyone looking for quirky facts to share at the pub table.
Why not try it…
In an 8-part series show on the streetcelebrities are taken out of the studio and presenter and veteran podcaster Alex Lugui takes the driver’s seat as they embark on a personal road trip through the places that shaped them.
just jack and will is the ultimate Will & Grace rewatch podcast with Sean Hayes and Eric McCormack.
Who is a good person? So who is the bad guy? alphabet boys Revealing secret investigations by the FBI, DEA, ATF, and other three-letter agencies in the United States.
Researchers at St. Jude Children’s Research Hospital have uncovered the structure of VMAT2, a crucial neurotransmitter transporter, shedding light on its interaction with drugs used to treat conditions like Tourette syndrome. This pioneering study offers insights into neurotransmitter transport and advances the field of neuropharmacology.
Neurons communicate through neurotransmitters, and experts at St. Jude Children’s Research Hospital have utilized their knowledge in structural biology to reveal the structure of vesicular monoamine transporter 2 (VMAT2), an essential component of neurotransmission.
By visualizing VMAT2 in different states, researchers can now better comprehend its function and how its different conformations impact drug binding. This knowledge is crucial for the development of drugs to treat hyperactivity disorders such as Tourette syndrome.
This work was recently published in the journal Nature. Monoamines, including dopamine, serotonin, and adrenaline, play a central role in neurotransmission by influencing various brain functions. Before they can be released, these molecules must be packaged into vesicles, which are compartments in cells that store neurotransmitters.
VMAT2 is a protein that moves monoamines into these vesicles, acting like a loading crane on a cargo ship. The study, led by researchers such as Dr. Chia-Hsueh Lee, Dr. Shabareesh Pidathala, and Dr. Yaxin Dai, utilized cryo-electron microscopy to analyze the structure of VMAT2 and its interactions with serotonin and drugs used to treat certain conditions.
The study revealed that different drugs bind to specific conformations of VMAT2, providing detailed insights that can aid in developing treatments for various disorders. The research also identified amino acids that facilitate neurotransmitter transport, laying the groundwork for future studies to fully understand the mechanisms involved.
The study was supported by grants from organizations such as the National Institutes of Health and the National Natural Science Foundation of China.
A new study investigated the relationship between shift work patterns, sociodemographic factors, and sleep disorders. They found that shift work, especially night shifts, significantly disrupted sleep, with about a third of all participants reporting at least one sleep disorder. The study also found that demographic factors such as gender, age, and education level influence sleep health.
A new study shows that working night shifts increases the incidence of sleep disorders, especially in young people with low levels of education.
Sleep is important not only for physical and mental health, but also for daytime and neurocognitive function. When people work in shifts (21% of workers in the European Union worked shifts in 2015), their circadian sleep-wake rhythms are often disrupted. Now, Dutch researchers have investigated the relationship between different shift work patterns, sociodemographic factors, and sleep disorders.
“Compared to working regular shifts during the day, working other shift types has been shown to have a higher incidence of sleep disturbances, especially those working rotational or regular night shifts,” GGZ Drenthe said Dr. Marike Lancel, a state mental health researcher.Institute and lead author of the study published in frontiers of psychiatry. “Notably, 51% of those working night shifts tested positive for at least one sleep disorder.”
ask about sleep
“There is a lot of evidence that shift work reduces sleep quality. However, there is little evidence of the impact that different types of shifts have on the prevalence of different sleep disorders and how this varies depending on demographic characteristics. “We know very little about whether they will,” Lancel continued.
To fill these gaps, researchers recruited more than 37,000 participants and provided demographic information indicating their shift work patterns (regular morning, evening, night, or switching between shifts).
They also completed a questionnaire screening on six common sleep disorder categories: insomnia, hypersomnia, parasomnias, sleep-related breathing disorders, sleep-related movement disorders, and circadian rhythm sleep-wake disorders.
Responses suggested that regular night shifts are the most debilitating condition when it comes to sleep. Half of night shift workers reported sleeping less than 6 hours in a 24-hour period, 51% reported one sleep disorder, and 26% reported two or more sleep disorders.
In the overall study population, approximately one-third tested positive for at least one sleep disorder and 12.6% tested positive for two or more sleep disorders.
Demographic factors and sleep health
Researchers also investigated whether demographic factors such as gender, age, and highest level of education influenced sleep health. We also considered whether participants lived alone, with a partner or children, or with others, such as friends or parents.
The results showed that although men slept less than women, sleep problems were more common in women. Age also affected sleep health. Although older participants tended to sleep less, most sleep disorders and their comorbidities were found to be more prevalent in the youngest participant group, those under 30 years of age.
Researchers found a correlation between education level and the likelihood of having disrupted sleep. “The effects of shift work on sleep are most pronounced among young people with low levels of education,” Lancel said. This group had shorter sleep duration and significantly higher prevalence of sleep disorders and their comorbidities.
Night shifts and sleep challenges
Researchers found that some people who work night shifts may have fewer sleep-related problems than others, but for the average night shift worker, this irregular work pattern can lead to less regular sleep-related problems. They said they would be more likely to struggle with healthy sleep. sleep. “People who work night shifts are unlikely to be completely immune to all the negative effects of night shifts, as they remain focused on their day jobs and out of sync with the environment in which they live,” Lancell said. explained.
The researchers also noted that their study had certain limitations. For example, people with sleep disorders may be more likely to participate in studies focused on sleep than people who sleep well. Nevertheless, the authors said their findings may provide important information for employers in occupations where shift work is common. It may also be used to educate strategies on how to best address and reduce the effects of night work and sleep days.
References: “Shift work is associated with widespread sleep disturbances, especially when working at night,” GJ Boersma, T. Mijnster, P. Vantyghem, GA Kerkhof, Marike Lancel, October 17, 2023. frontiers of psychiatry. DOI: 10.3389/fpsyt.2023.1233640
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