The Covid-19 pandemic may have hastened brain aging, even prior to infection. Studies indicate that early in the outbreak, the brain may have undergone changes equivalent to 5.5 months of aging, potentially attributed to stress and shifts in lifestyle.
Many individuals suffering from long Covid report experiencing brain fog. However, the wider neurological implications of the pandemic are not completely understood a few years post-Covid-19’s emergence.
To investigate this, Ali-Reza Mohammadi-Nejad at the University of Nottingham, along with his team, trained machine learning models using 15,000 brain scans to analyze structural changes related to aging.
A model was then applied to brain scans from 996 volunteers participating in the UK Biobank Study. This comprised 564 individuals who underwent both scans prior to March 2020, which acted as the control group. The remaining 432 volunteers had one scan before March 2020 and another later, with scans averaging three years apart and a minimum gap of two years.
The research revealed that the pandemic may have induced an acceleration of brain aging by 5.5 months, as evidenced by structural changes in both white and gray matter. This effect was also observed in individuals who had recorded Covid-19 infections as part of the Biobank project.
This accelerated aging effect was notably more significant among men and those from lower socioeconomic backgrounds. However, the results may not be generalizable, as biobank participants typically exhibit better health, higher income, and less ethnic diversity than other demographics within the UK.
Researchers propose that these alterations might have been driven by the isolation and stress of lockdowns, alongside changes in lifestyle factors like physical activity and alcohol use during that period.
In their study, the authors indicate that these structural brain changes could be “at least partially reversible,” while also acknowledging limitations stemming from the study’s UK-based participant pool, suggesting that the findings may not accurately represent lockdowns’ impact elsewhere. “Our conclusions may actually underestimate the pandemic’s effects on more vulnerable populations,” Mohammadi-Nejad asserts.
The pandemic may have changed people’s outlook for life
Disobeyart/Alamy
The Covid-19 pandemic has increased a stronger sense of purpose and life satisfaction as it deepened the appreciation of older adults in the UK for the simple things in life.
The happiness of some people Life satisfaction immersed in the early days of the pandemic however, after most restrictions have been lifted, what happened later is not much understood. “Unfortunately, most of the research conducted did not continue. [in the later years of] “Because it's a pandemic, there was a big gap in research.” Paola Zaninot University College London.
To address this, Zaninotto and her colleagues analyzed data from a survey on the well-being and depressive symptoms of approximately 4,000 people, primarily white.
Each participant completed the survey over two years from the second pandemic in the first year of the 2020 pandemic and the last participant between the end of 2021 and the last between 2023. The final survey of 2022 was after most infection control measures were concluded in the UK.
The team found that prior to the pandemic, participants rated their sense of purpose in life with an average score of 7.5 out of 10. This fell to 7.2 in 2020, rising from 7.6 in the final survey to 7.6 above pre-pandemic levels. .
Similarly, participants reported an average life satisfaction score of 7.3 prior to the pandemic, which fell to 6.9 early in the pandemic, but rose to 7.5 in the final survey.
These are small changes in happiness at the population level, but some individuals say they are experiencing major changes that affect their work and relationships. Rebecca Pierson At the University of Bristol, UK.
Zaninot may have reminded people of the importance of the global outbreak in life. “The pandemic has brought some challenges, but it has also brought a broad appreciation to our lives, perhaps about social connections and other meaningful activities,” she says.
The team also found that the average rate of depression (defined as having at least four depressive symptoms, such as feeling lonely) was more than doubled from the first to the second period. The final survey saw prices drop but exceeded pre-pandemic levels.
“People might feel like we've overcome it, I'm back to work, I've been able to see my family again.” You may be low at times and you may not be able to enjoy the same joy,” Pearson says. Furthermore, research needs to explore what drives these rates of depression increase, she says.
Additionally, additional studies say we need to investigate how results are converted to people elsewhere, Kelsey O'Connor At the National Institute of Statistics in Luxembourg. “The pandemic policy and the severity of the pandemic have been dramatically different in other countries,” he says. “You can't really generalize to young people, ethnic minorities, or marginalized groups.”
New coronavirus response hospital under construction in Wuhan, China
STR/AFP (via Getty Images)
It has been five years since the novel coronavirus disease emerged, causing a global pandemic with lasting impacts on societies, economies, and people's health.
Immediately after the virus was identified, many countries began making plans to treat the influx of severely ill people infected with COVID-19. The image above shows an excavator at the construction site of the purpose-built Huoshenshan Hospital in Wuhan, China, which became the initial epicenter of the outbreak on January 24, 2020.
