HHS discontinues research on vaccines and treatments for potential pandemics

The Trump administration has cancelled funds for dozens of research seeking new vaccines and treatments for Covid-19 and other pathogens that could cause a future pandemic.

The government’s rationale is that, according to internal NIH documents viewed by the New York Times, the community’s pandemic has ended and “provides a cause for the end of COVID-related grants.”

However, the research was not merely about Covid. 9 finished Award-funded center We will conduct research on antiviral drugs to combat so-called priority pathogens that could create an entirely new pandemic.

“This includes anti-viral projects designed to cover a wide range of families that could cause outbreaks or pandemics,” said a senior NIH official who spoke on condition of anonymity for fear of retaliation.

Vaccine research also didn’t focus on Covid, but on other coronaviruses that would one day jump from animals to humans.

Describing all studies as COVID-related is “completely inaccurate and merely a way to reduce infectious disease research,” officials said. Health Secretary Robert F. Kennedy Jr. said the NIH is focusing too much on infections, officials noted.

The funding suspension was first reported Science and Nature. The cancellation surprised scientists who relied on government support.

“The idea that there’s no need for further research to learn how to treat health issues caused by the coronavirus and prevent future pandemics is because “Covid-19 is over” is ridiculous,” says Pamela Bjorkman, a structural biologist at Caltech, who was studying the new vaccine.

The goal of the project was to prepare vaccines and drugs if a new pandemic hits it, rather than developing valuable months from scratch.

“In the last pandemic, we were really knocking down our pants,” said Paul Vienias, a virologist at Rockefeller University, working with Dr. Bjorkman.

“And unless you learn that lesson and prepare better for the next pandemic, you’ll rarely do better than last time.”

Dr. Beanius, Dr. Bjorkman and his colleagues were developing a vaccine that could protect them from a wide range of coronavirus species.

Researchers have discovered new strategies for caxing the immune system and learned how to recognize molecular features common to one or more viruses. The results of animal experiments were promising.

But now, their funds have been cut suddenly, and scientists say they doubted they could build on those outcomes. Dr. Vienias said the fire made him “angry, disappointed and frustrated.”

Other scientists were working on antiviral therapy, part of a program launched in 2021.

$577 million With support from the NIH, the lab’s nationwide network was studying how the virus was replicated and searching for drugs that could block them.

The researchers focused on the Viridae family, which contains the most worrying known pathogens, such as Ebola and Nipah virus. Scientists discovered many promising molecules and were moving forward towards clinical trials.

Reuben Harris, a molecular virologist at UT Health San Antonio, said the promising compounds revealed by the program include antiviral drugs that stop Ebola-related viruses from entering cells.

“We can deploy to help a lot of people quickly,” Dr. Harris said.

Several compounds appeared to work against many viral families. “We’ve seen a lot of experience in the world,” said Nevan Krogan, a systems biologist at the University of California, San Francisco.

On Wednesday morning, Dr. Krogan and dozens of colleagues gathered in the campus meeting room to confirm their results. And they also discussed what they could now, if any.

“One student asked me, ‘Well, I booked an experiment with this microscope tomorrow – can I do that?” “And I’m like, ‘Well, I don’t know.’ ”

Dr. Harris said that without ongoing support, the promising drugs he and others have discovered will not move into clinical trials. “It’s tragic – I don’t have too many words to explain it now,” he said.

In 2023, Kennedy said he wanted to take it. “break” From infectious disease research, instead focuses on chronic diseases.

Jason McClellan, a virologist at the University of Texas at Austin, was working on an antiviral drug program, but saw cancellations of pandemic research follow that promise.

Dr. McClellan, whose previous research was based on the creation of the 2020 Covid vaccine, said this week’s cuts made him wonder whether he could continue to study the pandemic in the United States.

“We’re starting to have conversations and plan to gather more information,” he said, noting the possibility of moving abroad.

“My lab is a structural virology lab focused on structural-based vaccine design,” he added. “If the focus is on chronic diseases, it doesn’t leave us much of a funding.”

Source: www.nytimes.com

Monitoring waste at only 20 airports can help identify potential pandemics

A network of airports like Hong Kong International Airport could effectively detect disease outbreaks

Yuen Man Cheung / Alamy

A global early warning system for disease outbreaks and future pandemics is possible with minimal surveillance. We test wastewater from just a few of our international flights at just 20 airports around the world.

If passengers fly while infected with bacteria or viruses, traces of these pathogens can be left in the waste, allowing airports to gather from the plane after the flight. “If you go to the airplane toilet, blow your nose and place it in the toilet, some of the genetic material from the pathogen can go. In the wastewater.” Guillaume St-Onge at Northeastern University, Massachusetts.

St-Onge and his colleagues used an A Simulator Called the Global Epidemic and Mobility Model, it analyzes how airport waste monitoring networks can detect new variants of the virus, such as those that cause Covid-19. By testing the model using different numbers and locations at airports, they have been able to provide 20 strategically located “sentinel airports” around the world and are as quickly as a network involving thousands of airports. It has been shown that occurrence can be detected efficiently. The larger network was only 20% faster, but cost more.

To detect new threats from anywhere in the world, your network should include major international airports in cities such as London, Paris, Dubai and Singapore. However, the team also showed how networks containing different airport sets could provide a more targeted detection of disease outbreaks that are likely to occur on a particular continent.

“This modeling study is the first to provide the actual number of sentinel airports needed to support effective global monitoring while optimizing resource use,” he says. jiaying li At the University of Sydney, Australia.

Additionally, airport-based networks provide useful information on disease outbreaks during an epidemic, such as how quickly diseases spread from person to person, and estimating people who may become infected from exposure to a single case. You can also do it, says ST-. Onge.

Such wastewater surveillance provides early warnings for known diseases and could also track new and emerging threats if genome data for bacterial or viral is available. “I don’t think I can look at the wastewater and say, ‘There’s a new pathogen out there.'” Temi Ibitoye At Brown University in Rhode Island. “But when new pathogens are announced, we can look at previous waste data very quickly and say, “Is this present in the sample?” “

A map of Sentinel Airport shows how quickly the network detects new disease outbreaks at various sites around the world

Northeastern University

There are still some nuances, such as the frequency of ingesting wastewater samples to track different pathogens. Other challenges include knowing the most efficient way to sample wastewater from an aircraft and assessing the actual effectiveness of the system, says Li.

Long-term surveillance programs also require cooperation from airlines and airports, along with consistent funding sources.

Individual airports can hesitate to participate as risks are recognized for business if infectious disease statistics become widely available. Unless a data processing agreement can alleviate such concerns, Trevor Charles At the University of Waterloo, Canada. He emphasized the importance of coordinated international funding to offset “local political considerations.”

However, given President Donald Trump’s launch of the US withdrawal from the organization, even coordination through international organizations such as the World Health Organization is bringing its own political complications, according to Ibitoye He said. Still, such research is “contributed to making it.” [the monitoring network] She says.

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Source: www.newscientist.com