People infected with covid-19 waiting for transit
STR/AFP (via Getty Images)
Huoshenshan was not the only hospital built in Wuhan as authorities prepared for the worst. In March 2020, people infected with the new coronavirus were photographed waiting to be transported from a general hospital in Wuhan to Leishenshan Hospital, which was also newly opened due to the pandemic.
Traffic decreases in New York City
Reuters/Andrew Kelly
Like many parts of the world, New York City began implementing restrictions around mid-March 2020. With the streets empty, ballet dancer Ashley Montague was able to perform in Times Square while wearing a gas mask.
COVID-19 wasn't the only thing going viral when this adorable baby started appearing on social media
Lillian Swanrunfa/AFP via Getty Images
Face shields were initially proposed as an alternative to masks to protect people from infection, but are increasingly discouraged as we learn more about the virus. Nevertheless, the above newborn photo taken at a hospital in Bangkok, Thailand, caught the internet's attention in early April 2020.
Social restrictions have forced some people to get creative.
Jim West/ZUMA Wire/Shutterstock
Like other public spaces, churches and other places of worship are closed in many parts of the world. A priest in Grosse Pointe Park, Michigan held a creative Easter service in April 2020, using water guns to hand out holy water while practicing social distancing.
Some people hugged through plastic due to concerns about infection.
Handout via Domenico Sartor/Reuters
Many nursing homes have been severely affected by the coronavirus, as the elderly are particularly susceptible to serious infections. The restrictions gave some visitors the chance to hug their loved ones through plastic sheets. The photo above was taken in November 2020 at a care home in Castelfranco Veneto, Italy.
Some people have turned their experiences living under the pandemic into works of art.
Reuters/Lim Huey Teng
The pandemic has inspired colorful and creative murals around the world. The photo above shows a young boy being swabbed for the SARS-CoV-2 virus in front of a COVID-19 artwork in Shah Alam, Malaysia, in December 2020.
Margaret Keenan from Coventry, UK, receives COVID-19 vaccination
Jacob King/Pool/EPA-EFE/Shutterstock
Expectations were high when the Pfizer/BioNTech vaccine was approved in the UK on December 2, 2020, after showing 95 per cent efficacy in late-stage trials. Six days later, 90-year-old Coventry resident Margaret Keenan became the first person to receive the vaccine outside of the trial.
Late Queen Elizabeth maintains social distancing at husband's funeral
Jonathan Brady – WPA Pool/Getty Images
Like many other queens, the late Queen Elizabeth II had to adhere to social distancing rules at her husband Prince Philip's funeral on April 17, 2021 at Windsor Castle, England. Due to pandemic restrictions, only 30 people were allowed to attend.
Monuments are being erected around the world to commemorate those who lost their lives to the new coronavirus infection.
Leon Neal/Getty Images
Britain's National Covid-19 Memorial Wall in London was built in March 2021 to commemorate those who have died from the disease. The photo above shows a woman leaving a message on the wall a year after it was created. Family members and volunteers painted more than 240,000 hearts on a 500-meter-long wall along the River Thames.
Public spaces were eventually opened up, but some things changed
Highly contagious avian influenza has been circulating around the world since 2020.
Ulises Ruiz/AFP via Getty Images
The H5N1 avian influenza virus that is circulating around the world is already more contagious than earlier strains. In addition, the single mutation allows it to infect cells lining the nose and throat, making it more likely to be transmitted through the air.
This change alone is not enough for the virus to cause a pandemic. But if a virus with this mutation swapped genes with a human influenza virus, it could acquire pandemic potential almost immediately.
“The more people are infected, the more likely this is to happen,” he says. Ian Wilson At the Scripps Research Institute in California. Despite this, Wilson believes the risk remains low.
A particularly virulent strain of avian influenza, H5N1, originated in the 1990s, probably in domestic birds in China, and spread around the world. Around 2020, a new variant of the virus emerged and spread even more widely, reaching as far as the Americas and Antarctica. In the United States, poultry is infected in large numbers, dairy cattle are also infected, and occasionally humans are infected.
team led by Debbie Van Riel Researchers at Erasmus University Medical Center in the Netherlands infected cells in human noses and throats with the 2005 and 2022 H5N1 variants. They showed for the first time that the 2022 mutant is better at binding to these cells and replicating within them. . “Bad news,” van Riel says.
“I don’t think it’s extremely likely that the virus will become a pandemic,” she says. However, the fact that this virus is better at infecting humans gives it more opportunity to acquire further mutations, increasing the likelihood of a pandemic.
Meanwhile, Wilson and his colleagues have been studying the key hemagglutinin protein of the influenza virus. This protein binds to receptors on the outside of cells and determines which cells the virus can infect. Because it sticks out from the virus, it is also the main target of the immune system.
Currently, H5N1 hemagglutinin primarily binds to receptors located deep in the lungs in humans. This means that although it can cause serious illness, it is unlikely to leave the body and infect others. For that to happen, the virus needs to infect the cells inside your nose and throat. This means that coughing and sneezing can expel the virus and infect others.
Van Riel's research suggests that the virus can do this to some extent, but it is not clear whether the virus binds to the main receptors on these cells. It was thought that multiple mutations were required for H5N1 to bind strongly to these receptors, but Wilson's team now shows that a single mutation is sufficient for the current H5N1 variants. Showed.
Team members say this change alone won’t prevent the virus from causing a pandemic. Jim Paulsonalso at the Scripps Research Institute. “We think this property is necessary, but importantly not sufficient, for pandemic virus transmission,” he says.
Paulson said other changes are also necessary for the virus to begin replicating and spreading from person to person, but they are not well understood. “There's a lot of biology we don’t know,” he says.
However, if H5N1 viruses that infect humans acquire receptor switching mutations, they may evolve these other changes as well.
Furthermore, it is possible, in theory, to acquire all the necessary abilities at once by exchanging genes with a human virus that infects the same individual. Several previous influenza pandemics have been caused by genetic swapping between animal and human influenza viruses, Paulson said.
“This is very worrying,” he says alice katsurakis from the University of Oxford was not involved in either study. “Every time it spreads to humans, it gives the virus a roll of the dice.”
What is the mortality rate of the H5N1 pandemic?
If H5N1 avian influenza begins to spread from person to person, the big question is how deadly it will be. Half of the people confirmed to have contracted the virus since 2003 have died. However, the actual infection fatality rate is likely to be even lower, as many cases likely go undetected and mild cases are likely to be missed.
Of the roughly 60 people infected in the U.S. since the dairy outbreak began, nearly all have had only mild symptoms. why not understoodbut one explanation is that many were infected through the eyes. “It’s known to have much more benign results,” Katzorakis says.
It is also thought to become less dangerous when the virus switches from binding to receptors deep in the lungs to binding to receptors in the upper airways. But puzzling aspects of the U.S. cases left Paulson unsure whether this also applied to H5N1. “To be honest, I don’t know what to think right now,” he says.
“I don’t think there’s any reason to be satisfied with this and expect that even if this virus were to be easily transmitted from person to person, it would be ‘mild,'” Katzourakis said.
Because Wilson’s team studied the hemagglutinin protein alone, there was no chance that the mutated protein could leak into the lab. “No viruses were used here at all,” he says.
People demonstrate outside the UK COVID-19 Inquiry site in London in October 2023.
Adrian Dennis/AFP via Getty Images
“The UK prepared for the wrong pandemic” This is the key conclusion from the first part of a government inquiry looking at the UK's response to the COVID-19 pandemic, in particular its preparedness and resilience.
“In 2019, it was widely believed, both in the UK and abroad, that the UK was not only well prepared to deal with a pandemic, but one of the best-prepared countries in the world. This belief proved dangerously wrong.” Heather HallettThe former judge leading the UK's coronavirus inquiry Video Statement Released at the same time Reports“The reality is that the UK was ill-prepared.”
“I have no hesitation in saying that the processes, plans and policies of the UK-wide civil emergency response arrangements have let down the people of all four countries,” Mr Hallett said. “There were serious errors on the part of the government and serious failings in the civil emergency system. This cannot be allowed to happen again.”
The main reason the UK was unprepared was because it planned on the assumption that the pandemic would be caused by a dangerous influenza strain or something similar, the report concluded, “which resulted in risk assessments being narrowly limited, excluding other types of pandemics.”
The next biggest mistake was assuming that because influenza spreads easily from person to person, there would be no way to stop the spread of a pandemic pathogen. “Plans were focused on dealing with the effects of the disease rather than preventing the spread of the disease,” the report said.
As a result, at the start of the COVID-19 pandemic, there were no plans to implement measures such as border controls, lockdowns, testing people or contact tracing to identify people who may have the coronavirus and stop them from infecting others.
“There was no preparation whatsoever for the fact that hygiene measures at the border might be necessary to protect the population,” the former health minister said. Matt Hancock Part of the problem, the inquiry said, is that because responsibility for health measures has been devolved between England, Scotland, Wales and Northern Ireland, it is not clear who can implement such measures.
The UK government also did not consider the possibility of a lockdown being necessary: ”There was no plan to introduce a lockdown.” Mark Woolhouse “Lockdowns were an ad-hoc public health intervention devised in real time in the face of a rapidly evolving public health emergency,” researchers from the University of Edinburgh in the UK said in a study.
Testing and tracing was envisioned as part of any response to new pathogens, but the capacity to do so was limited because it was assumed that any new infectious diseases would only have a small number of cases.
“One of the first lines of defence against a pandemic is containment, and this requires a test, trace and isolate system that can be rapidly expanded to meet the demands of a large outbreak,” Mr Hallett said. “This did not exist in the UK when the COVID-19 pandemic began.”
“The UK government's only pandemic plan, developed in 2011, was outdated and inadequate,” she said. “The UK government never applied or adapted it, and the principles on which it was based were ultimately abandoned, along with the 2011 strategy itself.”
The report does not explore the consequences of those failures, but a summary released with the report states that “further preparations could have avoided some of the enormous financial, economic and human costs of the COVID-19 pandemic.”
The inquiry will also look into decision-making and political governance in Westminster, Scotland, Wales and Northern Ireland, the impact on health systems across the UK, vaccines, medicines, anti-viral treatments, government procurement and PPE. [personal protective equipment]; the care sector, test and trace, the impact on children and young people, and the Government's business and finance response.
The latest report quoted a civil servant as saying: Chris Wormald “There's been a lot of discussion, of course, about countries like South Korea, who handled COVID very well. In fact, they had much higher standards of containment than we did, and that was a key difference.”
One of the aims of the review is to help the UK better prepare for the future. “The evidence overwhelmingly suggests that another, more infectious and deadly pandemic is likely in the near to medium term,” Hallett said. “This means that the UK will face another pandemic – one that, unless we prepare better, will cause untold suffering and huge economic loss, with the most vulnerable in society suffering the most.”
“This is a most urgent report because we are still not fully prepared for the next pandemic.” Duncan Robertson Loughborough University, UK Post to X.
When Gene Marrazzo was announced as director of the National Institute of Allergy and Infectious Diseases (NIAID) last year, he became one of the world's leading public health policymakers, and the responsibilities are heavier than ever before for the institute's new director, who will succeed Anthony Fauci, who held the position during the coronavirus pandemic and became a household name.
After decades of working on HIV prevention and sexually transmitted diseases, as well as overseeing COVID-19 treatment interventions, Marrazzo is now responsible for NIAID's $6.6 billion annual budget and the future of infectious disease control in the United States.
This includes working with the institute's 21 laboratories across the country, leading the fight against Ebola and HIV, and spearheading the development of new vaccines, treatments, diagnostics and technologies.
Top of Marrazzo's to-do list is tackling antimicrobial resistance (AMR), or drug-resistant superbugs, which are predicted to cause 10 million deaths a year and cost the global economy $1 trillion annually by 2050. In May, Britain's former chief medical officer warned that the rise of these pathogens could make pandemics seem “small” and that the problem is more serious than climate change.
Global warming is one of the factors contributing to the increase in drug-resistant bacteria, and changes in the climate conditions on Earth Salmonella Causes cholera Biblio To survive, we'll need to avoid our current antibiotic arsenal altogether. Here, Marrazzo outlines what we should probably fear most, and some developments we can expect in the near future.
‘TToday is the first day of your new life on this pristine and beautiful island. Well then, congratulations! ” says benevolent raccoon landlord Tom Nook minutes into Animal Crossing: New Horizons. (Nook gets a lot of hate online, but there’s no denying he’s very welcoming.) Many players read this comforting message during a time of uncertainty and fear in the real world. Animal Crossing: New Horizons was released on Nintendo Switch on March 20, 2020., days before the UK entered its first Covid lockdown.
This was fortuitous timing. When we were all stuck at home, thanks to this game you can plant local fruit, take care of your flowers, see what’s on offer in the shops in town, and play with Tom Nook. I was able to repay a large loan (thankfully interest free) and escape. Chaos and daily death toll. We opened the gates to our island and welcomed friends and strangers into our pristine little world. When real life fell apart, we started anew glasses cat, Sheep in a clown coat and rhinoceros like cake.
Due to the sudden popularity of the game Nintendo Switch sales status surge amid pandemic shortages. new horizons sold 44.79 million units By December 2023 – almost 3.5 times more than any other game in the Animal Crossing series since 2001. This is his second best-selling Switch game to date after Mario Kart 8 Deluxe.
“I visited a friend who was far away in real life”…Many people still play this game.
Player April said she and her partner Matthew have spent over 700 hours playing the game, turning their island into a collaborative…
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Strictly Necessary Cookies
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
